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Protein

Phosphatidylinositol 4-kinase alpha

Gene

Pi4ka

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Triton X-100, insensitive to inhibition by adenosine and inhibited by wortmannin (By similarity). The PI4K complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis. Interaction with TMEM150A regulates PtdIns4P synthesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase alpha (EC:2.7.1.67By similarity)
Short name:
PI4-kinase alpha
Short name:
PI4K-alpha
Short name:
PtdIns-4-kinase alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pi4kaImported
Synonyms:Pik4, Pik4ca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2448506 Pi4ka

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Early embryonic lethality. Conditional knockout mice show a dramatic depletion of cellular phosphatidylinositol 4-phosphate (PtdIns4P).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004356321 – 2105Phosphatidylinositol 4-kinase alphaAdd BLAST2105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei233PhosphoserineBy similarity1
Modified residuei259PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei265PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei432PhosphoserineBy similarity1
Modified residuei1439PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q3L2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q3L2

PeptideAtlas

More...
PeptideAtlasi
E9Q3L2

PRoteomics IDEntifications database

More...
PRIDEi
E9Q3L2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q3L2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q3L2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041720 Expressed in 298 organ(s), highest expression level in bed nucleus of stria terminalis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B). Interacts with TMEM150A; regulating recruitment to the plasma membrane.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
E9Q3L2, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q3L2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1533 – 1721PIK helicalPROSITE-ProRule annotationAdd BLAST189
Domaini1848 – 2105PI3K/PI4KPROSITE-ProRule annotationAdd BLAST258

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0902 Eukaryota
COG5032 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007272

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103255

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q3L2

KEGG Orthology (KO)

More...
KOi
K00888

Database of Orthologous Groups

More...
OrthoDBi
1147978at2759

TreeFam database of animal gene trees

More...
TreeFami
TF102041

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q3L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGARGGG GGGGGGGGGG SGSSSGSSTS RGFYFNTVLS LARSLAVQRP
60 70 80 90 100
ASLEKVQKLL CMCPVDFHGI FQLDERRRDA VIALGIFLIE SDLQHKDCVV
110 120 130 140 150
PYLLRLLRGL PKVYWVEEST ARKGRGNLPV AESFSFCLVT LLSDVACRDP
160 170 180 190 200
SLRDEILEAI LQVLHVLLGM CQALEIQEKE YLCKYAIPCL IGISRSFGRY
210 220 230 240 250
SNSEESLLSK LFPKVSPHSL RIPEELEGVR RRSFNDFRSI LPSNLLTVCQ
260 270 280 290 300
EGTLKRKTSS VSSISQVSPE RGIPPPSSPG GSAFHYFEAS CLPDGTALEP
310 320 330 340 350
EYYFSTISSS FSISPLFNGI TYKEFCIPLE MLRELLNLVK KIVEEPVLKS
360 370 380 390 400
LDAIVAGVME ANPSADLYYT TFSDPLYLTM FKMLRDTLYY MKDLPTSFVK
410 420 430 440 450
EIHDFVLEQF NMSQGELQKI LHDADRIHSE MSPLKLRCQA NAACVDLMVW
460 470 480 490 500
AVKDEQGAEN LCIKLSEKLQ SKTSSKVIIA HLPLLICCLQ GLGRLCERFP
510 520 530 540 550
VVVHSVTPSL RDFLVIPSPV LVKLYKYHSQ YHTVAGSDIK ISVTNEHSES
560 570 580 590 600
TLNVLPGKKN QPSMYEQLRD IAIDNICRCL KAGLTVDPVI VEAFLASLSN
610 620 630 640 650
RLYISQESDK DAHLIPDHTI RALGHIAVAL RDTPKVMEPI LQILQQKFCQ
660 670 680 690 700
PPSPLDVLII DQLGCLVITG NQYIYQEVWN LFQQISVKAS SVVYSATKDY
710 720 730 740 750
KDHGYRHCSL AVINALANIA ANIQEEHLVD ELLMNLLELF VQLGLEGKRA
760 770 780 790 800
SERASEKGPA LKASSSAGNL GVLIPVIAVL TRRLPPIKEA KPRLQKLFRD
810 820 830 840 850
FWLYSVLMGF AVEGSGLWPE EWYEGVCEIA TKSPLLTFPS KEPLRSVLQY
860 870 880 890 900
NSAMKNDTVT PAELSELRST IINLLDPPPE VSALINKLDF AMSTYLLSVY
910 920 930 940 950
RLEYMRVLRS TDPDRFQVMF CYFEDKAIQK DKSGMMQCVI AVADKVFDAF
960 970 980 990 1000
LNMMAEKAKT KENEEELERH AQFLLVNFNH IHKRIRRVAD KYLSGLVDKF
1010 1020 1030 1040 1050
PHLLWSGTVL KTMLDILQTL SLSLSADIHK DQPYYDIPDA PYRITVPDTY
1060 1070 1080 1090 1100
EARESIVKDF AARCGMILQE AMKWAPTVTK SHLQEYLNKH QNWVSGLSQH
1110 1120 1130 1140 1150
TGLAMATESI LHFAGYNKQN TTLGATQLTE RPACVKKDYS NFMASLNLRN
1160 1170 1180 1190 1200
RYAGEVHGMI RFSGATGQMS DLNKMMVQDL ITALDHSHPQ HYTQAMFKLT
1210 1220 1230 1240 1250
AMLISSKDCD PQLLHHLCWG PLRMFNEHGM ETALACWEWL LAGKNGVEVP
1260 1270 1280 1290 1300
FMREMAGAWH MTVEQKFGLF SVETKEADPL AASEASQPRP CPPEVTPHYI
1310 1320 1330 1340 1350
WIDFLVQRFE IAKYCSSDQV EIFSSLLQRS MSLNIGGARG SMNRHVAAIG
1360 1370 1380 1390 1400
PRFKLLTLGL SLLHADVVPN ATIRNVLREK IYSTAFDYFS CPPKFPTQGE
1410 1420 1430 1440 1450
KRLREDISIM IKFWTAMFSD KKYLTASQLV PPDNQDTRSN LDITVGSRQQ
1460 1470 1480 1490 1500
ATQGWINTYP LSSGMSTISK KSGMSKKTNR GSQLHKYYMK RRTLLLSLLA
1510 1520 1530 1540 1550
TEIERLITWY NPLSAPELEL DQAGENSVAN WRSKYISLSE KQWKDNVNLA
1560 1570 1580 1590 1600
WSISPYLAVQ LPARFKNTEA IGNEVTRLVR LDPGAVSDVP EAIKFLVTWH
1610 1620 1630 1640 1650
TIDADAPELS HVLCWAPTDP PTGLSYFSSM YPPHPLTAQY GVKVLRSFPP
1660 1670 1680 1690 1700
DAILFYIPQI VQALRYDKMG YVREYILWAA AKSQLLAHQF IWNMKTNIYL
1710 1720 1730 1740 1750
DEEGHQKDPD IGDLLEQLVE EITGSLSGPA KDFYQREFDF FNKITNVSAI
1760 1770 1780 1790 1800
IKPYPKGDER KKACLSALSE VKVQPGCYLP SNPEAIVLDI DYKSGTPMQS
1810 1820 1830 1840 1850
AAKAPYLAKF KVKRCGVSEL EKEGLQCRSD AEDECFSQEA DGKKICWQAA
1860 1870 1880 1890 1900
IFKVGDDCRQ DMLALQIIDL FKNIFQLVGL DLFVFPYRVV ATAPGCGVIE
1910 1920 1930 1940 1950
CIPDCTSRDQ LGRQTDFGMY DYFTRQYGDE STLAFQQARY NFIRSMAAYS
1960 1970 1980 1990 2000
LLLFLLQIKD RHNGNIMLDK KGHIIHIDFG FMFESSPGGN LGWEPDIKLT
2010 2020 2030 2040 2050
DEMVMIMGGK MEATPFKWFM EMCVRGYLAV RPYMDAVVSL VTLMLDTGLP
2060 2070 2080 2090 2100
CFRGQTIKLL KHRFSPNMTE REAANFIMKV IQNCFLSNRS RTYDMIQYYQ

