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Entry version 75 (29 Sep 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Centromere protein F

Gene

Cenpf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2500257, Resolution of Sister Chromatid Cohesion
R-MMU-5663220, RHO GTPases Activate Formins
R-MMU-68877, Mitotic Prometaphase
R-MMU-9648025, EML4 and NUDC in mitotic spindle formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centromere protein FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CenpfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1313302, Cenpf

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000026605

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9Q3P4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q3P4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q3P4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q3P4

PeptideAtlas

More...
PeptideAtlasi
E9Q3P4

PRoteomics IDEntifications database

More...
PRIDEi
E9Q3P4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
368122

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026605, Expressed in primary oocyte and 228 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q3P4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
E9Q3P4, 12 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000129738

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q3P4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q3P4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 300CENP-F_NInterPro annotationAdd BLAST300
Domaini1894 – 2035CENP-F_leu_zipInterPro annotationAdd BLAST142
Domaini2131 – 2270CENP-F_leu_zipInterPro annotationAdd BLAST140
Domaini2313 – 2449CENP-F_leu_zipInterPro annotationAdd BLAST137
Domaini2852 – 2896CENP-F_C_Rb_bdgInterPro annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 227DisorderedSequence analysisAdd BLAST22
Regioni462 – 490DisorderedSequence analysisAdd BLAST29
Regioni763 – 797DisorderedSequence analysisAdd BLAST35
Regioni1522 – 1548DisorderedSequence analysisAdd BLAST27
Regioni1711 – 1737DisorderedSequence analysisAdd BLAST27
Regioni2774 – 2997DisorderedSequence analysisAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 131Sequence analysisAdd BLAST119
Coiled coili159 – 186Sequence analysisAdd BLAST28
Coiled coili273 – 335Sequence analysisAdd BLAST63
Coiled coili343 – 395Sequence analysisAdd BLAST53
Coiled coili516 – 612Sequence analysisAdd BLAST97
Coiled coili623 – 643Sequence analysisAdd BLAST21
Coiled coili657 – 677Sequence analysisAdd BLAST21
Coiled coili710 – 737Sequence analysisAdd BLAST28
Coiled coili831 – 879Sequence analysisAdd BLAST49
Coiled coili905 – 939Sequence analysisAdd BLAST35
Coiled coili968 – 1005Sequence analysisAdd BLAST38
Coiled coili1010 – 1090Sequence analysisAdd BLAST81
Coiled coili1095 – 1115Sequence analysisAdd BLAST21
Coiled coili1131 – 1165Sequence analysisAdd BLAST35
Coiled coili1208 – 1256Sequence analysisAdd BLAST49
Coiled coili1269 – 1289Sequence analysisAdd BLAST21
Coiled coili1311 – 1331Sequence analysisAdd BLAST21
Coiled coili1550 – 1613Sequence analysisAdd BLAST64
Coiled coili1625 – 1645Sequence analysisAdd BLAST21
Coiled coili1790 – 1810Sequence analysisAdd BLAST21
Coiled coili1825 – 1852Sequence analysisAdd BLAST28
Coiled coili1883 – 1910Sequence analysisAdd BLAST28
Coiled coili1946 – 1997Sequence analysisAdd BLAST52
Coiled coili2023 – 2078Sequence analysisAdd BLAST56
Coiled coili2107 – 2127Sequence analysisAdd BLAST21
Coiled coili2142 – 2197Sequence analysisAdd BLAST56
Coiled coili2205 – 2285Sequence analysisAdd BLAST81
Coiled coili2324 – 2351Sequence analysisAdd BLAST28
Coiled coili2356 – 2457Sequence analysisAdd BLAST102
Coiled coili2465 – 2492Sequence analysisAdd BLAST28
Coiled coili2500 – 2534Sequence analysisAdd BLAST35
Coiled coili2559 – 2600Sequence analysisAdd BLAST42
Coiled coili2615 – 2709Sequence analysisAdd BLAST95
Coiled coili2719 – 2746Sequence analysisAdd BLAST28
Coiled coili2754 – 2774Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi206 – 226Polar residuesSequence analysisAdd BLAST21
Compositional biasi469 – 490Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2775 – 2816Polar residuesSequence analysisAdd BLAST42
Compositional biasi2837 – 2867Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi2882 – 2964Polar residuesSequence analysisAdd BLAST83

