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Entry version 73 (02 Jun 2021)
Sequence version 1 (05 Apr 2011)
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Protein

THO complex subunit 2

Gene

Thoc2l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
THO complex subunit 2ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Thoc2lImported
Synonyms:BC005561Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3040669, Thoc2l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9Q5E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q5E2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
346686

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079065, Expressed in camera-type eye and 232 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q5E2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130629

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q5E2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 418THOC2_NInterPro annotationAdd BLAST406
Domaini421 – 566THOC2_NInterPro annotationAdd BLAST146
Domaini568 – 643Thoc2InterPro annotationAdd BLAST76
Domaini873 – 1173Tho2InterPro annotationAdd BLAST301

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1184 – 1589DisorderedSequence analysisAdd BLAST406

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili298 – 318Sequence analysisAdd BLAST21
Coiled coili921 – 959Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1194 – 1210Polar residuesSequence analysisAdd BLAST17
Compositional biasi1221 – 1236Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1241 – 1263Polar residuesSequence analysisAdd BLAST23
Compositional biasi1264 – 1380Basic and acidic residuesSequence analysisAdd BLAST117
Compositional biasi1397 – 1414Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1445 – 1507Basic and acidic residuesSequence analysisAdd BLAST63
Compositional biasi1516 – 1582Basic and acidic residuesSequence analysisAdd BLAST67

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the THOC2 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1874, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00710000106792

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000511_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q5E2

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYMSIRN

Database of Orthologous Groups

More...
OrthoDBi
979205at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313127

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040007, Tho2
IPR021418, THO_THOC2_C
IPR021726, THO_THOC2_N
IPR032302, THOC2_N

