UniProtKB - E9Q394 (AKP13_MOUSE)

>sp|E9Q394|AKP13_MOUSE A-kinase anchor protein 13 OS=Mus musculus OX=10090 GN=Akap13 PE=1 SV=1
MKLSPQQAPLYGDCVVTVLLAEEDKVEDDAIFYLIFSGSTLYHCTSTRKVSSDTLETIAP
GHDCCETVKVLLCASREGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
RSGPPSRDVNSLDEKVALAFRHLKLPAEWNVLGTDHTLHDGGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNKEGATPVSLALERGYHELHQLLTEENAGEPDSWSSLSYEIPYG
DCSVRHHRELDIYTLTSESESHREPHGDSCTGHISKLMNIQQQLMKTNLKQMDNLMPLMV
TAQDSSCVPSVPETDGLFLPCVPEPSDHQHPPFEETKSTLCCQRSPGRMAESSCDLSSMV
EEENVICSHKKNKDVGRKGEEAEPASAMDSGSASHQDSCLQSVPDCGVKGREGLPSCGNR
NEVTGTNYSGVATCQQPLSSRSSVLQDAMVTEPDACQHSSGRELPDSSSTDVGAPEKAGE
LEHSLLTPDATTQNNKPQVGEGTKERLENSDSSTTETTAVQVLSEPMEKADITNHVFATS
AVGVNTPAEASPALSSEEIPTEKPGMETQERGCEGGTTSDQSSPVLPAAAIENKVLGGQE
PDTSIAGFCKTASPLDLTMPGPSSDGMPEQNSESHARPAQSLSGQALLCSTAEAGTPSAE
ATHQPSTVTSSGRLEECGSGKASLPESTMVQPSTQELCTTLCPEDPQADTVTSDTVKNTQ
KSVGVCHLCVSDAKNQGNGLKQDTPLTNVLEDVPRLPSVVSQTEKELAPDQVSPPASSFS
LASSPESESVTKDDALSLVPSQKEKGTATPQLHRTTACRDGPDGRDLSDTDKVGDGATDP
PPSSAVELRTSMGNTSPVGIGGEQEGSSPTATLEVLSDSLLHNVDKAALVSDFTLPEEGV
SVVVPESSTALGQDGKDRAMSCSSVKEDVHSSEMSREDQRTPPSGQEIPGLCEKPMSALC
AEEKAQQHTPSACLKTETKDIKEVAPQVSLLTEGGAAKSLVPPRTSLSADSKQKASSTEQ
SGSSLLPSGLPGASEALHCNQPSALDVVVENTQFQGETNACEVSRSAMEDVTVADASPAT
AEPRKKDASHCIKDIPISELLNQEKQMTPSLPEAFLDKGVTDLQEVITPEIEPLDCKRET
LEGTDLNCATSNSKETPIEKPMQPLARDLPTETGLSVINNNVPQADMKQVAQASIPAEES
NATTVSTQAADVPTRADSIEETATRIVEAVIRQVRASNALMAKVETQNPSLSSPETKQLE
NAYTESACAFLPGETPQIEKTHEDTTGQCGAETEEPEKIILPESAPGKQGKMPDTRTGDE
VDLLSRISAASEEEAVGNGAATPKMKQGPGTQAINRESWCAIEPCPEAASLLASKQSSEC
RSFIDVGLGTECASKEGMLQRVSGSESDLFHSPSDEMDSIIFPKPEEEQLLCDTTGSSSS
TDDTASLDRHSSHGSDVSLPQTSKLNRSRNHQSANGFFSPGVEAPESRESESEPAGSGEM
EEEEMDSITEVPANCSFLRSSMRSLSPFRRHSWGPGKNAASDAEMNQRSSMRALGHVVRR
PPIHRRSFSLEGLTGGGVGNKPSSSLEMSSANSSELRNPFGGEEQRNSLMSLSEEHLEPD
QRQHHRMFDQQTCYRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDSSRPFHSTSANLT
ESITEENCNFLPPSPSKKNFEEKSGTKVSRTFSYIRNKMSSSKKSKEKEKEKDKIKEKEK
DSKEKEKDKKTLNGHTFSPIPIVGPISCSQCMKPFTNKDAYTCAGCGAFVHKGCRENLAS
CAKVKMKQPKGSLQAHDTSSLPTVIMRNKSSQPKERPRSAVLLADEATAAPMFTNRRSQQ
SVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKICKVNESTESLTDEGVGTDMNE
GQLMGDFESDSKQLEAESWSRTVDSKFLKQQKKDVVKRQEVIYELMQTELHHIRTLKIMS
DVYSRGMMTDLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRI
GDVLVSQFSGESAERLKKTYGKFCGQHNQSVNYFKDLYTKDKRFQAFVKKKMSSSVVRRL
GIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLTQSLSLVKDVIGAVDSKVASYEK
KVRLGEIYTKTDSKSIMRMKSGQMFAKEDLRRKKLVRDGSVFLKSTTGRLKEVQAVLLTD
ILVFLQEKDQKYVFASLDHKSTVISLKKLIVREVAHEEKGLFLISMGVKDPEMVEVHASS
REERNSWIQIIQDTINSLNRDEDEGIPSENEEEKKLLDTKARELKEQLQQKDQQILLLLE
EKEMIFRDMTECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQSLVSG
SLGGTLGQSISSPVEQEVMAAPISLPRRAETFGGFDCHQMNASKGGEKEEGDDGQDLRRT
ESDSGLKKGGNGNLVFMLKRNSEQVVQSIVHLHELLSMLQGVVLQQDSYIEDQKLVLTEK
VLTRSASRPSSLIEQEKQRSLEKQRQDLANLQKQQAQHLEEKRRREREWEAREQELRDRE
AKLAEREETVRRRQQDLERDREELQQKKGTYQCDLERLRAAQKQLEREQEQLRRDTERLS
QRQMDQNLCQVSNKHGRLMRIPSFLPNSDEFSSPSAPSVTKSGSLDSELSVSPKRNSISR
TQKDKGPFHILGSASQTKVPEGQSQAPSSTSTSTRLFGLSKPKEKKEKKKKSKGSRTQPG
DGPASEVPAEGEEIFC

