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Protein
Submitted name:

Neuropeptide FF receptor 1

Gene

Npffr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Neuropeptide FF receptor 1Imported
Gene namesi
Name:Npffr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685082 Npffr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 69HelicalSequence analysisAdd BLAST28
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei121 – 139HelicalSequence analysisAdd BLAST19
Transmembranei159 – 182HelicalSequence analysisAdd BLAST24
Transmembranei215 – 237HelicalSequence analysisAdd BLAST23
Transmembranei270 – 295HelicalSequence analysisAdd BLAST26
Transmembranei315 – 334HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiE9Q468
PRIDEiE9Q468

PTM databases

PhosphoSitePlusiE9Q468

Expressioni

Gene expression databases

BgeeiENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020287

Structurei

3D structure databases

ProteinModelPortaliE9Q468
SMRiE9Q468
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 331G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST272

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
InParanoidiE9Q468
KOiK04240
OMAiMCPSAIT
OrthoDBiEOG091G098F
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005395 NPFF_rcpt
IPR005396 NPFF_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01570 NPFFRECEPTOR
PR01571 NPFFRECEPTR1
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q468-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEPSQPPN GSWPPSLNES DAETAPVASL TFSSYYQHSS PVAAMFIAAY
60 70 80 90 100
ALIFLLCMVG NTLVCFIVLK NRHMRTVTNM FILNLAVSDL LVGIFCMPTT
110 120 130 140 150
LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR
160 170 180 190 200
EKLTLRKALL TIAVIWALAL LIMCPSAVTL TVTREEHHFM LDARNRSYPL
210 220 230 240 250
YSCWEAWPEK GMRKVYTAVL FAHIYLAPLA LIVVMYARIA RKLCQAPGPA
260 270 280 290 300
RDAEEAVAEG GRASRRRARV VHMLVMVALF FTLSWLPLWV LLLLIDYGEL
310 320 330 340 350
SELQLHLLSV YAFPLAHWLA FFHSSANPII YGYFNENFRR GFQAAFRAQL
360 370 380 390 400
CWLPWAAHKQ AYSERPGRLL RRRVVVDVQP SDSGLPSESG PSSGVPGPNR
410 420 430
LPLRNGRVAH QDGPREGPGC NHMPLTIPAW NI
Length:432
Mass (Da):48,252
Last modified:April 5, 2011 - v1
Checksum:i9323CBD66A92C0E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124421 Genomic DNA No translation available.
RefSeqiNP_001170982.1, NM_001177511.1
UniGeneiMm.131297

Genome annotation databases

EnsembliENSMUST00000020287; ENSMUSP00000020287; ENSMUSG00000020090
GeneIDi237362
KEGGimmu:237362
UCSCiuc007fgd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124421 Genomic DNA No translation available.
RefSeqiNP_001170982.1, NM_001177511.1
UniGeneiMm.131297

3D structure databases

ProteinModelPortaliE9Q468
SMRiE9Q468
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020287

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiE9Q468

Proteomic databases

PaxDbiE9Q468
PRIDEiE9Q468

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020287; ENSMUSP00000020287; ENSMUSG00000020090
GeneIDi237362
KEGGimmu:237362
UCSCiuc007fgd.2 mouse

Organism-specific databases

CTDi64106
MGIiMGI:2685082 Npffr1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
InParanoidiE9Q468
KOiK04240
OMAiMCPSAIT
OrthoDBiEOG091G098F
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020090 Expressed in 13 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005395 NPFF_rcpt
IPR005396 NPFF_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01570 NPFFRECEPTOR
PR01571 NPFFRECEPTR1
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q468_MOUSE
AccessioniPrimary (citable) accession number: E9Q468
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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