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UniProtKB - E9Q394 (AKP13_MOUSE)

Protein

A-kinase anchor protein 13

Gene

Akap13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members (PubMed:23658642). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (By similarity). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (By similarity). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (PubMed:24161911). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (By similarity). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (PubMed:20139090). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:23658642, PubMed:24161911). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:17537920, PubMed:24161911). Plays a role in osteogenesis (PubMed:25892096).By similarity5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1754 – 1801Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 13
Short name:
AKAP-13
Alternative name(s):
AKAP-Lbc1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap13Imported
Synonyms:Brx1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2676556 Akap13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Complete embryonic lethality (PubMed:16469733, PubMed:20139090). Mutant embryos are present at the expected Mendelian rate and develop normally up to 8 dpc. At 10 dpc, mutant embryos appear smaller, have an enlarged heart and pericardiac effusion. The myocardium is thinner than normal and has reduced trabeculation. Sarcomeres are abnormal with incompleteley formed myofilaments that end blindly and do not form Z-disks, indicating a defect in cardiomyocyte differentiation (PubMed:20139090). Heterozygous mice are born at the expected Mendelian frequency and appear grossly normal (PubMed:16469733, PubMed:20139090). Heterozygous mice display a blunted response to glucocorticoids (PubMed:16469733). Heterozygous mice display reduced bone volume relative to body size, but no change of bone length. Heterozygous mice display reduced bone mineral density and reduced trabecular bone, similar to osteoporotic bone. The number of osteoblasts in trabecular bone is reduced (PubMed:25892096).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004363191 – 2776A-kinase anchor protein 13Add BLAST2776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei784PhosphoserineBy similarity1
Modified residuei809PhosphothreonineBy similarity1
Modified residuei941PhosphothreonineCombined sources1
Modified residuei1455PhosphoserineBy similarity1
Modified residuei1473PhosphoserineBy similarity1
Modified residuei1507PhosphoserineBy similarity1
Modified residuei1532PhosphoserineBy similarity1
Modified residuei1569PhosphoserineBy similarity1
Modified residuei1608PhosphoserineCombined sources1
Modified residuei1611PhosphoserineCombined sources1
Modified residuei1613PhosphoserineCombined sources1
Modified residuei1637N6-methyllysineBy similarity1
Modified residuei1839PhosphoserineCombined sources1
Modified residuei1858PhosphoserineBy similarity1
Modified residuei1892PhosphoserineCombined sources1
Modified residuei1893PhosphothreonineBy similarity1
Modified residuei1895PhosphoserineCombined sources1
Modified residuei1908PhosphoserineBy similarity1
Modified residuei2308PhosphoserineBy similarity1
Modified residuei2361PhosphoserineCombined sources1
Modified residuei2431PhosphothreonineBy similarity1
Modified residuei2527PhosphoserineCombined sources1
Modified residuei2530PhosphoserineCombined sources1
Modified residuei2673PhosphoserineBy similarity1
Modified residuei2692PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9Q394

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9Q394

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9Q394

PeptideAtlas

More...PeptideAtlasi		E9Q394

PRoteomics IDEntifications database

More...PRIDEi		E9Q394

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		E9Q394

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E9Q394

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryonic heart, limb bud, first branchial arch and forebrain (at protein level) (PubMed:20139090). Detected in heart (PubMed:20139090). Detected in perichondrium, but not in the bone growth plate (PubMed:25892096).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in head folds, notochord and somites at 8.5 dpc, with little or no expression in the looping heart. Detected in heart, vasculature, eye, ear, somites, gut and brain at 9.5 dpc. Expression in the heart increases by 10.5 dpc. Highly expressed in atrial and ventricular myocardium and endocardium, trabeculae and outflow tract at 14.5 dpc. Additionally, detected in skeletal muscle, tongue, gut, kidney, lung, urinary system and in the choroid plexus of the brain.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in the left heart ventricle in response to phenylephrine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000066406 Expressed in 240 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9Q394 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9Q394 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:21102438, PubMed:24161911, PubMed:23658642). Interacts with RHOA. Interacts also with RHOB and RHOC. Identified in a ternary complex with RHOA and PRKAR2A. Identified in a complex with NR3C1 and RHOA (By similarity). Interacts with BRAF and KSR1. Identified in a complex with BRAF and KSR1 (PubMed:21102438). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK. Interacts (phosphorylated form) with YWHAB and YWHAZ. Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases. Interacts with GNA12 (By similarity). Interacts with IKBKB (PubMed:23090968). Interacts with ESR1, THRA, PPARA and NME2 (By similarity). Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB (PubMed:20139090). Interacts (via the C-terminal domain after the PH domain) with PRKD1 (PubMed:23658642, PubMed:24161911).By similarity5 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000129784