Entry version 68 (13 Feb 2019)
Sequence version 1 (05 Apr 2011)
Previous versions | rss

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Protein

A-kinase anchor protein 13

Gene

Akap13

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members (PubMed:23658642). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (By similarity). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (By similarity). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (PubMed:24161911). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (By similarity). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (PubMed:20139090). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:23658642, PubMed:24161911). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:17537920, PubMed:24161911). Plays a role in osteogenesis (PubMed:25892096).By similarity5 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1754 – 1801	Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST		48

GO - Molecular functionⁱ

cAMP-dependent protein kinase activity Source: InterPro
MAP-kinase scaffold activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW
protein-containing complex scaffold activity Source: UniProtKB
protein kinase A binding Source: MGI
Rho GTPase binding Source: MGI
Rho guanyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23658642

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23658642
adrenergic receptor signaling pathway Source: UniProtKB
bone development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25892096
cardiac muscle cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20139090
cell growth involved in cardiac muscle cell development Source: MGI
G protein-coupled receptor signaling pathway Source: UniProtKB
heart development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20139090
nuclear export Source: MGI
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
positive regulation of MAP kinase activity Source: MGI
positive regulation of Rho protein signal transduction Source: UniProtKB
regulation of glucocorticoid mediated signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 16469733
regulation of sarcomere organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20139090

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factor
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193648 NRAGE signals death through JNK R-MMU-194840 Rho GTPase cycle

Reactomeⁱ

R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: A-kinase anchor protein 13 Short name: AKAP-13 Alternative name(s): AKAP-Lbc1 Publication
Gene namesⁱ	Name:Akap13Imported Synonyms:Brx1 Publication
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2676556 Akap13

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Complete embryonic lethality (PubMed:16469733, PubMed:20139090). Mutant embryos are present at the expected Mendelian rate and develop normally up to 8 dpc. At 10 dpc, mutant embryos appear smaller, have an enlarged heart and pericardiac effusion. The myocardium is thinner than normal and has reduced trabeculation. Sarcomeres are abnormal with incompleteley formed myofilaments that end blindly and do not form Z-disks, indicating a defect in cardiomyocyte differentiation (PubMed:20139090). Heterozygous mice are born at the expected Mendelian frequency and appear grossly normal (PubMed:16469733, PubMed:20139090). Heterozygous mice display a blunted response to glucocorticoids (PubMed:16469733). Heterozygous mice display reduced bone volume relative to body size, but no change of bone length. Heterozygous mice display reduced bone mineral density and reduced trabecular bone, similar to osteoporotic bone. The number of osteoblasts in trabecular bone is reduced (PubMed:25892096).3 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000436319	1 – 2776	A-kinase anchor protein 13Add BLAST		2776

