UniProtKB - E9Q401 (RYR2_MOUSE)
Ryanodine receptor 2
Ryr2
Functioni
Activity regulationi
GO - Molecular functioni
- calcium channel activity Source: UniProtKB
- calcium-induced calcium release activity Source: MGI
- calcium ion binding Source: GO_Central
- calcium-release channel activity Source: UniProtKB
- calmodulin binding Source: MGI
- enzyme binding Source: BHF-UCL
- identical protein binding Source: IntAct
- organic cyclic compound binding Source: MGI
- protein kinase A catalytic subunit binding Source: MGI
- protein kinase A regulatory subunit binding Source: MGI
- protein kinase binding Source: BHF-UCL
- protein self-association Source: UniProtKB
- ryanodine-sensitive calcium-release channel activity Source: MGI
- scaffold protein binding Source: MGI
- suramin binding Source: MGI
GO - Biological processi
- calcium ion transmembrane transport Source: MGI
- calcium ion transport Source: UniProtKB
- calcium ion transport into cytosol Source: MGI
- calcium-mediated signaling Source: UniProtKB
- calcium-mediated signaling using intracellular calcium source Source: MGI
- cardiac muscle contraction Source: MGI
- cardiac muscle hypertrophy Source: MGI
- cellular calcium ion homeostasis Source: UniProtKB
- cellular response to caffeine Source: UniProtKB
- cellular response to epinephrine stimulus Source: BHF-UCL
- cytosolic calcium ion transport Source: MGI
- detection of calcium ion Source: MGI
- embryonic heart tube morphogenesis Source: UniProtKB
- establishment of protein localization to endoplasmic reticulum Source: MGI
- ion transmembrane transport Source: MGI
- left ventricular cardiac muscle tissue morphogenesis Source: MGI
- manganese ion transmembrane transport Source: MGI
- negative regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of ATPase-coupled calcium transmembrane transporter activity Source: MGI
- positive regulation of heart rate Source: MGI
- positive regulation of sequestering of calcium ion Source: MGI
- positive regulation of the force of heart contraction Source: MGI
- Purkinje myocyte to ventricular cardiac muscle cell signaling Source: BHF-UCL
- regulation of atrial cardiac muscle cell action potential Source: MGI
- regulation of AV node cell action potential Source: MGI
- regulation of cardiac muscle contraction Source: MGI
- regulation of cardiac muscle contraction by calcium ion signaling Source: MGI
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
- regulation of cytosolic calcium ion concentration Source: MGI
- regulation of heart rate Source: BHF-UCL
- regulation of SA node cell action potential Source: MGI
- regulation of ventricular cardiac muscle cell action potential Source: MGI
- release of sequestered calcium ion into cytosol Source: MGI
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
- response to caffeine Source: UniProtKB
- response to calcium ion Source: MGI
- response to hypoxia Source: BHF-UCL
- response to magnesium ion Source: MGI
- response to muscle activity Source: MGI
- response to muscle stretch Source: MGI
- response to redox state Source: MGI
- sarcoplasmic reticulum calcium ion transport Source: MGI
- type B pancreatic cell apoptotic process Source: BHF-UCL
- ventricular cardiac muscle cell action potential Source: BHF-UCL
Keywordsi
Molecular function | Calcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels R-MMU-5578775, Ion homeostasis |
Protein family/group databases
MoonDBi | E9Q401, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Ryanodine receptor 2Short name: RYR-2 Short name: RyR2 Alternative name(s): Cardiac muscle ryanodine receptor Cardiac muscle ryanodine receptor-calcium release channel Type 2 ryanodine receptor |
Gene namesi | Name:Ryr2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99685, Ryr2 |
Subcellular locationi
Other locations
- Sarcoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
- Membrane 1 Publication; Multi-pass membrane protein 1 Publication
- Sarcoplasmic reticulum By similarity
Note: The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- sarcoplasmic reticulum Source: BHF-UCL
- sarcoplasmic reticulum membrane Source: MGI
- smooth endoplasmic reticulum Source: MGI
