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Protein

AT-rich interactive domain-containing protein 1B

Gene

Arid1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Binds DNA non-specifically.2 PublicationsBy similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: MGI
  • dendritic cell dendrite assembly Source: MGI
  • dendritic spine development Source: MGI
  • neuron-neuron synaptic transmission Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 1B
Short name:
ARID domain-containing protein 1BCurated
Alternative name(s):
BRG1-associated factor 250bCurated
Short name:
BAF250BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arid1bImported
Synonyms:Baf250bCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1926129 Arid1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004424281 – 2244AT-rich interactive domain-containing protein 1BAdd BLAST2244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358Asymmetric dimethylarginineCombined sources1
Modified residuei454PhosphoserineBy similarity1
Modified residuei468PhosphoserineBy similarity1
Modified residuei477Asymmetric dimethylarginineCombined sources1
Modified residuei509Asymmetric dimethylarginineBy similarity1
Modified residuei1550PhosphoserineBy similarity1
Modified residuei1563PhosphoserineCombined sources1
Modified residuei1567PhosphoserineBy similarity1
Modified residuei1723PhosphoserineBy similarity1
Modified residuei1785N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q4N7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q4N7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
E9Q4N7

PeptideAtlas

More...
PeptideAtlasi
E9Q4N7

PRoteomics IDEntifications database

More...
PRIDEi
E9Q4N7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000069729 Expressed in 272 organ(s), highest expression level in pineal body

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q4N7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q4N7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of a SWI/SNF-like EBAFb complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, SMARCC1/BAF155, SMARCC2/BAF170, ARID1B/BAF250B, MLLT1/ENL and actin. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Interacts with SMARCC1/BAF155 (By similarity).2 PublicationsBy similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4Q3TKT45EBI-6900614,EBI-1210244

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
E9Q4N7, 3 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000111463

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
E9Q4N7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1061 – 1152ARIDPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi373 – 377LXXLLBy similarity5
Motifi1366 – 1385Nuclear localization signalBy similarityAdd BLAST20
Motifi2044 – 2048LXXLLBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 49His-richPROSITE-ProRule annotationAdd BLAST27
Compositional biasi52 – 78Gln-richPROSITE-ProRule annotationAdd BLAST27
Compositional biasi61 – 103Pro-richPROSITE-ProRule annotationAdd BLAST43
Compositional biasi87 – 355Gly-richPROSITE-ProRule annotationAdd BLAST269
Compositional biasi272 – 445Ala-richPROSITE-ProRule annotationAdd BLAST174
Compositional biasi898 – 1046Ser-richPROSITE-ProRule annotationAdd BLAST149
Compositional biasi1726 – 1753Glu-richPROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2510 Eukaryota
ENOG410Y034 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155634

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q4N7

KEGG Orthology (KO)

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KOi
K11653

Identification of Orthologs from Complete Genome Data

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OMAi
HQAKSHR

Database of Orthologous Groups

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OrthoDBi
256110at2759

TreeFam database of animal gene trees

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TreeFami
TF320364

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038040 ARID1B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C