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		E9Q394

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9Q394

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1957 – 2154DHPROSITE-ProRule annotationAdd BLAST198
Domaini2194 – 2296PHPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni493 – 515Important for interaction with PRKAR2ABy similarityAdd BLAST23
Regioni1552 – 1678Important for interaction with MAP2K3By similarityAdd BLAST127
Regioni1882 – 2776Interaction with ESR1By similarityAdd BLAST895

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2308 – 2345Sequence analysisAdd BLAST38
Coiled coili2532 – 2646Sequence analysisAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1437 – 1440Poly-SerSequence analysis4
Compositional biasi1499 – 1504Poly-GluSequence analysis6
Compositional biasi1697 – 1750Lys-richPROSITE-ProRule annotationAdd BLAST54
Compositional biasi2741 – 2753Poly-LysSequence analysisAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA. Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes.By similarity
The PH domain does not play a role in lipid-binding. Instead, it inhibits the guanine nucleotide exchange (GEF) activity of the isolated DH domain (in vitro).By similarity
The C-terminal domain after the PH domain is involved in protein-protein interactions that are required for normal, compensatory cardiac hypertrophy in response to pressure overload.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1754 – 1801Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3520 Eukaryota
COG5422 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154146

KEGG Orthology (KO)

More...KOi		K16529

Identification of Orthologs from Complete Genome Data

More...OMAi		HRELDVY

Database of Orthologous Groups

More...OrthoDBi		69816at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028852 AKAP13
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR13944:SF18 PTHR13944:SF18, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: E9Q394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLSPQQAPL YGDCVVTVLL AEEDKVEDDA IFYLIFSGST LYHCTSTRKV 
        60         70         80         90        100
SSDTLETIAP GHDCCETVKV LLCASREGLP VFVVAEEDFH FVQDEAYDAA 
       110        120        130        140        150
QFLATSAGNQ QALNFTRFLD RSGPPSRDVN SLDEKVALAF RHLKLPAEWN 
       160        170        180        190        200
VLGTDHTLHD GGPRETLMHF AVRLGLLRLT WFLLQKPGGR GALSIHNKEG 
       210        220        230        240        250
ATPVSLALER GYHELHQLLT EENAGEPDSW SSLSYEIPYG DCSVRHHREL 
       260        270        280        290        300
DIYTLTSESE SHREPHGDSC TGHISKLMNI QQQLMKTNLK QMDNLMPLMV 
       310        320        330        340        350
TAQDSSCVPS VPETDGLFLP CVPEPSDHQH PPFEETKSTL CCQRSPGRMA 
       360        370        380        390        400
ESSCDLSSMV EEENVICSHK KNKDVGRKGE EAEPASAMDS GSASHQDSCL 
       410        420        430        440        450
QSVPDCGVKG REGLPSCGNR NEVTGTNYSG VATCQQPLSS RSSVLQDAMV 
       460        470        480        490        500
TEPDACQHSS GRELPDSSST DVGAPEKAGE LEHSLLTPDA TTQNNKPQVG 
       510        520        530        540        550
EGTKERLENS DSSTTETTAV QVLSEPMEKA DITNHVFATS AVGVNTPAEA 
       560        570        580        590        600
SPALSSEEIP TEKPGMETQE RGCEGGTTSD QSSPVLPAAA IENKVLGGQE 
       610        620        630        640        650
PDTSIAGFCK TASPLDLTMP GPSSDGMPEQ NSESHARPAQ SLSGQALLCS 
       660        670        680        690        700
TAEAGTPSAE ATHQPSTVTS SGRLEECGSG KASLPESTMV QPSTQELCTT 
       710        720        730        740        750
LCPEDPQADT VTSDTVKNTQ KSVGVCHLCV SDAKNQGNGL KQDTPLTNVL 
       760        770        780        790        800
EDVPRLPSVV SQTEKELAPD QVSPPASSFS LASSPESESV TKDDALSLVP 
       810        820        830        840        850
SQKEKGTATP QLHRTTACRD GPDGRDLSDT DKVGDGATDP PPSSAVELRT 
       860        870        880        890        900
SMGNTSPVGI GGEQEGSSPT ATLEVLSDSL LHNVDKAALV SDFTLPEEGV 
       910        920        930        940        950
SVVVPESSTA LGQDGKDRAM SCSSVKEDVH SSEMSREDQR TPPSGQEIPG 
       960        970        980        990       1000
LCEKPMSALC AEEKAQQHTP SACLKTETKD IKEVAPQVSL LTEGGAAKSL 