Nucleus
- nuclear envelope Source: MGI
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: MGI
- plasma membrane Source: MGI
- sarcolemma Source: MGI
Other locations
- A band Source: MGI
- calcium channel complex Source: BHF-UCL
- cytoplasm Source: MGI
- cytoplasmic vesicle membrane Source: GO_Central
- integral component of membrane Source: MGI
- membrane Source: MGI
- neuron projection Source: MGI
- protein-containing complex Source: MGI
- sarcomere Source: BHF-UCL
- Z disc Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4231 | CytoplasmicSequence analysisAdd BLAST | 4231 | |
Transmembranei | 4232 – 4252 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 4278 – 4298 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 4502 – 4522 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 4579 – 4599 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 4729 – 4749 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 4768 – 4788 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 4819 – 4828 | Pore-formingCurated | 10 | |
Transmembranei | 4849 – 4869 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 4870 – 4966 | CytoplasmicSequence analysisAdd BLAST | 97 |
Keywords - Cellular componenti
Membrane, Sarcoplasmic reticulumPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 77 | A → V: No change to global protein fold or protein stability. Alters local protein folding. 1 Publication | 1 | |
Mutagenesisi | 186 | V → M: No change to global protein fold or protein stability. Alters local protein folding. 1 Publication | 1 | |
Mutagenesisi | 2813 | S → A: Protects against tachycardia and subsequent death due to heart failure. 1 Publication | 1 | |
Mutagenesisi | 2813 | S → D: Abolishes phosphorylation by CaMK2D. Tendency to tachycardia and subsequent death due to heart failure. 1 Publication | 1 | |
Mutagenesisi | 4819 | G → A: Strongly reduced calcium channel activity. Abolishes ryanodine binding. 1 Publication | 1 | |
Mutagenesisi | 4821 | R → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication | 1 | |
Mutagenesisi | 4823 | G → A: Reduced calcium channel activity. Reduces single channel conductance by 97%. No effect on ryaodine binding. 1 Publication | 1 | |
Mutagenesisi | 4824 | G → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication | 1 | |
Mutagenesisi | 4825 | G → A: Strongly reduced calcium channel activity. Abolishes ryanodine binding. 1 Publication | 1 | |
Mutagenesisi | 4827 | G → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication | 1 | |
Mutagenesisi | 4828 | D → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000415582 | 1 – 4966 | Ryanodine receptor 2Add BLAST | 4966 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1341 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1870 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2030 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 2368 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2696 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2796 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2807 | Phosphoserine; by CaMK2D and PKACombined sources2 Publications | 1 | |
Modified residuei | 2810 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2813 | Phosphoserine; by CaMK2DCombined sources1 Publication | 1 | |
Modified residuei | 2946 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | E9Q401 |
MaxQBi | E9Q401 |
PaxDbi | E9Q401 |
PeptideAtlasi | E9Q401 |
PRIDEi | E9Q401 |
PTM databases
iPTMneti | E9Q401 |
PhosphoSitePlusi | E9Q401 |
SwissPalmi | E9Q401 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000021313, Expressed in myocardium of ventricle and 174 other tissues |
Genevisiblei | E9Q401, MM |
Interactioni
Subunit structurei
Homotetramer. Can also form heterotetramers with RYR1 and RYR3.
Interacts with CALM and S100A1; these interactions regulate channel activity.
Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1.
Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity).
Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca2+ leaks.
Interacts with SELENON (By similarity).
Identified in a complex, composed of FSD2, CMYA5 and RYR2 (PubMed:28740084).