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	784	PhosphoserineBy similarity	1
Modified residueⁱ	809	PhosphothreonineBy similarity	1
Modified residueⁱ	941	PhosphothreonineCombined sources	1
Modified residueⁱ	1455	PhosphoserineBy similarity	1
Modified residueⁱ	1473	PhosphoserineBy similarity	1
Modified residueⁱ	1507	PhosphoserineBy similarity	1
Modified residueⁱ	1532	PhosphoserineBy similarity	1
Modified residueⁱ	1569	PhosphoserineBy similarity	1
Modified residueⁱ	1608	PhosphoserineCombined sources	1
Modified residueⁱ	1611	PhosphoserineCombined sources	1
Modified residueⁱ	1613	PhosphoserineCombined sources	1
Modified residueⁱ	1637	N6-methyllysineBy similarity	1
Modified residueⁱ	1839	PhosphoserineCombined sources	1
Modified residueⁱ	1858	PhosphoserineBy similarity	1
Modified residueⁱ	1892	PhosphoserineCombined sources	1
Modified residueⁱ	1893	PhosphothreonineBy similarity	1
Modified residueⁱ	1895	PhosphoserineCombined sources	1
Modified residueⁱ	1908	PhosphoserineBy similarity	1
Modified residueⁱ	2308	PhosphoserineBy similarity	1
Modified residueⁱ	2361	PhosphoserineCombined sources	1
Modified residueⁱ	2431	PhosphothreonineBy similarity	1
Modified residueⁱ	2527	PhosphoserineCombined sources	1
Modified residueⁱ	2530	PhosphoserineCombined sources	1
Modified residueⁱ	2673	PhosphoserineBy similarity	1
Modified residueⁱ	2692	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

jPOSTⁱ	E9Q394
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9Q394
PaxDbⁱ	E9Q394
PeptideAtlas More...PeptideAtlasⁱ	E9Q394
PRIDEⁱ	E9Q394

PTM databases

iPTMnetⁱ	E9Q394
PhosphoSitePlusⁱ	E9Q394

Expressionⁱ

Tissue specificityⁱ

Detected in embryonic heart, limb bud, first branchial arch and forebrain (at protein level) (PubMed:20139090). Detected in heart (PubMed:20139090). Detected in perichondrium, but not in the bone growth plate (PubMed:25892096).2 Publications

Developmental stageⁱ

Detected in head folds, notochord and somites at 8.5 dpc, with little or no expression in the looping heart. Detected in heart, vasculature, eye, ear, somites, gut and brain at 9.5 dpc. Expression in the heart increases by 10.5 dpc. Highly expressed in atrial and ventricular myocardium and endocardium, trabeculae and outflow tract at 14.5 dpc. Additionally, detected in skeletal muscle, tongue, gut, kidney, lung, urinary system and in the choroid plexus of the brain.1 Publication

Inductionⁱ

Up-regulated in the left heart ventricle in response to phenylephrine.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000066406 Expressed in 240 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasⁱ	E9Q394 baseline and differential
Genevisibleⁱ	E9Q394 MM

Interactionⁱ

Subunit structureⁱ

Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:21102438, PubMed:24161911, PubMed:23658642). Interacts with RHOA. Interacts also with RHOB and RHOC. Identified in a ternary complex with RHOA and PRKAR2A. Identified in a complex with NR3C1 and RHOA (By similarity). Interacts with BRAF and KSR1. Identified in a complex with BRAF and KSR1 (PubMed:21102438). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK. Interacts (phosphorylated form) with YWHAB and YWHAZ. Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases. Interacts with GNA12 (By similarity). Interacts with IKBKB (PubMed:23090968). Interacts with ESR1, THRA, PPARA and NME2 (By similarity). Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB (PubMed:20139090). Interacts (via the C-terminal domain after the PH domain) with PRKD1 (PubMed:23658642, PubMed:24161911).By similarity5 Publications

GO - Molecular functionⁱ

MAP-kinase scaffold activity Source: UniProtKB
protein-containing complex scaffold activity Source: UniProtKB
protein kinase A binding Source: MGI
Rho GTPase binding Source: MGI
Rho guanyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23658642

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000129784

STRINGⁱ

10090.ENSMUSP00000129784

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E9Q394
SMRⁱ	E9Q394
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1957 – 2154	DHPROSITE-ProRule annotationAdd BLAST		198
Domainⁱ	2194 – 2296	PHPROSITE-ProRule annotationAdd BLAST		103

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	493 – 515	Important for interaction with PRKAR2ABy similarityAdd BLAST	23
Regionⁱ	1552 – 1678	Important for interaction with MAP2K3By similarityAdd BLAST	127
Regionⁱ	1882 – 2776	Interaction with ESR1By similarityAdd BLAST	895

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	2308 – 2345	Sequence analysisAdd BLAST		38
Coiled coilⁱ	2532 – 2646	Sequence analysisAdd BLAST		115

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1437 – 1440	Poly-SerSequence analysis	4
Compositional biasⁱ	1499 – 1504	Poly-GluSequence analysis	6
Compositional biasⁱ	1697 – 1750	Lys-richPROSITE-ProRule annotationAdd BLAST	54
Compositional biasⁱ	2741 – 2753	Poly-LysSequence analysisAdd BLAST	13

Domainⁱ

The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA. Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes.By similarity

The PH domain does not play a role in lipid-binding. Instead, it inhibits the guanine nucleotide exchange (GEF) activity of the isolated DH domain (in vitro).By similarity

The C-terminal domain after the PH domain is involved in protein-protein interactions that are required for normal, compensatory cardiac hypertrophy in response to pressure overload.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1754 – 1801	Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST		48

