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Entry version 60 (16 Oct 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Synaptopodin

Gene

Synpo

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SynaptopodinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SynpoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1099446 Synpo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q3E2

PeptideAtlas

More...
PeptideAtlasi
E9Q3E2

PRoteomics IDEntifications database

More...
PRIDEi
E9Q3E2

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q3E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043079 Expressed in 302 organ(s), highest expression level in ascending aorta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q3E2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 77DisorderedSequence analysisAdd BLAST24
Regioni111 – 243DisorderedSequence analysisAdd BLAST133
Regioni280 – 382DisorderedSequence analysisAdd BLAST103
Regioni395 – 416DisorderedSequence analysisAdd BLAST22
Regioni497 – 520DisorderedSequence analysisAdd BLAST24
Regioni539 – 595DisorderedSequence analysisAdd BLAST57
Regioni688 – 714DisorderedSequence analysisAdd BLAST27
Regioni770 – 1073DisorderedSequence analysisAdd BLAST304

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 173PolarSequence analysisAdd BLAST26
Compositional biasi180 – 198PolarSequence analysisAdd BLAST19
Compositional biasi213 – 227Pro-richSequence analysisAdd BLAST15
Compositional biasi280 – 296PolarSequence analysisAdd BLAST17
Compositional biasi304 – 363PolarSequence analysisAdd BLAST60
Compositional biasi396 – 416PolarSequence analysisAdd BLAST21
Compositional biasi550 – 579PolarSequence analysisAdd BLAST30
Compositional biasi812 – 833PolarSequence analysisAdd BLAST22
Compositional biasi866 – 883PolarSequence analysisAdd BLAST18
Compositional biasi918 – 936Pro-richSequence analysisAdd BLAST19
Compositional biasi937 – 953PolarSequence analysisAdd BLAST17
Compositional biasi982 – 1003Pro-richSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHBK Eukaryota
ENOG4111RGH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183054

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCSEKAN

Database of Orthologous Groups

More...
OrthoDBi
691538at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028753 Synpo

The PANTHER Classification System

More...
PANTHERi
PTHR24217:SF13 PTHR24217:SF13, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q3E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGAHFPPPP LGASEGRAAP CTFQIPDGSY RCLALEAEES SSEDGLQGEV
60 70 80 90 100
RLVDLEEEGT SQSRANHGTP PLSRAPAIIQ PSSCHREARG GFQRSDRPSH
110 120 130 140 150
DWDVVQARKV MTASGSSSPV PRVAQKPALG RSTSFTENDL KEAKARSQQI
160 170 180 190 200
AAQLTTPPSS NSRGVQLFNR RRQRVNEFTL ESRGQRSPKL NQEALQTGRP
210 220 230 240 250
LSPIGHAPGP SVKPTSPSKP GSPKHPSPQS PSRGVAGHIM EGYSEEASLL
260 270 280 290 300
RHLEKVASEE EEVPLVVYLK ENAALLTANG LHLSQSRETQ QSSPNPPDTE
310 320 330 340 350
VPSPAADINQ NPSSPNATLT TLASSSHHSQ PTADINQNPP AAITPVPQNS
360 370 380 390 400
SQAQCSPNGT LDSKPGTLCA DDGQSPVPAE EVRSSILLID KVSAPPSAAS
410 420 430 440 450
TFSREATPLS SSGPPAADLM SSSLLIDMQP STLVAPAEQE VPGHVAVTTP
460 470 480 490 500
TKVYSEVHLT LAKPASVVNR TARPFGIQSP GTSQIEQSPM MGRRQFGEKA
510 520 530 540 550
WAPPASSMAD RSPQPQRHIM SRSPMVERRL LGQRSPVLER RPLGNFTPPP
560 570 580 590 600
TYAETLSTAP VASRVRSPPS YSTLYPSSDP KPSHLKGQVA PANKTGILEE
610 620 630 640 650
SMARRGSRKS MFTFVEKPKV TPNPDLLDLV QTADEKRRQR DHGEVGMEEE
660 670 680 690 700
PFALGAEASN FQQEPIARDR ASPAAAEEAV PEWASCLKSP RIQAKPKPKP
710 720 730 740 750
NQNLSEASGK GAELYARRQS RMEKYVIESS GHAELARCPS PTMSLPSSWK
760 770 780 790 800
YTTNAPGGFR VASLSPARTP PASLYHGYLP ENGVLRPEPT KQQPYQMRPS
810 820 830 840 850
LYALSPVKEP AKASSRATSS RTPSRTVSPR AASPAKPSSL DLVPNLPRAG
860 870 880 890 900
LPPSPALPRP SRSSPGLYTA PVQDSLQPTA DRPESLPTSP PWTPAASRPP
910 920 930 940 950
SSLDGWVSPG PWEPGRGSSM SSPPPLPPPP PMSPSWSERS VSPLRSETEA
960 970 980 990 1000
RPPSRQLQAL LARNIINAAR RKSASPRPAP AETLRPFSPP QGPPPPPARM
1010 1020 1030 1040 1050
RSPQPASPAR NFRGAAFSPI PRSPLPIGPS SCASPRSPQA APSRPFPYRR
1060 1070 1080 1090 1100
SPTDSDVSLD SEDSGLKSPG ILGYNICPRG WNGSLRLKRG SLPTEASCTT
Length:1,100
Mass (Da):117,515
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2502E314FC22C0E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CC35SYNPO_MOUSE
Synaptopodin
Synpo Kiaa1029
929Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYK1E0CYK1_MOUSE
Synaptopodin
Synpo
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC149216 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006525535.1, XM_006525472.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000130360; ENSMUSP00000115355; ENSMUSG00000043079

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
104027

UCSC genome browser

More...
UCSCi
uc008faq.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149216 Genomic DNA No translation available.
RefSeqiXP_006525535.1, XM_006525472.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiE9Q3E2

Proteomic databases

MaxQBiE9Q3E2
PeptideAtlasiE9Q3E2
PRIDEiE9Q3E2

Genome annotation databases

EnsembliENSMUST00000130360; ENSMUSP00000115355; ENSMUSG00000043079
GeneIDi104027
UCSCiuc008faq.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11346
MGIiMGI:1099446 Synpo

Phylogenomic databases

eggNOGiENOG410IHBK Eukaryota
ENOG4111RGH LUCA
GeneTreeiENSGT00950000183054
OMAiGCSEKAN
OrthoDBi691538at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Synpo mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043079 Expressed in 302 organ(s), highest expression level in ascending aorta
ExpressionAtlasiE9Q3E2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028753 Synpo
PANTHERiPTHR24217:SF13 PTHR24217:SF13, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q3E2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q3E2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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