The PANTHER Classification System

More...
PANTHERi
PTHR12656 PTHR12656, 1 hit
PTHR12656:SF11 PTHR12656:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q4N7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METGLLPNHK LKAVGEAPAA PPHQQHHHHH AHHHHHHHAH HLHHLHHHHA
60 70 80 90 100
LQQQLNQFQQ PQPPQPQQQQ PPPPPQQQHP TANNSLGGAG GGAPQPGPDM
110 120 130 140 150
EQPQHGGAKD SVAGNQADPQ GQPLLSKPGD EDDAPPKMGE PAGSRYEHPG
160 170 180 190 200
LGAQQQPAPV AVPGGGGGPA AVSEFNNYYG SAAPASGGPG GRAGPCFDQH
210 220 230 240 250
GGQQSPGMGM MHSASAAAGA PSSMDPLQNS HEGYPNSQYN HYPGYSRPGA
260 270 280 290 300
GGGGGGGGGG GGSGGGGGGG GAGGAGGAAA AAAGAGAVAA AAAAAAAAAA
310 320 330 340 350
AAGGGGGGGY GSSSSGYGVL SSPRQQGGGM MMGPGGGGAA SLSKAAAGAA
360 370 380 390 400
AAAGGFQRFA GQNQHPSGAT PTLNQLLTSP SPMMRSYGGS YPDYSSSSAP
410 420 430 440 450
PPPSQPQSQA AAGAAAGGQQ AAAGMGLGKD LGAQYAAASP AWAAAQQRSH
460 470 480 490 500
PAMSPGTPGP TMGRSQGSPM DPMVMKRPQL YGMGTHPHSQ PQQSSPYPGG
510 520 530 540 550
SYGPPGAQRY PLGMQGRAPG ALGGLQYPQQ QMPPQYGQQA VSGYCQQGQQ
560 570 580 590 600
PYYNQQPQPS HLPPQAQYLQ PAAAQSQQRY QPQQDMSQEG YGTRSQPPLA
610 620 630 640 650
PGKSNHEDLN LIQQERPSSL PDLSGSIDDL PTGTEATLSS AVSASGSTSS
660 670 680 690 700
QGDQSNPAQS PFSPHASPHL SSIPGGPSPS PVGSPVGSNQ SRSGPISPAS
710 720 730 740 750
IPGSQMPPQP PGSQSESSSH PALSQSPMPQ ERGFMTGTQR NPQMSQYGPQ
760 770 780 790 800
QTGPSMSPHP SPGGQMHPGI SNFQQSNSSG TYGPQMSQYG PQGNYSRTPT
810 820 830 840 850
YSGVPSASYS GPGPGMGINA NNQMHGQGPA QPCGAMPLGR MPSAGMQNRP
860 870 880 890 900
FPGTMSSVTP SSPGMSQQGG PGMGPPMPTV NRKAQEAAAA VMQAAANSAQ
910 920 930 940 950
SRQGSFPGMN QSGLVASSSP YSQSMNNNSS LMSTQAQPYS MTPTMVNSST
960 970 980 990 1000
ASMGLADMMS PSESKLSVPL KADGKEEGVS QPESKSKDSY GSQGISQPPT
1010 1020 1030 1040 1050
PGNLPVPSPM SPSSASISSF HGDESDSISS PGWPKTPSSP KSSSSSTTGE
1060 1070 1080 1090 1100
KITKVYELGN EPERKLWVDR YLTFMEERGS PVSSLPAVGK KPLDLFRLYV
1110 1120 1130 1140 1150
CVKEIGGLAQ VNKNKKWREL ATNLNVGTSS SAASSLKKQY IQYLFAFECK
1160 1170 1180 1190 1200
TERGEEPPPE VFSTGDSKKQ PKLQPPSPAN SGSLQGPQTP QSTGSNSMAE
1210 1220 1230 1240 1250
VPGDLKPPTP ASTPHGQMTP MQSGRSSTVS VHDPFSDVSD SAYPKRNSMT
1260 1270 1280 1290 1300
PNAPYQQGMG MPDMMGRMPY EPNKDPFSGM RKVPGSSEPF MTQGQVPNSG
1310 1320 1330 1340 1350
MQDMYNQSPS GAMSNLGMGQ RQQFPYGTSY DRRHEAYGQQ YPGQGPPTGQ
1360 1370 1380 1390 1400
PPYGGHQPGL YPQQPNYKRH MDGMYGPPAK RHEGDMYNMQ YGSQQQEMYN
1410 1420 1430 1440 1450
QYGGSYSGPD RRPIQGQYPY PYNRERMQGP GQMQPHGIPP QMMGGPMQSS
1460 1470 1480 1490 1500
SSEGPQQNMW ATRNDMPYPY QSRQGPGGPA QAPPYPGMNR TDDMMVPEQR
1510 1520 1530 1540 1550
INHESQWPSH VSQRQPYMSS SASMQPITRP PQSSYQTPPS LPNHISRAPS
1560 1570 1580 1590 1600
PASFQRSLES RMSPSKSPFL PTMKMQKVMP TVPTSQVTGP PPQPPPIRRE
1610 1620 1630 1640 1650
ITFPPGSVEA SQPILKQRRK ITSKDIVTPE AWRVMMSLKS GLLAESTWAL
1660 1670 1680 1690 1700
DTINILLYDD STVATFNLSQ LSGFLELLVE YFRKCLIDIF GILMEYEVGD
1710 1720 1730 1740 1750
PSQKALDHRS GKKDDSQSLE DDSGKEDDDA ECLVEEEEEE EEEEEDSEKI
1760 1770 1780 1790 1800
ESEGKSSPAL AAPDASVDPK ETPKQASKFD KLPIKIVKKN KLFVVDRSDK
1810 1820 1830 1840 1850
LGRVQEFSSG LLHWQLGGGD TTEHIQTHFE SKMEIPPRRR PPPPLSSTGK
1860 1870 1880 1890 1900
KKELEGKGDS EEQPEKSIIA TIDDVLSARP GALPEDTNPG PQTDSGKFPF
1910 1920 1930 1940 1950
GIQQAKSHRN IRLLEDEPRS RDETPLCTIA HWQDSLAKRC ICVSNIVRSL
1960 1970 1980 1990 2000
SFVPGNDAEM SKHPGLVLIL GKLILLHHEH PERKRAPQTY EKEEDEDKGV
2010 2020 2030 2040 2050
ACSKDEWWWD CLEVLRDNTL VTLANISGQL DLSAYTESIC LPILDGLLHW
2060 2070 2080 2090 2100
MVCPSAEAQD PFPTVGPNSV LSPQRLVLET LCKLSIQDNN VDLILATPPF
2110 2120 2130 2140 2150
SRQEKFYATL VRYVGDRKNP VCREMSMALL SNLAQGDTLA ARAIAVQKGS
2160 2170 2180 2190 2200
IGNLISFLED GVTMAQYQQS QHNLMHMQPP PLEPPSVDMM CRAAKALLAM
2210 2220 2230 2240
ARVDENRSEF LLHEGRLLDI SISAVLNSLV ASVICDVLFQ IGQL
Length:2,244
Mass (Da):237,795
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51AA79A5AE8B30A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6R4E9Q6R4_MOUSE
AT-rich interactive domain-containi...
Arid1b
2,243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q4N6E9Q4N6_MOUSE
AT-rich interactive domain-containi...
Arid1b
1,762Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6U8A0A338P6U8_MOUSE
AT-rich interactive domain-containi...
Arid1b
2,296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC126929 Genomic DNA No translation available.
AC132611 Genomic DNA No translation available.
AC166064 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS49929.1