By similarity4 PublicationsBinary interactionsi
Hide detailsE9Q401
GO - Molecular functioni
- calmodulin binding Source: MGI
- enzyme binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein kinase A catalytic subunit binding Source: MGI
- protein kinase A regulatory subunit binding Source: MGI
- protein kinase binding Source: BHF-UCL
- protein self-association Source: UniProtKB
- scaffold protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203046, 22 interactors |
ComplexPortali | CPX-3137, Ryanodine 2 complex |
IntActi | E9Q401, 66 interactors |
MINTi | E9Q401 |
STRINGi | 10090.ENSMUSP00000021750 |
Miscellaneous databases
RNActi | E9Q401, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | E9Q401 |
SMRi | E9Q401 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 110 – 165 | MIR 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 172 – 217 | MIR 2PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 225 – 280 | MIR 3PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 286 – 343 | MIR 4PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 351 – 408 | MIR 5PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 599 – 809 | B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST | 211 | |
Repeati | 853 – 966 | 1Add BLAST | 114 | |
Repeati | 967 – 1080 | 2Add BLAST | 114 | |
Domaini | 1025 – 1222 | B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 1357 – 1563 | B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST | 207 | |
Repeati | 2691 – 2809 | 3Add BLAST | 119 | |
Repeati | 2811 – 2924 | 4Add BLAST | 114 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 853 – 2924 | 4 X approximate repeatsAdd BLAST | 2072 | |
Regioni | 3580 – 3609 | Interaction with CALMBy similarityAdd BLAST | 30 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2243, Eukaryota |
GeneTreei | ENSGT00940000154906 |
HOGENOMi | CLU_000040_2_0_1 |
InParanoidi | E9Q401 |
OMAi | NYFQPYL |
OrthoDBi | 5161at2759 |
TreeFami | TF315244 |
Family and domain databases
CDDi | cd12877, SPRY1_RyR, 1 hit cd12878, SPRY2_RyR, 1 hit cd12879, SPRY3_RyR, 1 hit |
Gene3Di | 2.60.120.920, 3 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR014821, Ins145_P3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR013333, Ryan_recept IPR003032, Ryanodine_rcpt IPR009460, Ryanrecept_TM4-6 IPR035910, RyR/IP3R_RIH_dom_sf IPR035761, SPRY1_RyR IPR035764, SPRY2_RyR IPR035762, SPRY3_RyR IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF06459, RR_TM4-6, 1 hit PF01365, RYDR_ITPR, 2 hits PF02026, RyR, 4 hits PF00622, SPRY, 3 hits |
PRINTSi | PR00795, RYANODINER |
SMARTi | View protein in SMART SM00472, MIR, 4 hits SM00449, SPRY, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF47473, SSF47473, 1 hit SSF49899, SSF49899, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 3 hits PS50919, MIR, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE
60 70 80 90 100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF
110 120 130 140 150
MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ
160 170 180 190 200
EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNSS
210 220 230 240 250
WHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG
260 270 280 290 300
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV
310 320 330 340 350
TTGKYLSLME DKNLLLMDKE KADVKSTAFA FRSSKEKLDV GVRKEVDGMG
360 370 380 390 400