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3520 Eukaryota COG5422 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154146
KEGG Orthology (KO) More...KOⁱ	K16529
OMAⁱ	HRELDVY
Database of Orthologous Groups More...OrthoDBⁱ	69816at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00160 RhoGEF, 1 hit
Gene3Dⁱ	1.20.900.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR028852 AKAP13 IPR035899 DBL_dom_sf IPR000219 DH-domain IPR002219 PE/DAG-bd IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR13944:SF18 PTHR13944:SF18, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00621 RhoGEF, 1 hit
SMARTⁱ	View protein in SMART SM00109 C1, 1 hit SM00233 PH, 1 hit SM00325 RhoGEF, 1 hit
SUPFAMⁱ	SSF48065 SSF48065, 1 hit
PROSITEⁱ	View protein in PROSITE PS50010 DH_2, 1 hit PS50003 PH_DOMAIN, 1 hit PS00479 ZF_DAG_PE_1, 1 hit PS50081 ZF_DAG_PE_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: E9Q394-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MKLSPQQAPL YGDCVVTVLL AEEDKVEDDA IFYLIFSGST LYHCTSTRKV 
        60         70         80         90        100
SSDTLETIAP GHDCCETVKV LLCASREGLP VFVVAEEDFH FVQDEAYDAA 
       110        120        130        140        150
QFLATSAGNQ QALNFTRFLD RSGPPSRDVN SLDEKVALAF RHLKLPAEWN 
       160        170        180        190        200
VLGTDHTLHD GGPRETLMHF AVRLGLLRLT WFLLQKPGGR GALSIHNKEG 
       210        220        230        240        250
ATPVSLALER GYHELHQLLT EENAGEPDSW SSLSYEIPYG DCSVRHHREL 
       260        270        280        290        300
DIYTLTSESE SHREPHGDSC TGHISKLMNI QQQLMKTNLK QMDNLMPLMV 
       310        320        330        340        350
TAQDSSCVPS VPETDGLFLP CVPEPSDHQH PPFEETKSTL CCQRSPGRMA 
       360        370        380        390        400
ESSCDLSSMV EEENVICSHK KNKDVGRKGE EAEPASAMDS GSASHQDSCL 
       410        420        430        440        450
QSVPDCGVKG REGLPSCGNR NEVTGTNYSG VATCQQPLSS RSSVLQDAMV 
       460        470        480        490        500
TEPDACQHSS GRELPDSSST DVGAPEKAGE LEHSLLTPDA TTQNNKPQVG 
       510        520        530        540        550
EGTKERLENS DSSTTETTAV QVLSEPMEKA DITNHVFATS AVGVNTPAEA 
       560        570        580        590        600
SPALSSEEIP TEKPGMETQE RGCEGGTTSD QSSPVLPAAA IENKVLGGQE 
       610        620        630        640        650
PDTSIAGFCK TASPLDLTMP GPSSDGMPEQ NSESHARPAQ SLSGQALLCS 
       660        670        680        690        700
TAEAGTPSAE ATHQPSTVTS SGRLEECGSG KASLPESTMV QPSTQELCTT 
       710        720        730        740        750
LCPEDPQADT VTSDTVKNTQ KSVGVCHLCV SDAKNQGNGL KQDTPLTNVL 
       760        770        780        790        800
EDVPRLPSVV SQTEKELAPD QVSPPASSFS LASSPESESV TKDDALSLVP 
       810        820        830        840        850
SQKEKGTATP QLHRTTACRD GPDGRDLSDT DKVGDGATDP PPSSAVELRT 
       860        870        880        890        900
SMGNTSPVGI GGEQEGSSPT ATLEVLSDSL LHNVDKAALV SDFTLPEEGV 
       910        920        930        940        950
SVVVPESSTA LGQDGKDRAM SCSSVKEDVH SSEMSREDQR TPPSGQEIPG 
       960        970        980        990       1000
LCEKPMSALC AEEKAQQHTP SACLKTETKD IKEVAPQVSL LTEGGAAKSL 
      1010       1020       1030       1040       1050
VPPRTSLSAD SKQKASSTEQ SGSSLLPSGL PGASEALHCN QPSALDVVVE 
      1060       1070       1080       1090       1100
NTQFQGETNA CEVSRSAMED VTVADASPAT AEPRKKDASH CIKDIPISEL 
      1110       1120       1130       1140       1150
LNQEKQMTPS LPEAFLDKGV TDLQEVITPE IEPLDCKRET LEGTDLNCAT 
      1160       1170       1180       1190       1200
