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Entry version 55 (08 May 2019)
Sequence version 1 (05 Apr 2011)
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Protein

C2 domain-containing protein 2

Gene

C2cd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C2 domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2cd2Imported
Synonyms:Kiaa40451 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891883 C2cd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004396471 – 696C2 domain-containing protein 2Add BLAST696

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei54PhosphoserineCombined sources1
Modified residuei436PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei581PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q3C1

MaxQB - The MaxQuant DataBase

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MaxQBi
E9Q3C1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q3C1

PeptideAtlas

More...
PeptideAtlasi
E9Q3C1

PRoteomics IDEntifications database

More...
PRIDEi
E9Q3C1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q3C1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q3C1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045975 Expressed in 242 organ(s), highest expression level in gastrocnemius

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q3C1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127368

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q3C1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 238SMP-LBDCuratedAdd BLAST194
Domaini277 – 357C2PROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGE7 Eukaryota
ENOG4112CMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063764

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008704

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q3C1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RHQQKDP

Database of Orthologous Groups

More...
OrthoDBi
890695at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331604

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR039934 C2CD2/C2CD2L
IPR040885 SMP_C2CD2L

The PANTHER Classification System

More...
PANTHERi
PTHR21119 PTHR21119, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF18696 SMP_C2CD2L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q3C1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSWLSEVQW LFLVSLFVAA LGTVGLYLAQ WALAKARPPP RRRAEPDELR
60 70 80 90 100
RRESDTLLSW ILTRDSWGNQ WQAAWVTALN YEAEKRGGPL RLSFQKDPRP
110 120 130 140 150
QSLQLTVEKV SSVVKSTQEK VVICHVVGET LQFLVSAGPA SATGSECQLY
160 170 180 190 200
DVHLSPFHLK VEFHMEEKRE DIQIRWSFTH VPETAIKIQP QAPGEKQALG
210 220 230 240 250
VNMLSEALED LFKHLVNAAS PSVFLSTKPT QVKEAQSLQC PSSTAQEPCP
260 270 280 290 300
PKPPRAHELK LQVKNIRVSL INHPGASGLS HVCVAQLNDP EQRFISTLVR
310 320 330 340 350
NTTDLSWEEE FTFELNAKSK ELVLQISQDG CSSEGLLGIA TIHLDLFRKQ
360 370 380 390 400
PNGPQTFRLI SGTEPDSLVL GSVTAEFSYV EPGELKSWPA PPPVSAAKIE
410 420 430 440 450
KDRTVMPCGT VVTTVTAVKT KPRFDTGRAT PLNSESPVRT PVTVKVIEKD
460 470 480 490 500
ISVQAISCHS APVSKTFSSS DTELLVLNGS DPVAEVAIRQ LSESSKLKLK
510 520 530 540 550
SPRKKSTIII SGISKTSLSQ DHNAALMLDY AASMDSTNQG DATSALCHPE
560 570 580 590 600
ATEASATTPP EENEPAQTLP ALKPRENDLD SWELEKESPV ASWSGPALQE
610 620 630 640 650
PDGDELSESS LSTSELGAMK KHKGGLLRKG AKLFFRRRHQ QKDPGLSQSH
660 670 680 690
NDLVFLQQPE GRQKKGATLG RLLNRKLLTR HRGKHTMNGV PREPCI
Length:696
Mass (Da):76,536
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75C92EA0AF01D4FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P6I3A0A338P6I3_MOUSE
C2 domain-containing protein 2
C2cd2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P7E6A0A338P7E6_MOUSE
C2 domain-containing protein 2
C2cd2
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6Y2A0A338P6Y2_MOUSE
C2 domain-containing protein 2
C2cd2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90483 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83A → S in BAE41447 (PubMed:16141072).Curated1
Sequence conflicti196K → N in BAE41447 (PubMed:16141072).Curated1
Sequence conflicti197Q → K in BAD90483 (Ref. 1) Curated1
Sequence conflicti197Q → K in AAH43688 (Ref. 3) Curated1
Sequence conflicti197Q → K in EDL03644 (PubMed:15489334).Curated1
Sequence conflicti197Q → K in BAE41447 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220454 mRNA Translation: BAD90483.1 Different initiation.
AC121560 Genomic DNA No translation available.
AC226122 Genomic DNA No translation available.
CH466602 Genomic DNA Translation: EDL03644.1
BC043688 mRNA Translation: AAH43688.1
AK143875 mRNA Translation: BAE25577.1
AK169902 mRNA Translation: BAE41447.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28361.1

NCBI Reference Sequences

More...
RefSeqi
NP_777272.2, NM_174847.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000170757; ENSMUSP00000127368; ENSMUSG00000045975

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
207781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:207781

UCSC genome browser

More...
UCSCi
uc008ads.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220454 mRNA Translation: BAD90483.1 Different initiation.
AC121560 Genomic DNA No translation available.
AC226122 Genomic DNA No translation available.
CH466602 Genomic DNA Translation: EDL03644.1
BC043688 mRNA Translation: AAH43688.1
AK143875 mRNA Translation: BAE25577.1
AK169902 mRNA Translation: BAE41447.1
CCDSiCCDS28361.1
RefSeqiNP_777272.2, NM_174847.2

3D structure databases

SMRiE9Q3C1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127368

PTM databases

iPTMnetiE9Q3C1
PhosphoSitePlusiE9Q3C1

Proteomic databases

jPOSTiE9Q3C1
MaxQBiE9Q3C1
PaxDbiE9Q3C1
PeptideAtlasiE9Q3C1
PRIDEiE9Q3C1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170757; ENSMUSP00000127368; ENSMUSG00000045975
GeneIDi207781
KEGGimmu:207781
UCSCiuc008ads.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25966
MGIiMGI:1891883 C2cd2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IGE7 Eukaryota
ENOG4112CMM LUCA
GeneTreeiENSGT00530000063764
HOGENOMiHOG000008704
InParanoidiE9Q3C1
OMAiRHQQKDP
OrthoDBi890695at2759
TreeFamiTF331604

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C2cd2 mouse

Protein Ontology

More...
PROi
PR:E9Q3C1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045975 Expressed in 242 organ(s), highest expression level in gastrocnemius
GenevisibleiE9Q3C1 MM

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR039934 C2CD2/C2CD2L
IPR040885 SMP_C2CD2L
PANTHERiPTHR21119 PTHR21119, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF18696 SMP_C2CD2L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC2CD2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q3C1
Secondary accession number(s): Q3TE01
, Q3UP20, Q5DTR6, Q80XM8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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