TSEIKYGDSI CYIQHVDTGL WLTYQAVDVK SARMGSIQRK AIMHHEGHMD
410 420 430 440 450
DGLNLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKV KLPTIDLPIE
460 470 480 490 500
SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE
510 520 530 540 550
CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ
560 570 580 590 600
FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL
610 620 630 640 650
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN
660 670 680 690 700
HVSSMRPNIF LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST
710 720 730 740 750
EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART VSSPNQHLLR
760 770 780 790 800
TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV
810 820 830 840 850
RFLLGGRHGE FKFLPPPGYA ACYEAVLPKE KLKVEHSREY KQERTYTRDL
860 870 880 890 900
LGPTVSLTQA AFTPVPVDTS QIVLPPHLER IRERLAENIH ELWVMNKIEL
910 920 930 940 950
GWQYGPVRDD NKRQHPCLVE FCKLPEQERN YNLQMSLETL KTLLALGCHV
960 970 980 990 1000
GIADEHAEEK VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA
1010 1020 1030 1040 1050
ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL
1060 1070 1080 1090 1100
REAVRTLLGY GYHLEAPDQD HASRAEVCSG TGERFRIFRA EKTYAVKAGR
1110 1120 1130 1140 1150
WYFEFEAVTA GDMRVGWSRP GCQPDLELGS DDRAFAFDGF KAQRWHQGNE
1160 1170 1180 1190 1200
HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG
1210 1220 1230 1240 1250
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW
1260 1270 1280 1290 1300
LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNNNTDIM
1310 1320 1330 1340 1350
FYRLSMPIEC AEVFSKSVAG GLPGAGFYGP KNDLEDFDVD SDFEVLMKTA
1360 1370 1380 1390 1400
HGHLVPDRID KDKETPKPEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTG
1410 1420 1430 1440 1450
HSARLTEDVL ADDRDDYEYL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF
1460 1470 1480 1490 1500
HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR
1510 1520 1530 1540 1550
NNSNGLEIGC VVDAASGLLT FIANGKELST YYQVEPSTKL FPAVFAQATS
1560 1570 1580 1590 1600
PNVFQFELGR IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM
1610 1620 1630 1640 1650
PNQFLKVDVS RISERQGWLV QCLDPLQFMS LHIPEENRSV DILELTEQEE
1660 1670 1680 1690 1700
LLQFHYHTLR LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR
1710 1720 1730 1740 1750
AGYYDLLIDI HLSSYATARL MMNNEFIVPM TEETKSITLF PDENKKHGLP
1760 1770 1780 1790 1800
GIGLSTSLRP RMRFSSPSFV SISNDCYQYS PEFPLDILKA KTIQMLTEAV
1810 1820 1830 1840 1850
KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS
1860 1870 1880 1890 1900
VFKEAAVPEE EGGTPEKEIS IEDAKLEGEE EAKGGKRPKE GLLQMKLPEP
1910 1920 1930 1940 1950
VKLQMCLLLQ YLCDCQVRHR IEAIVAFSDD FVAKLQDNQR FRYNEVMQAL
1960 1970 1980 1990 2000
NMSAALTARK TREFRSPPQE QINMLLNFKD DKSECPCPEE IRDQLLDFHE
2010 2020 2030 2040 2050
DLMTHCGIEL DEDGSLDGSN DLTIRGRLLS LVEKVTYLKK KQAEKPVASD
2060 2070 2080 2090 2100
SRKCSSLQQL ISETMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRA
2110 2120 2130 2140 2150
LPKTYTINGV SVEDTINLLA SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN
2160 2170 2180 2190 2200
NKVFYQHPNL MRALGMHETV MEVMVNVLGG GESKEITFPK MVANCCRFLC
2210 2220 2230 2240 2250
YFCRISRQNQ KAMFDHLSYL LENSSVGLAS PAMRGSTPLD VAAASVMDNN
2260 2270 2280 2290 2300
ELALALREPD LEKVVRYLAG CGLQSCQMLV SKGYPDIGWN PVEGERYLDF
2310 2320 2330 2340 2350
LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN GLLAAMEEAI
2360 2370 2380 2390 2400
