Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate kinase

Gene

Pklr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (Gapdhs), Glyceraldehyde-3-phosphate dehydrogenase (Gm10358), Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Glyceraldehyde-3-phosphate dehydrogenase (Gapdhs), Glyceraldehyde-3-phosphate dehydrogenase (Gm3839), Glyceraldehyde-3-phosphate dehydrogenase (Gapdhs), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  2. Phosphoglycerate kinase 1 (Pgk1), Phosphoglycerate kinase 2 (Pgk2), Phosphoglycerate kinase (Pgk1), Phosphoglycerate kinase (Pgk1)
  3. no protein annotated in this organism
  4. Gamma-enolase (Eno2), Beta-enolase (Eno3), Enolase 4 (Eno4), Alpha-enolase (Eno1)
  5. Pyruvate kinase PKLR (Pklr), Pyruvate kinase PKM (Pkm), Pyruvate kinase (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase (Pklr), Pyruvate kinase (Pklr)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis
UniPathwayi
UPA00109;UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:PklrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:97604 Pklr

PTM / Processingi

Proteomic databases

MaxQBiE9Q509
PeptideAtlasiE9Q509
PRIDEiE9Q509

Expressioni

Gene expression databases

BgeeiENSMUSG00000041237 Expressed in 161 organ(s), highest expression level in liver
ExpressionAtlasiE9Q509 baseline and differential
GenevisibleiE9Q509 MM

Structurei

3D structure databases

ProteinModelPortaliE9Q509
SMRiE9Q509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 406PKInterPro annotationAdd BLAST352
Domaini423 – 540PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
GeneTreeiENSGT00390000008859
KOiK12406
OMAiMEGPAGY

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGPAGYLRR ASVAQLTQEL GTAFFQQQQL PAAMADTFLE HLCLLDIDSE
60 70 80 90 100
PVAARSTSII ATIGPASRSV DRLKEMIKAG MNIARLNFSH GSHEYHAESI
110 120 130 140 150
ANIREAAESF ATSPLSYRPV AIALDTKGPE IRTGVLQGGP ESEVEIVKGS
160 170 180 190 200
QVLVTVDPKF RTRGDAKTVW VDYHNITQVV AVGGRIYIDD GLISLVVRKI
210 220 230 240 250
GPEGLVTEVE HGGFLGNRKG VNLPNAEVDL PGLSEQDLLD LRFGVEHNVD
260 270 280 290 300
IIFASFVRKA SDVVAVRDAL GPEGRGIKII SKIENHEGVK KFDEILEVSD
310 320 330 340 350
GIMVARGDLG IEIPAEKVFL AQKMMIGRCN LAGKPVVCAT QMLESMITKA
360 370 380 390 400
RPTRAETSDV ANAVLDGADC IMLSGETAKG SFPVEAVKMQ HAIAREAEAA
410 420 430 440 450
VYHRQLFEEL RRAAPLSRDP TEVTAIGAVE ASFKCCAAAI IVLTKTGRSA
460 470 480 490 500
QLLSRYRPRA AVIAVTRSAQ AARQVHLSRG VFPLLYREPP EAVWADDVDR
510 520 530 540
RVQFGIESGK LRGFLRVGDL VIVVTGWRPG SGYTNIMRVL TIS
Length:543
Mass (Da):58,821
Last modified:April 5, 2011 - v1
Checksum:i23F15CD3840F26D9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P53657KPYR_MOUSE
Pyruvate kinase PKLR
Pklr
574Annotation score:
G3X925G3X925_MOUSE
Pyruvate kinase
Pklr mCG_17567
574Annotation score:
D3Z2C4D3Z2C4_MOUSE
Pyruvate kinase PKLR
Pklr
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161600 Genomic DNA No translation available.
RefSeqiNP_001093249.1, NM_001099779.1
UniGeneiMm.383180

Genome annotation databases

EnsembliENSMUST00000107482; ENSMUSP00000103106; ENSMUSG00000041237
GeneIDi18770
KEGGimmu:18770
UCSCiuc008pxq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161600 Genomic DNA No translation available.
RefSeqiNP_001093249.1, NM_001099779.1
UniGeneiMm.383180

3D structure databases

ProteinModelPortaliE9Q509
SMRiE9Q509
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9Q509
PeptideAtlasiE9Q509
PRIDEiE9Q509

Protocols and materials databases

DNASUi18770
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107482; ENSMUSP00000103106; ENSMUSG00000041237
GeneIDi18770
KEGGimmu:18770
UCSCiuc008pxq.1 mouse

Organism-specific databases

CTDi5313
MGIiMGI:97604 Pklr

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
GeneTreeiENSGT00390000008859
KOiK12406
OMAiMEGPAGY

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

ReactomeiR-MMU-70171 Glycolysis

Miscellaneous databases

ChiTaRSiPklr mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041237 Expressed in 161 organ(s), highest expression level in liver
ExpressionAtlasiE9Q509 baseline and differential
GenevisibleiE9Q509 MM

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q509_MOUSE
AccessioniPrimary (citable) accession number: E9Q509
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again