Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 68 (16 Oct 2019)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Major vault protein

Gene

Mvp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Major vault proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MvpImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925638 Mvp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q3X0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q3X0

PeptideAtlas

More...
PeptideAtlasi
E9Q3X0

PRoteomics IDEntifications database

More...
PRIDEi
E9Q3X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030681 Expressed in 178 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q3X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q3X0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 118Vault_2InterPro annotationAdd BLAST60
Domaini122 – 162VaultInterPro annotationAdd BLAST41
Domaini176 – 215VaultInterPro annotationAdd BLAST40
Domaini229 – 271VaultInterPro annotationAdd BLAST43
Domaini282 – 329Vault_2InterPro annotationAdd BLAST48
Domaini333 – 376VaultInterPro annotationAdd BLAST44
Domaini388 – 448Vault_4InterPro annotationAdd BLAST61
Domaini466 – 527Vault_3InterPro annotationAdd BLAST62
Domaini528 – 656MVP_shoulderInterPro annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili708 – 728Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF6T Eukaryota
ENOG410ZCU8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008969

KEGG Orthology (KO)

More...
KOi
K17266

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVMVPPR

Database of Orthologous Groups

More...
OrthoDBi
256008at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329353

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08825 MVP_shoulder, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039059 MVP
IPR041139 MVP_rep_dom
IPR021870 MVP_shoulder
IPR041134 Vault_2
IPR040989 Vault_3
IPR041136 Vault_4
IPR002499 Vault_N

The PANTHER Classification System

More...
PANTHERi
PTHR14165 PTHR14165, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PF17794 Vault_2, 2 hits
PF17795 Vault_3, 1 hit
PF17796 Vault_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51224 MVP, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q3X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGRGLGFTM ATEEAIIRIP PYHYIHVLDQ NSNVSRVEVG PKTYIRQDNE
60 70 80 90 100
RVLFAPVRMV TVPPRHYCIV ANPVSRDAQS SVLFDVTGQV RLRHADQEIR
110 120 130 140 150
LAQDPFPLYP GELLEKDITP LQVVLPNTAL HLKALLDFED KNGDKVMAGD
160 170 180 190 200
EWLFEGPGTY IPQKEVEVVE IIQATVIKQN QALRLRARKE CFDRDGKERV
210 220 230 240 250
TGEEWLVRSV GAYLPAVFEE VLDLVDAVIL TEKTALHLRA RQNFKDLRGV
260 270 280 290 300
AHRTGEEWLV TVQDTEAHVP DVYEEVLGVV PITTLGPRHY CVILDPMGPD
310 320 330 340 350
GKNQLGQKRV VKGEKSFFLQ PGERLERGIQ DVYVLSEQQG LLLKALQPLE
360 370 380 390 400
EGEGEEKVAH QAGDRWLIRG PLEYVPSAKV EVVEERQAIP LDQNEGIYVQ
410 420 430 440 450
DVKTGKVRAV IGSTYMLTQD EVLWEKELPS GVEELLNLGH DPLADRGQKG
460 470 480 490 500
TAKVLQPSAA RNKTRVVSYR VPHNAAVQVY DYRAKRARVV FGPELVSLDP
510 520 530 540 550
EEQFTVLSLS AGRPKRPHAR RALCLLLGPD FFTDVITIET ADHARLQLQL
560 570 580 590 600
AYNWHFELKN RNDPEETAKL FSVPDFVGDA CKAIASRVRG AVASVTFDDF
610 620 630 640 650
HKNSARIIRM AVFGFEMSED AGPDGALLPR ARDRAVFPQN GLVVSSVDVQ
660 670 680 690 700
SVEPVDQRTR DALQRSVQLA IEITTNSQEA AAKHEAQRLE QEARGRLERQ
710 720 730 740 750
KILDQSEAEK ARKELLELEA MSMAVESTGN AKAEAESRAE AARIEGEGSV
760 770 780 790 800
LQAKLKAQAL AIETEAELER VKKVREMELI YSRAQLELEV SKAQQLADVE
810 820 830 840 850
AKKFKEMTEA LGPGTIRDLA VAGPEMQVKL LQSLGLKSTL ITDGSSPINL
860 870
FNTAFGLLGL GSDGQPPVQK
Length:870
Mass (Da):96,857
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA40A26AF469DB2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9EQK5MVP_MOUSE
Major vault protein
Mvp
861Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2N7D3Z2N7_MOUSE
Major vault protein
Mvp
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122863 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_542369.2, NM_080638.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000165096; ENSMUSP00000127250; ENSMUSG00000030681

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:78388

UCSC genome browser

More...
UCSCi
uc009jtw.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122863 Genomic DNA No translation available.
RefSeqiNP_542369.2, NM_080638.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiE9Q3X0
MaxQBiE9Q3X0
PeptideAtlasiE9Q3X0
PRIDEiE9Q3X0

Genome annotation databases

EnsembliENSMUST00000165096; ENSMUSP00000127250; ENSMUSG00000030681
GeneIDi78388
KEGGimmu:78388
UCSCiuc009jtw.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9961
MGIiMGI:1925638 Mvp

Phylogenomic databases

eggNOGiENOG410IF6T Eukaryota
ENOG410ZCU8 LUCA
GeneTreeiENSGT00390000008969
KOiK17266
OMAiMVMVPPR
OrthoDBi256008at2759
TreeFamiTF329353

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mvp mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030681 Expressed in 178 organ(s), highest expression level in colon
ExpressionAtlasiE9Q3X0 baseline and differential
GenevisibleiE9Q3X0 MM

Family and domain databases

CDDicd08825 MVP_shoulder, 1 hit
InterProiView protein in InterPro
IPR039059 MVP
IPR041139 MVP_rep_dom
IPR021870 MVP_shoulder
IPR041134 Vault_2
IPR040989 Vault_3
IPR041136 Vault_4
IPR002499 Vault_N
PANTHERiPTHR14165 PTHR14165, 1 hit
PfamiView protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PF17794 Vault_2, 2 hits
PF17795 Vault_3, 1 hit
PF17796 Vault_4, 1 hit
PROSITEiView protein in PROSITE
PS51224 MVP, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q3X0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q3X0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again