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UniProtKB - E9Q401 (RYR2_MOUSE)

Entry version 94 (29 Sep 2021)
Sequence version 1 (05 Apr 2011)
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Protein

Ryanodine receptor 2

Gene

Ryr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2672351, Stimuli-sensing channels
R-MMU-5578775, Ion homeostasis

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		E9Q401, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 2
Short name:
RYR-2
Short name:
RyR2
Alternative name(s):
Cardiac muscle ryanodine receptor
Cardiac muscle ryanodine receptor-calcium release channel
Type 2 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ryr2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:99685, Ryr2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000021313

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4231CytoplasmicSequence analysisAdd BLAST4231
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4232 – 4252HelicalSequence analysisAdd BLAST21
Transmembranei4278 – 4298HelicalSequence analysisAdd BLAST21
Transmembranei4502 – 4522HelicalSequence analysisAdd BLAST21
Transmembranei4579 – 4599HelicalSequence analysisAdd BLAST21
Transmembranei4729 – 4749HelicalSequence analysisAdd BLAST21
Transmembranei4768 – 4788HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4819 – 4828Pore-formingCurated10
Transmembranei4849 – 4869HelicalSequence analysisAdd BLAST21
Topological domaini4870 – 4966CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonically lethal. Embryos die at about 10 dpc, due to defects in heart tube development. Cardiac myotubes display enlarged rough endoplasmic reticulum and cytoplasmic vesicles that contain high levels of Ca2+.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi77A → V: No change to global protein fold or protein stability. Alters local protein folding. 1 Publication1
Mutagenesisi186V → M: No change to global protein fold or protein stability. Alters local protein folding. 1 Publication1
Mutagenesisi2813S → A: Protects against tachycardia and subsequent death due to heart failure. 1 Publication1
Mutagenesisi2813S → D: Abolishes phosphorylation by CaMK2D. Tendency to tachycardia and subsequent death due to heart failure. 1 Publication1
Mutagenesisi4819G → A: Strongly reduced calcium channel activity. Abolishes ryanodine binding. 1 Publication1
Mutagenesisi4821R → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication1
Mutagenesisi4823G → A: Reduced calcium channel activity. Reduces single channel conductance by 97%. No effect on ryaodine binding. 1 Publication1
Mutagenesisi4824G → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication1
Mutagenesisi4825G → A: Strongly reduced calcium channel activity. Abolishes ryanodine binding. 1 Publication1
Mutagenesisi4827G → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication1
Mutagenesisi4828D → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004155821 – 4966Ryanodine receptor 2Add BLAST4966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1341PhosphoserineCombined sources1
Modified residuei1870PhosphoserineBy similarity1
Modified residuei2030Phosphoserine; by PKA1 Publication1
Modified residuei2368PhosphoserineCombined sources1
Modified residuei2696PhosphoserineBy similarity1
Modified residuei2796PhosphoserineCombined sources1
Modified residuei2807Phosphoserine; by CaMK2D and PKACombined sources2 Publications1
Modified residuei2810PhosphoserineCombined sources1
Modified residuei2813Phosphoserine; by CaMK2DCombined sources1 Publication1
Modified residuei2946PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2807 and Ser-2813 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca2+ levels.3 Publications
Phosphorylation at Ser-2030 by PKA enhances the response to lumenal calcium.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9Q401

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9Q401

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9Q401

PeptideAtlas

More...PeptideAtlasi		E9Q401

PRoteomics IDEntifications database

More...PRIDEi		E9Q401

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		260963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		E9Q401

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E9Q401

SwissPalm database of S-palmitoylation events

More...SwissPalmi		E9Q401

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, lung, cerebellum and brain. Detected at lower levels in adrenal gland, stomach, thymus, esophagus and ovary.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000021313, Expressed in myocardium of ventricle and 185 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9Q401, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Can also form heterotetramers with RYR1 and RYR3.

Interacts with CALM and S100A1; these interactions regulate channel activity.

Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1.

Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity).

Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca2+ leaks.

Interacts with SELENON (By similarity).

Identified in a complex, composed of FSD2, CMYA5 and RYR2 (PubMed:28740084).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		203046, 22 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3137, Ryanodine 2 complex

Protein interaction database and analysis system

More...IntActi		E9Q401, 67 interactors

Molecular INTeraction database

More...MINTi		E9Q401

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000021750

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		E9Q401, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14966
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		E9Q401

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9Q401

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 165MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini172 – 217MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini225 – 280MIR 3PROSITE-ProRule annotationAdd BLAST56
Domaini286 – 343MIR 4PROSITE-ProRule annotationAdd BLAST58
Domaini351 – 408MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini599 – 809B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST211
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati853 – 9661Add BLAST114
Repeati967 – 10802Add BLAST114
Domaini1025 – 1222B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST198
Domaini1357 – 1563B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST207
Repeati2691 – 28093Add BLAST119
Repeati2811 – 29244Add BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni853 – 29244 X approximate repeatsAdd BLAST2072
Regioni1358 – 1377DisorderedSequence analysisAdd BLAST20
Regioni1857 – 1890DisorderedSequence analysisAdd BLAST34
Regioni2353 – 2372DisorderedSequence analysisAdd BLAST20
Regioni3580 – 3609Interaction with CALMBy similarityAdd BLAST30
Regioni4335 – 4363DisorderedSequence analysisAdd BLAST29
Regioni4417 – 4466DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1859 – 1890Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi4343 – 4363Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2243, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154906

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000040_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E9Q401

Identification of Orthologs from Complete Genome Data

More...OMAi		SDDFVAC

Database of Orthologous Groups

More...OrthoDBi		5161at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E9Q401

TreeFam database of animal gene trees

More...TreeFami		TF315244

Family and domain databases

Conserved Domains Database

More...CDDi		cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q401-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE 
        60         70         80         90        100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF 
       110        120        130        140        150
MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ 
       160        170        180        190        200
EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNSS 
       210        220        230        240        250
WHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG 
       260        270        280        290        300
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV 
       310        320        330        340        350
TTGKYLSLME DKNLLLMDKE KADVKSTAFA FRSSKEKLDV GVRKEVDGMG 
       360        370        380        390        400
TSEIKYGDSI CYIQHVDTGL WLTYQAVDVK SARMGSIQRK AIMHHEGHMD 
       410        420        430        440        450
DGLNLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKV KLPTIDLPIE 
       460        470        480        490        500
SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE 
       510        520        530        540        550
CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ 
       560        570        580        590        600
FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL 
       610        620        630        640        650
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN 
       660        670        680        690        700
HVSSMRPNIF LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST 
       710        720        730        740        750
EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART VSSPNQHLLR 
       760        770        780        790        800
TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV 
       810        820        830        840        850
RFLLGGRHGE FKFLPPPGYA ACYEAVLPKE KLKVEHSREY KQERTYTRDL 
       860        870        880        890        900
LGPTVSLTQA AFTPVPVDTS QIVLPPHLER IRERLAENIH ELWVMNKIEL 
       910        920        930        940        950
GWQYGPVRDD NKRQHPCLVE FCKLPEQERN YNLQMSLETL KTLLALGCHV 
       960        970        980        990       1000
GIADEHAEEK VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA 
      1010       1020       1030       1040       1050
ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL 
      1060       1070       1080       1090       1100
REAVRTLLGY GYHLEAPDQD HASRAEVCSG TGERFRIFRA EKTYAVKAGR 
      1110       1120       1130       1140       1150
WYFEFEAVTA GDMRVGWSRP GCQPDLELGS DDRAFAFDGF KAQRWHQGNE 
      1160       1170       1180       1190       1200
HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG 
      1210       1220       1230       1240       1250
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW 
      1260       1270       1280       1290       1300
LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNNNTDIM 
      1310       1320       1330       1340       1350
FYRLSMPIEC AEVFSKSVAG GLPGAGFYGP KNDLEDFDVD SDFEVLMKTA 
      1360       1370       1380       1390       1400
HGHLVPDRID KDKETPKPEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTG 
      1410       1420       1430       1440       1450
HSARLTEDVL ADDRDDYEYL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF 
      1460       1470       1480       1490       1500
HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR 
      1510       1520       1530       1540       1550
NNSNGLEIGC VVDAASGLLT FIANGKELST YYQVEPSTKL FPAVFAQATS 
      1560       1570       1580       1590       1600
PNVFQFELGR IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM 
      1610       1620       1630       1640       1650
PNQFLKVDVS RISERQGWLV QCLDPLQFMS LHIPEENRSV DILELTEQEE 
      1660       1670       1680       1690       1700
LLQFHYHTLR LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR 
      1710       1720       1730       1740       1750
AGYYDLLIDI HLSSYATARL MMNNEFIVPM TEETKSITLF PDENKKHGLP 
      1760       1770       1780       1790       1800
GIGLSTSLRP RMRFSSPSFV SISNDCYQYS PEFPLDILKA KTIQMLTEAV 
      1810       1820       1830       1840       1850
KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS 
      1860       1870       1880       1890       1900
VFKEAAVPEE EGGTPEKEIS IEDAKLEGEE EAKGGKRPKE GLLQMKLPEP 
      1910       1920       1930       1940       1950
VKLQMCLLLQ YLCDCQVRHR IEAIVAFSDD FVAKLQDNQR FRYNEVMQAL 
      1960       1970       1980       1990       2000
NMSAALTARK TREFRSPPQE QINMLLNFKD DKSECPCPEE IRDQLLDFHE 
      2010       2020       2030       2040       2050
DLMTHCGIEL DEDGSLDGSN DLTIRGRLLS LVEKVTYLKK KQAEKPVASD 
      2060       2070       2080       2090       2100
SRKCSSLQQL ISETMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRA 
      2110       2120       2130       2140       2150
LPKTYTINGV SVEDTINLLA SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN 
      2160       2170       2180       2190       2200
NKVFYQHPNL MRALGMHETV MEVMVNVLGG GESKEITFPK MVANCCRFLC 
      2210       2220       2230       2240       2250
YFCRISRQNQ KAMFDHLSYL LENSSVGLAS PAMRGSTPLD VAAASVMDNN 
      2260       2270       2280       2290       2300
ELALALREPD LEKVVRYLAG CGLQSCQMLV SKGYPDIGWN PVEGERYLDF 
      2310       2320       2330       2340       2350
LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN GLLAAMEEAI 
      2360       2370       2380       2390       2400
KIAEDPSRDG PSPTSGSSKT LDIEEEEDDT IHMGNAIMTF YAALIDLLGR 
      2410       2420       2430       2440       2450
CAPEMHLIHA GKGEAIRIRS ILRSLIPLGD LVGVISIAFQ MPTIAKDGKV 
      2460       2470       2480       2490       2500
VEPDMSAGFC PDHKAAMVLF LDRVYGIEVQ DFLLHLLEVG FLPDLRAAAS 
      2510       2520       2530       2540       2550
LDTAALSATD MALALNRYLC TAVLPLLTRC APLFAGTEHH ASLIDSLLHT 
      2560       2570       2580       2590       2600
VYRLSKGCSL TKAQRDSIEV CLLSICGQLR PSMMQHLLRR LVFDVPLLNE 
      2610       2620       2630       2640       2650
HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS RKLFWGIFDA 
      2660       2670       2680       2690       2700
LSQKKYEQEL FKLALPCLSA VAGALPPDYM ESNYVSMMEK QSSMDSEGNF 
      2710       2720       2730       2740       2750
NPQPVDTSNI TIPEKLEYFI NKYAEHSHDK WSMDKLANGW IYGEIYSDSS 
      2760       2770       2780       2790       2800
KIQPLMKPYK LLSEKEKEIY RWPIKESLKT MLAWGWRIER TREGDSMALY 
      2810       2820       2830       2840       2850
NRTRRISQTS QVSIDAAHGY SPRAIDMSNV TLSRDLHAMA EMMAENYHNI 
      2860       2870       2880       2890       2900
WAKKKKLELE SKGGGNHPLL VPYDTLTAKE KAKDREKAQD IFKFLQISGY 
      2910       2920       2930       2940       2950
VVSRGFKDLD LDTPSIEKRF AYSFLQQLIR YVDEAHQYIL EFDGGSRSKG 
      2960       2970       2980       2990       3000
EHFPYEQEIK FFAKVVLPLI DQYFKNHRLY FLSAASRPLC TGGHASNKEK 
      3010       3020       3030       3040       3050
EMVTSLFCKL GVLVRHRISL FGNDATSIVN CLHILGQTLD ARTVMKTGLD 
      3060       3070       3080       3090       3100
SVKSALRAFL DNAAEDLEKT MENLKQGQFT HTRSQPKGVT QIINYTTVAL 
      3110       3120       3130       3140       3150
LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG TSKSIYVERQ 
      3160       3170       3180       3190       3200
RSALGECLAA FAGAFPIAFL ETHLDKHNVY SIYNTRSSRE RAALSLPANV 
      3210       3220       3230       3240       3250
EDVCPNIPSL EKLMTEIIEL AESGIRYTQM PYMMEVVLPM LCSYMSRWWE 
      3260       3270       3280       3290       3300
HGPENHPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV 
      3310       3320       3330       3340       3350
FSQPIINKVK PQLLKTHFLP LMEKLKKKAA MVVSEEDHLK AEARGDMSEA 
      3360       3370       3380       3390       3400
ELLILDEFTT LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE 
      3410       3420       3430       3440       3450
VFIYWSKSHN FKREEQNFVV QNEINNMSFL ITDTKSKMSK AAISDQERKK 
      3460       3470       3480       3490       3500
MKRKGDRYSM QTSLIVAALK RLLPIGLNIC APGDQELIAL AKNRFSLKDT 
      3510       3520       3530       3540       3550
EEEVRDIIRS NIHLQGKLED PAIRWQMALY KDLPNRTEDP SDPERTVERV 
      3560       3570       3580       3590       3600
LGIANVLFHL EQKSKYTGRG YFSLVEHPQR SKKAVWHKLL SKQRKRAVVA 
      3610       3620       3630       3640       3650
CFRMAPLYNL PRHRAVNLFL QGYEKSWIET EEHYFEDKLI EDLAKPGAEL 
      3660       3670       3680       3690       3700
PEEDEAMKRV DPLHQLILLF SRTALTEKCK LEEDFLYMAY ADIMAKSCHD 
      3710       3720       3730       3740       3750
EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL QTISASKGET 
      3760       3770       3780       3790       3800
GPMVAATLKL GIAILNGGNS TVQQKMLDYL KEKKDVGFFQ SLAGLMQSCS 
      3810       3820       3830       3840       3850
VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR FLQLLCEGHN 
      3860       3870       3880       3890       3900
SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDIIDEQ 
      3910       3920       3930       3940       3950
GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF 
      3960       3970       3980       3990       4000
AHMQMKLSQD SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD 
      4010       4020       4030       4040       4050
MLVESSNNVE MILKFFDMFL KLKDLTSSDT FKEYDPDGKG VISKRDFHKA 
      4060       4070       4080       4090       4100
MESHKHYTQS ETEFLLSCAE TDENETLDYE EFVKRFHEPA KDIGFNVAVL 
      4110       4120       4130       4140       4150
LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS AKRIERVYFE 
      4160       4170       4180       4190       4200
ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ 
      4210       4220       4230       4240       4250
LAAQISESDL NERLANKEES EKERPEEQAP RMGFFSLLTI QSALFALRYN 
      4260       4270       4280       4290       4300
VLTLVRMLSL KSLKKQMKRM KKMTVKDMVL AFFSSYWSVF VTLLHFVASV 
      4310       4320       4330       4340       4350
CRGFFRIVSS LLLGGSLVEG AKKIKVAELL ANMPDPTQDE VRGDEEEGER 
      4360       4370       4380       4390       4400
KPLESALPSE DLTDLKELTE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG 
      4410       4420       4430       4440       4450
LSDLMTNPVP VPEVQEKFQE QKAKEEKEEK EETKSEPEKA EGEDGEKEEK 
      4460       4470       4480       4490       4500
AKDEKSKQKL RQLHTHRYGE PEVPESAFWK KIIAYQQKLL NYFARNFYNM 
      4510       4520       4530       4540       4550
RMLALFVAFA INFILLFYKV STSSVVEGKE LPTRTSSDTA KVTNSLDSSP 
      4560       4570       4580       4590       4600
HRIIAVHYVL EESSGYMEPT LRILAILHTI ISFFCIIGYY CLKVPLVIFK 
      4610       4620       4630       4640       4650
REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTQSFP NNYWDKFVKR 
      4660       4670       4680       4690       4700
KVMDKYGEFY GRDRISELLG MDKAALDFSD AREKKKPKKD SSLSAVLNSI 
      4710       4720       4730       4740       4750
DVKYQMWKLG VVFTDNSFLY LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK 
      4760       4770       4780       4790       4800
TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT 
      4810       4820       4830       4840       4850
PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI YRIIFDITFF 
      4860       4870       4880       4890       4900
FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV 
      4910       4920       4930       4940       4950
PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWEF 
      4960 
FPAGDCFRKQ YEDQLN
Length:4,966
Mass (Da):564,819
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF43425091AF7114F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6U7V1F6U7V1_MOUSE
Ryanodine receptor 2
Ryr2
4,966Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJP1A0A1Y7VJP1_MOUSE
Ryanodine receptor 2
Ryr2
1,028Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80ZZ5Q80ZZ5_MOUSE
Ryanodine receptor 2
Ryr2
1,020Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VK09A0A1Y7VK09_MOUSE
Ryanodine receptor 2
Ryr2
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1332N → S in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti1412D → G in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti1962R → K in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti2265V → VA in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti2532P → R in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti3192A → T in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti3533L → F in AAG34081 (PubMed:10473538).Curated1
Sequence conflicti4324I → T in CAA58785 (PubMed:7876312).Curated1
Sequence conflicti4853V → E in CAA58785 (PubMed:7876312).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF295105 mRNA Translation: AAG34081.1
AC131329 Genomic DNA No translation available.
AC159208 Genomic DNA No translation available.
CT010468 Genomic DNA No translation available.
CT572985 Genomic DNA No translation available.
AB012003 Genomic DNA Translation: BAA25137.1
X83933 mRNA Translation: CAA58785.1
D38217 mRNA Translation: BAA07392.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS49206.1