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVMD, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111187

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000551_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q3P4

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNAQLVQ

Database of Orthologous Groups

More...
OrthoDBi
205405at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9Q3P4

TreeFam database of animal gene trees

More...
TreeFami
TF101133

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043513, Cenp-F
IPR018302, CenpF/LEK1_Rb-prot-bd
IPR019513, Centromere_CenpF_leu-rich_rpt
IPR018463, Centromere_CenpF_N

The PANTHER Classification System

More...
PANTHERi
PTHR18874, PTHR18874, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10490, CENP-F_C_Rb_bdg, 1 hit
PF10473, CENP-F_leu_zip, 3 hits
PF10481, CENP-F_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q3P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK
60 70 80 90 100
QKQKVEDGKT EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ
110 120 130 140 150
ESQLSSCKKQ IEKLEQELKR CKSEFERSQQ VAQSADVSLN PCSTPQKLFA
160 170 180 190 200
TPLTPSSTYE DLKEKYNKEV EERKRLEEEV KALHAKKVSL PVSQATMNHR
210 220 230 240 250
DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH FLGEEVSPNK
260 270 280 290 300
SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE
310 320 330 340 350
MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC
360 370 380 390 400
TTLEQKLKTL TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF
410 420 430 440 450
QALDSEYTQM KTRLTQELQQ VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR
460 470 480 490 500
LKLSRAEQAL QASQVAENEL RRSSEEMKKE NSLIRSQSEQ RTREVCHLEE
510 520 530 540 550
ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ ENSLTLEKLK
560 570 580 590 600
LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK
610 620 630 640 650
ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS
660 670 680 690 700
PDSNERIRTL EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE
710 720 730 740 750
SSDQKHQKEI ENMCLKANKL TGQVESLECK LQLLSSEVVT KDQQYQDLRM
760 770 780 790 800
EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ RSSEDNQRGS LAFEQQPAVS
810 820 830 840 850
DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS LESSLESQNQ
860 870 880 890 900
MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV
910 920 930 940 950
HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL
960 970 980 990 1000
QLLSDTLSSE KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL
1010 1020 1030 1040 1050
QKHEKITSCI AEQERSIAEL SDQYKQERLQ LLQRCEETEA VLEDLRGNYK
1060 1070 1080 1090 1100
TAQENNAKLE CMLSECTALC ENRKNELEQL KETFAKEQQE FLTKLAFAEE
1110 1120 1130 1140 1150
QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT LNEEQNEQQN
1160 1170 1180 1190 1200
EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD
1210 1220 1230 1240 1250
IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL
1260 1270 1280 1290 1300
ETKSSQDPQS QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA
1310 1320 1330 1340 1350
VNKLNELGKM CDVLRVEKLQ LESELNDSRT ECITATSQMT AEVEKLVSEM
1360 1370 1380 1390 1400
KMLNHESALS QNELMKDTSG GEFHDKANHS SVFLTPLDSS NFCEQMTLSS
1410 1420 1430 1440 1450
KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS YVDTLKAENS
1460 1470 1480 1490 1500
ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD
1510 1520 1530 1540 1550
VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV
1560 1570 1580 1590 1600
EGLEVLCQVY LQSLKNLEEK TESQRIMKNK EIEKLEQLLS SERKELSCLR
1610 1620 1630 1640 1650
KQYLSEKEQW QQKLTSVTLE MESKLAEEKQ QTKTLSLELE VARLQLQELD
1660 1670 1680 1690 1700
LSSRSLLGTD LESVVRCQND NYDIKESEVY ISETTEKTPK QDTDQTCDKD
1710 1720 1730 1740 1750
IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK TQDCSECISE
1760 1770 1780 1790 1800
LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL
1810 1820 1830 1840 1850
LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP
1860 1870 1880 1890 1900
CNQEVCLRVE RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM
1910 1920 1930 1940 1950
ERELTRIKSE KANIEHHILS VETNLEVVQA EKLCLERDTE SKQKVIIDLK
1960 1970 1980 1990 2000
EELFTVISER NRLREELDNV SKESKALDQM SKKMKEKIEE LESHQRESLR
2010 2020 2030 2040 2050
HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL QNDSQELSLA
2060 2070 2080 2090 2100
IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK
2110 2120 2130 2140 2150
GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD
2160 2170 2180 2190 2200
SLKDTVETLE RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI
2210 2220 2230 2240 2250
FELDLVTVRT ERENLAKQLQ EKQSRVSELD ERCSSLRRLL EEKEQARVQM
2260 2270 2280 2290 2300
EEDSKSAMLM LQMQLKELRE EVAALCNDQE TLKAQEQSLD QPGEEVHHLK
2310 2320 2330 2340 2350
SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN LEQELILSEK
2360 2370 2380 2390 2400
NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLMKELKK
2410 2420 2430 2440 2450
EQERVSDLET INSSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET
2460 2470 2480 2490 2500
VVSLCNDQEV SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV
2510 2520 2530 2540 2550
NALTQEVEAG KQKLEKGEKE IRTLKEQLKS QEQLVCKLAQ VEGEQQLWQK
2560 2570 2580 2590 2600
QKLELRNVTM ALEQKVQVLQ SENNTLQSTY EALQNSHKSL ESELGLIKLE
2610 2620 2630 2640 2650
KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK NRLTEEVEVL
2660 2670 2680 2690 2700
REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL
2710 2720 2730 2740 2750
SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL
2760 2770 2780 2790 2800
LISHEELEKA KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS
2810 2820 2830 2840 2850
EMKSASGQNK ASGKRQRSSG IWEHGKRAAP STAETFSKKS RKSDSKSTRP
2860 2870 2880 2890 2900
AEHEQETEFE PEGLPEVVKK GFADIPTGKT SPYILRRTTM ATRTSPRFAT
2910 2920 2930 2940 2950
QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD SHTAFQELPA
2960 2970 2980 2990
KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ
Length:2,997
Mass (Da):342,472
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AEE30F1D554DEC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PY14E9PY14_MOUSE
Centromere protein F
Cenpf
952Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V6F0F6V6F0_MOUSE
Centromere protein F
Cenpf
119Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q776E9Q776_MOUSE
Centromere protein F
Cenpf
88Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001074832.2, NM_001081363.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000171929; ENSMUSP00000129738; ENSMUSG00000026605

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:108000

UCSC genome browser

More...
UCSCi
uc007eao.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001074832.2, NM_001081363.2

3D structure databases

SMRiE9Q3P4
ModBaseiSearch...

Protein-protein interaction databases

IntActiE9Q3P4, 12 interactors
STRINGi10090.ENSMUSP00000129738

Proteomic databases

EPDiE9Q3P4
jPOSTiE9Q3P4
MaxQBiE9Q3P4
PaxDbiE9Q3P4
PeptideAtlasiE9Q3P4
PRIDEiE9Q3P4
ProteomicsDBi368122

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4038, 269 antibodies

Genome annotation databases

EnsembliENSMUST00000171929; ENSMUSP00000129738; ENSMUSG00000026605
GeneIDi108000
KEGGimmu:108000
UCSCiuc007eao.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1063
MGIiMGI:1313302, Cenpf
VEuPathDBiHostDB:ENSMUSG00000026605

Phylogenomic databases

eggNOGiENOG502QVMD, Eukaryota
GeneTreeiENSGT00730000111187
HOGENOMiCLU_000551_0_0_1
InParanoidiE9Q3P4
OMAiYNAQLVQ
OrthoDBi205405at2759
PhylomeDBiE9Q3P4
TreeFamiTF101133

Enzyme and pathway databases

ReactomeiR-MMU-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2500257, Resolution of Sister Chromatid Cohesion
R-MMU-5663220, RHO GTPases Activate Formins
R-MMU-68877, Mitotic Prometaphase
R-MMU-9648025, EML4 and NUDC in mitotic spindle formation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
108000, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cenpf, mouse
RNActiE9Q3P4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000026605, Expressed in primary oocyte and 228 other tissues
GenevisibleiE9Q3P4, MM

Family and domain databases

InterProiView protein in InterPro
IPR043513, Cenp-F
IPR018302, CenpF/LEK1_Rb-prot-bd
IPR019513, Centromere_CenpF_leu-rich_rpt
IPR018463, Centromere_CenpF_N
PANTHERiPTHR18874, PTHR18874, 2 hits
PfamiView protein in Pfam
PF10490, CENP-F_C_Rb_bdg, 1 hit
PF10473, CENP-F_leu_zip, 3 hits
PF10481, CENP-F_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q3P4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q3P4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 29, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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