NDIPY
Length:2,105
Mass (Da):237,042
Last modified:February 17, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25EB66874330ED51
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8I9A0A140T8I9_MOUSE
Phosphatidylinositol 4-kinase alpha
Pi4ka
2,044Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6S0A0A338P6S0_MOUSE
Phosphatidylinositol 4-kinase alpha
Pi4ka
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P7D3A0A338P7D3_MOUSE
Phosphatidylinositol 4-kinase alpha
Pi4ka
319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6F9A0A338P6F9_MOUSE
Phosphatidylinositol 4-kinase alpha
Pi4ka
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti861P → L in AAH75629 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC110573 Genomic DNA No translation available.
BC049252 mRNA Translation: AAH49252.1
BC055479 mRNA Translation: AAH55479.1
BC075629 mRNA Translation: AAH75629.1
AK136942 mRNA Translation: BAE23184.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001983.2, NM_001001983.2
XP_006522097.1, XM_006522034.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.5718

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
224020

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:224020

UCSC genome browser

More...
UCSCi
uc007ykq.2 mouse
uc007ykr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110573 Genomic DNA No translation available.
BC049252 mRNA Translation: AAH49252.1
BC055479 mRNA Translation: AAH55479.1
BC075629 mRNA Translation: AAH75629.1
AK136942 mRNA Translation: BAE23184.1
RefSeqiNP_001001983.2, NM_001001983.2
XP_006522097.1, XM_006522034.1
UniGeneiMm.5718

3D structure databases

SMRiE9Q3L2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q3L2, 5 interactors
STRINGi10090.ENSMUSP00000036162

PTM databases

iPTMnetiE9Q3L2
PhosphoSitePlusiE9Q3L2

Proteomic databases

jPOSTiE9Q3L2
PaxDbiE9Q3L2
PeptideAtlasiE9Q3L2
PRIDEiE9Q3L2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi224020
KEGGimmu:224020
UCSCiuc007ykq.2 mouse
uc007ykr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5297
MGIiMGI:2448506 Pi4ka

Phylogenomic databases

eggNOGiKOG0902 Eukaryota
COG5032 LUCA
HOGENOMiHOG000007272
HOVERGENiHBG103255
InParanoidiE9Q3L2
KOiK00888
OrthoDBi1147978at2759
TreeFamiTF102041

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pi4ka mouse

Protein Ontology

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PROi
PR:E9Q3L2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000041720 Expressed in 298 organ(s), highest expression level in bed nucleus of stria terminalis

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI4KA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q3L2
Secondary accession number(s): Q3UVT5
, Q6DIC7, Q7TNG2, Q80Y45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: February 17, 2016
Last modified: January 16, 2019
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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