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Protein
Submitted name:

Rearranged L-myc fusion sequence

Gene

Rlf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • chromosome organization Source: MGI
  • DNA integration Source: MGI
  • histone H3-K4 monomethylation Source: MGI
  • regulation of DNA methylation Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rearranged L-myc fusion sequenceImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RlfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924705 Rlf

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q532

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q532

PRoteomics IDEntifications database

More...
PRIDEi
E9Q532

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q532

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q532

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049878 Expressed in 280 organ(s), highest expression level in saccule of membranous labyrinth

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q532 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q532 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127068

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini471 – 498C2H2-typeInterPro annotationAdd BLAST28
Domaini557 – 587C2H2-typeInterPro annotationAdd BLAST31
Domaini600 – 627C2H2-typeInterPro annotationAdd BLAST28
Domaini628 – 657C2H2-typeInterPro annotationAdd BLAST30
Domaini657 – 686C2H2-typeInterPro annotationAdd BLAST30
Domaini687 – 716C2H2-typeInterPro annotationAdd BLAST30
Domaini839 – 864C2H2-typeInterPro annotationAdd BLAST26
Domaini1057 – 1080C2H2-typeInterPro annotationAdd BLAST24
Domaini1193 – 1223C2H2-typeInterPro annotationAdd BLAST31
Domaini1245 – 1275C2H2-typeInterPro annotationAdd BLAST31
Domaini1290 – 1320C2H2-typeInterPro annotationAdd BLAST31

