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Entry version 60 (08 May 2019)
Sequence version 2 (16 Mar 2016)
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Protein

E3 ubiquitin-protein ligase RNF213

Gene

Rnf213

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3947 – 3986RING-typePROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transferase
Biological processAngiogenesis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF213 (EC:2.3.2.27By similarity, EC:3.6.4.-By similarity)
Alternative name(s):
Mysterin1 Publication
RING finger protein 213Curated
RING-type E3 ubiquitin transferase RNF213Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rnf213Imported
Synonyms:Mystr1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1289196 Rnf213

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. Males and female are fertile and produce normal-sized litters (PubMed:23410753, PubMed:24440776). Mice do not spontaneously develop Moyamoya disease, a chronic occlusive cerebrovascular disease (PubMed:24440776). Mice show elevated expression of MMP9 (PubMed:25383461).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4757R → K: Knockin mice grow normally and do not show any visible phenotype. Slightly impaired angiogenesis. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004159181 – 5152E3 ubiquitin-protein ligase RNF213Add BLAST5152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei196PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2234PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
E9Q555

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
E9Q555

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
E9Q555

PeptideAtlas

More...
PeptideAtlasi
E9Q555

PRoteomics IDEntifications database

More...
PRIDEi
E9Q555

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
E9Q555

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
E9Q555

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q555

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000070327 Expressed in 234 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
E9Q555 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
E9Q555 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; probably forms homohexamers.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
E9Q555, 1 interactor

Molecular INTeraction database

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MINTi
E9Q555

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091429

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3435 – 3465Sequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3947 – 3986RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHNB Eukaryota
ENOG410XTAN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00630000089884