      1010       1020       1030       1040       1050
VPPRTSLSAD SKQKASSTEQ SGSSLLPSGL PGASEALHCN QPSALDVVVE 
      1060       1070       1080       1090       1100
NTQFQGETNA CEVSRSAMED VTVADASPAT AEPRKKDASH CIKDIPISEL 
      1110       1120       1130       1140       1150
LNQEKQMTPS LPEAFLDKGV TDLQEVITPE IEPLDCKRET LEGTDLNCAT 
      1160       1170       1180       1190       1200
SNSKETPIEK PMQPLARDLP TETGLSVINN NVPQADMKQV AQASIPAEES 
      1210       1220       1230       1240       1250
NATTVSTQAA DVPTRADSIE ETATRIVEAV IRQVRASNAL MAKVETQNPS 
      1260       1270       1280       1290       1300
LSSPETKQLE NAYTESACAF LPGETPQIEK THEDTTGQCG AETEEPEKII 
      1310       1320       1330       1340       1350
LPESAPGKQG KMPDTRTGDE VDLLSRISAA SEEEAVGNGA ATPKMKQGPG 
      1360       1370       1380       1390       1400
TQAINRESWC AIEPCPEAAS LLASKQSSEC RSFIDVGLGT ECASKEGMLQ 
      1410       1420       1430       1440       1450
RVSGSESDLF HSPSDEMDSI IFPKPEEEQL LCDTTGSSSS TDDTASLDRH 
      1460       1470       1480       1490       1500
SSHGSDVSLP QTSKLNRSRN HQSANGFFSP GVEAPESRES ESEPAGSGEM 
      1510       1520       1530       1540       1550
EEEEMDSITE VPANCSFLRS SMRSLSPFRR HSWGPGKNAA SDAEMNQRSS 
      1560       1570       1580       1590       1600
MRALGHVVRR PPIHRRSFSL EGLTGGGVGN KPSSSLEMSS ANSSELRNPF 
      1610       1620       1630       1640       1650
GGEEQRNSLM SLSEEHLEPD QRQHHRMFDQ QTCYRSKQQG FNYCTSAISS 
      1660       1670       1680       1690       1700
PLTKSISLMT ISHPGLDSSR PFHSTSANLT ESITEENCNF LPPSPSKKNF 
      1710       1720       1730       1740       1750
EEKSGTKVSR TFSYIRNKMS SSKKSKEKEK EKDKIKEKEK DSKEKEKDKK 
      1760       1770       1780       1790       1800
TLNGHTFSPI PIVGPISCSQ CMKPFTNKDA YTCAGCGAFV HKGCRENLAS 
      1810       1820       1830       1840       1850
CAKVKMKQPK GSLQAHDTSS LPTVIMRNKS SQPKERPRSA VLLADEATAA 
      1860       1870       1880       1890       1900
PMFTNRRSQQ SVSLSKSVSI QNITGVGNDE NMSNTWKFLS HSTDSLNKIC 
      1910       1920       1930       1940       1950
KVNESTESLT DEGVGTDMNE GQLMGDFESD SKQLEAESWS RTVDSKFLKQ 
      1960       1970       1980       1990       2000
QKKDVVKRQE VIYELMQTEL HHIRTLKIMS DVYSRGMMTD LLFEQQMVEK 
      2010       2020       2030       2040       2050
LFPCLDELIS IHSQFFQRIL ERKKESLVDK SEKNFLIKRI GDVLVSQFSG 
      2060       2070       2080       2090       2100
ESAERLKKTY GKFCGQHNQS VNYFKDLYTK DKRFQAFVKK KMSSSVVRRL 
      2110       2120       2130       2140       2150
GIPECILLVT QRITKYPVLF QRILQCTKDN EVEQEDLTQS LSLVKDVIGA 
      2160       2170       2180       2190       2200
VDSKVASYEK KVRLGEIYTK TDSKSIMRMK SGQMFAKEDL RRKKLVRDGS 
      2210       2220       2230       2240       2250
VFLKSTTGRL KEVQAVLLTD ILVFLQEKDQ KYVFASLDHK STVISLKKLI 
      2260       2270       2280       2290       2300
VREVAHEEKG LFLISMGVKD PEMVEVHASS REERNSWIQI IQDTINSLNR 
      2310       2320       2330       2340       2350
DEDEGIPSEN EEEKKLLDTK ARELKEQLQQ KDQQILLLLE EKEMIFRDMT 
      2360       2370       2380       2390       2400
ECSTPLPEDC SPTHSPRVLF RSNTEEALKG GPLMKSAINE VEILQSLVSG 
      2410       2420       2430       2440       2450
SLGGTLGQSI SSPVEQEVMA APISLPRRAE TFGGFDCHQM NASKGGEKEE 
      2460       2470       2480       2490       2500
GDDGQDLRRT ESDSGLKKGG NGNLVFMLKR NSEQVVQSIV HLHELLSMLQ 
      2510       2520       2530       2540       2550
GVVLQQDSYI EDQKLVLTEK VLTRSASRPS SLIEQEKQRS LEKQRQDLAN 
      2560       2570       2580       2590       2600
LQKQQAQHLE EKRRREREWE AREQELRDRE AKLAEREETV RRRQQDLERD 
      2610       2620       2630       2640       2650
REELQQKKGT YQCDLERLRA AQKQLEREQE QLRRDTERLS QRQMDQNLCQ 
      2660       2670       2680       2690       2700
VSNKHGRLMR IPSFLPNSDE FSSPSAPSVT KSGSLDSELS VSPKRNSISR 
      2710       2720       2730       2740       2750
TQKDKGPFHI LGSASQTKVP EGQSQAPSST STSTRLFGLS KPKEKKEKKK 
      2760       2770 
KSKGSRTQPG DGPASEVPAE GEEIFC
Length:2,776
Mass (Da):303,976
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A27E2B4986306EE
GO
Isoform 2 (identifier: E9Q394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1307-1311: GKQGK → E
     1548-1565: Missing.

