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Protein

AT-rich interactive domain-containing protein 1B

Gene

Arid1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Binds DNA non-specifically.2 PublicationsBy similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: MGI
  • dendritic cell dendrite assembly Source: MGI
  • dendritic spine development Source: MGI
  • neuron-neuron synaptic transmission Source: MGI

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 1B
Short name:
ARID domain-containing protein 1BCurated
Alternative name(s):
BRG1-associated factor 250bCurated
Short name:
BAF250BCurated
Gene namesi
Name:Arid1bImported
Synonyms:Baf250bCurated
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1926129 Arid1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004424281 – 2244AT-rich interactive domain-containing protein 1BAdd BLAST2244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei358Asymmetric dimethylarginineCombined sources1
Modified residuei454PhosphoserineBy similarity1
Modified residuei468PhosphoserineBy similarity1
Modified residuei477Asymmetric dimethylarginineCombined sources1
Modified residuei509Asymmetric dimethylarginineBy similarity1
Modified residuei1550PhosphoserineBy similarity1
Modified residuei1563PhosphoserineCombined sources1
Modified residuei1567PhosphoserineBy similarity1
Modified residuei1723PhosphoserineBy similarity1
Modified residuei1785N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiE9Q4N7
PaxDbiE9Q4N7
PeptideAtlasiE9Q4N7
PRIDEiE9Q4N7

Expressioni

Gene expression databases

BgeeiENSMUSG00000069729 Expressed in 272 organ(s), highest expression level in pineal body
ExpressionAtlasiE9Q4N7 baseline and differential
GenevisibleiE9Q4N7 MM

Interactioni

Subunit structurei

Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of a SWI/SNF-like EBAFb complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, SMARCC1/BAF155, SMARCC2/BAF170, ARID1B/BAF250B, MLLT1/ENL and actin. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Interacts with SMARCC1/BAF155 (By similarity).2 PublicationsBy similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4Q3TKT45EBI-6900614,EBI-1210244

Protein-protein interaction databases

IntActiE9Q4N7, 3 interactors
STRINGi10090.ENSMUSP00000111463

Structurei

3D structure databases

ProteinModelPortaliE9Q4N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1061 – 1152ARIDPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi373 – 377LXXLLBy similarity5
Motifi1366 – 1385Nuclear localization signalBy similarityAdd BLAST20
Motifi2044 – 2048LXXLLBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 49His-richPROSITE-ProRule annotationAdd BLAST27
Compositional biasi52 – 78Gln-richPROSITE-ProRule annotationAdd BLAST27
Compositional biasi61 – 103Pro-richPROSITE-ProRule annotationAdd BLAST43
Compositional biasi87 – 355Gly-richPROSITE-ProRule annotationAdd BLAST269
Compositional biasi272 – 445Ala-richPROSITE-ProRule annotationAdd BLAST174
Compositional biasi898 – 1046Ser-richPROSITE-ProRule annotationAdd BLAST149
Compositional biasi1726 – 1753Glu-richPROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00550000074575
InParanoidiE9Q4N7
KOiK11653
OMAiHQAKSHR
OrthoDBiEOG091G00GP
TreeFamiTF320364