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q555

Identification of Orthologs from Complete Genome Data

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OMAi
SARHLEW

TreeFam database of animal gene trees

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TreeFami
TF329577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR031248 RNF213
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR22605 PTHR22605, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382 AAA, 2 hits
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q555-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECPQCGHVS SEKAPKFCSE CGQKLPSAAT VQGDLKNDNT LVVSSTPEGK
60 70 80 90 100
TEQGAVLREE EVLLSSTDPG KELEKPEESD SNASWTTQMS KKEKRRRKRQ
110 120 130 140 150
GTISSSEAPS SGLWSLDMPP SPGSHNSALP QNQAQQGGAA SQPGHPLDTE
160 170 180 190 200
NMPMEDGFVH TEGSGSPLQG QAAERTDAQS NLAPSDLAEV KDLNTSKPSV
210 220 230 240 250
DKGLPLDGGP ALSAFKGHPK MTDASQKAPL PESKGETSGQ EKKVPPIDAA
260 270 280 290 300
ASPVKTAGKE TGEDVRKPKP SPVSPVASKH GDQEAELKGK LATPVRKSNE
310 320 330 340 350
GGNTQPEDQR KPGEGRNFAA AVKTQQAAAP QQAAAPEPTS AFNPRDTVTV
360 370 380 390 400
YFHAIVSRHF GFNPEEHKVY VRGGEGLGQK GWTDACEMYC TQDLHDLGSL
410 420 430 440 450
VEGKMDIPRQ SLDKPIPYKY VIHRGGSSKD TVEYEFIYEQ AQKKGEHVNR
460 470 480 490 500
CLRVVSTSLG NGDWHQYDDI ICMRSTGFFQ QAKNRILDST RKELLKGKKQ
510 520 530 540 550
AAVVMLDRIF SVLQPWSDIN LQSFMTQFLQ FYSVVREPMI HDGRARKWTS
560 570 580 590 600
LQYEEKEVWT NLWEHVKKQM APFLEGKSGE SLPADCPVRS KLTLGLSILF
610 620 630 640 650
MVEAAEFTVP KKDLDSLCYL LIPSAGSPEA LHSDLSPVLR IRQRWRIYLT
660 670 680 690 700
NLCLRCIDER CDRWLGILPL LHTCMQKSPP KKNSKSQPED TWAGLEGISF
710 720 730 740 750
SEFRDKAPTR SQPLQFMQSK MALLRVDEYL FRSWLSVVPL ESLSSYLENS
760 770 780 790 800
IDYLSDVPVR VLDCLQGISY RLPGLRKISN QNMKKDVENV FKMLMHLVDI
810 820 830 840 850
YQHRIFGENL LQIYLTECLT LHETVCNITA NHQFFEIPAL SAELICKLLE
860 870 880 890 900
LSPPGHTDEG LPEKSYEDLV TSTLQEALAT TRNWLRSLFK SRMLSISSAY
910 920 930 940 950
VRLTYSEEMA VWRRLVEIGF PEKHGWKGSL LGDMEGRLKQ EPPRLQISFF
960 970 980 990 1000
CSSQCRDGGL HDSVSRSFEK CVIEAVSSAC QSQTSVLEGL SCQDLQKFGT
1010 1020 1030 1040 1050
LLSAVITKSW PVHNGEPVFD VDEIFKYLLK WPDVRQLFEL CGTNEKIIDN
1060 1070 1080 1090 1100
ITEEGRQLMA TAESVFQKVA GELENGTIVV GQLELILEHQ SQFLDIWNLN
1110 1120 1130 1140 1150
RRRLPSQEKA CDVRSLLKRR RDDLLFLKQE KRYVESLLRQ LGRVKHLVQV
1160 1170 1180 1190 1200
DFGNIEIIHS QDLSNKKLNE AVIKLPNSSS YKRETHYCLS PDIREMASKL
1210 1220 1230 1240 1250
DSLKDSHIFQ DFWQETAESL NTLDKDPREL KVSLPEVLEY LYNPCYDNFY
1260 1270 1280 1290 1300
TLYENLKSGK ITFAEVDAIF KDFVDKYDEL KNDLKFMCTM NPQDQKGWIS
1310 1320 1330 1340 1350
ERVGQIKEYH TLHQAVSSAK VILQVRRALG VTGDFSVLNP LLNFADSFED
1360 1370 1380 1390 1400
FGNEKLDQIS PQFIKAKQLL QDISEPRQRC LEELARQTEL VAWLHKALED
1410 1420 1430 1440 1450
INELKVFVDL ASISAGENDI DVDRVACFHD AVQGYASLLY KMDERTNFSD
1460 1470 1480 1490 1500
FMNHLQELWR ALDNDQHLPD KLKDSARNLE WLKTVKESHG SVELSSLSLA
1510 1520 1530 1540 1550
TAINSRGVYV IEAPKDGQKI SPDTVLRLLL PDGHGYPEAL RTYSTEELKE
1560 1570 1580 1590 1600
LLNKLMLMSG KKDHNSNTEV EKFSEVFSNM QRLVHVFIKL HCAGNMLFRT
1610 1620 1630 1640 1650
WTAKVYCCPD GGIFMNFGLE LLSQLTEKGD VIQLLGALCR QMEDFLDNWK
1660 1670 1680 1690 1700
TVVAQKRAEH FYLNFYTAEQ LVYLSSELRK PRPSEAALMM LSFIKGKCTV
1710 1720 1730 1740 1750
QDLVQATSAC ESKADRYCLR EVMKKLPQQL LSEPSLMGKL QVIMMQSLVY
1760 1770 1780 1790 1800
MSAFLPHCLD LDALGRCLAH LATMGGTPVE RPLPKGLQAG QPNLILCGHS
1810 1820 1830 1840 1850
EVLPAALAIY MQAPRQPLPT FDEVLLCTPA TTIEEVELLL RRCLTSGSQG
1860 1870 1880 1890 1900
HKVYSLLFAD QLSYEVGCQA EEFFQSLCTR AHREDYQLVI LCDAAREHCY
1910 1920 1930 1940 1950
IPSTFSQYKV PLVPQAPLPN IQAYLQSHYQ VPKRLLSAAT VFRDGLCVGI
1960 1970 1980 1990 2000
VTSERAGVGK SLYVNTLHTK LKAKLRDETV PLKIIRLTEP HLDENQVLSA
2010 2020 2030 2040 2050
LLPFLKEKYQ KMPVIFHIDI STSVQTGIPI FLFKLLILQY LMDINGKIWR
2060 2070 2080 2090 2100
RSPGHLYLVE IPQGLSVQPK RSSKLNARAP LFKFLDLFPK VTCRPPKEVI
2110 2120 2130 2140 2150
DMELTPERSH TDPAMDPVEF CSEAFQRPYQ YLKRFHQQQN LDTFQYEKGS
2160 2170 2180 2190 2200
VEGSPEECLQ HFLIYCGLIN PSWSELRNFA WFLNCQLKDC EASIFCKSAF
2210 2220 2230 2240 2250
TGDTLRGFKN FVVTFMILMA RDFATPTLHT SDQSPGRQSV TIGEVVEEDL
2260 2270 2280 2290 2300
APFSLRKRWE SEPHPYVFFN GDHMTMTFIG FHLETNNNGY VDAINPSNGK
2310 2320 2330 2340 2350
VIKKDVMTKE LFDGLRLQRV PFNIDFDNLP RYEKLERLCL ALGIEWPIDP
2360 2370 2380 2390 2400
DETYELTTDN MLKILAIEMR FRCGIPVIIM GETGCGKTRL IKFLSDLKRG
2410 2420 2430 2440 2450
SVEAETMKLV KVHGGTTPSM IYSKVKEAER TAFSNKAQHK LDTILFFDEA
2460 2470 2480 2490 2500
NTTEAVSCIK EILCDRTVDG EHLHEDSGLH IIAACNPYRK HSQEMILRLE
2510 2520 2530 2540 2550
SAGLGYRVSA EETADRLGSI PLRQLVYRVH ALPPSLIPLV WDFGQLNDSA
2560 2570 2580 2590 2600
EKLYIQQIVQ RLVDSVSVNP SETCVIADVL SASQMFMRKR ENECGFVSLR
2610 2620 2630 2640 2650
DVERCVKVFR WFHDHSDMLL KELDKFLHES SDSTHTFERD PVLWSLVMAI
2660 2670 2680 2690 2700
GVCYHASLEE KASYRTAIAR CFPKPYNSSR AILDEVTHVQ DLFLRGAPIR
2710 2720 2730 2740 2750
TNIARNLALK ENVFMMVICI ELKIPLFLVG KPGSSKSLAK IIVADAMQGQ
2760 2770 2780 2790 2800
AAFSELFRCL KQVHLVSFQC SPHSTPQGII STFKQCARFQ QGKDLGQYVS
2810 2820 2830 2840 2850
VVVLDEVGLA EDSPKMPLKT LHPLLEDGCI EDDPAPYKKV GFVGISNWAL
2860 2870 2880 2890 2900
DPAKMNRGIF VSRGSPNEKE LIESAEGICS SDRLVQDKIR GYFAPFAKAY
2910 2920 2930 2940 2950
ETVCQKQDKE FFGLRDYYSL IKMVFAKAKA SKRGLSPQDI THAVLRNFSG
2960 2970 2980 2990 3000
KDNIQALSIF TASLPEARYK EEVSTVELIK QNIYPGPQAS SRGLDGAESR
3010 3020 3030 3040 3050
YLLVLTRNYV ALQILQQTFF EGQQPEIIFG SSFPQDQEYT QICRNINRVK
3060 3070 3080 3090 3100
ICMETGKMVV LLNLQNLYES LYDALNQYYV YLGGQKYVDL GLGTHRVKCR
3110 3120 3130 3140 3150
VHTAFRLIVI EEKDVVYKQF PVPLINRLEK HYLDMNTVLQ PWQKSIVQEL
3160 3170 3180 3190 3200
QQWAHEFADV KADQFIARHK YSPADVFIGY HSDACASVVL QAVERQGCRD
3210 3220 3230 3240 3250
LTEELYRKVS EEARSILLDC ATPDAVVRLS GSSLGSFTAK QLSQEYYYAQ
3260 3270 3280 3290 3300
QHNSFVDFLQ AHLRMTHHEC RAVFTEITTF SRLLTGNDCD VLASELRGLA
3310 3320 3330 3340 3350
SKPVVLSLQQ YDTEYSFLKD VRSWLTNPGK RKVLVIQADF DDGTRSAQLV