NCBI Reference Sequences

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RefSeqi
NP_001078824.1, NM_001085355.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.133401

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000115797; ENSMUSP00000111463; ENSMUSG00000069729

Database of genes from NCBI RefSeq genomes

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GeneIDi
239985

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:239985

UCSC genome browser

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UCSCi
uc008aey.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126929 Genomic DNA No translation available.
AC132611 Genomic DNA No translation available.
AC166064 Genomic DNA No translation available.
CCDSiCCDS49929.1
RefSeqiNP_001078824.1, NM_001085355.1
UniGeneiMm.133401

3D structure databases

ProteinModelPortaliE9Q4N7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q4N7, 3 interactors
STRINGi10090.ENSMUSP00000111463

Proteomic databases

jPOSTiE9Q4N7
MaxQBiE9Q4N7
PaxDbiE9Q4N7
PeptideAtlasiE9Q4N7
PRIDEiE9Q4N7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115797; ENSMUSP00000111463; ENSMUSG00000069729
GeneIDi239985
KEGGimmu:239985
UCSCiuc008aey.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57492
MGIiMGI:1926129 Arid1b

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00940000155634
InParanoidiE9Q4N7
KOiK11653
OMAiHQAKSHR
OrthoDBi256110at2759
TreeFamiTF320364

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arid1b mouse

Protein Ontology

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PROi
PR:E9Q4N7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000069729 Expressed in 272 organ(s), highest expression level in pineal body
ExpressionAtlasiE9Q4N7 baseline and differential
GenevisibleiE9Q4N7 MM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR038040 ARID1B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
PANTHERiPTHR12656 PTHR12656, 1 hit
PTHR12656:SF11 PTHR12656:SF11, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI1B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q4N7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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