Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Thyroid stimulating hormone beta subunit

Gene

Tshb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones
R-MMU-209968 Thyroxine biosynthesis
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Thyroid stimulating hormone beta subunitImported
Submitted name:
Thyrotropin subunit betaImported
Gene namesi
Name:TshbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:98848 Tshb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501509036219 – 138Sequence analysisAdd BLAST120

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000027857 Expressed in 54 organ(s), highest expression level in pituitary gland

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 125Cys_knotInterPro annotationAdd BLAST106

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IXJG Eukaryota
ENOG410YSY0 LUCA
GeneTreeiENSGT00390000010115
KOiK05251
OMAiDVCTYRD
OrthoDBiEOG091G0XFH
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q4F3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAVLLSVL FALACGQAAS FCIPTEYTMY VDRRECAYCL TINTTICAGY
60 70 80 90 100
CMTRDINGKL FLPKYALSQD VCTYRDFIYR TVEIPGCPHH VTPYFSFPVA
110 120 130
ISCKCGKCNT DNSDCIHEAV RTNYCTKPQS FYLGGFSV
Length:138
Mass (Da):15,387
Last modified:April 5, 2011 - v1
Checksum:i87386FF3E16FE3D0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P12656TSHB_MOUSE
Thyrotropin subunit beta
Tshb
138Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134871 Genomic DNA No translation available.
HF564717 Genomic DNA Translation: CCP37922.1
RefSeqiNP_001159411.1, NM_001165939.1
NP_001159412.1, NM_001165940.1
NP_033458.2, NM_009432.2
XP_006501364.1, XM_006501301.3
XP_006501367.1, XM_006501304.3
XP_006501368.1, XM_006501305.3
XP_017175024.1, XM_017319535.1
UniGeneiMm.110730

Genome annotation databases

EnsembliENSMUST00000029450; ENSMUSP00000029450; ENSMUSG00000027857
ENSMUST00000170856; ENSMUSP00000127165; ENSMUSG00000027857
ENSMUST00000172026; ENSMUSP00000128440; ENSMUSG00000027857
ENSMUST00000197322; ENSMUSP00000142670; ENSMUSG00000027857
ENSMUST00000200041; ENSMUSP00000142782; ENSMUSG00000027857
GeneIDi22094
KEGGimmu:22094
UCSCiuc008qrx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134871 Genomic DNA No translation available.
HF564717 Genomic DNA Translation: CCP37922.1
RefSeqiNP_001159411.1, NM_001165939.1
NP_001159412.1, NM_001165940.1
NP_033458.2, NM_009432.2
XP_006501364.1, XM_006501301.3
XP_006501367.1, XM_006501304.3
XP_006501368.1, XM_006501305.3
XP_017175024.1, XM_017319535.1
UniGeneiMm.110730

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029450; ENSMUSP00000029450; ENSMUSG00000027857
ENSMUST00000170856; ENSMUSP00000127165; ENSMUSG00000027857
ENSMUST00000172026; ENSMUSP00000128440; ENSMUSG00000027857
ENSMUST00000197322; ENSMUSP00000142670; ENSMUSG00000027857
ENSMUST00000200041; ENSMUSP00000142782; ENSMUSG00000027857
GeneIDi22094
KEGGimmu:22094
UCSCiuc008qrx.1 mouse

Organism-specific databases

CTDi7252
MGIiMGI:98848 Tshb

Phylogenomic databases

eggNOGiENOG410IXJG Eukaryota
ENOG410YSY0 LUCA
GeneTreeiENSGT00390000010115
KOiK05251
OMAiDVCTYRD
OrthoDBiEOG091G0XFH
TreeFamiTF332940

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones
R-MMU-209968 Thyroxine biosynthesis
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027857 Expressed in 54 organ(s), highest expression level in pituitary gland

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q4F3_MOUSE
AccessioniPrimary (citable) accession number: E9Q4F3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again