3360 3370 3380 3390 3400
ASAKYTAINE INKTQGTKDF VFVYFVTKLS RMGSGTSYVG FHGGLWRSVH
3410 3420 3430 3440 3450
IDDLRRSTIM ASDVTKLQNV TISQLFKPED KPEQEEMEIE TSQSKELAEE
3460 3470 3480 3490 3500
QMEVEDSEEM KKASDPRSCD CSQFLDTTRL VQSCVQGAVG MLRDQNESCA
3510 3520 3530 3540 3550
RNMRRVTILL DLLNEDNTRN ASFLRESKMR LHVLLNKQEE NQVRSLKEWV
3560 3570 3580 3590 3600
TREAANQDAL QEAGTFRHTL WKRVQDVVTP ILASMIAHID RDGNLELLAQ
3610 3620 3630 3640 3650
PDSPAWVQDL WMFIYSDIKF LNISLVLNNT RSNSEMSFIL VQSHMNLLKD
3660 3670 3680 3690 3700
AYNAVPFSWR IRDYLEELWV QAQYITDTEG LSKKFVEIFQ KTPLGVFLAQ
3710 3720 3730 3740 3750
FPVAQQQKLL QSYLKDFLLL TMKVSSREEL MFLQMALWSC LRELQEASGT
3760 3770 3780 3790 3800
PDETYKFPLS LPWVHLAFQH FRTRLQNFSR ILTIHPQVLS SLSQAAEKHS
3810 3820 3830 3840 3850
LAGCEMTLDA FAAMACAEML KGDLLKPSPK AWLQLVKNLS TPLELVCSEG
3860 3870 3880 3890 3900
YLCDSGSMTR SVIQEVRALW NRIFSIALFV EHVLLGTESH IPELSPLVTT
3910 3920 3930 3940 3950
YVSLLDKCLE EDSNLKTCRP FVAVMTTLCD CKDKASKKFS RFGIQPCFIC
3960 3970 3980 3990 4000
HGDAQDPVCL PCDHVYCLRC IQTWLIPGQM MCPYCLTDLP DKFSPTVSQD
4010 4020 4030 4040 4050
HRKAIEKHAQ FRHMCNSFFV DLVSTMCFKD NTPPEKSVID TLLSLLFVQK
4060 4070 4080 4090 4100
ELLRDASQKH REHTKSLSPF DDVVDQTPVI RSVLLKLLLK YSFHEVKDYI
4110 4120 4130 4140 4150
QNYLTQLEKK AFLTEDKTEL YLLFISCLED SVHQKTSAGC RNLEQVLREE
4160 4170 4180 4190 4200
GHFLRTYSPG LQGQEPVRIA SVEYLQEVAR VRLCLDLAAD FLSELQEGSE
4210 4220 4230 4240 4250
LAEDKRRFLK HVEEFCTRVN NDWHRVYLVR KLSSQRGMEF VQSFSKQGHP
4260 4270 4280 4290 4300
CQWVFPRKVI AQQVRNRKDH VSLMDRYLVH GNEYKAVRDA TAKAVLECKT
4310 4320 4330 4340 4350
LDIGNALMAC RSPKPQQTAY LLLALYTEVA ALYRSPNGSL HPEAKQLEAV
4360 4370 4380 4390 4400
NKFIKESKIL SDPNIRCFAR SLVDNTLPLL KIRSANSILK GTVTEMAVHV
4410 4420 4430 4440 4450
ATILLCGHNQ ILKPLRNLAF YPVNMANAFL PTMPEDLLVH ARTWRGLENV
4460 4470 4480 4490 4500
TWYTCPRGHP CSVGECGRPM QESTCLDCGL PVGGLNHTPH EGFSAIRNNE
4510 4520 4530 4540 4550
DRTQTGHVLG SPQSSGVAEV SDRGQSPVVF ILTRLLTHLA MLVGATHNPQ
4560 4570 4580 4590 4600
ALTVIIKPWV QDPQGFLQQH IQRDLEQLTK MLGRSADETI HVVHLILSSL
4610 4620 4630 4640 4650
LRVQSHGVLN FNAELSTKGC RNNWEKHFET LLLRELKHLD KNLPAINALI
4660 4670 4680 4690 4700
SQDERISSNP VTKIIYGDPA TFLPHLPQKS IIHCSKIWSC RRKITVEYLQ
4710 4720 4730 4740 4750
HIVEQKNGKE TVPVLWHFLQ KEAELRLVKF LPEILALQRD LVKQFQNVSR
4760 4770 4780 4790 4800
VEYSSIRGFI HSHSSDGLRK LLHDRITIFL STWNALRRSL ETNGEIKLPK
4810 4820 4830 4840 4850
DYCCSDLDLD AEFEVILPRR QGLGLCGTAL VSYLISLHNN MVYTVQKFSN
4860 4870 4880 4890 4900
EDNSYSVDIS EVADLHVISY EVERDLNPLI LSNCQYQVQQ GGETSQEFDL
4910 4920 4930 4940 4950
EKIQRQISSR FLQGKPRLTL KGIPTLVYRR DWNYEHLFMD IKNKMAQSSL
4960 4970 4980 4990 5000
PNLAISTISG QLQSYSDACE ALSIIEITLG FLSTAGGDPG MDLNVYIEEV
5010 5020 5030 5040 5050
LRMCDQTAQV LKAFSRCQLR HIIALWQFLS AHKSEQRLRL NKELFREIDV
5060 5070 5080 5090 5100
QYKEELSTQH QRLLGTFLNE AGLDAFLLEL HEMIVLKLKG PRAANSFNPN
5110 5120 5130 5140 5150
WSLKDTLVSY METKDSDILS EVESQFPEEI LMSSCISVWK IAATRKWDRQ

