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Protein
Submitted name:

Histocompatibility 2, O region beta locus

Gene

H2-Ob

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation

Names & Taxonomyi

Protein namesi
Submitted name:
Histocompatibility 2, O region beta locusImported
Gene namesi
Name:H2-ObImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95925 H2-Ob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 221HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500324568522 – 245Sequence analysisAdd BLAST224

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9Q479
PRIDEiE9Q479

Expressioni

Gene expression databases

BgeeiENSMUSG00000041538 Expressed in 74 organ(s), highest expression level in lymph node
ExpressionAtlasiE9Q479 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9Q479
SMRiE9Q479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 187Ig-likeInterPro annotationAdd BLAST106

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140849

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGRAPWVV ALLVNLMRLD SFMIEGRDSP ENFVIQAKAD CYFTNGTEKV
60 70 80 90 100
HLLVRFIFNL EEYLHFDSDL GMFVALTELG EPDADQWNKR LDLLETSRAA
110 120 130 140 150
VNMVCRQKYK LGAPFTVERN GFYPGDISVK WFRNGQEERS GVMSTGLVRN
160 170 180 190 200
GDWTFQTTVM LEMIPELGDI YSCLVEHPGL LRPVSVAWMA QSEYSWKKIL
210 220 230 240
SGAAVFLLGL IVFLVGVVIH LKAQKASVET QPGNEASRES LHSQP
Length:245
Mass (Da):27,535
Last modified:April 5, 2011 - v1
Checksum:i75D919AC03C15073
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O35424O35424_MOUSE
Histocompatibility 2, O region beta...
H2-Ob H2-IAbeta2
271Annotation score:
G3UY15G3UY15_MOUSE
Histocompatibility 2, O region beta...
H2-Ob
205Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000167280; ENSMUSP00000129657; ENSMUSG00000041538
UCSCiuc008cbz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9Q479
SMRiE9Q479
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9Q479
PRIDEiE9Q479

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167280; ENSMUSP00000129657; ENSMUSG00000041538
UCSCiuc008cbz.1 mouse

Organism-specific databases

MGIiMGI:95925 H2-Ob

Phylogenomic databases

GeneTreeiENSGT00900000140849

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041538 Expressed in 74 organ(s), highest expression level in lymph node
ExpressionAtlasiE9Q479 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q479_MOUSE
AccessioniPrimary (citable) accession number: E9Q479
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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