UniProtKB - E9Q468 (E9Q468_MOUSE)
Protein
Submitted name:
Neuropeptide FF receptor 1
Gene
Npffr1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- neuropeptide receptor activity Source: InterPro
GO - Biological processi
- cellular response to hormone stimulus Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-MMU-416476 G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Submitted name: Neuropeptide FF receptor 1Imported |
Gene namesi | Name:Npffr1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685082 Npffr1 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 42 – 69 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 121 – 139 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 159 – 182 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 215 – 237 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 270 – 295 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 315 – 334 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn |
Structurei
3D structure databases
ProteinModelPortali | E9Q468 |
SMRi | E9Q468 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 331 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 272 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000153486 |
InParanoidi | E9Q468 |
KOi | K04240 |
OMAi | MCPSAIT |
OrthoDBi | 1308959at2759 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR005395 NPFF_rcpt IPR005396 NPFF_rcpt_1 |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01570 NPFFRECEPTOR PR01571 NPFFRECEPTR1 |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
E9Q468-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAEPSQPPN GSWPPSLNES DAETAPVASL TFSSYYQHSS PVAAMFIAAY
60 70 80 90 100
ALIFLLCMVG NTLVCFIVLK NRHMRTVTNM FILNLAVSDL LVGIFCMPTT
110 120 130 140 150
LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR
160 170 180 190 200
EKLTLRKALL TIAVIWALAL LIMCPSAVTL TVTREEHHFM LDARNRSYPL
210 220 230 240 250
YSCWEAWPEK GMRKVYTAVL FAHIYLAPLA LIVVMYARIA RKLCQAPGPA
260 270 280 290 300
RDAEEAVAEG GRASRRRARV VHMLVMVALF FTLSWLPLWV LLLLIDYGEL
310 320 330 340 350
SELQLHLLSV YAFPLAHWLA FFHSSANPII YGYFNENFRR GFQAAFRAQL
360 370 380 390 400
CWLPWAAHKQ AYSERPGRLL RRRVVVDVQP SDSGLPSESG PSSGVPGPNR
410 420 430
LPLRNGRVAH QDGPREGPGC NHMPLTIPAW NI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124421 Genomic DNA No translation available. |
RefSeqi | NP_001170982.1, NM_001177511.1 |
UniGenei | Mm.131297 |
Genome annotation databases
Ensembli | ENSMUST00000020287; ENSMUSP00000020287; ENSMUSG00000020090 |
GeneIDi | 237362 |
KEGGi | mmu:237362 |
UCSCi | uc007fgd.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124421 Genomic DNA No translation available. |
RefSeqi | NP_001170982.1, NM_001177511.1 |
UniGenei | Mm.131297 |
3D structure databases
ProteinModelPortali | E9Q468 |
SMRi | E9Q468 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000020287 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | E9Q468 |
Proteomic databases
PaxDbi | E9Q468 |
PRIDEi | E9Q468 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000020287; ENSMUSP00000020287; ENSMUSG00000020090 |
GeneIDi | 237362 |
KEGGi | mmu:237362 |
UCSCi | uc007fgd.2 mouse |
Organism-specific databases
CTDi | 64106 |
MGIi | MGI:2685082 Npffr1 |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000153486 |
InParanoidi | E9Q468 |
KOi | K04240 |
OMAi | MCPSAIT |
OrthoDBi | 1308959at2759 |
TreeFami | TF315303 |
Enzyme and pathway databases
Reactomei | R-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-MMU-416476 G alpha (q) signalling events |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR005395 NPFF_rcpt IPR005396 NPFF_rcpt_1 |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01570 NPFFRECEPTOR PR01571 NPFFRECEPTR1 |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | E9Q468_MOUSE | |
Accessioni | E9Q468Primary (citable) accession number: E9Q468 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 16, 2019 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |