UniProtKB - E9Q401 (RYR2_MOUSE)

BLAST

>sp|E9Q401|RYR2_MOUSE Ryanodine receptor 2 OS=Mus musculus OX=10090 GN=Ryr2 PE=1 SV=1
MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL
LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD
LILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH
MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV
TTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSI
CYIQHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR
STVFLFNRFIRGLDALSKKVKLPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR
ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL
IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL
LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF
LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD
DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE
NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREY
KQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIEL
GWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK
VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI
QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSG
TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGF
KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG
FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ
VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNNNTDIMFYRLSMPIECAEVFSKSVAG
GLPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEK
PSRLKQRFLLRRTKPDYSTGHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPAN
VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR
NNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGR
IKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLV
QCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSH
VDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLF
PDENKKHGLPGIGLSTSLRPRMRFSSPSFVSISNDCYQYSPEFPLDILKAKTIQMLTEAV
KEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAAVPEE
EGGTPEKEISIEDAKLEGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHR
IEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTREFRSPPQEQINMLLNFKD
DKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKK
KQAEKPVASDSRKCSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRA
LPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL
MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL
LENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLV
SKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN
GLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDIEEEEDDTIHMGNAIMTFYAALIDLLGR
CAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFC
PDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLC
TAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLR
PSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLS
RKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNF
NPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYK
LLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGY
SPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKE
KAKDREKAQDIFKFLQISGYVVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYIL
EFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEK
EMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFL
DNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDL
ILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVY
SIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMMEVVLPM
LCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAV
FSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTT
LARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVV
QNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNIC
APGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDP
SDPERTVERVLGIANVLFHLEQKSKYTGRGYFSLVEHPQRSKKAVWHKLLSKQRKRAVVA
CFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAELPEEDEAMKRV
DPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEK
QKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYL
KEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFR
FLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIDEQ
GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQD
SSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFL
KLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYE
EFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGS
AKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ
LAAQISESDLNERLANKEESEKERPEEQAPRMGFFSLLTIQSALFALRYNVLTLVRMLSL
KSLKKQMKRMKKMTVKDMVLAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEG
AKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFG
LDLKREGGQYKLIPHNPNAGLSDLMTNPVPVPEVQEKFQEQKAKEEKEEKEETKSEPEKA
EGEDGEKEEKAKDEKSKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNM
RMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTSSDTAKVTNSLDSSPHRIIAVHYVL
EESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQP
SEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSD
AREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAA
HLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDT
PDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAI
IQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFF
LMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN

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History
Entry version 75 (07 Nov 2018)
Sequence version 1 (05 Apr 2011)
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Protein

Ryanodine receptor 2

Gene

Ryr2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Calcium channel that mediates the release of Ca²⁺ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca²⁺ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.4 Publications

Activity regulationⁱ

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP. Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites (By similarity).By similarity

GO - Molecular functionⁱ

calcium channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9628868
calcium-induced calcium release activity Source: MGI
calcium ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium-release channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10473538
calmodulin binding
Source: MGI
Inferred from direct assayⁱ
- 17431507
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 12324472
- 20427316
organic cyclic compound binding
Source: MGI
Inferred from physical interactionⁱ
- 17431507
protein kinase A catalytic subunit binding Source: MGI
protein kinase A regulatory subunit binding Source: MGI
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12676814
protein self-association
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10473538
ryanodine-sensitive calcium-release channel activity
Source: MGI
Inferred from direct assayⁱ
- 14593104
- 17431507
scaffold protein binding Source: MGI
suramin binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

BMP signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 17360443
calcium ion transmembrane transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 21673970
calcium ion transport
Source: UniProtKB
Inferred from direct assayⁱ
- 10473538
calcium ion transport into cytosol Source: MGI
calcium-mediated signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9628868
calcium-mediated signaling using intracellular calcium source Source: MGI
canonical Wnt signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 17360443
cardiac muscle contraction Source: MGI
cardiac muscle hypertrophy
Source: MGI
Inferred from mutant phenotypeⁱ
- 17431507
cellular calcium ion homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9628868
cellular response to caffeine
Source: UniProtKB
Inferred from direct assayⁱ
- 9628868
cellular response to epinephrine stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17872467
cytosolic calcium ion transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 17431507
detection of calcium ion Source: MGI
embryonic heart tube morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9628868
establishment of protein localization to endoplasmic reticulum Source: MGI
ion transmembrane transport Source: MGI
left ventricular cardiac muscle tissue morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17431507
manganese ion transmembrane transport Source: MGI
negative regulation of cytosolic calcium ion concentration Source: MGI
positive regulation of calcium-transporting ATPase activity Source: MGI
positive regulation of heart rate
Source: MGI
Inferred from mutant phenotypeⁱ
- 12089338
- 17431507
positive regulation of sequestering of calcium ion Source: MGI
positive regulation of the force of heart contraction Source: MGI
Purkinje myocyte to ventricular cardiac muscle cell signaling
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17872467
regulation of atrial cardiac muscle cell action potential Source: MGI
regulation of AV node cell action potential Source: MGI
regulation of cardiac muscle contraction Source: MGI
regulation of cardiac muscle contraction by calcium ion signaling Source: MGI
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 12837242
regulation of cytosolic calcium ion concentration Source: MGI
regulation of heart rate
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17872467
regulation of SA node cell action potential Source: MGI
regulation of ventricular cardiac muscle cell action potential Source: MGI
release of sequestered calcium ion into cytosol Source: MGI
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Source: BHF-UCL
Inferred from direct assayⁱ
- 20226167
response to caffeine
Source: UniProtKB
Inferred from direct assayⁱ
- 10473538
response to calcium ion Source: MGI
response to hypoxia
Source: BHF-UCL
Inferred from direct assayⁱ
- 19120137
response to magnesium ion Source: MGI
response to muscle activity Source: MGI
response to muscle stretch Source: MGI
response to redox state Source: MGI
sarcoplasmic reticulum calcium ion transport Source: MGI
type B pancreatic cell apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15044459
ventricular cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17872467

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel
Biological process	Calcium transport, Ion transport, Transport
Ligand	Calcium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels R-MMU-5578775 Ion homeostasis

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels
R-MMU-5578775 Ion homeostasis

Protein family/group databases

MoonDBⁱ	E9Q401 Predicted

MoonDBⁱ

E9Q401 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ryanodine receptor 2 Short name: RYR-2 Short name: RyR2 Alternative name(s): Cardiac muscle ryanodine receptor Cardiac muscle ryanodine receptor-calcium release channel Type 2 ryanodine receptor
Gene namesⁱ	Name:Ryr2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:99685 Ryr2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 4231	CytoplasmicSequence analysisAdd BLAST	4231
Transmembraneⁱ	4232 – 4252	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	4278 – 4298	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	4502 – 4522	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	4579 – 4599	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	4729 – 4749	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	4768 – 4788	HelicalSequence analysisAdd BLAST	21
Intramembraneⁱ	4819 – 4828	Pore-formingCurated	10
Transmembraneⁱ	4849 – 4869	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	4870 – 4966	CytoplasmicSequence analysisAdd BLAST	97

Keywords - Cellular componentⁱ

Membrane, Sarcoplasmic reticulum

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Embryonically lethal. Embryos die at about 10 dpc, due to defects in heart tube development. Cardiac myotubes display enlarged rough endoplasmic reticulum and cytoplasmic vesicles that contain high levels of Ca²⁺.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	77	A → V: No change to global protein fold or protein stability. Alters local protein folding. 1 Publication	1
Mutagenesisⁱ	186	V → M: No change to global protein fold or protein stability. Alters local protein folding. 1 Publication	1
Mutagenesisⁱ	2813	S → A: Protects against tachycardia and subsequent death due to heart failure. 1 Publication	1
Mutagenesisⁱ	2813	S → D: Abolishes phosphorylation by CaMK2D. Tendency to tachycardia and subsequent death due to heart failure. 1 Publication	1
Mutagenesisⁱ	4819	G → A: Strongly reduced calcium channel activity. Abolishes ryanodine binding. 1 Publication	1
Mutagenesisⁱ	4821	R → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication	1
Mutagenesisⁱ	4823	G → A: Reduced calcium channel activity. Reduces single channel conductance by 97%. No effect on ryaodine binding. 1 Publication	1
Mutagenesisⁱ	4824	G → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication	1
Mutagenesisⁱ	4825	G → A: Strongly reduced calcium channel activity. Abolishes ryanodine binding. 1 Publication	1
Mutagenesisⁱ	4827	G → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication	1
Mutagenesisⁱ	4828	D → A: No effect on calcium channel activity. Abolishes ryanodine binding. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000415582	1 – 4966	Ryanodine receptor 2Add BLAST		4966

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1341	PhosphoserineCombined sources	1
Modified residueⁱ	1870	PhosphoserineBy similarity	1
Modified residueⁱ	2030	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	2368	PhosphoserineCombined sources	1
Modified residueⁱ	2696	PhosphoserineBy similarity	1
Modified residueⁱ	2796	PhosphoserineCombined sources	1
Modified residueⁱ	2807	Phosphoserine; by CaMK2D and PKACombined sources2 Publications	1
Modified residueⁱ	2810	PhosphoserineCombined sources	1
Modified residueⁱ	2813	Phosphoserine; by CaMK2DCombined sources1 Publication	1
Modified residueⁱ	2946	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2807 and Ser-2813 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca²⁺ levels.3 Publications

Phosphorylation at Ser-2030 by PKA enhances the response to lumenal calcium.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9Q401
PaxDbⁱ	E9Q401
PeptideAtlas More...PeptideAtlasⁱ	E9Q401
PRIDEⁱ	E9Q401

PTM databases

iPTMnetⁱ	E9Q401
PhosphoSitePlusⁱ	E9Q401
SwissPalmⁱ	E9Q401

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021313 Expressed in 152 organ(s), highest expression level in myocardium of ventricle
ExpressionAtlasⁱ	E9Q401 baseline and differential
Genevisibleⁱ	E9Q401 MM

Interactionⁱ

Subunit structureⁱ

Homotetramer. Can also form heterotetramers with RYR1 and RYR3. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca²⁺ leaks. Interacts with SELENON (By similarity). Identified in a complex, composed of FSD2, CMYA5 and RYR2 (PubMed:28740084).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		7	EBI-643628,EBI-643628
Camk2d	Q6PHZ2	2	EBI-643628,EBI-2308458
Fkbp1b	Q9Z2I2	3	EBI-643628,EBI-6379859
HRC	P23327	3	EBI-643628,EBI-9639760	From Homo sapiens.
Plce1	Q8K4S1	2	EBI-643628,EBI-6902760

GO - Molecular functionⁱ

calmodulin binding
Source: MGI
Inferred from direct assayⁱ
- 17431507
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 12324472
- 20427316
protein kinase A catalytic subunit binding Source: MGI
protein kinase A regulatory subunit binding Source: MGI
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12676814
protein self-association
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10473538
scaffold protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203046, 6 interactors
ComplexPortalⁱ	CPX-3137 Ryanodine 2 complex
IntActⁱ	E9Q401, 66 interactors
Molecular INTeraction database More...MINTⁱ	E9Q401
STRINGⁱ	10090.ENSMUSP00000021750

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	15 – 17	Combined sources	3
Beta strandⁱ	19 – 28	Combined sources	10
Beta strandⁱ	31 – 38	Combined sources	8
Beta strandⁱ	41 – 43	Combined sources	3
Beta strandⁱ	48 – 51	Combined sources	4
Turnⁱ	53 – 57	Combined sources	5
Helixⁱ	62 – 64	Combined sources	3
Beta strandⁱ	67 – 73	Combined sources	7
Helixⁱ	75 – 84	Combined sources	10
Beta strandⁱ	97 – 102	Combined sources	6
Beta strandⁱ	118 – 123	Combined sources	6
Turnⁱ	124 – 126	Combined sources	3
Beta strandⁱ	129 – 132	Combined sources	4
Beta strandⁱ	145 – 151	Combined sources	7
Beta strandⁱ	154 – 156	Combined sources	3
Beta strandⁱ	159 – 167	Combined sources	9
Beta strandⁱ	180 – 185	Combined sources	6
Turnⁱ	186 – 188	Combined sources	3
Beta strandⁱ	191 – 196	Combined sources	6
Beta strandⁱ	198 – 208	Combined sources	11
Beta strandⁱ	212 – 216	Combined sources	5
Helixⁱ	220 – 222	Combined sources	3
Beta strandⁱ	233 – 238	Combined sources	6
Turnⁱ	239 – 242	Combined sources	4
Beta strandⁱ	243 – 246	Combined sources	4
Helixⁱ	256 – 258	Combined sources	3
Beta strandⁱ	261 – 264	Combined sources	4
Helixⁱ	265 – 269	Combined sources	5
Helixⁱ	271 – 273	Combined sources	3
Beta strandⁱ	275 – 280	Combined sources	6
Turnⁱ	283 – 286	Combined sources	4
Beta strandⁱ	294 – 299	Combined sources	6
Turnⁱ	300 – 302	Combined sources	3
Beta strandⁱ	305 – 308	Combined sources	4
Beta strandⁱ	314 – 317	Combined sources	4
Helixⁱ	319 – 321	Combined sources	3
Helixⁱ	324 – 327	Combined sources	4
Beta strandⁱ	329 – 333	Combined sources	5
Turnⁱ	356 – 358	Combined sources	3
Beta strandⁱ	360 – 365	Combined sources	6
Turnⁱ	366 – 368	Combined sources	3
Beta strandⁱ	371 – 374	Combined sources	4
Beta strandⁱ	389 – 396	Combined sources	8
Beta strandⁱ	403 – 407	Combined sources	5
Helixⁱ	410 – 436	Combined sources	27
Helixⁱ	449 – 462	Combined sources	14
Helixⁱ	472 – 491	Combined sources	20
Helixⁱ	494 – 505	Combined sources	12
Beta strandⁱ	508 – 510	Combined sources	3
Helixⁱ	511 – 518	Combined sources	8
Helixⁱ	520 – 541	Combined sources	22
Beta strandⁱ	653 – 658	Combined sources	6
Beta strandⁱ	672 – 681	Combined sources	10
Beta strandⁱ	693 – 699	Combined sources	7
Helixⁱ	700 – 702	Combined sources	3
Beta strandⁱ	704 – 706	Combined sources	3
Helixⁱ	707 – 709	Combined sources	3
Beta strandⁱ	710 – 712	Combined sources	3
Beta strandⁱ	724 – 727	Combined sources	4
Beta strandⁱ	729 – 734	Combined sources	6
Beta strandⁱ	737 – 740	Combined sources	4
Beta strandⁱ	754 – 760	Combined sources	7
Turnⁱ	761 – 764	Combined sources	4
Beta strandⁱ	765 – 770	Combined sources	6
Beta strandⁱ	788 – 794	Combined sources	7
Beta strandⁱ	799 – 803	Combined sources	5
Helixⁱ	822 – 825	Combined sources	4
Beta strandⁱ	833 – 839	Combined sources	7
Beta strandⁱ	1086 – 1089	Combined sources	4
Helixⁱ	1092 – 1094	Combined sources	3
Beta strandⁱ	1096 – 1109	Combined sources	14
Beta strandⁱ	1111 – 1118	Combined sources	8
Beta strandⁱ	1130 – 1138	Combined sources	9
Turnⁱ	1139 – 1142	Combined sources	4
Beta strandⁱ	1143 – 1153	Combined sources	11
Beta strandⁱ	1161 – 1167	Combined sources	7
Turnⁱ	1168 – 1171	Combined sources	4
Beta strandⁱ	1172 – 1177	Combined sources	6
Beta strandⁱ	1191 – 1194	Combined sources	4
Beta strandⁱ	1201 – 1207	Combined sources	7
Beta strandⁱ	1213 – 1216	Combined sources	4
Helixⁱ	1221 – 1223	Combined sources	3
Turnⁱ	1227 – 1235	Combined sources	9
Helixⁱ	1239 – 1242	Combined sources	4
Helixⁱ	2714 – 2716	Combined sources	3
Helixⁱ	2717 – 2737	Combined sources	21
Turnⁱ	2748 – 2751	Combined sources	4
Helixⁱ	2759 – 2761	Combined sources	3
Helixⁱ	2764 – 2783	Combined sources	20
Beta strandⁱ	2787 – 2790	Combined sources	4
Helixⁱ	2796 – 2799	Combined sources	4
Helixⁱ	2817 – 2819	Combined sources	3
Helixⁱ	2827 – 2829	Combined sources	3
Helixⁱ	2834 – 2861	Combined sources	28
Helixⁱ	2873 – 2875	Combined sources	3
Helixⁱ	2878 – 2897	Combined sources	20
Beta strandⁱ	2900 – 2903	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	E9Q401
SMRⁱ	E9Q401
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	110 – 165	MIR 1PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	172 – 217	MIR 2PROSITE-ProRule annotationAdd BLAST	46
Domainⁱ	225 – 280	MIR 3PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	286 – 343	MIR 4PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	351 – 408	MIR 5PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	599 – 809	B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST	211
Repeatⁱ	853 – 966	1Add BLAST	114
Repeatⁱ	967 – 1080	2Add BLAST	114
Domainⁱ	1025 – 1222	B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST	198
Domainⁱ	1357 – 1563	B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST	207
Repeatⁱ	2691 – 2809	3Add BLAST	119
Repeatⁱ	2811 – 2924	4Add BLAST	114

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	853 – 2924	4 X approximate repeatsAdd BLAST		2072
Regionⁱ	3580 – 3609	Interaction with CALMBy similarityAdd BLAST		30

Domainⁱ

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

Sequence similaritiesⁱ

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2243 Eukaryota ENOG410YCNW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119152
HOGENOMⁱ	HOG000231428
HOVERGENⁱ	HBG006699
InParanoidⁱ	E9Q401
KEGG Orthology (KO) More...KOⁱ	K04962
OMAⁱ	RFSMKDT
TreeFamⁱ	TF315244

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12877 SPRY1_RyR, 1 hit cd12878 SPRY2_RyR, 1 hit cd12879 SPRY3_RyR, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR013320 ConA-like_dom_sf IPR011992 EF-hand-dom_pair IPR002048 EF_hand_dom IPR014821 Ins145_P3_rcpt IPR005821 Ion_trans_dom IPR036300 MIR_dom_sf IPR016093 MIR_motif IPR013662 RIH_assoc-dom IPR000699 RIH_dom IPR013333 Ryan_recept IPR003032 Ryanodine_rcpt IPR015925 Ryanodine_recept-rel IPR009460 Ryanrecept_TM4-6 IPR035910 RyR/IP3R_RIH_dom_sf IPR035761 SPRY1_RyR IPR035764 SPRY2_RyR IPR035762 SPRY3_RyR IPR003877 SPRY_dom
PANTHERⁱ	PTHR13715 PTHR13715, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13833 EF-hand_8, 1 hit PF08709 Ins145_P3_rec, 1 hit PF00520 Ion_trans, 1 hit PF02815 MIR, 1 hit PF08454 RIH_assoc, 1 hit PF06459 RR_TM4-6, 1 hit PF01365 RYDR_ITPR, 2 hits PF02026 RyR, 4 hits PF00622 SPRY, 3 hits
PRINTSⁱ	PR00795 RYANODINER
SMARTⁱ	View protein in SMART SM00472 MIR, 4 hits SM00449 SPRY, 3 hits
SUPFAMⁱ	SSF100909 SSF100909, 2 hits SSF47473 SSF47473, 1 hit SSF49899 SSF49899, 2 hits SSF82109 SSF82109, 2 hits
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 3 hits PS50919 MIR, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

E9Q401-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADAGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE 
        60         70         80         90        100
STSNSKNVPP DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF 
       110        120        130        140        150
MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ 
       160        170        180        190        200
EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNSS 
       210        220        230        240        250
WHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG 
       260        270        280        290        300
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV 
       310        320        330        340        350
TTGKYLSLME DKNLLLMDKE KADVKSTAFA FRSSKEKLDV GVRKEVDGMG 
       360        370        380        390        400
TSEIKYGDSI CYIQHVDTGL WLTYQAVDVK SARMGSIQRK AIMHHEGHMD 
       410        420        430        440        450
DGLNLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKV KLPTIDLPIE 
       460        470        480        490        500
SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE 
       510        520        530        540        550
CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ 
       560        570        580        590        600
FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL 
       610        620        630        640        650
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN 
       660        670        680        690        700
HVSSMRPNIF LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST 
       710        720        730        740        750
EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART VSSPNQHLLR 
       760        770        780        790        800
TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV 
       810        820        830        840        850
RFLLGGRHGE FKFLPPPGYA ACYEAVLPKE KLKVEHSREY KQERTYTRDL 
       860        870        880        890        900
LGPTVSLTQA AFTPVPVDTS QIVLPPHLER IRERLAENIH ELWVMNKIEL 
       910        920        930        940        950
GWQYGPVRDD NKRQHPCLVE FCKLPEQERN YNLQMSLETL KTLLALGCHV 
       960        970        980        990       1000
GIADEHAEEK VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA 
      1010       1020       1030       1040       1050
ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL 
      1060       1070       1080       1090       1100
REAVRTLLGY GYHLEAPDQD HASRAEVCSG TGERFRIFRA EKTYAVKAGR 
      1110       1120       1130       1140       1150
WYFEFEAVTA GDMRVGWSRP GCQPDLELGS DDRAFAFDGF KAQRWHQGNE 
      1160       1170       1180       1190       1200
HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG 
      1210       1220       1230       1240       1250
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW 
      1260       1270       1280       1290       1300
LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNNNTDIM 
      1310       1320       1330       1340       1350
FYRLSMPIEC AEVFSKSVAG GLPGAGFYGP KNDLEDFDVD SDFEVLMKTA 
      1360       1370       1380       1390       1400
HGHLVPDRID KDKETPKPEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTG 
      1410       1420       1430       1440       1450
HSARLTEDVL ADDRDDYEYL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF 
      1460       1470       1480       1490       1500
HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR 
      1510       1520       1530       1540       1550
NNSNGLEIGC VVDAASGLLT FIANGKELST YYQVEPSTKL FPAVFAQATS 
      1560       1570       1580       1590       1600
PNVFQFELGR IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM 
      1610       1620       1630       1640       1650
PNQFLKVDVS RISERQGWLV QCLDPLQFMS LHIPEENRSV DILELTEQEE 
      1660       1670       1680       1690       1700
LLQFHYHTLR LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR 
      1710       1720       1730       1740       1750
AGYYDLLIDI HLSSYATARL MMNNEFIVPM TEETKSITLF PDENKKHGLP 
      1760       1770       1780       1790       1800
GIGLSTSLRP RMRFSSPSFV SISNDCYQYS PEFPLDILKA KTIQMLTEAV 
      1810       1820       1830       1840       1850
KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS 
      1860       1870       1880       1890       1900
VFKEAAVPEE EGGTPEKEIS IEDAKLEGEE EAKGGKRPKE GLLQMKLPEP 
      1910       1920       1930       1940       1950
VKLQMCLLLQ YLCDCQVRHR IEAIVAFSDD FVAKLQDNQR FRYNEVMQAL 
      1960       1970       1980       1990       2000
NMSAALTARK TREFRSPPQE QINMLLNFKD DKSECPCPEE IRDQLLDFHE 
      2010       2020       2030       2040       2050
DLMTHCGIEL DEDGSLDGSN DLTIRGRLLS LVEKVTYLKK KQAEKPVASD 
      2060       2070       2080       2090       2100
SRKCSSLQQL ISETMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRA 
      2110       2120       2130       2140       2150
LPKTYTINGV SVEDTINLLA SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN 
      2160       2170       2180       2190       2200
NKVFYQHPNL MRALGMHETV MEVMVNVLGG GESKEITFPK MVANCCRFLC 
      2210       2220       2230       2240       2250
YFCRISRQNQ KAMFDHLSYL LENSSVGLAS PAMRGSTPLD VAAASVMDNN 
      2260       2270       2280       2290       2300
ELALALREPD LEKVVRYLAG CGLQSCQMLV SKGYPDIGWN PVEGERYLDF 
      2310       2320       2330       2340       2350
LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN GLLAAMEEAI 
      2360       2370       2380       2390       2400
KIAEDPSRDG PSPTSGSSKT LDIEEEEDDT IHMGNAIMTF YAALIDLLGR 
      2410       2420       2430       2440       2450
CAPEMHLIHA GKGEAIRIRS ILRSLIPLGD LVGVISIAFQ MPTIAKDGKV 
      2460       2470       2480       2490       2500
VEPDMSAGFC PDHKAAMVLF LDRVYGIEVQ DFLLHLLEVG FLPDLRAAAS 
      2510       2520       2530       2540       2550
LDTAALSATD MALALNRYLC TAVLPLLTRC APLFAGTEHH ASLIDSLLHT 
      2560       2570       2580       2590       2600
VYRLSKGCSL TKAQRDSIEV CLLSICGQLR PSMMQHLLRR LVFDVPLLNE 
      2610       2620       2630       2640       2650
HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS RKLFWGIFDA 
      2660       2670       2680       2690       2700
LSQKKYEQEL FKLALPCLSA VAGALPPDYM ESNYVSMMEK QSSMDSEGNF 
      2710       2720       2730       2740       2750
NPQPVDTSNI TIPEKLEYFI NKYAEHSHDK WSMDKLANGW IYGEIYSDSS 
      2760       2770       2780       2790       2800
KIQPLMKPYK LLSEKEKEIY RWPIKESLKT MLAWGWRIER TREGDSMALY 
      2810       2820       2830       2840       2850
NRTRRISQTS QVSIDAAHGY SPRAIDMSNV TLSRDLHAMA EMMAENYHNI 
      2860       2870       2880       2890       2900
WAKKKKLELE SKGGGNHPLL VPYDTLTAKE KAKDREKAQD IFKFLQISGY 
      2910       2920       2930       2940       2950
VVSRGFKDLD LDTPSIEKRF AYSFLQQLIR YVDEAHQYIL EFDGGSRSKG 
      2960       2970       2980       2990       3000
EHFPYEQEIK FFAKVVLPLI DQYFKNHRLY FLSAASRPLC TGGHASNKEK 
      3010       3020       3030       3040       3050
EMVTSLFCKL GVLVRHRISL FGNDATSIVN CLHILGQTLD ARTVMKTGLD 
      3060       3070       3080       3090       3100
SVKSALRAFL DNAAEDLEKT MENLKQGQFT HTRSQPKGVT QIINYTTVAL 
      3110       3120       3130       3140       3150
LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG TSKSIYVERQ 
      3160       3170       3180       3190       3200
RSALGECLAA FAGAFPIAFL ETHLDKHNVY SIYNTRSSRE RAALSLPANV 
      3210       3220       3230       3240       3250
EDVCPNIPSL EKLMTEIIEL AESGIRYTQM PYMMEVVLPM LCSYMSRWWE 
      3260       3270       3280       3290       3300
HGPENHPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV 
      3310       3320       3330       3340       3350
FSQPIINKVK PQLLKTHFLP LMEKLKKKAA MVVSEEDHLK AEARGDMSEA 
      3360       3370       3380       3390       3400
ELLILDEFTT LARDLYAFYP LLIRFVDYNR AKWLKEPNPE AEELFRMVAE 
      3410       3420       3430       3440       3450
VFIYWSKSHN FKREEQNFVV QNEINNMSFL ITDTKSKMSK AAISDQERKK 
      3460       3470       3480       3490       3500
MKRKGDRYSM QTSLIVAALK RLLPIGLNIC APGDQELIAL AKNRFSLKDT 
      3510       3520       3530       3540       3550
EEEVRDIIRS NIHLQGKLED PAIRWQMALY KDLPNRTEDP SDPERTVERV 
      3560       3570       3580       3590       3600
LGIANVLFHL EQKSKYTGRG YFSLVEHPQR SKKAVWHKLL SKQRKRAVVA 
      3610       3620       3630       3640       3650
CFRMAPLYNL PRHRAVNLFL QGYEKSWIET EEHYFEDKLI EDLAKPGAEL 
      3660       3670       3680       3690       3700
PEEDEAMKRV DPLHQLILLF SRTALTEKCK LEEDFLYMAY ADIMAKSCHD 
      3710       3720       3730       3740       3750
EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL QTISASKGET 
      3760       3770       3780       3790       3800
GPMVAATLKL GIAILNGGNS TVQQKMLDYL KEKKDVGFFQ SLAGLMQSCS 
      3810       3820       3830       3840       3850
VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR FLQLLCEGHN 
      3860       3870       3880       3890       3900
SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDIIDEQ 
      3910       3920       3930       3940       3950
GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF 
      3960       3970       3980       3990       4000
AHMQMKLSQD SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD 
      4010       4020       4030       4040       4050
MLVESSNNVE MILKFFDMFL KLKDLTSSDT FKEYDPDGKG VISKRDFHKA 
      4060       4070       4080       4090       4100
MESHKHYTQS ETEFLLSCAE TDENETLDYE EFVKRFHEPA KDIGFNVAVL 
      4110       4120       4130       4140       4150
LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS AKRIERVYFE 
      4160       4170       4180       4190       4200
ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ 
      4210       4220       4230       4240       4250
LAAQISESDL NERLANKEES EKERPEEQAP RMGFFSLLTI QSALFALRYN 
      4260       4270       4280       4290       4300
VLTLVRMLSL KSLKKQMKRM KKMTVKDMVL AFFSSYWSVF VTLLHFVASV 
      4310       4320       4330       4340       4350
CRGFFRIVSS LLLGGSLVEG AKKIKVAELL ANMPDPTQDE VRGDEEEGER 
      4360       4370       4380       4390       4400
KPLESALPSE DLTDLKELTE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG 
      4410       4420       4430       4440       4450
LSDLMTNPVP VPEVQEKFQE QKAKEEKEEK EETKSEPEKA EGEDGEKEEK 
      4460       4470       4480       4490       4500
AKDEKSKQKL RQLHTHRYGE PEVPESAFWK KIIAYQQKLL NYFARNFYNM 
      4510       4520       4530       4540       4550
RMLALFVAFA INFILLFYKV STSSVVEGKE LPTRTSSDTA KVTNSLDSSP 
      4560       4570       4580       4590       4600
HRIIAVHYVL EESSGYMEPT LRILAILHTI ISFFCIIGYY CLKVPLVIFK 
      4610       4620       4630       4640       4650
REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTQSFP NNYWDKFVKR 
      4660       4670       4680       4690       4700
KVMDKYGEFY GRDRISELLG MDKAALDFSD AREKKKPKKD SSLSAVLNSI 
      4710       4720       4730       4740       4750
DVKYQMWKLG VVFTDNSFLY LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK 
      4760       4770       4780       4790       4800
TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT 
      4810       4820       4830       4840       4850
PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI YRIIFDITFF 
      4860       4870       4880       4890       4900
FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV 
      4910       4920       4930       4940       4950
PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWEF 
      4960 
FPAGDCFRKQ YEDQLN

Length:4,966

Mass (Da):564,819

Last modified:April 5, 2011 - v1

Checksum:ⁱF43425091AF7114F

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F6U7V1	F6U7V1_MOUSE	Ryanodine receptor 2 Ryanodine receptor 2	Ryr2	4,966	Annotation score:
A0A1Y7VJP1	A0A1Y7VJP1_MOUSE	Ryanodine receptor 2 Ryanodine receptor 2	Ryr2	1,028	Annotation score:
Q80ZZ5	Q80ZZ5_MOUSE	Ryanodine receptor 2 Ryanodine receptor 2 (Ryr2 protein)	Ryr2	1,020	Annotation score:
A0A1Y7VK09	A0A1Y7VK09_MOUSE	Ryanodine receptor 2 Ryanodine receptor 2	Ryr2	369	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1332	N → S in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	1412	D → G in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	1962	R → K in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	2265	V → VA in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	2532	P → R in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	3192	A → T in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	3533	L → F in AAG34081 (PubMed:10473538).Curated	1
Sequence conflictⁱ	4324	I → T in CAA58785 (PubMed:7876312).Curated	1
Sequence conflictⁱ	4853	V → E in CAA58785 (PubMed:7876312).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF295105 mRNA Translation: AAG34081.1 AC131329 Genomic DNA No translation available. AC159208 Genomic DNA No translation available. CT010468 Genomic DNA No translation available. CT572985 Genomic DNA No translation available. AB012003 Genomic DNA Translation: BAA25137.1 X83933 mRNA Translation: CAA58785.1 D38217 mRNA Translation: BAA07392.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49206.1
PIRⁱ	I48742
NCBI Reference Sequences More...RefSeqⁱ	NP_076357.2, NM_023868.2
UniGeneⁱ	Mm.239871

Genome annotation databases

Ensemblⁱ	ENSMUST00000021750; ENSMUSP00000021750; ENSMUSG00000021313
GeneIDⁱ	20191
KEGGⁱ	mmu:20191
UCSC genome browser More...UCSCⁱ	uc007pld.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
E9Q401	Ryanodine receptor 2	)	HUMAN		4967	UniRef90_Q92736
Ryanodine receptor 2		RABIT		4969
Ryanodine receptor 2	)	RAT		4953
Uncharacterized protein		ALLMI		4987
Ryanodine receptor 2		FICAL		4972
+233

Protein	Similar proteins		Species	Score	Length	Source
E9Q401	Ryanodine receptor 2	)	HUMAN		4967	UniRef50_Q92736
Ryanodine receptor 2		RABIT		4969
Ryanodine receptor 2	)	RAT		4953
Ryanodine receptor 3		MOUSE		4863
Uncharacterized protein		ALLMI		4987
+1247

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF295105 mRNA Translation: AAG34081.1 AC131329 Genomic DNA No translation available. AC159208 Genomic DNA No translation available. CT010468 Genomic DNA No translation available. CT572985 Genomic DNA No translation available. AB012003 Genomic DNA Translation: BAA25137.1 X83933 mRNA Translation: CAA58785.1 D38217 mRNA Translation: BAA07392.1
CCDSⁱ	CCDS49206.1
PIRⁱ	I48742
RefSeqⁱ	NP_076357.2, NM_023868.2
UniGeneⁱ	Mm.239871

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MC2	NMR	-	A	10-224	[»]
	3IM5	X-ray	2.55	A/B	1-217	[»]
	3IM6	X-ray	1.70	A	1-217	[»]
	3IM7	X-ray	2.21	A	1-217	[»]
	3QR5	X-ray	2.30	A/B	1-217	[»]
	4ETV	X-ray	1.65	A/B	2699-2904	[»]
	4KEI	X-ray	2.41	A	1-217	[»]
	4KEJ	X-ray	2.55	A	1-217	[»]
	4KEK	X-ray	2.15	A	1-217	[»]
	4L4H	X-ray	2.00	A	1-547	[»]
	4L4I	X-ray	2.15	A	1-547	[»]
	4P9I	X-ray	1.34	A	1080-1253	[»]
	4P9L	X-ray	1.44	A	1080-1253	[»]
	5C33	X-ray	1.21	A/B	650-844	[»]
	5VSN	X-ray	1.44	A	1084-1252	[»]
ProteinModelPortalⁱ	E9Q401
SMRⁱ	E9Q401
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203046, 6 interactors
ComplexPortalⁱ	CPX-3137 Ryanodine 2 complex
IntActⁱ	E9Q401, 66 interactors
MINTⁱ	E9Q401
STRINGⁱ	10090.ENSMUSP00000021750

Protein family/group databases

MoonDBⁱ	E9Q401 Predicted

MoonDBⁱ

E9Q401 Predicted

PTM databases

iPTMnetⁱ	E9Q401
PhosphoSitePlusⁱ	E9Q401
SwissPalmⁱ	E9Q401

Proteomic databases

MaxQBⁱ	E9Q401
PaxDbⁱ	E9Q401
PeptideAtlasⁱ	E9Q401
PRIDEⁱ	E9Q401

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021750; ENSMUSP00000021750; ENSMUSG00000021313
GeneIDⁱ	20191
KEGGⁱ	mmu:20191
UCSCⁱ	uc007pld.1 mouse

Organism-specific databases

CTDⁱ	6262
MGIⁱ	MGI:99685 Ryr2

Phylogenomic databases

eggNOGⁱ	KOG2243 Eukaryota ENOG410YCNW LUCA
GeneTreeⁱ	ENSGT00760000119152
HOGENOMⁱ	HOG000231428
HOVERGENⁱ	HBG006699
InParanoidⁱ	E9Q401
KOⁱ	K04962
OMAⁱ	RFSMKDT
TreeFamⁱ	TF315244

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels R-MMU-5578775 Ion homeostasis

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels
R-MMU-5578775 Ion homeostasis

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:E9Q401
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021313 Expressed in 152 organ(s), highest expression level in myocardium of ventricle
ExpressionAtlasⁱ	E9Q401 baseline and differential
Genevisibleⁱ	E9Q401 MM

Family and domain databases

CDDⁱ	cd12877 SPRY1_RyR, 1 hit cd12878 SPRY2_RyR, 1 hit cd12879 SPRY3_RyR, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR013320 ConA-like_dom_sf IPR011992 EF-hand-dom_pair IPR002048 EF_hand_dom IPR014821 Ins145_P3_rcpt IPR005821 Ion_trans_dom IPR036300 MIR_dom_sf IPR016093 MIR_motif IPR013662 RIH_assoc-dom IPR000699 RIH_dom IPR013333 Ryan_recept IPR003032 Ryanodine_rcpt IPR015925 Ryanodine_recept-rel IPR009460 Ryanrecept_TM4-6 IPR035910 RyR/IP3R_RIH_dom_sf IPR035761 SPRY1_RyR IPR035764 SPRY2_RyR IPR035762 SPRY3_RyR IPR003877 SPRY_dom
PANTHERⁱ	PTHR13715 PTHR13715, 1 hit
Pfamⁱ	View protein in Pfam PF13833 EF-hand_8, 1 hit PF08709 Ins145_P3_rec, 1 hit PF00520 Ion_trans, 1 hit PF02815 MIR, 1 hit PF08454 RIH_assoc, 1 hit PF06459 RR_TM4-6, 1 hit PF01365 RYDR_ITPR, 2 hits PF02026 RyR, 4 hits PF00622 SPRY, 3 hits
PRINTSⁱ	PR00795 RYANODINER
SMARTⁱ	View protein in SMART SM00472 MIR, 4 hits SM00449 SPRY, 3 hits
SUPFAMⁱ	SSF100909 SSF100909, 2 hits SSF47473 SSF47473, 1 hit SSF49899 SSF49899, 2 hits SSF82109 SSF82109, 2 hits
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 3 hits PS50919 MIR, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RYR2_MOUSE
Accessionⁱ	E9Q401Primary (citable) accession number: E9Q401 Secondary accession number(s): O70181 , Q62174, Q62197, Q9ERN6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 22, 2012
	Last sequence update:	April 5, 2011
	Last modified:	November 7, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - E9Q401 (RYR2_MOUSE)

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Ryanodine receptor 2

Ryr2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

Sequence databases

Genome annotation databases

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Proteomic databases

Protocols and materials databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