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Protein

Mitogen-activated protein kinase kinase kinase 19

Gene

Map3k19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1072ATPPROSITE-ProRule annotation1
Active sitei1169Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1050 – 1058ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)
Alternative name(s):
SPS1/STE20-related protein kinase YSK4
Gene namesi
Name:Map3k19
Synonyms:Ysk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1203481 Map3k19

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004210221 – 1311Mitogen-activated protein kinase kinase kinase 19Add BLAST1311

Proteomic databases

MaxQBiE9Q3S4
PaxDbiE9Q3S4
PRIDEiE9Q3S4

PTM databases

iPTMnetiE9Q3S4
PhosphoSitePlusiE9Q3S4

Expressioni

Gene expression databases

BgeeiENSMUSG00000051590 Expressed in 23 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
ExpressionAtlasiE9Q3S4 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiE9Q3S4, 1 interactor
STRINGi10090.ENSMUSP00000056254

Structurei

3D structure databases

ProteinModelPortaliE9Q3S4
SMRiE9Q3S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1044 – 1307Protein kinasePROSITE-ProRule annotationAdd BLAST264

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0198 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00800000124036
InParanoidiE9Q3S4
KOiK17533
OrthoDBiEOG091G0AR6
PhylomeDBiE9Q3S4
TreeFamiTF332735

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q3S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSMPRPERH AESLLDICHE AGSTPMEMTV SQTENLTLQS ISSSEDFDLE
60 70 80 90 100
DDFSPFILAR EGAAPRGENW PRRTEGVEII VTFPPDPLQE ASQEDLKESN
110 120 130 140 150
QVTSEHQERE QVHPVSPPDD AEMVGLTGRM LTTQPSLLKT DGSSEELCGV
160 170 180 190 200
DVALSPPRPC LDSSLAASAA GEVAPCVLKE QQRQSDEFPT SDISYSSRRT
210 220 230 240 250
GLPLPPLSCL PMRSCIFNME KSPKSPRHRE RKVPSLSLSV PKLLEPLSRP
260 270 280 290 300
LSQSAEFSSS KNHQEVTQEG PVEHTLRGSN CTLWSRNMCS FRKSGKQGVA
310 320 330 340 350
ESWPSQEMEG WDKTKTSGFK EGPSLFSCES VKEDTTPTER ERDSGYHVSE
360 370 380 390 400
MQRGGEDSQY LSSRKKESWT ARVVERDSGV EHPILCKLLE VSNSEMTPAE
410 420 430 440 450
EKEIGNENVP DAKSNSVHKS GAMEPHAASE EVSVPKNGPS VNSDGPAEEL
460 470 480 490 500
EGHRDIEQNR KIPMEEETNP EMNGVVPLTH IAFPGEGTSK GPARAEPHLQ
510 520 530 540 550
RRKRPAQNSN SFNLLAHREH DKLQTNTHRT KLDSRTKARN RAPPNLMVSI
560 570 580 590 600
QASIKPNMHK NSIKTQVFPA LELIDHRPHP SSKFQRRAPL TEKKSTHQTQ
610 620 630 640 650
KPKKQAFPRI GKHAGIKKPG IPLSAETTDP RLHFLDLKYS DMFKEINSAS
660 670 680 690 700
NGPGIYEMFG TPVYCHIREA ERHDHRCYRE IRTAPSGRCV VNKCQSSESD
710 720 730 740 750
RCSNSRARLL QKRQHIKPPK PLHGLRQKHR GFISKDKGCK DMGGHTEDSV
760 770 780 790 800
SEPDGQMKSP GNDFLSSKDD AQLMHLIPIP ELSPEQKAPA PVSDLSIVEE
810 820 830 840 850
IFTEECADEE GILNDDSLTQ SLGDLKEPEG LHPQAPLVPS ENSWAVLSEK
860 870 880 890 900
RSGKRVSPEK HNVEPLDKIN AEQMFPGYLE FDSLSEKSKT LVSFSSCSFQ
910 920 930 940 950
ENLERAPSPT EQHWARSLEQ DSLENNSTTY QTFGKISQEI LDPGKNEELT
960 970 980 990 1000
DELLGCLVEE LLALDEKDNN SCQIMTNEAD AKNLNLVFSR RGNTIEELGR
1010 1020 1030 1040 1050
ETTDVKLQRC INGFRIYDEE NFLTSNEKKT LSDKSLNHEE AIFWTKGEIL
1060 1070 1080 1090 1100
GRGAYGTVYC GLTSLGQLIA VKQVALDTSD KLATEKEYRK LQEEVDLLKA
1110 1120 1130 1140 1150
LKHVNIVAYL GTCLEENTLS IFMEFVPGGS ISSIINRFGP LPEMVFCKYT
1160 1170 1180 1190 1200
RQILQGVAYL HDNCVVHRDI KGNNVMLMPT GIIKLIDFGC AKRLAWAGLN
1210 1220 1230 1240 1250
GTHSDMLKSM RGTPYWMAPE VINESGYGRK SDIWSIGCTV FEMATGKPPL
1260 1270 1280 1290 1300
ASMDRMAAMF YIGAHRGLMP PLPARFSEPA ADFVRLCLTR DQHERPSALQ
1310
LLKHSFLKRS Q
Length:1,311
Mass (Da):146,412
Last modified:April 5, 2011 - v1
Checksum:iC69E361F52305D44
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHL6A0A140LHL6_MOUSE
Mitogen-activated protein kinase ki...
Map3k19
1,515Annotation score:
A0A087WSG0A0A087WSG0_MOUSE
Mitogen-activated protein kinase ki...
Map3k19
515Annotation score:
A0A087WS76A0A087WS76_MOUSE
Mitogen-activated protein kinase ki...
Map3k19
1,211Annotation score:
A0A087WR30A0A087WR30_MOUSE
Mitogen-activated protein kinase ki...
Map3k19
467Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121883 Genomic DNA No translation available.
AC163690 Genomic DNA No translation available.
CCDSiCCDS48347.1
RefSeqiNP_035867.1, NM_011737.1
UniGeneiMm.246566

Genome annotation databases

EnsembliENSMUST00000061512; ENSMUSP00000056254; ENSMUSG00000051590
GeneIDi22625
KEGGimmu:22625
UCSCiuc011wra.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121883 Genomic DNA No translation available.
AC163690 Genomic DNA No translation available.
CCDSiCCDS48347.1
RefSeqiNP_035867.1, NM_011737.1
UniGeneiMm.246566

3D structure databases

ProteinModelPortaliE9Q3S4
SMRiE9Q3S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q3S4, 1 interactor
STRINGi10090.ENSMUSP00000056254

PTM databases

iPTMnetiE9Q3S4
PhosphoSitePlusiE9Q3S4

Proteomic databases

MaxQBiE9Q3S4
PaxDbiE9Q3S4
PRIDEiE9Q3S4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061512; ENSMUSP00000056254; ENSMUSG00000051590
GeneIDi22625
KEGGimmu:22625
UCSCiuc011wra.1 mouse

Organism-specific databases

CTDi80122
MGIiMGI:1203481 Map3k19

Phylogenomic databases

eggNOGiKOG0198 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00800000124036
InParanoidiE9Q3S4
KOiK17533
OrthoDBiEOG091G0AR6
PhylomeDBiE9Q3S4
TreeFamiTF332735

Miscellaneous databases

PROiPR:E9Q3S4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051590 Expressed in 23 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
ExpressionAtlasiE9Q3S4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM3K19_MOUSE
AccessioniPrimary (citable) accession number: E9Q3S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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