SR
Length:5,152
Mass (Da):584,784
Last modified:March 16, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i306631B8DC82EBE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A171EBL2A0A171EBL2_MOUSE
E3 ubiquitin-protein ligase RNF213
Rnf213
5,151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3U0U2Q3U0U2_MOUSE
E3 ubiquitin-protein ligase RNF213
Rnf213 D11Ertd759e
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC37048 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645911 Genomic DNA No translation available.
AK077880 mRNA Translation: BAC37048.1 Different initiation.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093902; ENSMUSP00000091429; ENSMUSG00000070327

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645911 Genomic DNA No translation available.
AK077880 mRNA Translation: BAC37048.1 Different initiation.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiE9Q555, 1 interactor
MINTiE9Q555
STRINGi10090.ENSMUSP00000091429

PTM databases

iPTMnetiE9Q555
PhosphoSitePlusiE9Q555
SwissPalmiE9Q555

Proteomic databases

EPDiE9Q555
jPOSTiE9Q555
PaxDbiE9Q555
PeptideAtlasiE9Q555
PRIDEiE9Q555

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093902; ENSMUSP00000091429; ENSMUSG00000070327

Organism-specific databases

MGIiMGI:1289196 Rnf213

Phylogenomic databases

eggNOGiENOG410IHNB Eukaryota
ENOG410XTAN LUCA
GeneTreeiENSGT00630000089884
InParanoidiE9Q555
OMAiSARHLEW
TreeFamiTF329577

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E9Q555

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000070327 Expressed in 234 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiE9Q555 baseline and differential
GenevisibleiE9Q555 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR031248 RNF213
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR22605 PTHR22605, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN213_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q555
Secondary accession number(s): F7A6H4, Q8BVK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 16, 2016
Last modified: May 8, 2019
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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