SNSKETPIEK PMQPLARDLP TETGLSVINN NVPQADMKQV AQASIPAEES 
      1210       1220       1230       1240       1250
NATTVSTQAA DVPTRADSIE ETATRIVEAV IRQVRASNAL MAKVETQNPS 
      1260       1270       1280       1290       1300
LSSPETKQLE NAYTESACAF LPGETPQIEK THEDTTGQCG AETEEPEKII 
      1310       1320       1330       1340       1350
LPESAPGKQG KMPDTRTGDE VDLLSRISAA SEEEAVGNGA ATPKMKQGPG 
      1360       1370       1380       1390       1400
TQAINRESWC AIEPCPEAAS LLASKQSSEC RSFIDVGLGT ECASKEGMLQ 
      1410       1420       1430       1440       1450
RVSGSESDLF HSPSDEMDSI IFPKPEEEQL LCDTTGSSSS TDDTASLDRH 
      1460       1470       1480       1490       1500
SSHGSDVSLP QTSKLNRSRN HQSANGFFSP GVEAPESRES ESEPAGSGEM 
      1510       1520       1530       1540       1550
EEEEMDSITE VPANCSFLRS SMRSLSPFRR HSWGPGKNAA SDAEMNQRSS 
      1560       1570       1580       1590       1600
MRALGHVVRR PPIHRRSFSL EGLTGGGVGN KPSSSLEMSS ANSSELRNPF 
      1610       1620       1630       1640       1650
GGEEQRNSLM SLSEEHLEPD QRQHHRMFDQ QTCYRSKQQG FNYCTSAISS 
      1660       1670       1680       1690       1700
PLTKSISLMT ISHPGLDSSR PFHSTSANLT ESITEENCNF LPPSPSKKNF 
      1710       1720       1730       1740       1750
EEKSGTKVSR TFSYIRNKMS SSKKSKEKEK EKDKIKEKEK DSKEKEKDKK 
      1760       1770       1780       1790       1800
TLNGHTFSPI PIVGPISCSQ CMKPFTNKDA YTCAGCGAFV HKGCRENLAS 
      1810       1820       1830       1840       1850
CAKVKMKQPK GSLQAHDTSS LPTVIMRNKS SQPKERPRSA VLLADEATAA 
      1860       1870       1880       1890       1900
PMFTNRRSQQ SVSLSKSVSI QNITGVGNDE NMSNTWKFLS HSTDSLNKIC 
      1910       1920       1930       1940       1950
KVNESTESLT DEGVGTDMNE GQLMGDFESD SKQLEAESWS RTVDSKFLKQ 
      1960       1970       1980       1990       2000
QKKDVVKRQE VIYELMQTEL HHIRTLKIMS DVYSRGMMTD LLFEQQMVEK 
      2010       2020       2030       2040       2050
LFPCLDELIS IHSQFFQRIL ERKKESLVDK SEKNFLIKRI GDVLVSQFSG 
      2060       2070       2080       2090       2100
ESAERLKKTY GKFCGQHNQS VNYFKDLYTK DKRFQAFVKK KMSSSVVRRL 
      2110       2120       2130       2140       2150
GIPECILLVT QRITKYPVLF QRILQCTKDN EVEQEDLTQS LSLVKDVIGA 
      2160       2170       2180       2190       2200
VDSKVASYEK KVRLGEIYTK TDSKSIMRMK SGQMFAKEDL RRKKLVRDGS 
      2210       2220       2230       2240       2250
VFLKSTTGRL KEVQAVLLTD ILVFLQEKDQ KYVFASLDHK STVISLKKLI 
      2260       2270       2280       2290       2300
VREVAHEEKG LFLISMGVKD PEMVEVHASS REERNSWIQI IQDTINSLNR 
      2310       2320       2330       2340       2350
DEDEGIPSEN EEEKKLLDTK ARELKEQLQQ KDQQILLLLE EKEMIFRDMT 
      2360       2370       2380       2390       2400
ECSTPLPEDC SPTHSPRVLF RSNTEEALKG GPLMKSAINE VEILQSLVSG 
      2410       2420       2430       2440       2450
SLGGTLGQSI SSPVEQEVMA APISLPRRAE TFGGFDCHQM NASKGGEKEE 
      2460       2470       2480       2490       2500
GDDGQDLRRT ESDSGLKKGG NGNLVFMLKR NSEQVVQSIV HLHELLSMLQ 
      2510       2520       2530       2540       2550
GVVLQQDSYI EDQKLVLTEK VLTRSASRPS SLIEQEKQRS LEKQRQDLAN 
      2560       2570       2580       2590       2600
LQKQQAQHLE EKRRREREWE AREQELRDRE AKLAEREETV RRRQQDLERD 
      2610       2620       2630       2640       2650
REELQQKKGT YQCDLERLRA AQKQLEREQE QLRRDTERLS QRQMDQNLCQ 
      2660       2670       2680       2690       2700
VSNKHGRLMR IPSFLPNSDE FSSPSAPSVT KSGSLDSELS VSPKRNSISR 
      2710       2720       2730       2740       2750
TQKDKGPFHI LGSASQTKVP EGQSQAPSST STSTRLFGLS KPKEKKEKKK 
      2760       2770 
KSKGSRTQPG DGPASEVPAE GEEIFC