The PANTHER Classification System

More...
PANTHERi
PTHR21597, PTHR21597, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11262, Tho2, 1 hit
PF11732, Thoc2, 1 hit
PF16134, THOC2_N, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q5E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMTSTTVVV PAEWIKTWEK SGRGEFLRLC RILSESKSRD TFAWRDFQQA
60 70 80 90 100
LYELSYHVIK GTLKPEQASN VLNDISEFRE DIPFILADIF CILDIETNCL
110 120 130 140 150
EEKSKRDHFT QLILACLYLV SDTVLKERLD PETLGSLGLI KQSQQFNQKS
160 170 180 190 200
VKIKTKLFYK QQKFNLLREE NEGYAKLIVE LGQDLSGNIT SDLILEILKS
210 220 230 240 250
LIGCFNLDPN RVLDIILEVF ECRPEHHDFF ISLLEAYMSM CEPHTLCHIL
260 270 280 290 300
GFKFKFYQEP NGETPSSLYR AAAVLLQFNL IDLDDLYVHL LPADSCIVSE
310 320 330 340 350
YKREIVEAKQ IVKKLTMVVL PSEKSDEREK EKKKDDKVEK APDNQKLGLL
360 370 380 390 400
EALLIIGDWK HAQSIMDHMP PYYATSHKVI ALAICNLIHI TIEPIYRRVG
410 420 430 440 450
VPKGAKGSPV NALQNKKAPK QAESFEDLRR DVFSMFYYLG PHLSHDPILF
460 470 480 490 500
AKVVRIGKSF MKEFQSDGKQ ENKEKMEAIL SCLLSVTDQV LLPSLSLMDC
510 520 530 540 550
NACMSEELWG MFKTFPYQHR YRLYGQWKNE TYNSHPLLVK VKAYTIDRAK
560 570 580 590 600
YIMKRLTKEN VKPSGRQIGK LSHSNPTILF DYILSQIQKY DNLITPVVDS
610 620 630 640 650
LKYLTALNYD VLAYCIIEAL ANPEKERMKH DDTTISNWLQ SLASFCGAVF
660 670 680 690 700
RKYPIDLAGL LQYVANQLKA GKSFDLLILK EVVQKMAGIE VTEEMTMEQL
710 720 730 740 750
EAMTGGEQLK AEGGYFGQIR NTKKSSQRLK DALLDHDLAL PLCLLMAQQR
760 770 780 790 800
NGVIFQEGGE KHLKLVGKLY DQCHDTLVQF GGFLASNLST DDYIKRVPSI
810 820 830 840 850
DVLCNEFHTP HDAAFFLSRP MYAHHISSKY DELKKSEKGS KQQHKVHKYI
860 870 880 890 900
MSCEMVMAPV HEAVVSLHIS KVWDDISPQF YTTFWSLTMY DLAVPHTSYE
910 920 930 940 950
REVNKLKIQM KAVDDSQEMP LNKKKKEKER CTALQDKLLE EEKKQTEHVQ
960 970 980 990 1000
RVLHRLKLEK DNWLLAKSTK NETITKFLQL CIFPRCIFSA IDSVYCAHFV
1010 1020 1030 1040 1050
ELVHQQKTPN FSTLLCYDRV FSDIIYMVAS FTENEASRYG RFLCCMLETV
1060 1070 1080 1090 1100
TRWHSDRSTY EKECGNYPGF LTILRATGFD GGNKADQLDY ENFRHVVHKW
1110 1120 1130 1140 1150
HYKLTKASVH CLETGEYTHI RNILIVLTKI LPWYPKVLNL GQALERRVHK
1160 1170 1180 1190 1200
ICQEEKEKKP DLYALAMVYS GQLKSRKSYM IPENEFHHKD PPPRNTATNL
1210 1220 1230 1240 1250
QPSGPCSGLP SSIGSMCKLD ESSAEEADKS RERAQCAVKA ANKASSVTPK
1260 1270 1280 1290 1300
GNLSNGNSGS NSKAVKENDK EKGKEKEKEK KEKTPAVTPE ARVLGKDSKE
1310 1320 1330 1340 1350
KPKEEQPNKD EKIREAKERM PKSDKDKEKL KKEEKAKDEK FRIIVANVES
1360 1370 1380 1390 1400
KSTQEREKEK EPSKERDLAK EMKSKENVKG GEKAPVSGSL KSPISRTDIT
1410 1420 1430 1440 1450
EPEREKRRKV DSHPSPSHSS TIKDSLVKLK ESSAKLYINH IPPLLCKSKE
1460 1470 1480 1490 1500
READKKDLDK SRERSREREK KEEKDRKERK RDYSNNDREA PLDLIKRRKD
1510 1520 1530 1540 1550
ENGILGVSKH KSESPCESLY PNEKDKEKMK SKSSGKEKGD SFKPEKIDKI
1560 1570 1580
SSGKKESGHD KEKIEKKEKW DGSGDKEEKK HHKTSDKHR
Length:1,589
Mass (Da):182,671
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54B81F9EB09ADF4E
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001160053.1, NM_001166581.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096452; ENSMUSP00000130629; ENSMUSG00000097392
ENSMUST00000239307; ENSMUSP00000159241; ENSMUSG00000097392
ENSMUST00000239420; ENSMUSP00000159295; ENSMUSG00000097392

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100042165

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100042165

UCSC genome browser

More...
UCSCi
uc008ykm.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001160053.1, NM_001166581.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130629

Proteomic databases

EPDiE9Q5E2
PaxDbiE9Q5E2
ProteomicsDBi346686

Genome annotation databases

EnsembliENSMUST00000096452; ENSMUSP00000130629; ENSMUSG00000097392
ENSMUST00000239307; ENSMUSP00000159241; ENSMUSG00000097392
ENSMUST00000239420; ENSMUSP00000159295; ENSMUSG00000097392
GeneIDi100042165
KEGGimmu:100042165
UCSCiuc008ykm.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100042165
MGIiMGI:3040669, Thoc2l

Phylogenomic databases

eggNOGiKOG1874, Eukaryota
GeneTreeiENSGT00710000106792
HOGENOMiCLU_000511_5_0_1
InParanoidiE9Q5E2
OMAiNYMSIRN
OrthoDBi979205at2759
TreeFamiTF313127

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100042165, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BC005561, mouse
RNActiE9Q5E2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079065, Expressed in camera-type eye and 232 other tissues
GenevisibleiE9Q5E2, MM

Family and domain databases

InterProiView protein in InterPro
IPR040007, Tho2
IPR021418, THO_THOC2_C
IPR021726, THO_THOC2_N
IPR032302, THOC2_N
PANTHERiPTHR21597, PTHR21597, 1 hit
PfamiView protein in Pfam
PF11262, Tho2, 1 hit
PF11732, Thoc2, 1 hit
PF16134, THOC2_N, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q5E2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q5E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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