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Protein

Ankyrin repeat domain-containing protein 11

Gene

Ankrd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (PubMed:25556659). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (By similarity). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (PubMed:17986521).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankrd11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924337 Ankrd11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2502E → K in Yoda; protein degradation is impaired. Homozygotes are embryonic lethal. Heterozygotes have reduced body size, craniofacial abnormalities, and reduced bone mineral density. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004363761 – 2643Ankyrin repeat domain-containing protein 11Add BLAST2643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei276PhosphoserineCombined sources1
Modified residuei408PhosphoserineBy similarity1
Modified residuei410PhosphothreonineBy similarity1
Modified residuei411PhosphoserineBy similarity1
Modified residuei838PhosphoserineBy similarity1
Modified residuei1070PhosphoserineCombined sources1
Modified residuei1111PhosphothreonineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1676PhosphoserineCombined sources1
Modified residuei1777PhosphoserineBy similarity1
Modified residuei1832PhosphoserineCombined sources1
Modified residuei1835PhosphotyrosineCombined sources1
Modified residuei1836PhosphotyrosineCombined sources1
Modified residuei1837PhosphoserineCombined sources1
Modified residuei1844PhosphoserineCombined sources1
Modified residuei1981PhosphoserineBy similarity1
Modified residuei2139PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Subject to proteasomal degradation which is probably essential to regulate its activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q4F7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q4F7

PRoteomics IDEntifications database

More...
PRIDEi
E9Q4F7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q4F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q4F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the cerebral cortex from embryonic stage E11 through to postnatal stage P3, where it is primarily expressed in neural precursors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035569 Expressed in 245 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q4F7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q4F7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the PAS region of the p160 coactivators.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000095939

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q4F7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati167 – 196ANK 1Sequence analysisAdd BLAST30
Repeati200 – 229ANK 2Sequence analysisAdd BLAST30
Repeati233 – 262ANK 3Sequence analysisAdd BLAST30
Repeati266 – 292ANK 4Sequence analysisAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2349 – 2643Important for protein degradationBy similarityAdd BLAST295

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi478 – 588Ser-richPROSITE-ProRule annotationAdd BLAST111
Compositional biasi625 – 1639Lys-richPROSITE-ProRule annotationAdd BLAST1015
Compositional biasi1819 – 1899Pro-richPROSITE-ProRule annotationAdd BLAST81
Compositional biasi2150 – 2262Pro-richPROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ47 Eukaryota
ENOG4110UQU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155966

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168254

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106759

KEGG Orthology (KO)