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR038040 ARID1B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
PANTHERiPTHR12656 PTHR12656, 1 hit
PTHR12656:SF11 PTHR12656:SF11, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q4N7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METGLLPNHK LKAVGEAPAA PPHQQHHHHH AHHHHHHHAH HLHHLHHHHA
60 70 80 90 100
LQQQLNQFQQ PQPPQPQQQQ PPPPPQQQHP TANNSLGGAG GGAPQPGPDM
110 120 130 140 150
EQPQHGGAKD SVAGNQADPQ GQPLLSKPGD EDDAPPKMGE PAGSRYEHPG
160 170 180 190 200
LGAQQQPAPV AVPGGGGGPA AVSEFNNYYG SAAPASGGPG GRAGPCFDQH
210 220 230 240 250
GGQQSPGMGM MHSASAAAGA PSSMDPLQNS HEGYPNSQYN HYPGYSRPGA
260 270 280 290 300
GGGGGGGGGG GGSGGGGGGG GAGGAGGAAA AAAGAGAVAA AAAAAAAAAA
310 320 330 340 350
AAGGGGGGGY GSSSSGYGVL SSPRQQGGGM MMGPGGGGAA SLSKAAAGAA
360 370 380 390 400
AAAGGFQRFA GQNQHPSGAT PTLNQLLTSP SPMMRSYGGS YPDYSSSSAP
410 420 430 440 450
PPPSQPQSQA AAGAAAGGQQ AAAGMGLGKD LGAQYAAASP AWAAAQQRSH
460 470 480 490 500
PAMSPGTPGP TMGRSQGSPM DPMVMKRPQL YGMGTHPHSQ PQQSSPYPGG
510 520 530 540 550
SYGPPGAQRY PLGMQGRAPG ALGGLQYPQQ QMPPQYGQQA VSGYCQQGQQ
560 570 580 590 600
PYYNQQPQPS HLPPQAQYLQ PAAAQSQQRY QPQQDMSQEG YGTRSQPPLA
610 620 630 640 650
PGKSNHEDLN LIQQERPSSL PDLSGSIDDL PTGTEATLSS AVSASGSTSS
660 670 680 690 700
QGDQSNPAQS PFSPHASPHL SSIPGGPSPS PVGSPVGSNQ SRSGPISPAS
710 720 730 740 750
IPGSQMPPQP PGSQSESSSH PALSQSPMPQ ERGFMTGTQR NPQMSQYGPQ
760 770 780 790 800
QTGPSMSPHP SPGGQMHPGI SNFQQSNSSG TYGPQMSQYG PQGNYSRTPT
810 820 830 840 850
YSGVPSASYS GPGPGMGINA NNQMHGQGPA QPCGAMPLGR MPSAGMQNRP
860 870 880 890 900
FPGTMSSVTP SSPGMSQQGG PGMGPPMPTV NRKAQEAAAA VMQAAANSAQ
910 920 930 940 950
SRQGSFPGMN QSGLVASSSP YSQSMNNNSS LMSTQAQPYS MTPTMVNSST
960 970 980 990 1000
ASMGLADMMS PSESKLSVPL KADGKEEGVS QPESKSKDSY GSQGISQPPT
1010 1020 1030 1040 1050
PGNLPVPSPM SPSSASISSF HGDESDSISS PGWPKTPSSP KSSSSSTTGE
1060 1070 1080 1090 1100
KITKVYELGN EPERKLWVDR YLTFMEERGS PVSSLPAVGK KPLDLFRLYV
1110 1120 1130 1140 1150
CVKEIGGLAQ VNKNKKWREL ATNLNVGTSS SAASSLKKQY IQYLFAFECK
1160 1170 1180 1190 1200
TERGEEPPPE VFSTGDSKKQ PKLQPPSPAN SGSLQGPQTP QSTGSNSMAE
1210 1220 1230 1240 1250
VPGDLKPPTP ASTPHGQMTP MQSGRSSTVS VHDPFSDVSD SAYPKRNSMT
1260 1270 1280 1290 1300
PNAPYQQGMG MPDMMGRMPY EPNKDPFSGM RKVPGSSEPF MTQGQVPNSG
1310 1320 1330 1340 1350
MQDMYNQSPS GAMSNLGMGQ RQQFPYGTSY DRRHEAYGQQ YPGQGPPTGQ
1360 1370 1380 1390 1400
PPYGGHQPGL YPQQPNYKRH MDGMYGPPAK RHEGDMYNMQ YGSQQQEMYN
1410 1420 1430 1440 1450
QYGGSYSGPD RRPIQGQYPY PYNRERMQGP GQMQPHGIPP QMMGGPMQSS
1460 1470 1480 1490 1500
SSEGPQQNMW ATRNDMPYPY QSRQGPGGPA QAPPYPGMNR TDDMMVPEQR
1510 1520 1530 1540 1550
INHESQWPSH VSQRQPYMSS SASMQPITRP PQSSYQTPPS LPNHISRAPS
1560 1570 1580 1590 1600
PASFQRSLES RMSPSKSPFL PTMKMQKVMP TVPTSQVTGP PPQPPPIRRE
1610 1620 1630 1640 1650
ITFPPGSVEA SQPILKQRRK ITSKDIVTPE AWRVMMSLKS GLLAESTWAL
1660 1670 1680 1690 1700
DTINILLYDD STVATFNLSQ LSGFLELLVE YFRKCLIDIF GILMEYEVGD
1710 1720 1730 1740 1750
PSQKALDHRS GKKDDSQSLE DDSGKEDDDA ECLVEEEEEE EEEEEDSEKI
1760 1770 1780 1790 1800
ESEGKSSPAL AAPDASVDPK ETPKQASKFD KLPIKIVKKN KLFVVDRSDK
1810 1820 1830 1840 1850
LGRVQEFSSG LLHWQLGGGD TTEHIQTHFE SKMEIPPRRR PPPPLSSTGK
1860 1870 1880 1890 1900
KKELEGKGDS EEQPEKSIIA TIDDVLSARP GALPEDTNPG PQTDSGKFPF
1910 1920 1930 1940 1950
GIQQAKSHRN IRLLEDEPRS RDETPLCTIA HWQDSLAKRC ICVSNIVRSL
1960 1970 1980 1990 2000
SFVPGNDAEM SKHPGLVLIL GKLILLHHEH PERKRAPQTY EKEEDEDKGV
2010 2020 2030 2040 2050
ACSKDEWWWD CLEVLRDNTL VTLANISGQL DLSAYTESIC LPILDGLLHW
2060 2070 2080 2090 2100
MVCPSAEAQD PFPTVGPNSV LSPQRLVLET LCKLSIQDNN VDLILATPPF
2110 2120 2130 2140 2150
SRQEKFYATL VRYVGDRKNP VCREMSMALL SNLAQGDTLA ARAIAVQKGS
2160 2170 2180 2190 2200
IGNLISFLED GVTMAQYQQS QHNLMHMQPP PLEPPSVDMM CRAAKALLAM
2210 2220 2230 2240
ARVDENRSEF LLHEGRLLDI SISAVLNSLV ASVICDVLFQ IGQL
Length:2,244
Mass (Da):237,795
Last modified:April 5, 2011 - v1
Checksum:i51AA79A5AE8B30A9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6R4E9Q6R4_MOUSE
AT-rich interactive domain-containi...
Arid1b
2,243Annotation score:
E9Q4N6E9Q4N6_MOUSE
AT-rich interactive domain-containi...
Arid1b
1,762Annotation score:
A0A338P6U8A0A338P6U8_MOUSE
AT-rich interactive domain-containi...
Arid1b
2,296Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126929 Genomic DNA No translation available.
AC132611 Genomic DNA No translation available.
AC166064 Genomic DNA No translation available.
CCDSiCCDS49929.1
RefSeqiNP_001078824.1, NM_001085355.1
UniGeneiMm.133401