KIAEDPSRDG PSPTSGSSKT LDIEEEEDDT IHMGNAIMTF YAALIDLLGR
2410 2420 2430 2440 2450
CAPEMHLIHA GKGEAIRIRS ILRSLIPLGD LVGVISIAFQ MPTIAKDGKV
2460 2470 2480 2490 2500
VEPDMSAGFC PDHKAAMVLF LDRVYGIEVQ DFLLHLLEVG FLPDLRAAAS
2510 2520 2530 2540 2550
LDTAALSATD MALALNRYLC TAVLPLLTRC APLFAGTEHH ASLIDSLLHT
2560 2570 2580 2590 2600
VYRLSKGCSL TKAQRDSIEV CLLSICGQLR PSMMQHLLRR LVFDVPLLNE
2610 2620 2630 2640 2650
HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS RKLFWGIFDA
2660 2670 2680 2690 2700
LSQKKYEQEL FKLALPCLSA VAGALPPDYM ESNYVSMMEK QSSMDSEGNF
2710 2720 2730 2740 2750
NPQPVDTSNI TIPEKLEYFI NKYAEHSHDK WSMDKLANGW IYGEIYSDSS
2760 2770 2780 2790 2800
KIQPLMKPYK LLSEKEKEIY RWPIKESLKT MLAWGWRIER TREGDSMALY
2810 2820 2830 2840 2850
NRTRRISQTS QVSIDAAHGY SPRAIDMSNV TLSRDLHAMA EMMAENYHNI
2860 2870 2880 2890 2900
WAKKKKLELE SKGGGNHPLL VPYDTLTAKE KAKDREKAQD IFKFLQISGY
2910 2920 2930 2940 2950
VVSRGFKDLD LDTPSIEKRF AYSFLQQLIR YVDEAHQYIL EFDGGSRSKG
2960 2970 2980 2990 3000
EHFPYEQEIK FFAKVVLPLI DQYFKNHRLY FLSAASRPLC TGGHASNKEK
3010 3020 3030 3040 3050
EMVTSLFCKL GVLVRHRISL FGNDATSIVN CLHILGQTLD ARTVMKTGLD
3060 3070 3080 3090 3100
SVKSALRAFL DNAAEDLEKT MENLKQGQFT HTRSQPKGVT QIINYTTVAL
3110 3120 3130 3140 3150
LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG TSKSIYVERQ
3160 3170 3180 3190 3200
RSALGECLAA FAGAFPIAFL ETHLDKHNVY SIYNTRSSRE RAALSLPANV
3210 3220 3230 3240 3250
EDVCPNIPSL EKLMTEIIEL AESGIRYTQM PYMMEVVLPM LCSYMSRWWE
3260 3270 3280 3290 3300
HGPENHPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV
3310 3320 3330 3340 3350
FSQPIINKVK PQLLKTHFLP LMEKLKKKAA MVVSEEDHLK AEARGDMSEA
3360 3370 3380 3390 3400
ELLILDEFTT LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE
3410 3420 3430 3440 3450
VFIYWSKSHN FKREEQNFVV QNEINNMSFL ITDTKSKMSK AAISDQERKK
3460 3470 3480 3490 3500
MKRKGDRYSM QTSLIVAALK RLLPIGLNIC APGDQELIAL AKNRFSLKDT
3510 3520 3530 3540 3550
EEEVRDIIRS NIHLQGKLED PAIRWQMALY KDLPNRTEDP SDPERTVERV
3560 3570 3580 3590 3600
LGIANVLFHL EQKSKYTGRG YFSLVEHPQR SKKAVWHKLL SKQRKRAVVA
3610 3620 3630 3640 3650
CFRMAPLYNL PRHRAVNLFL QGYEKSWIET EEHYFEDKLI EDLAKPGAEL
3660 3670 3680 3690 3700
PEEDEAMKRV DPLHQLILLF SRTALTEKCK LEEDFLYMAY ADIMAKSCHD
3710 3720 3730 3740 3750
EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL QTISASKGET
3760 3770 3780 3790 3800
GPMVAATLKL GIAILNGGNS TVQQKMLDYL KEKKDVGFFQ SLAGLMQSCS
3810 3820 3830 3840 3850
VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR FLQLLCEGHN
3860 3870 3880 3890 3900
SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDIIDEQ
3910 3920 3930 3940 3950
GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF
3960 3970 3980 3990 4000
AHMQMKLSQD SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD
4010 4020 4030 4040 4050
MLVESSNNVE MILKFFDMFL KLKDLTSSDT FKEYDPDGKG VISKRDFHKA
4060 4070 4080 4090 4100
MESHKHYTQS ETEFLLSCAE TDENETLDYE EFVKRFHEPA KDIGFNVAVL
4110 4120 4130 4140 4150
LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS AKRIERVYFE
4160 4170 4180 4190 4200
ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ
4210 4220 4230 4240 4250
LAAQISESDL NERLANKEES EKERPEEQAP RMGFFSLLTI QSALFALRYN
4260 4270 4280 4290 4300
VLTLVRMLSL KSLKKQMKRM KKMTVKDMVL AFFSSYWSVF VTLLHFVASV
4310 4320 4330 4340 4350
CRGFFRIVSS LLLGGSLVEG AKKIKVAELL ANMPDPTQDE VRGDEEEGER
4360 4370 4380 4390 4400
KPLESALPSE DLTDLKELTE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG
4410 4420 4430 4440 4450
LSDLMTNPVP VPEVQEKFQE QKAKEEKEEK EETKSEPEKA EGEDGEKEEK
4460 4470 4480 4490 4500
AKDEKSKQKL RQLHTHRYGE PEVPESAFWK KIIAYQQKLL NYFARNFYNM
4510 4520 4530 4540 4550
RMLALFVAFA INFILLFYKV STSSVVEGKE LPTRTSSDTA KVTNSLDSSP
4560 4570 4580 4590 4600
HRIIAVHYVL EESSGYMEPT LRILAILHTI ISFFCIIGYY CLKVPLVIFK
4610 4620 4630 4640 4650
REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTQSFP NNYWDKFVKR
4660 4670 4680 4690 4700
KVMDKYGEFY GRDRISELLG MDKAALDFSD AREKKKPKKD SSLSAVLNSI
4710 4720 4730 4740 4750
DVKYQMWKLG VVFTDNSFLY LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK
4760 4770 4780 4790 4800
TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT
4810 4820 4830 4840 4850
PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI YRIIFDITFF
4860 4870 4880 4890 4900
FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV
4910 4920 4930 4940 4950
PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWEF
4960
FPAGDCFRKQ YEDQLN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6U7V1 | F6U7V1_MOUSE | Ryanodine receptor 2 | Ryr2 | 4,966 | Annotation score: | ||
A0A1Y7VJP1 | A0A1Y7VJP1_MOUSE | Ryanodine receptor 2 | Ryr2 | 1,028 | Annotation score: | ||
Q80ZZ5 | Q80ZZ5_MOUSE | Ryanodine receptor 2 | Ryr2 | 1,020 | Annotation score: | ||
A0A1Y7VK09 | A0A1Y7VK09_MOUSE | Ryanodine receptor 2 | Ryr2 | 369 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1332 | N → S in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 1412 | D → G in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 1962 | R → K in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 2265 | V → VA in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 2532 | P → R in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 3192 | A → T in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 3533 | L → F in AAG34081 (PubMed:10473538).Curated | 1 | |
Sequence conflicti | 4324 | I → T in CAA58785 (PubMed:7876312).Curated | 1 | |
Sequence conflicti | 4853 | V → E in CAA58785 (PubMed:7876312).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF295105 mRNA Translation: AAG34081.1 AC131329 Genomic DNA No translation available. AC159208 Genomic DNA No translation available. CT010468 Genomic DNA No translation available. CT572985 Genomic DNA No translation available. AB012003 Genomic DNA Translation: BAA25137.1 X83933 mRNA Translation: CAA58785.1 D38217 mRNA Translation: BAA07392.1 |
CCDSi | CCDS49206.1 |
PIRi | I48742 |
RefSeqi | NP_076357.2, NM_023868.2 |
Genome annotation databases
Ensembli | ENSMUST00000021750; ENSMUSP00000021750; ENSMUSG00000021313 |
GeneIDi | 20191 |
KEGGi | mmu:20191 |
UCSCi | uc007pld.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF295105 mRNA Translation: AAG34081.1 AC131329 Genomic DNA No translation available. AC159208 Genomic DNA No translation available. CT010468 Genomic DNA No translation available. CT572985 Genomic DNA No translation available. AB012003 Genomic DNA Translation: BAA25137.1 X83933 mRNA Translation: CAA58785.1 D38217 mRNA Translation: BAA07392.1 |
CCDSi | CCDS49206.1 |
PIRi | I48742 |
RefSeqi | NP_076357.2, NM_023868.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MC2 | NMR | - | A | 10-224 | [»] | |
3IM5 | X-ray | 2.55 | A/B | 1-217 | [»] | |
3IM6 | X-ray | 1.70 | A | 1-217 | [»] | |
3IM7 | X-ray | 2.21 | A | 1-217 | [»] | |