More...
KOi
K21436

Identification of Orthologs from Complete Genome Data

More...
OMAi
DQNRPTG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q4F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGGCSKTP QQEDFALSND MVEKQTGKKD KDKVSLTKTP KLDRSDGGKE
60 70 80 90 100
VRERATKRKL PFTVGANGEQ KDSDTEKQGP ERKRIKKEPV ARKSGLLFGM
110 120 130 140 150
GLSGIRAGYP LSERQQVALL MQMTAEESAN SPVDTTPKHP SQSTVCQKGT
160 170 180 190 200
PNSASKTKDK VNKRNERGET RLHRAAIRGD ARRIKELISE GADVNVKDFA
210 220 230 240 250
GWTALHEACN RGYYDIAKQL LAAGAEVNTK GLDDDTPLHD AANNGHYKVV
260 270 280 290 300
KLLLRYGGNP QQSNRKGETP LKVANSPTMV NLLLGKGTYT SSEESSTESS
310 320 330 340 350
EEEDAPSFAP SSSVDGNNTD SEFEKGLKLK AKNPEPQKTV TPVKDEYEFD
360 370 380 390 400
EDDEQDRVPP VDDKHLLKKD YRKEAKANSF ISIPKMEVKS YSKNNTLAPK
410 420 430 440 450
KAAHRILSDT SDEEDVSVSI GAGEKLRLSA HTMLPGSKAR ESSSSRQQKE
460 470 480 490 500
KNKLKKKRKK ETKGKEVRFG KRSDKFCSSG SESESSESEE DDGDSVGSSG
510 520 530 540 550
CLKGSPLVLK DPSLFSSLSA SSTSSHGSAV AQKHGSGHTD QHTKHWRTDN
560 570 580 590 600
WKAISSPAWS EVSSLSDSSR TGLTSESDCS SEGSSVESLK PTRRKQEHRK
610 620 630 640 650
RGVLQSAPSE KRSSFHPCTD GAVPKLDKEG KVVKKHKTKH KHKHKEKGQC
660 670 680 690 700
SVSQELKLKS FTYEYEDSKQ KSDKAILLES DLSTENKLKV LKHDREHLKK
710 720 730 740 750
EDKLGRMKPE DKDWLFKDEK VLKRIKDANK DMSRAFREDK DRASKAERER
760 770 780 790 800
ATKDKSPKEE KLRLYKEERK KKSKDRASRL ERKNDMKEDK LSKEKEKAFK
810 820 830 840 850
EDKEKLKKEK LYREDAAFDD YCNKSQFLDH EDTKFSLSDD QQERWFSDLS
860 870 880 890 900
DSSFDFKGED SWDSVTDYRD IKNDSVAKLI LETVKEDSKE KKRDNKIREK
910 920 930 940 950
RDFKDSFFRK RDRDCLDKNS EKRRDQTEKH KSIPSYLSEK DKKRRESAEG
960 970 980 990 1000
GRDRRDGRIR SEEVHREDLK ECGFESSFKD KSDCDFPKNL EPWERPHAAR
1010 1020 1030 1040 1050
EKEKKDALEK ERKEKGRADK YKEKSSERER SDKSTLDKCQ KDKEFEKCFK
1060 1070 1080 1090 1100
EKKDGKEKHK DIHSKDRKAS FDQLREKKEK VFSSIISEDF SERKDDRKGK
1110 1120 1130 1140 1150
EKSWYIADIF TDESEDEKDD CVAGSFKATE ASDTQRVDGL PEKEEGREHP
1160 1170 1180 1190 1200
SDRHRKSSSD RQHTEKPRDK EPKEKKKDRG ASEGGKDKKE KMEKIFEKHK
1210 1220 1230 1240 1250
EKKDKECAER YKDRKERASA DSAPEKKNKQ KLPEKVEKKH FAEDKVKSKH
1260 1270 1280 1290 1300
KEKPEKEHSR ERERKPSRGP DVEKSLLEKL EEEALHDYRE DSNDKISEVS
1310 1320 1330 1340 1350
SDSFADHGQE PSLSTLLEVS FSEPPAEDKA RDSACLSEKL REKERHRHSS
1360 1370 1380 1390 1400
SSSKKSHERE RAKKEKAEKK EKSEDYKDSI SSVRKDASQF EKDFLDAETY
1410 1420 1430 1440 1450
GVSYPTKADV EEELDKAIEL FSSEKKDRSD PEREPAKRIE KELKPYGSSA
1460 1470 1480 1490 1500
ISILKEKKKR EKHRERWREE KERHRDKHVD GFLRHHKDEP KPAAKDKDNP
1510 1520 1530 1540 1550
PNSFKEKSRE ESLKLSETKL KEKFKENTER EKGDSIKMSN GNDKLVPSRD
1560 1570 1580 1590 1600
SGKKDSRPRE KLLGDGDLMM TSFERMLSQK DLEIEERHKR HKERMKQMEK
1610 1620 1630 1640 1650
MRHRSGDPKL KEKKPTEDGR KKSLDFPSKK ALGLDKKVKE PAPTLTTGES
1660 1670 1680 1690 1700
KPHSGPGTES KDWLSGQPLK EVLPASPRTE QSRPTGVPTP TSVVSCPSYE
1710 1720 1730 1740 1750
EVMHTPRTPS CSADDYPDLV FDCTDSQHSM PVSTASTSAC SPPFFDRFSV
1760 1770 1780 1790 1800
ASSVVSENAA GQTPTRPIST NLYRSISVDI RRTPEEEFSA GDKLFRQQSV
1810 1820 1830 1840 1850
PAPSSFDSPV QHLLEEKAPL PPVPAEKFAC LSPGYYSPDY GIPSPKVDTL
1860 1870 1880 1890 1900
HCPPTAVVSA TPPPDSVFSN LPPKSSPSPR GELLSPAIEG TLPPDLGLPL
1910 1920 1930 1940 1950
DATEDQQATA AILPQEPSYL EPLDEGPFTT VITEEPVEWT HTAAEQGLSS
1960 1970 1980 1990 2000
SSLIASASEN PVSWPVGSEL MLKSPQRFAE SPKHFCPGES LHSTTPGPYS
2010 2020 2030 2040 2050
AAEPTYPVSP GSYPLPAPEP ALEEVKDGGT GAIPVAISAA EGAAPYAAPA
2060 2070 2080 2090 2100
RLESFFSNCK SHPDAPLDTA PEPTGVTAVA QVEALGPLES SFLDSNPSIS
2110 2120 2130 2140 2150
TLSQVEPVSW HEAFTSPEDD LDLGPFSLPE LPLQAKDASD VEAEAAKASP
2160 2170 2180 2190 2200
VPPAESPPGP TGVLGGGDVP APAAEEPPAP PPQEASPQLS TEPEPSEEPK
2210 2220 2230 2240 2250
LDVVLEATVE TEVLADDSAP EASISNSVPA PSPPQQQPPG GGDEEAETED
2260 2270 2280 2290 2300
PSATPCCAPD GPTTDGLAQA HNSAEASCVV AAAEGPPGNV QAEATDPEPK
2310 2320 2330 2340 2350
PTSEVPKAPK VEEVPQRMTR NRAQMLASQS KQGIPAAEKD PMPTPASRAK
2360 2370 2380 2390 2400
GRASEEEDAQ AQHPRKRRFQ RSSQQLQQQL NTSTQQTREV IQQTLAAIVD
2410 2420 2430 2440 2450
AIKLDAIEPY HSDRSNPYFE YLQIRKKIEE KRKILCCITP QAPQCYAEYV
2460 2470 2480 2490 2500
TYTGSYLLDG KPLSKLHIPV IAPPPSLAEP LKELFKQQEA VRGKLRLQHS
2510 2520 2530 2540 2550
IEREKLIVSC EQEILRVHCR AARTIANQAV PFSACTMLLD SEVYNMPLES
2560 2570 2580 2590 2600
QGDENKSVRD RFNARQFISW LQDVDDKYDR MKTCLLMRQQ HEAAALNAVQ
2610 2620 2630 2640
RMEWQLKAQE LDPAGHKSLC VNEVPSFYVP MVDVNDDFVL LPA
Length:2,643
Mass (Da):296,186
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9442C1C4500DC15A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4F8E9Q4F8_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd11
2,664Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UY79G3UY79_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd11
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM64A0A1D5RM64_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd11
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLV9A0A1D5RLV9_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd11
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239H → R in AAI58044 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC132287 Genomic DNA No translation available.
BC059876 mRNA Translation: AAH59876.1
BC158043 mRNA Translation: AAI58044.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40507.2