Genome annotation databases

EnsembliENSMUST00000115797; ENSMUSP00000111463; ENSMUSG00000069729
GeneIDi239985
KEGGimmu:239985
UCSCiuc008aey.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126929 Genomic DNA No translation available.
AC132611 Genomic DNA No translation available.
AC166064 Genomic DNA No translation available.
CCDSiCCDS49929.1
RefSeqiNP_001078824.1, NM_001085355.1
UniGeneiMm.133401

3D structure databases

ProteinModelPortaliE9Q4N7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q4N7, 3 interactors
STRINGi10090.ENSMUSP00000111463

Proteomic databases

MaxQBiE9Q4N7
PaxDbiE9Q4N7
PeptideAtlasiE9Q4N7
PRIDEiE9Q4N7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115797; ENSMUSP00000111463; ENSMUSG00000069729
GeneIDi239985
KEGGimmu:239985
UCSCiuc008aey.1 mouse

Organism-specific databases

CTDi57492
MGIiMGI:1926129 Arid1b

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00550000074575
InParanoidiE9Q4N7
KOiK11653
OMAiHQAKSHR
OrthoDBiEOG091G00GP
TreeFamiTF320364

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRSiArid1b mouse
PROiPR:E9Q4N7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069729 Expressed in 272 organ(s), highest expression level in pineal body
ExpressionAtlasiE9Q4N7 baseline and differential
GenevisibleiE9Q4N7 MM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR038040 ARID1B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
PANTHERiPTHR12656 PTHR12656, 1 hit
PTHR12656:SF11 PTHR12656:SF11, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARI1B_MOUSE
AccessioniPrimary (citable) accession number: E9Q4N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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