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UniProtKB - E9Q447 (E9Q447_MOUSE)
Protein
Submitted name:
Spectrin alpha chain, non-erythrocytic 1
Gene
Sptan1
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 2342 – 2353 | PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 2385 – 2396 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
GO - Biological processi
- actin filament capping Source: UniProtKB-KW
Keywordsi
Molecular function | Actin cappingARBA annotation, Actin-bindingARBA annotation, Calmodulin-bindingARBA annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Spectrin alpha chain, non-erythrocytic 1Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98386, Sptan1 |
VEuPathDBi | HostDB:ENSMUSG00000057738 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- cell cortex ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
- supramolecular fiber Source: UniProt
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Proteomic databases
jPOSTi | E9Q447 |
MaxQBi | E9Q447 |
PeptideAtlasi | E9Q447 |
ProteomicsDBi | 314666 |
PTM databases
iPTMneti | E9Q447 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000057738, Expressed in facial nucleus and 328 other tissues |
ExpressionAtlasi | E9Q447, baseline and differential |
Genevisiblei | E9Q447, MM |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 967 – 1026 | SH3InterPro annotationAdd BLAST | 60 | |
Domaini | 2329 – 2364 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 2372 – 2407 | EF-handInterPro annotationAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 184 – 204 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 290 – 324 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 386 – 416 | Sequence analysisAdd BLAST | 31 | |
Coiled coili | 502 – 522 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 614 – 634 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 713 – 733 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 858 – 889 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 1106 – 1140 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1248 – 1268 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1678 – 1712 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 2157 – 2189 | Sequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the spectrin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156662 |
PhylomeDBi | E9Q447 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit cd11808, SH3_Alpha_Spectrin, 1 hit |
InterProi | View protein in InterPro IPR035825, Alpha_Spectrin_SH3 IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF08726, EFhand_Ca_insen, 1 hit PF00018, SH3_1, 1 hit PF00435, Spectrin, 20 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00326, SH3, 1 hit SM00150, SPEC, 20 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
E9Q447-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ
60 70 80 90 100
RDAEELEKWI QEKLQVASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV
110 120 130 140 150
KLDETGNLMI SEGHFASETI RTRLMELHRQ WELLLEKMRE KGIKLLQAQK
160 170 180 190 200
LVQYLRECED VMDWINDKEA IVTSEELGQD LEHVEVLQKK FEEFQTDLAA
210 220 230 240 250
HEERVNEVSQ FAAKLIQEQH PEEELIKTKQ DEVNAAWQRL KGLALQRQGK
260 270 280 290 300
LFGAAEVQRF NRDVDETIGW IKEKEQLMAS DDFGRDLASV QALLRKHEGL
310 320 330 340 350
ERDLAALEDK VKALCAEADR LQQSHPLSAS QIQVKREELI TNWEQIRTLA
360 370 380 390 400
AERHARLDDS YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL
410 420 430 440 450
DRHQEHKGEI DAHEDSFKSA DESGQALLAA SHYASDEVRE KLSILSEERT
460 470 480 490 500
ALLELWELRR QQYEQCMDLQ LFYRDTEQVD NWMSKQEAFL LNEDLGDSLD
510 520 530 540 550
SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA MEDVATRRDA
560 570 580 590 600
LLSRRNALHE RAMHRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
610 620 630 640 650
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKEEVA
660 670 680 690 700
ARMNEVISLW KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH
710 720 730 740 750
LASDDYGKDL TNVQNLQKKH ALLEADVAAH QDRIDGITIQ ARQFQDAGHF
760 770 780 790 800
DAENIKKKQE ALVARYEALK EPMVARKQKL ADSLRLQQLF RDVEDEETWI
810 820 830 840 850
REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI KAVTQKGNAM
860 870 880 890 900
VEEGHFAAED VKAKLSELNQ KWEALKAKAS QRRQDLEDSL QAQQYFADAN
910 920 930 940 950
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR
960 970 980 990 1000
EQAQSCRQQV APMDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST
1010 1020 1030 1040 1050
NKDWWKVEVN DRQGFVPAAY VKKLDPAQSA SRENLLEEQG SIALRQGQID
1060 1070 1080 1090 1100