3QR5 | X-ray | 2.30 | A/B | 1-217 | [»] | |
4ETV | X-ray | 1.65 | A/B | 2699-2904 | [»] | |
4KEI | X-ray | 2.41 | A | 1-217 | [»] | |
4KEJ | X-ray | 2.55 | A | 1-217 | [»] | |
4KEK | X-ray | 2.15 | A | 1-217 | [»] | |
4L4H | X-ray | 2.00 | A | 1-547 | [»] | |
4L4I | X-ray | 2.15 | A | 1-547 | [»] | |
4P9I | X-ray | 1.34 | A | 1080-1253 | [»] | |
4P9L | X-ray | 1.44 | A | 1080-1253 | [»] | |
5C33 | X-ray | 1.21 | A/B | 650-844 | [»] | |
5VSN | X-ray | 1.44 | A | 1084-1252 | [»] | |
6J6L | X-ray | 1.45 | A/B | 650-844 | [»] | |
6MM5 | X-ray | 1.95 | C | 2799-2810 | [»] | |
6MM6 | X-ray | 2.39 | D/F | 2699-2904 | [»] | |
6MM7 | X-ray | 1.85 | C/E | 2699-2904 | [»] | |
6MM8 | X-ray | 1.85 | D | 2699-2904 | [»] | |
6WOU | electron microscopy | 3.27 | A/B/C/D | 1-4966 | [»] | |
6WOV | electron microscopy | 5.10 | A/B/C/D | 1-4966 | [»] | |
BMRBi | E9Q401 | |||||
SMRi | E9Q401 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 203046, 22 interactors |
ComplexPortali | CPX-3137, Ryanodine 2 complex |
IntActi | E9Q401, 66 interactors |
MINTi | E9Q401 |
STRINGi | 10090.ENSMUSP00000021750 |
Protein family/group databases
MoonDBi | E9Q401, Predicted |
PTM databases
iPTMneti | E9Q401 |
PhosphoSitePlusi | E9Q401 |
SwissPalmi | E9Q401 |
Proteomic databases
jPOSTi | E9Q401 |
MaxQBi | E9Q401 |
PaxDbi | E9Q401 |
PeptideAtlasi | E9Q401 |
PRIDEi | E9Q401 |
Protocols and materials databases
Antibodypediai | 3476, 224 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021750; ENSMUSP00000021750; ENSMUSG00000021313 |
GeneIDi | 20191 |
KEGGi | mmu:20191 |
UCSCi | uc007pld.1, mouse |
Organism-specific databases
CTDi | 6262 |
MGIi | MGI:99685, Ryr2 |
Phylogenomic databases
eggNOGi | KOG2243, Eukaryota |
GeneTreei | ENSGT00940000154906 |
HOGENOMi | CLU_000040_2_0_1 |
InParanoidi | E9Q401 |
OMAi | NYFQPYL |
OrthoDBi | 5161at2759 |
TreeFami | TF315244 |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels R-MMU-5578775, Ion homeostasis |
Miscellaneous databases
BioGRID-ORCSi | 20191, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ryr2, mouse |
PROi | PR:E9Q401 |
RNActi | E9Q401, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021313, Expressed in myocardium of ventricle and 174 other tissues |
Genevisiblei | E9Q401, MM |
Family and domain databases
CDDi | cd12877, SPRY1_RyR, 1 hit cd12878, SPRY2_RyR, 1 hit cd12879, SPRY3_RyR, 1 hit |
Gene3Di | 2.60.120.920, 3 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR014821, Ins145_P3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR013333, Ryan_recept IPR003032, Ryanodine_rcpt IPR009460, Ryanrecept_TM4-6 IPR035910, RyR/IP3R_RIH_dom_sf IPR035761, SPRY1_RyR IPR035764, SPRY2_RyR IPR035762, SPRY3_RyR IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF06459, RR_TM4-6, 1 hit PF01365, RYDR_ITPR, 2 hits PF02026, RyR, 4 hits PF00622, SPRY, 3 hits |
PRINTSi | PR00795, RYANODINER |
SMARTi | View protein in SMART SM00472, MIR, 4 hits SM00449, SPRY, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF47473, SSF47473, 1 hit SSF49899, SSF49899, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 3 hits PS50919, MIR, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RYR2_MOUSE | |
Accessioni | E9Q401Primary (citable) accession number: E9Q401 Secondary accession number(s): O70181 Q9ERN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families