Length:2,776

Mass (Da):303,976

Last modified:April 5, 2011 - v1

Checksum:ⁱ1A27E2B4986306EE

Isoform 2 (identifier: E9Q394-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1307-1311: GKQGK → E
1548-1565: Missing.

« Hide

        10         20         30         40         50
MKLSPQQAPL YGDCVVTVLL AEEDKVEDDA IFYLIFSGST LYHCTSTRKV 
        60         70         80         90        100
SSDTLETIAP GHDCCETVKV LLCASREGLP VFVVAEEDFH FVQDEAYDAA 
       110        120        130        140        150
QFLATSAGNQ QALNFTRFLD RSGPPSRDVN SLDEKVALAF RHLKLPAEWN 
       160        170        180        190        200
VLGTDHTLHD GGPRETLMHF AVRLGLLRLT WFLLQKPGGR GALSIHNKEG 
       210        220        230        240        250
ATPVSLALER GYHELHQLLT EENAGEPDSW SSLSYEIPYG DCSVRHHREL 
       260        270        280        290        300
DIYTLTSESE SHREPHGDSC TGHISKLMNI QQQLMKTNLK QMDNLMPLMV 
       310        320        330        340        350
TAQDSSCVPS VPETDGLFLP CVPEPSDHQH PPFEETKSTL CCQRSPGRMA 
       360        370        380        390        400
ESSCDLSSMV EEENVICSHK KNKDVGRKGE EAEPASAMDS GSASHQDSCL 
       410        420        430        440        450
QSVPDCGVKG REGLPSCGNR NEVTGTNYSG VATCQQPLSS RSSVLQDAMV 
       460        470        480        490        500
TEPDACQHSS GRELPDSSST DVGAPEKAGE LEHSLLTPDA TTQNNKPQVG 
       510        520        530        540        550
EGTKERLENS DSSTTETTAV QVLSEPMEKA DITNHVFATS AVGVNTPAEA 
       560        570        580        590        600
SPALSSEEIP TEKPGMETQE RGCEGGTTSD QSSPVLPAAA IENKVLGGQE 
       610        620        630        640        650
PDTSIAGFCK TASPLDLTMP GPSSDGMPEQ NSESHARPAQ SLSGQALLCS 
       660        670        680        690        700
TAEAGTPSAE ATHQPSTVTS SGRLEECGSG KASLPESTMV QPSTQELCTT 
       710        720        730        740        750
LCPEDPQADT VTSDTVKNTQ KSVGVCHLCV SDAKNQGNGL KQDTPLTNVL 
       760        770        780        790        800
EDVPRLPSVV SQTEKELAPD QVSPPASSFS LASSPESESV TKDDALSLVP 
       810        820        830        840        850
SQKEKGTATP QLHRTTACRD GPDGRDLSDT DKVGDGATDP PPSSAVELRT 
       860        870        880        890        900
SMGNTSPVGI GGEQEGSSPT ATLEVLSDSL LHNVDKAALV SDFTLPEEGV 
       910        920        930        940        950
SVVVPESSTA LGQDGKDRAM SCSSVKEDVH SSEMSREDQR TPPSGQEIPG 
       960        970        980        990       1000
LCEKPMSALC AEEKAQQHTP SACLKTETKD IKEVAPQVSL LTEGGAAKSL 
      1010       1020       1030       1040       1050
VPPRTSLSAD SKQKASSTEQ SGSSLLPSGL PGASEALHCN QPSALDVVVE 
      1060       1070       1080       1090       1100
NTQFQGETNA CEVSRSAMED VTVADASPAT AEPRKKDASH CIKDIPISEL 
      1110       1120       1130       1140       1150
LNQEKQMTPS LPEAFLDKGV TDLQEVITPE IEPLDCKRET LEGTDLNCAT 
      1160       1170       1180       1190       1200
SNSKETPIEK PMQPLARDLP TETGLSVINN NVPQADMKQV AQASIPAEES 
      1210       1220       1230       1240       1250
NATTVSTQAA DVPTRADSIE ETATRIVEAV IRQVRASNAL MAKVETQNPS 
      1260       1270       1280       1290       1300
LSSPETKQLE NAYTESACAF LPGETPQIEK THEDTTGQCG AETEEPEKII 
      1310       1320       1330       1340       1350