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153847

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKKIFAC

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q532-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWHLIYYSNF ITYLHSYLHC RSCFELLLSV SESELPCEVW VPFLQSLQES
60 70 80 90 100
HDALLEFGNN NLQILVHVTK EGVWKNPILL KILSQQPVET EEVNKLIAQE
110 120 130 140 150
GPSFLQMRIK HLLKSNCIPQ ATALSKLCAE SKELAQVSCF QQAYITCLCS
160 170 180 190 200
MLPSEEAIQE IAKVDCKDVL DIICNLESEG QDNTAFVLCT TYLTQQLQTA
210 220 230 240 250
SVYCSWELTL FWSKLQRRID PSLETFLERC RQFGVIAKTQ QHLFCLIRVI
260 270 280 290 300
QTEAQDAGIG VSILLCVRAL QLRSSEDEEM KASVCKTISC LLPEDLEVRR
310 320 330 340 350
ACQLTEFLIE PSLDGFNMLE ELYLQPDQKF DEENAPVPNS LRCELLLALK
360 370 380 390 400
AHWPFDPEFW DWKTLKRHCH QLLGQEASDS DDDLSGYEMS INDTDVLESF
410 420 430 440 450
LSDYDDGKED KQYRRSLTDQ NKEKRDKKPI GSSERYQRWL QYKFFCLLCK
460 470 480 490 500
RECIEARILH HSKMHMEDGI YTCPVCIKKF KRKELFVPHV MEHVKMPPSR
510 520 530 540 550
SHRSRKKLLL KSAQRGIYPK SPTGSLEQNP EQARGESHEY VTFSKLEDRR
560 570 580 590 600
LQDRDLYPCP GTDCSRVFKQ FKYLSVHLKA EHQNNDENAK HYLDMKNRRE
610 620 630 640 650
KCTYCRRHFM SAFHLREHEQ VHCGPQPYMC VSIDCYARFG SVNELLNHKQ
660 670 680 690 700
KHDDLRYKCE LNGCNIVFSD LGQLYHHEAQ HFRDASYTCN VLGCKKFYYS
710 720 730 740 750
KIEYQNHLSM HNVESPDGEL KKSVKLEEPG AGGKQDCVDQ SHLLDETEKS
760 770 780 790 800
HSLEDHHLCP GSASAHIDTT ETLKDNSDSN SSDQLSHSSS TSITEELIDT
810 820 830 840 850
LDHSETMQDL LLSHEKVFVP SSLKDKCSNV AVCFDGTKFT CGFDGCGSTY
860 870 880 890 900
KNARGMQKHL RKVHPYHCKP RKIKTKDLFN CLDDKHNEAD KFDAEPKPSS
910 920 930 940 950
DTNSDSPDEG PDHSIHTKCK REHQGYSPEP SICASKRPCT EDTMLELLLR
960 970 980 990 1000
LKHLSLKNSI AHGSFSGSLQ GCPSSGAKSL QSVPSSISDV NLQNQDENMP
1010 1020 1030 1040 1050
SQYLAQLAAK PFFCELQGCK YEFVTREALL MHYLKKHNYS KEKVLQLTMF
1060 1070 1080 1090 1100
QHRYSPFRCH ICQRSFTRKT HLRIHYKNKH QIGSDRATHR LLDSEKCDHE
1110 1120 1130 1140 1150
GPCSVDRLKG DCSTELGPNS NSETTQCHSK KDECSSETDL ESSCEETESK
1160 1170 1180 1190 1200
ISGISSPIGS HREEGEEKEG RGSRRTVAKG NLCYILNKYH KPFHCIHKTC
1210 1220 1230 1240 1250
NSSFTNLKGL IRHYRTVHQY NKEQLCLEKD KARTKRELVK CKKLFACKYK
1260 1270 1280 1290 1300
DCNKRFLCSK ALAKHCSDSH NLDHIEESKV LSETESAARF SCNQPQCPAV
1310 1320 1330 1340 1350
FYSFSKLKHH LLEQHNIEGE IHSDYEIHCT LNGCGQIFSH RSNYFQHVYY
1360 1370 1380 1390 1400
RHKDYYDNLF SSQKVANERL LRSEKVCQTT QAQGLTQTQG QTQGQTQGQE
1410 1420 1430 1440 1450
QQAAKRPFNT KAKKCGLLKD KKAPITFKTR AEAIHMCVEH SEHTQYPCMV
1460 1470 1480 1490 1500
QGCLSVVKLE SSIVRHYKRT HQMNSAYLEQ QLENLVVCVK YGTKIKDEPP
1510 1520 1530 1540 1550
SEVEPCVKKE ESTSCESVHT ENGAPGDSSV PLPNTDSTCP AEQDVGQKGC
1560 1570 1580 1590 1600
SERNPVFDTH SLLYRGTLKC NHSSETTSLE QCNIAQSSPC KIESPIPNPS
1610 1620 1630 1640 1650
GTESGTYFTD FQLPLPRIKE EPGQHSSGQE NTVKNATQVP KENIRKHSQP
1660 1670 1680 1690 1700
RSFDLKTYKP MGFESSFLKF IQESEEKDDD FDDWEPSEHL TLNNSSHPSN
1710 1720 1730 1740 1750
DLTGNVVADT IVNESAPQVD IPHSSSDPPV SENLTAVPPL VVAEATAVPS
1760 1770 1780 1790 1800
LENLRVVLDK ALTDCGELAL KQLHYLRPVV VLERSKFSTP ILDLFPTKKT

DELCVGSS
Length:1,808
Mass (Da):206,278
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF422BC639AEBD36E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A7F4A2A7F4_MOUSE
MCG122876
Rlf mCG_122876
1,918Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606927 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000168615; ENSMUSP00000127068; ENSMUSG00000049878

UCSC genome browser

More...
UCSCi
uc008uoa.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606927 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127068

PTM databases

iPTMnetiE9Q532
PhosphoSitePlusiE9Q532

Proteomic databases

MaxQBiE9Q532
PaxDbiE9Q532
PRIDEiE9Q532

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168615; ENSMUSP00000127068; ENSMUSG00000049878
UCSCiuc008uoa.1 mouse

Organism-specific databases

MGIiMGI:1924705 Rlf

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153847
OMAiCKKIFAC

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rlf mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049878 Expressed in 280 organ(s), highest expression level in saccule of membranous labyrinth
ExpressionAtlasiE9Q532 baseline and differential
GenevisibleiE9Q532 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q532_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q532
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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