Show »
Length:2,754
Mass (Da):301,499
Checksum:iFCB658ABA85C936A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJJ5A0A140LJJ5_MOUSE
A-kinase anchor protein 13
Akap13
2,794Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHG3A0A140LHG3_MOUSE
A-kinase anchor protein 13
Akap13
607Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHQ3A0A140LHQ3_MOUSE
A-kinase anchor protein 13
Akap13
423Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LIX0A0A140LIX0_MOUSE
A-kinase anchor protein 13
Akap13
870Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LID7A0A140LID7_MOUSE
A-kinase anchor protein 13
Akap13
569Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0583441307 – 1311GKQGK → E in isoform 2. 5
Alternative sequenceiVSP_0583451548 – 1565Missing in isoform 2. Add BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC113019 Genomic DNA No translation available.
AC158749 Genomic DNA No translation available.
AK149507 mRNA Translation: BAE28926.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS52276.1 [E9Q394-1]

NCBI Reference Sequences

More...RefSeqi		NP_083608.1, NM_029332.1 [E9Q394-1]
XP_006541318.1, XM_006541255.3 [E9Q394-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.216107

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000166315; ENSMUSP00000129784; ENSMUSG00000066406 [E9Q394-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		75547

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:75547

UCSC genome browser

More...UCSCi		uc009hwq.1 mouse
uc009hwx.2 mouse [E9Q394-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113019 Genomic DNA No translation available.
AC158749 Genomic DNA No translation available.
AK149507 mRNA Translation: BAE28926.1
CCDSiCCDS52276.1 [E9Q394-1]
RefSeqiNP_083608.1, NM_029332.1 [E9Q394-1]
XP_006541318.1, XM_006541255.3 [E9Q394-2]
UniGeneiMm.216107

3D structure databases

ProteinModelPortaliE9Q394
SMRiE9Q394
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129784

PTM databases

iPTMnetiE9Q394
PhosphoSitePlusiE9Q394

Proteomic databases

jPOSTiE9Q394
MaxQBiE9Q394
PaxDbiE9Q394
PeptideAtlasiE9Q394
PRIDEiE9Q394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166315; ENSMUSP00000129784; ENSMUSG00000066406 [E9Q394-1]
GeneIDi75547
KEGGimmu:75547
UCSCiuc009hwq.1 mouse
uc009hwx.2 mouse [E9Q394-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11214
MGIiMGI:2676556 Akap13

Phylogenomic databases

eggNOGiKOG3520 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00940000154146
KOiK16529
OMAiHRELDVY
OrthoDBi69816at2759

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Akap13 mouse

Protein Ontology

More...PROi		PR:E9Q394

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000066406 Expressed in 240 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiE9Q394 baseline and differential
GenevisibleiE9Q394 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR028852 AKAP13
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR13944:SF18 PTHR13944:SF18, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKP13_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q394
Secondary accession number(s): Q3UEI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 8, 2016
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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