Npffr1

Functionⁱ

GO - Molecular functionⁱ

neuropeptide receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hormone stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-MMU-416476 G alpha (q) signalling events

Reactomeⁱ

R-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Neuropeptide FF receptor 1Imported
Gene namesⁱ	Name:Npffr1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:2685082 Npffr1

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	42 – 69	HelicalSequence analysisAdd BLAST	28
Transmembraneⁱ	81 – 101	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	121 – 139	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	159 – 182	HelicalSequence analysisAdd BLAST	24
Transmembraneⁱ	215 – 237	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	270 – 295	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	315 – 334	HelicalSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	E9Q468
PRIDEⁱ	E9Q468

PTM databases

PhosphoSitePlusⁱ	E9Q468

PhosphoSitePlusⁱ

E9Q468

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn

Bgeeⁱ

ENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000020287

STRINGⁱ

10090.ENSMUSP00000020287

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E9Q468
SMRⁱ	E9Q468
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	60 – 331	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		272

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150833
InParanoidⁱ	E9Q468
KEGG Orthology (KO) More...KOⁱ	K04240
OMAⁱ	MCPSAIT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G098F
TreeFamⁱ	TF315303

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR005395 NPFF_rcpt IPR005396 NPFF_rcpt_1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01570 NPFFRECEPTOR PR01571 NPFFRECEPTR1
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

E9Q468-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAEPSQPPN GSWPPSLNES DAETAPVASL TFSSYYQHSS PVAAMFIAAY 
        60         70         80         90        100
ALIFLLCMVG NTLVCFIVLK NRHMRTVTNM FILNLAVSDL LVGIFCMPTT 
       110        120        130        140        150
LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR 
       160        170        180        190        200
EKLTLRKALL TIAVIWALAL LIMCPSAVTL TVTREEHHFM LDARNRSYPL 
       210        220        230        240        250
YSCWEAWPEK GMRKVYTAVL FAHIYLAPLA LIVVMYARIA RKLCQAPGPA 
       260        270        280        290        300
RDAEEAVAEG GRASRRRARV VHMLVMVALF FTLSWLPLWV LLLLIDYGEL 
       310        320        330        340        350
SELQLHLLSV YAFPLAHWLA FFHSSANPII YGYFNENFRR GFQAAFRAQL 
       360        370        380        390        400
CWLPWAAHKQ AYSERPGRLL RRRVVVDVQP SDSGLPSESG PSSGVPGPNR 
       410        420        430 
LPLRNGRVAH QDGPREGPGC NHMPLTIPAW NI

Length:432

Mass (Da):48,252

Last modified:April 5, 2011 - v1

Checksum:ⁱ9323CBD66A92C0E7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC124421 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001170982.1, NM_001177511.1
UniGeneⁱ	Mm.131297

Genome annotation databases

Ensemblⁱ	ENSMUST00000020287; ENSMUSP00000020287; ENSMUSG00000020090
GeneIDⁱ	237362
KEGGⁱ	mmu:237362
UCSC genome browser More...UCSCⁱ	uc007fgd.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
E9Q468	Neuropeptide FF receptor 1 (Fragment)		MOUSE		107	UniRef100_E9Q468
UPI0005AB9B35		MOUSE		315

Protein	Similar proteins		Species	Score	Length	Source
E9Q468	Neuropeptide FF receptor 1		RAT		432	UniRef90_Q9EP86
neuropeptide FF receptor 1		MESAU		432
Neuropeptide FF receptor 1 (Fragment)		MOUSE		107
UPI000A306724		MUSPA		432
UPI000B4F1553		MERUN		432
+9

Protein	Similar proteins		Species	Score	Length	Source
E9Q468	Neuropeptide FF receptor 1		HUMAN		430	UniRef50_Q9GZQ6
Neuropeptide FF receptor 1		RAT		432
Neuropeptide FF receptor 1		BOVIN		443
Uncharacterized protein		RHIRO		432
Uncharacterized protein		RHIBE		432
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC124421 Genomic DNA No translation available.
RefSeqⁱ	NP_001170982.1, NM_001177511.1
UniGeneⁱ	Mm.131297

3D structure databases

ProteinModelPortalⁱ	E9Q468
SMRⁱ	E9Q468
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000020287

STRINGⁱ

10090.ENSMUSP00000020287

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	E9Q468

PhosphoSitePlusⁱ

E9Q468

Proteomic databases

PaxDbⁱ	E9Q468
PRIDEⁱ	E9Q468

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020287; ENSMUSP00000020287; ENSMUSG00000020090
GeneIDⁱ	237362
KEGGⁱ	mmu:237362
UCSCⁱ	uc007fgd.2 mouse

Organism-specific databases

CTDⁱ	64106
MGIⁱ	MGI:2685082 Npffr1

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00930000150833
InParanoidⁱ	E9Q468
KOⁱ	K04240
OMAⁱ	MCPSAIT
OrthoDBⁱ	EOG091G098F
TreeFamⁱ	TF315303

Enzyme and pathway databases

Reactomeⁱ	R-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-MMU-416476 G alpha (q) signalling events

Reactomeⁱ

R-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn

Bgeeⁱ

ENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR005395 NPFF_rcpt IPR005396 NPFF_rcpt_1
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01570 NPFFRECEPTOR PR01571 NPFFRECEPTR1
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9Q468_MOUSE
Accessionⁱ	E9Q468Primary (citable) accession number: E9Q468
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	April 5, 2011
	Last modified:	November 7, 2018
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9Q468 (E9Q468_MOUSE)

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Neuropeptide FF receptor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