Protein sequence database of the Protein Information Resource

More...PIRi		I48742

NCBI Reference Sequences

More...RefSeqi		NP_076357.2, NM_023868.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000021750; ENSMUSP00000021750; ENSMUSG00000021313

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20191

UCSC genome browser

More...UCSCi		uc007pld.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295105 mRNA Translation: AAG34081.1
AC131329 Genomic DNA No translation available.
AC159208 Genomic DNA No translation available.
CT010468 Genomic DNA No translation available.
CT572985 Genomic DNA No translation available.
AB012003 Genomic DNA Translation: BAA25137.1
X83933 mRNA Translation: CAA58785.1
D38217 mRNA Translation: BAA07392.1
CCDSiCCDS49206.1
PIRiI48742
RefSeqiNP_076357.2, NM_023868.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MC2NMR-A10-224[»]
3IM5X-ray2.55A/B1-217[»]
3IM6X-ray1.70A1-217[»]
3IM7X-ray2.21A1-217[»]
3QR5X-ray2.30A/B1-217[»]
4ETVX-ray1.65A/B2699-2904[»]
4KEIX-ray2.41A1-217[»]
4KEJX-ray2.55A1-217[»]
4KEKX-ray2.15A1-217[»]
4L4HX-ray2.00A1-547[»]
4L4IX-ray2.15A1-547[»]
4P9IX-ray1.34A1080-1253[»]
4P9LX-ray1.44A1080-1253[»]
5C33X-ray1.21A/B650-844[»]
5VSNX-ray1.44A1084-1252[»]
6J6LX-ray1.45A/B650-844[»]
6MM5X-ray1.95C2799-2810[»]
6MM6X-ray2.39D/F2699-2904[»]
6MM7X-ray1.85C/E2699-2904[»]
6MM8X-ray1.85D2699-2904[»]
6WOUelectron microscopy3.27A/B/C/D1-4966[»]
6WOVelectron microscopy5.10A/B/C/D1-4966[»]
BMRBiE9Q401
SMRiE9Q401
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi203046, 22 interactors
ComplexPortaliCPX-3137, Ryanodine 2 complex
IntActiE9Q401, 67 interactors
MINTiE9Q401
STRINGi10090.ENSMUSP00000021750

Protein family/group databases

MoonDBiE9Q401, Predicted

PTM databases

iPTMnetiE9Q401
PhosphoSitePlusiE9Q401
SwissPalmiE9Q401

Proteomic databases

jPOSTiE9Q401
MaxQBiE9Q401
PaxDbiE9Q401
PeptideAtlasiE9Q401
PRIDEiE9Q401
ProteomicsDBi260963

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3476, 243 antibodies

The DNASU plasmid repository

More...DNASUi		20191

Genome annotation databases

EnsembliENSMUST00000021750; ENSMUSP00000021750; ENSMUSG00000021313
GeneIDi20191
KEGGimmu:20191
UCSCiuc007pld.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6262
MGIiMGI:99685, Ryr2
VEuPathDBiHostDB:ENSMUSG00000021313

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
GeneTreeiENSGT00940000154906
HOGENOMiCLU_000040_2_0_1
InParanoidiE9Q401
OMAiSDDFVAC
OrthoDBi5161at2759
PhylomeDBiE9Q401
TreeFamiTF315244

Enzyme and pathway databases

ReactomeiR-MMU-2672351, Stimuli-sensing channels
R-MMU-5578775, Ion homeostasis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		20191, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ryr2, mouse

Protein Ontology

More...PROi		PR:E9Q401
RNActiE9Q401, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000021313, Expressed in myocardium of ventricle and 185 other tissues
GenevisibleiE9Q401, MM

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q401
Secondary accession number(s): O70181
, Q62174, Q62197, Q9ERN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: September 29, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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