NCBI Reference Sequences

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RefSeqi
NP_001074848.2, NM_001081379.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.31567

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000098334; ENSMUSP00000095939; ENSMUSG00000035569

Database of genes from NCBI RefSeq genomes

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GeneIDi
77087

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:77087

UCSC genome browser

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UCSCi
uc009ntz.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132287 Genomic DNA No translation available.
BC059876 mRNA Translation: AAH59876.1
BC158043 mRNA Translation: AAI58044.1
CCDSiCCDS40507.2
RefSeqiNP_001074848.2, NM_001081379.2
UniGeneiMm.31567

3D structure databases

SMRiE9Q4F7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095939

PTM databases

iPTMnetiE9Q4F7
PhosphoSitePlusiE9Q4F7

Proteomic databases

MaxQBiE9Q4F7
PaxDbiE9Q4F7
PRIDEiE9Q4F7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098334; ENSMUSP00000095939; ENSMUSG00000035569
GeneIDi77087
KEGGimmu:77087
UCSCiuc009ntz.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29123
MGIiMGI:1924337 Ankrd11

Phylogenomic databases

eggNOGiENOG410IJ47 Eukaryota
ENOG4110UQU LUCA
GeneTreeiENSGT00940000155966
HOGENOMiHOG000168254
HOVERGENiHBG106759
KOiK21436
OMAiDQNRPTG

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ankrd11 mouse

Protein Ontology

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PROi
PR:E9Q4F7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035569 Expressed in 245 organ(s), highest expression level in heart
ExpressionAtlasiE9Q4F7 baseline and differential
GenevisibleiE9Q4F7 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR11_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q4F7
Secondary accession number(s): B2RY01, Q6PB57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 8, 2016
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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