LPESAPEMPD TRTGDEVDLL SRISAASEEE AVGNGAATPK MKQGPGTQAI 
      1360       1370       1380       1390       1400
NRESWCAIEP CPEAASLLAS KQSSECRSFI DVGLGTECAS KEGMLQRVSG 
      1410       1420       1430       1440       1450
SESDLFHSPS DEMDSIIFPK PEEEQLLCDT TGSSSSTDDT ASLDRHSSHG 
      1460       1470       1480       1490       1500
SDVSLPQTSK LNRSRNHQSA NGFFSPGVEA PESRESESEP AGSGEMEEEE 
      1510       1520       1530       1540       1550
MDSITEVPAN CSFLRSSMRS LSPFRRHSWG PGKNAASDAE MNQRSFSLEG 
      1560       1570       1580       1590       1600
LTGGGVGNKP SSSLEMSSAN SSELRNPFGG EEQRNSLMSL SEEHLEPDQR 
      1610       1620       1630       1640       1650
QHHRMFDQQT CYRSKQQGFN YCTSAISSPL TKSISLMTIS HPGLDSSRPF 
      1660       1670       1680       1690       1700
HSTSANLTES ITEENCNFLP PSPSKKNFEE KSGTKVSRTF SYIRNKMSSS 
      1710       1720       1730       1740       1750
KKSKEKEKEK DKIKEKEKDS KEKEKDKKTL NGHTFSPIPI VGPISCSQCM 
      1760       1770       1780       1790       1800
KPFTNKDAYT CAGCGAFVHK GCRENLASCA KVKMKQPKGS LQAHDTSSLP 
      1810       1820       1830       1840       1850
TVIMRNKSSQ PKERPRSAVL LADEATAAPM FTNRRSQQSV SLSKSVSIQN 
      1860       1870       1880       1890       1900
ITGVGNDENM SNTWKFLSHS TDSLNKICKV NESTESLTDE GVGTDMNEGQ 
      1910       1920       1930       1940       1950
LMGDFESDSK QLEAESWSRT VDSKFLKQQK KDVVKRQEVI YELMQTELHH 
      1960       1970       1980       1990       2000
IRTLKIMSDV YSRGMMTDLL FEQQMVEKLF PCLDELISIH SQFFQRILER 
      2010       2020       2030       2040       2050
KKESLVDKSE KNFLIKRIGD VLVSQFSGES AERLKKTYGK FCGQHNQSVN 
      2060       2070       2080       2090       2100
YFKDLYTKDK RFQAFVKKKM SSSVVRRLGI PECILLVTQR ITKYPVLFQR 
      2110       2120       2130       2140       2150
ILQCTKDNEV EQEDLTQSLS LVKDVIGAVD SKVASYEKKV RLGEIYTKTD 
      2160       2170       2180       2190       2200
SKSIMRMKSG QMFAKEDLRR KKLVRDGSVF LKSTTGRLKE VQAVLLTDIL 
      2210       2220       2230       2240       2250
VFLQEKDQKY VFASLDHKST VISLKKLIVR EVAHEEKGLF LISMGVKDPE 
      2260       2270       2280       2290       2300
MVEVHASSRE ERNSWIQIIQ DTINSLNRDE DEGIPSENEE EKKLLDTKAR 
      2310       2320       2330       2340       2350
ELKEQLQQKD QQILLLLEEK EMIFRDMTEC STPLPEDCSP THSPRVLFRS 
      2360       2370       2380       2390       2400
NTEEALKGGP LMKSAINEVE ILQSLVSGSL GGTLGQSISS PVEQEVMAAP 
      2410       2420       2430       2440       2450
ISLPRRAETF GGFDCHQMNA SKGGEKEEGD DGQDLRRTES DSGLKKGGNG 
      2460       2470       2480       2490       2500
NLVFMLKRNS EQVVQSIVHL HELLSMLQGV VLQQDSYIED QKLVLTEKVL 
      2510       2520       2530       2540       2550
TRSASRPSSL IEQEKQRSLE KQRQDLANLQ KQQAQHLEEK RRREREWEAR 
      2560       2570       2580       2590       2600
EQELRDREAK LAEREETVRR RQQDLERDRE ELQQKKGTYQ CDLERLRAAQ 
      2610       2620       2630       2640       2650
KQLEREQEQL RRDTERLSQR QMDQNLCQVS NKHGRLMRIP SFLPNSDEFS 
      2660       2670       2680       2690       2700
SPSAPSVTKS GSLDSELSVS PKRNSISRTQ KDKGPFHILG SASQTKVPEG 
      2710       2720       2730       2740       2750
QSQAPSSTST STRLFGLSKP KEKKEKKKKS KGSRTQPGDG PASEVPAEGE 

EIFC

Show »

Length:2,754

Mass (Da):301,499

Checksum:ⁱFCB658ABA85C936A

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140LJJ5	A0A140LJJ5_MOUSE	A-kinase anchor protein 13 A-kinase anchor protein 13	Akap13	2,794	Annotation score:
A0A140LHG3	A0A140LHG3_MOUSE	A-kinase anchor protein 13 A-kinase anchor protein 13	Akap13	607	Annotation score:
A0A140LHQ3	A0A140LHQ3_MOUSE	A-kinase anchor protein 13 A-kinase anchor protein 13	Akap13	423	Annotation score:
A0A140LIX0	A0A140LIX0_MOUSE	A-kinase anchor protein 13 A-kinase anchor protein 13	Akap13	870	Annotation score:
A0A140LID7	A0A140LID7_MOUSE	A-kinase anchor protein 13 A-kinase anchor protein 13	Akap13	569	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058344	1307 – 1311	GKQGK → E in isoform 2.		5
Alternative sequenceⁱVSP_058345	1548 – 1565	Missing in isoform 2. Add BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC113019 Genomic DNA No translation available. AC158749 Genomic DNA No translation available. AK149507 mRNA Translation: BAE28926.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52276.1 [E9Q394-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_083608.1, NM_029332.1 [E9Q394-1] XP_006541318.1, XM_006541255.3 [E9Q394-2]
UniGeneⁱ	Mm.216107

Genome annotation databases

Ensemblⁱ	ENSMUST00000166315; ENSMUSP00000129784; ENSMUSG00000066406 [E9Q394-1]
GeneIDⁱ	75547
KEGGⁱ	mmu:75547
UCSC genome browser More...UCSCⁱ	uc009hwq.1 mouse uc009hwx.2 mouse [E9Q394-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
E9Q394-2	A-kinase anchor protein 13 (Fragment)		MOUSE		870	UniRef90_E9Q394-2

Protein	Similar proteins		Species	Score	Length	Source
E9Q394	A-kinase anchor protein 13 isoform X3		Enhydra lutris kenyoni		2779	UniRef50_E9Q394
A kinase anchor protein 13 (Fragment)		MUSPF		120
A-kinase anchor protein 13		wild yak		2750
Isoform 2 of A-kinase anchor protein 13		MOUSE		2754
Uncharacterized protein		MONDO		2593
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC113019 Genomic DNA No translation available. AC158749 Genomic DNA No translation available. AK149507 mRNA Translation: BAE28926.1
CCDSⁱ	CCDS52276.1 [E9Q394-1]
RefSeqⁱ	NP_083608.1, NM_029332.1 [E9Q394-1] XP_006541318.1, XM_006541255.3 [E9Q394-2]
UniGeneⁱ	Mm.216107

3D structure databases

ProteinModelPortalⁱ	E9Q394
SMRⁱ	E9Q394
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000129784

STRINGⁱ

10090.ENSMUSP00000129784

PTM databases

iPTMnetⁱ	E9Q394
PhosphoSitePlusⁱ	E9Q394

Proteomic databases

jPOSTⁱ	E9Q394
MaxQBⁱ	E9Q394
PaxDbⁱ	E9Q394
PeptideAtlasⁱ	E9Q394
PRIDEⁱ	E9Q394

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000166315; ENSMUSP00000129784; ENSMUSG00000066406 [E9Q394-1]
GeneIDⁱ	75547
KEGGⁱ	mmu:75547
UCSCⁱ	uc009hwq.1 mouse uc009hwx.2 mouse [E9Q394-1]

Organism-specific databases

CTDⁱ	11214
MGIⁱ	MGI:2676556 Akap13

Phylogenomic databases

eggNOGⁱ	KOG3520 Eukaryota COG5422 LUCA
GeneTreeⁱ	ENSGT00940000154146
KOⁱ	K16529
OMAⁱ	HRELDVY
OrthoDBⁱ	69816at2759

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193648 NRAGE signals death through JNK R-MMU-194840 Rho GTPase cycle

Reactomeⁱ

R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSⁱ	Akap13 mouse
Protein Ontology More...PROⁱ	PR:E9Q394
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000066406 Expressed in 240 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasⁱ	E9Q394 baseline and differential
Genevisibleⁱ	E9Q394 MM

Family and domain databases

CDDⁱ	cd00160 RhoGEF, 1 hit
Gene3Dⁱ	1.20.900.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR028852 AKAP13 IPR035899 DBL_dom_sf IPR000219 DH-domain IPR002219 PE/DAG-bd IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR13944:SF18 PTHR13944:SF18, 1 hit
Pfamⁱ	View protein in Pfam PF00621 RhoGEF, 1 hit
SMARTⁱ	View protein in SMART SM00109 C1, 1 hit SM00233 PH, 1 hit SM00325 RhoGEF, 1 hit
SUPFAMⁱ	SSF48065 SSF48065, 1 hit
PROSITEⁱ	View protein in PROSITE PS50010 DH_2, 1 hit PS50003 PH_DOMAIN, 1 hit PS00479 ZF_DAG_PE_1, 1 hit PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AKP13_MOUSE
Accessionⁱ	E9Q394Primary (citable) accession number: E9Q394 Secondary accession number(s): Q3UEI5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 8, 2016
	Last sequence update:	April 5, 2011
	Last modified:	February 13, 2019
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - E9Q394 (AKP13_MOUSE)

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A-kinase anchor protein 13

Akap13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Cytosol

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