Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G-protein coupled receptor F2

Gene

Adgrf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

Miscellaneous

Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor F2
Alternative name(s):
G-protein coupled receptor 111
G-protein coupled receptor PGR20
Gene namesi
Name:Adgrf2
Synonyms:Gpr111, Pgr20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2182728 Adgrf2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 386ExtracellularCuratedAdd BLAST368
Transmembranei387 – 407Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini408 – 422CytoplasmicCuratedAdd BLAST15
Transmembranei423 – 443Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini444 – 465ExtracellularCuratedAdd BLAST22
Transmembranei466 – 486Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini487 – 493CytoplasmicCurated7
Transmembranei494 – 514Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini515 – 541ExtracellularCuratedAdd BLAST27
Transmembranei542 – 562Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini563 – 585CytoplasmicCuratedAdd BLAST23
Transmembranei586 – 606Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini607 – 610ExtracellularCurated4
Transmembranei611 – 631Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000043322819 – 644Adhesion G-protein coupled receptor F2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiE9Q4J9
PRIDEiE9Q4J9

PTM databases

iPTMnetiE9Q4J9
PhosphoSitePlusiE9Q4J9

Expressioni

Tissue specificityi

Mainly expressed in skin and heart, and very weakly in lung and spleen. Detected in all epidermal layers of skin.1 Publication

Developmental stagei

Expressed during embryonic development in the skin starting at embryonic day 12 with the formation of the basal layer of the skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000057899 Expressed in 10 organ(s), highest expression level in zone of skin

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109244

Structurei

3D structure databases

ProteinModelPortaliE9Q4J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 376GPSPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOGENOMiHOG000112762
HOVERGENiHBG051768
InParanoidiE9Q4J9
KOiK08454
OMAiILIVFHT
OrthoDBiEOG091G03WY
TreeFamiTF316380

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9Q4J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPAHWLYCL MLLLPIESCR ILCQASSKSK EKVTSRPHDV CDGVCNNNGT
60 70 80 90 100
PCFQSCPPDS EGNMKFACKA KKWHKVTETC HTLNTHSIFE EDKELYSVQS
110 120 130 140 150
SDSTIRTHMF HRELKTIMDT LMEKCPKDLS CVIKGIERSP RMPGNIAVVV
160 170 180 190 200
QLLHNISTTL TKDVNEEKMQ SYSAMANHIL NSKSISNWTF IQDRNSSCVL
210 220 230 240 250
LQSIHSFASK LFMKEHLINI SHVFIHTLGT VVSRGSLGKN FTFSMRINET
260 270 280 290 300
SDKVTGRLLL SPEELQKVPS AFQVISIAFP TLGAILEASL LENVTVNGLV
310 320 330 340 350
LSVILPEELK NISLIFEKIR KSGERKSQCV GWHSLESRWD WRACKTIQEN
360 370 380 390 400
SRQAVCRCRP NKLYTSFSIL MSPNTLESPV LTYITYIGLG ISICSLIICL
410 420 430 440 450
AIEVLVWSQV TKTEISYLRH LCIANIAATL LMADAWFIVA SFLSGPVLHH
460 470 480 490 500
NGCVAATFFV HFFYLSVFFW MLAKALLILY GILIVFHTLP KSCLVASLFS
510 520 530 540 550
VGYGCPLVIA IITLAVTEPG KGYLRPEACW LNWDMTKALL AFVVPALAIV
560 570 580 590 600
VVNLITVTMV IIKTQRAAIG SSMFQEVRAI VRICKNIAIL TPLLGLTWGF
610 620 630 640
GIATVINGHS LAFHIIFSLL NALQVSPDAA VDSELRECVH RFCG
Length:644
Mass (Da):71,764
Last modified:April 5, 2011 - v1
Checksum:i37F13B998F5FAA66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341W → R in AAI41354 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117257 Genomic DNA No translation available.
BC141353 mRNA Translation: AAI41354.1
CCDSiCCDS28792.2
RefSeqiNP_001028665.2, NM_001033493.2
UniGeneiMm.136350

Genome annotation databases

EnsembliENSMUST00000113614; ENSMUSP00000109244; ENSMUSG00000057899
GeneIDi435529
KEGGimmu:435529
UCSCiuc008cos.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117257 Genomic DNA No translation available.
BC141353 mRNA Translation: AAI41354.1
CCDSiCCDS28792.2
RefSeqiNP_001028665.2, NM_001033493.2
UniGeneiMm.136350

3D structure databases

ProteinModelPortaliE9Q4J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109244

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiE9Q4J9
PhosphoSitePlusiE9Q4J9

Proteomic databases

PaxDbiE9Q4J9
PRIDEiE9Q4J9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113614; ENSMUSP00000109244; ENSMUSG00000057899
GeneIDi435529
KEGGimmu:435529
UCSCiuc008cos.1 mouse

Organism-specific databases

CTDi222611
MGIiMGI:2182728 Adgrf2

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOGENOMiHOG000112762
HOVERGENiHBG051768
InParanoidiE9Q4J9
KOiK08454
OMAiILIVFHT
OrthoDBiEOG091G03WY
TreeFamiTF316380

Miscellaneous databases

PROiPR:E9Q4J9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057899 Expressed in 10 organ(s), highest expression level in zone of skin

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGRF2_MOUSE
AccessioniPrimary (citable) accession number: E9Q4J9
Secondary accession number(s): B9EJ67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again