NQYQSLLELG EKRKGMLEKS CKKFMLFREA NELQQWITEK EAALTNEEVG
1110 1120 1130 1140 1150
ADLEQVEVLQ KKFDDFQKDL KANESRLKDI NKVAEDLESE GLMAEEVQAV
1160 1170 1180 1190 1200
QQQEVYGAMP RDEADSKTAS PWKSARLMVH TVATFNSIKE LNERWRSLQQ
1210 1220 1230 1240 1250
LAEERSQLLG SAHEVQRFHR DADETKEWIE EKNQALNTDN YGHDLASVQA
1260 1270 1280 1290 1300
LQRKHEGFER DLAALGDKVN SLGETAQRLI QSHPESAEDL KEKCTELNQA
1310 1320 1330 1340 1350
WTSLGKRADQ RKAKLGDSHD LQRFLSDFRD LMSWINGIRG LVSSDELAKD
1360 1370 1380 1390 1400
VTGAEALLER HQEHRTEIDA RAGTFQAFEQ FGQQLLAHGH YASPEIKEKL
1410 1420 1430 1440 1450
DILDQERTDL EKAWVQRRMM LDHCLELQLF HRDCEQAENW MAAREAFLNT
1460 1470 1480 1490 1500
EDKGDSLDSV EALIKKHEDF DKAINVQEEK IAALQAFADQ LIAVDHYAKG
1510 1520 1530 1540 1550
DIANRRNEVL DRWRRLKAQM IEKRSKLGES QTLQQFSRDV DEIEAWISEK
1560 1570 1580 1590 1600
LQTASDESYK DPTNIQLSKL LSKHQKHQAF EAELHANADR IRGVIDMGNS
1610 1620 1630 1640 1650
LIERGACAGS EDAVKARLAA LADQWQFLVQ KSAEKSQKLK EANKQQNFNT
1660 1670 1680 1690 1700
GIKDFDFWLS EVEALLASED YGKDLASVNN LLKKHQLLEA DISAHEDRLK
1710 1720 1730 1740 1750
DLNSQADSLM TSSAFDTSQV KEKRDTINGR FQKIKSMATS RRAKLSESHR
1760 1770 1780 1790 1800
LHQFFRDMDD EESWIKEKKL LVSSEDYGRD LTGVQNLRKK HKRLEAELAA
1810 1820 1830 1840 1850
HEPAIQGVLD TGKKLSDDNT IGQEEIQQRL AQFVEHWKEL KQLAAARGQR
1860 1870 1880 1890 1900
LEESLEYQQF VANVEEEEAW INEKMTLVAS EDYGDTLAAI QGLLKKHEAF
1910 1920 1930 1940 1950
ETDFTVHKDR VNDVCTNGQD LIKKNNHHEE NISSKMKGLN GKVSDLEKAA
1960 1970 1980 1990 2000
AQRKAKLDEN SAFLQFNWKA DVVESWIGEK ENSLKTDDYG RDLSSVQTLL
2010 2020 2030 2040 2050
TKQETFDAGL QAFQQEGIAN ITALKDQLLA AKHIQSKAIE ARHASLMKRW
2060 2070 2080 2090 2100
TQLLANSATR KKKLLEAQSH FRKVEDLFLT FAKKASAFNS WFENAEEDLT
2110 2120 2130 2140 2150
DPVRCNSLEE IKALREAHDA FRSSLSSAQA DFNQLAELDR QIKSFRVASN
2160 2170 2180 2190 2200
PYTWFTMEAL EETWRNLQKI IKERELELQK EQRRQEENDK LRQEFAQHAN
2210 2220 2230 2240 2250
AFHQWIQETR TYLLDGIAYR RVIRVCQYEV GDDLSGRSCM VEESGTLESQ
2260 2270 2280 2290 2300
LEATKRKHQE IRAMRSQLKK IEDLGAAMEE ALILDNKYTE HSTVGLAQQW
2310 2320 2330 2340 2350
DQLDQLGMRM QHNLEQQIQA RNTTGVTEEA LKEFSMMFKH FDKDKSGRLN
2360 2370 2380 2390 2400
HQEFKSCLRS LGYDLPMVEE GEPDPEFEAI LDTVDPNRDG HVSLQEYMAF
2410 2420 2430 2440 2450
MISRETENVK SSEEIESAFR ALSSEGKPYV TKEELYQNLT REQADYCVSH
2460 2470
MKPYVDGKGR ELPTAFDYVE FTRSLFVN
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP16546 | SPTN1_MOUSE | Spectrin alpha chain, non-erythrocy... | Sptan1 Spna2, Spta2 | 2,472 | Annotation score: | ||
A3KGU9 | A3KGU9_MOUSE | Spectrin alpha chain, non-erythrocy... | Sptan1 Spna2 | 2,498 | Annotation score: | ||
A3KGU7 | A3KGU7_MOUSE | Spectrin alpha chain, non-erythrocy... | Sptan1 Spna2 | 2,477 | Annotation score: | ||
A3KGU5 | A3KGU5_MOUSE | Spectrin alpha chain, non-erythrocy... | Sptan1 Spna2 | 2,457 | Annotation score: | ||
A3KGU4 | A3KGU4_MOUSE | Spectrin alpha chain, non-erythrocy... | Sptan1 Spna2 | 219 | Annotation score: | ||
A0A5F8MQC3 | A0A5F8MQC3_MOUSE | Spectrin alpha chain, non-erythrocy... | Sptan1 | 112 | Annotation score: |
Genome annotation databases
Ensembli | ENSMUST00000113719; ENSMUSP00000109348; ENSMUSG00000057738 |
UCSCi | uc008jar.1, mouse |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | E9Q447 |
ModBasei | Search... |
PTM databases
iPTMneti | E9Q447 |
Proteomic databases
jPOSTi | E9Q447 |
MaxQBi | E9Q447 |
PeptideAtlasi | E9Q447 |
ProteomicsDBi | 314666 |
Protocols and materials databases
Antibodypediai | 1910, 467 antibodies from 44 providers |
Genome annotation databases
Ensembli | ENSMUST00000113719; ENSMUSP00000109348; ENSMUSG00000057738 |
UCSCi | uc008jar.1, mouse |
Organism-specific databases
MGIi | MGI:98386, Sptan1 |
VEuPathDBi | HostDB:ENSMUSG00000057738 |
Phylogenomic databases
GeneTreei | ENSGT00940000156662 |
PhylomeDBi | E9Q447 |
Miscellaneous databases
ChiTaRSi | Sptan1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000057738, Expressed in facial nucleus and 328 other tissues |
ExpressionAtlasi | E9Q447, baseline and differential |
Genevisiblei | E9Q447, MM |
Family and domain databases
CDDi | cd00051, EFh, 1 hit cd11808, SH3_Alpha_Spectrin, 1 hit |
InterProi | View protein in InterPro IPR035825, Alpha_Spectrin_SH3 IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF08726, EFhand_Ca_insen, 1 hit PF00018, SH3_1, 1 hit PF00435, Spectrin, 20 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00326, SH3, 1 hit SM00150, SPEC, 20 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9Q447_MOUSE | |
Accessioni | E9Q447Primary (citable) accession number: E9Q447 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |