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Protein

Centrosome-associated protein 350

Gene

Cep350

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosome-associated protein 350
Short name:
Cep350
Gene namesi
Name:Cep350Imported
Synonyms:Kiaa04801 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921331 Cep350

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004406281 – 3095Centrosome-associated protein 350Add BLAST3095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei468PhosphoserineBy similarity1
Modified residuei503PhosphoserineBy similarity1
Modified residuei691PhosphoserineBy similarity1
Modified residuei874PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei1057PhosphoserineBy similarity1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1253PhosphothreonineBy similarity1
Modified residuei1256PhosphoserineBy similarity1
Modified residuei1259PhosphoserineBy similarity1
Modified residuei1606PhosphoserineCombined sources1
Modified residuei1641PhosphoserineBy similarity1
Modified residuei1646PhosphoserineBy similarity1
Modified residuei1812PhosphoserineCombined sources1
Modified residuei1930PhosphoserineCombined sources1
Modified residuei2108PhosphoserineBy similarity1
Modified residuei2198PhosphoserineBy similarity1
Modified residuei2421PhosphoserineCombined sources1
Modified residuei2450PhosphoserineBy similarity1
Modified residuei2671PhosphothreonineBy similarity1
Modified residuei2809PhosphoserineCombined sources1
Modified residuei2818PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiE9Q309
PaxDbiE9Q309
PeptideAtlasiE9Q309
PRIDEiE9Q309

PTM databases

iPTMnetiE9Q309
PhosphoSitePlusiE9Q309

Expressioni

Gene expression databases

BgeeiENSMUSG00000033671 Expressed in 279 organ(s), highest expression level in placenta
GenevisibleiE9Q309 MM

Interactioni

Subunit structurei

Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts (via C-terminus) directly with FGFR1OP (via N-terminus). Interacts with NR1H3, PPARA, PPARD and PPARG. Interacts directly with microtubules. Interacts with the fusion protein FGFR1OP-FGFR1, and by doing so recruits and activates PI3K and PLC-gamma. Interacts with CYLD (By similarity). Interacts with CFAP157 (PubMed:27965440). Interacts with CEP19 (via C-terminus) (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9Q309, 12 interactors
MINTiE9Q309
STRINGi10090.ENSMUSP00000120085

Structurei

3D structure databases

ProteinModelPortaliE9Q309
SMRiE9Q309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2504 – 2546CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili596 – 641Sequence analysisAdd BLAST46
Coiled coili1363 – 1402Sequence analysisAdd BLAST40
Coiled coili1700 – 1793Sequence analysisAdd BLAST94
Coiled coili1850 – 1893Sequence analysisAdd BLAST44
Coiled coili2043 – 2092Sequence analysisAdd BLAST50
Coiled coili2700 – 2731Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1496 – 1550Ser-richPROSITE-ProRule annotationAdd BLAST55
Compositional biasi2347 – 2442Ser-richPROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ISTJ Eukaryota
ENOG410YQD7 LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000111528
HOVERGENiHBG095435
InParanoidiE9Q309
KOiK16768
OMAiEKEFCAG
OrthoDBiEOG091G0038
TreeFamiTF329845

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028750 CEP350
PANTHERiPTHR13958 PTHR13958, 1 hit
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q309-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSSKSKEVP LPNPRNSQSK ETIQDVTTSW DALSQTKAAL RHIENKLEVT
60 70 80 90 100
PTSTAVIDSV MDTKKSASAT RKISRKDGRC LDDSWASAPT SKFSKPRKEK
110 120 130 140 150
SRSPLRATTL ESNVKKNNRV EFREPLVSYR ETHGTPFSLS PSHLESKHVY
160 170 180 190 200
CIHEEKPESG KQMVVSREDR NIQCCDFESA QPSVISDTVV RFLNDGPAID
210 220 230 240 250
ALHSSECLMK MGVHVRTEDE MPNRTKGSEN NSKPSLNNME HDVDPKVMLL
260 270 280 290 300
SDSSPSSSAC NSQRSDISKR QQHDIKLEKL KERIRKQWEH SEEINGQAQT
310 320 330 340 350
LGHIDHPVMV VNVDNSVTTK VRKVATAPPA PAYKGFNPSE TKIRTPDGKV
360 370 380 390 400
WQEAEFQSMS RELYRDLALQ FTDDTSVKEK PVEKSKEKKV VKPVRKIQKV
410 420 430 440 450
TQLSNPECKT GSSRLISTSS WRDGQKLVKK ILGPAPKMEQ KERRPTSNDR
460 470 480 490 500
SGRERVAKFG GHIGRAESDP KLDVSHKQLP RSSARSRSSR AWSETNIVKS
510 520 530 540 550
ALSLPDNKQE ESAALNKDFL PVEIRGILDD LQLDSSAQAV RQEAGEGQNQ
560 570 580 590 600
KSSAPEQVPR SHSPVKRKPD KITANEDPPV ISKKRHYDTD EVRQYIVRQQ
610 620 630 640 650
EERRRRQHEE KKAQKEATEQ KNKRLQELYR RQREAFSKAK TVPPSDPLVS
660 670 680 690 700
RRLQETYSKL LLEKTLLEEP ARQHVTQDIQ ARPGYQPSGE SDKENKIQER
710 720 730 740 750
PPSASSSSDL SLSEPPQPLA RRDLMEPTWM QPDRLSPRVH SSQAQPLAGT
760 770 780 790 800
TENLLSHLLH LEHVGILHKD YESVLPAKKS HNTASGPLTF TPQPYLTSQA
810 820 830 840 850
PHPDALLKPS TSQYKTKLDR IEALKATAAS LSSRIESEAK KLAGASINYG
860 870 880 890 900
SVWNTECDVK LAPQENGPWT KAISPPVKED IEDAFSARIQ KMLGTCVSHA
910 920 930 940 950
AFDDELPGVG SLSEYKKLPE MIRPQSAISS LRMKSPSPKP GGLLAQLCRR
960 970 980 990 1000
QTDSSSSDIQ ACSQERAKRS LCSSIDSVSE GPLLSEGSLS EEEERRDARP
1010 1020 1030 1040 1050
LLKVAEILKE KEFCAGERNS YEPIKEFQKE AEKFLPLFGH IGGTQSKGPW
1060 1070 1080 1090 1100
EELAKGSPHS VINIFTKSYQ LYGKGFEDRG TLVSRPLNAT ATPLSSVSYE
1110 1120 1130 1140 1150
DDFVSSPGSG TLTERKSTLE SQVDGSSLGV QEEHLSRQFA CDLASVDATS
1160 1170 1180 1190 1200
QHSSGARSAG STRSSSASKG KKGKKDKMDW LDSLTGSAQN PLIDEEKVQS
1210 1220 1230 1240 1250
DSERGSHPSR KLGTGSKLAV GDSEQTLDAE STLEDLSGHS VSGSSDKGRS
1260 1270 1280 1290 1300
QKTPTSPLSP SSQKLLQFDL PGTSLERSKS SVIVPPTTTG FKPTAAFTDV
1310 1320 1330 1340 1350
NKTEMASAPG PQRFSPAGLQ HRMAAELSYL SALEESVRQL SDVERVRGIA
1360 1370 1380 1390 1400
LAQQESVSLA QIIKAQQQRH ERDLALLKLK AEQEALECQR QLEETRNKTA
1410 1420 1430 1440 1450
QVHAESLQQV VKSQREVTEV LQEATCKIAA QQSETARLTT DAARQICEMA
1460 1470 1480 1490 1500
ELTRTHLADA ITTSGVPLAT LYDHQRQHFP DFMRKLRTKA ETDRISHSAS
1510 1520 1530 1540 1550
HSQSKEGAVD SKRQKFSPSR DSYSESSRYK SHDYRSSGSS RQDSPSVPPS
1560 1570 1580 1590 1600
KENEKPFHGE KMESSVDEQL QTAADDSLRS DSIPSLPDEK DSTSIATEYS
1610 1620 1630 1640 1650
LKFDESMTED EIEEKSFRSL LPSESHRRFN MEKKRGHHDD SDEDASPDKT
1660 1670 1680 1690 1700
ALSSTKELSM PFSGGQDSFS KFTMEMVRQY MKEEEVRAAH QSSLLRLREK
1710 1720 1730 1740 1750
ALKEKTKAEL AWLEHQKKHL RDKGEDDKMP PLRKKQRGLL LRLQQEKAEI
1760 1770 1780 1790 1800
KRLQEANKAA RKERQLILKQ QEEIERIRQT TIKLQEKLKS AGEKKLGSLA
1810 1820 1830 1840 1850
DDDEAEDNKA ASPGPPGLET RSPSPISISS SETSSIMQKL KSMRSRMDEK
1860 1870 1880 1890 1900
FLTKREQKLM QRRQHAEELL EWKRRLDAEE AEIQQMEKQA LAAWDKELVK
1910 1920 1930 1940 1950
PRTPKKEQES QRTEQKGIAS EEGSPMPSYS PRNSESCIPE DLGSPSDLCV
1960 1970 1980 1990 2000
PSEARVQAQP GSPEHSTLTE EMVFSQELES TSPSKHSPPK SCLSMSKQES
2010 2020 2030 2040 2050
SKASHRTEGH CHLPVKSHQP CYSWSDESLS MTQSETTSDQ SDIEGRIRAL
2060 2070 2080 2090 2100
KDELRKRKSV VEQLKREQRK RQKERLKAQE ASLLRQLETY DEFIKKTEGE
2110 2120 2130 2140 2150
LSQDLDISPT SKFQMKTLSS VSEKPKIKPH PLHRSETAKT WKSVTESERS
2160 2170 2180 2190 2200
RGSLASIAEH VDSSLSCSER AISERSLSAY AKRGVELDSR IEHLQASSPD
2210 2220 2230 2240 2250
LSSRKAQTES RDSLESAPSL SPVKELNAPD RIYDVSEAKA EDTSQKSEIQ
2260 2270 2280 2290 2300
EIESMKLESS EVEDACCKQS GGSEVLLKLD LASETLSSKE LPSDSANVQQ
2310 2320 2330 2340 2350
DLDKPATETS HEKEEALKED QSNHSTDDRS PDIQSAGGIP EQGCRESGDS
2360 2370 2380 2390 2400
TCSGQLSVPK ESSYSEDFEV SSFRKGISAD EISKDDSEGS SPSSLRKDSQ
2410 2420 2430 2440 2450
SHRDRSQLTR SSRSRATGSG SDEEISECLG EKSLSVHSGV HSERLLELRS
2460 2470 2480 2490 2500
PTELMKSKER SDVGHEQGGT EPLPLAATEE LLDFHIGDRV LIGSVQPGTL
2510 2520 2530 2540 2550
RFKGETDFAK GFWAGVELDK PEGNNNGTYD GIVYFVCKDK HGIFAPPQKI
2560 2570 2580 2590 2600
SHLLENFDDT DINEDEESYS DEQYQPYNQE QKDIKCLKDR ENNIAEYFCE
2610 2620 2630 2640 2650
KSLPSMHNTD ASVDKDRSLN IETDTSEVLE VHGHQQPSVD PLISYKENKV
2660 2670 2680 2690 2700
LVSDATESVP AAAGAATSDN TFSGESKQQQ LAEKEENFYS QVLEKPSTPL
2710 2720 2730 2740 2750
LDLLTREKNQ LEAQLKSSIS EEKKSKQQLE TVSLLTDSLL QVFVKDTVSQ
2760 2770 2780 2790 2800
LQQVKKARNE KIQLSNQEFL DQKKVPPQDL PQNTEEQSPS VPSCFLRSEL
2810 2820 2830 2840 2850
EDEKEEISSP DMCPRPESPV FGASGQEELA KRLAELEISR EFLSALDDQD
2860 2870 2880 2890 2900
WFDEDFGLSS SHKIQKNKAE ETIVPLMAEP KRAPQKPCET LLAVPHTAEE
2910 2920 2930 2940 2950
VESLVHNAAE ELWKWKELGQ DLHGLSLPTT FLGGASKGLD IGSTSRRVYK
2960 2970 2980 2990 3000
QAVFDLTKEI FEEIFAEDPN VNQPVWMKPC RINSSYFRRV KNPNNLDEIK
3010 3020 3030 3040 3050
HFITTEVLKL LSLKKEPNHK TDWQKMMKFG RKKRDRVDHI LVQELHEEEA
3060 3070 3080 3090
QWVNYDEDEL CVKMQLADGI FETLIKDTID VLNQISEKQG RMLLV
Length:3,095
Mass (Da):346,456
Last modified:April 5, 2011 - v1
Checksum:iDE26691E49024B63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2050L → P in BAD32234 (PubMed:15368895).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120391 Genomic DNA No translation available.
AC121314 Genomic DNA No translation available.
AK044664 mRNA Translation: BAC32024.1
AK172956 mRNA Translation: BAD32234.1
CCDSiCCDS48400.1
RefSeqiNP_001034273.1, NM_001039184.1
UniGeneiMm.260247

Genome annotation databases

EnsembliENSMUST00000138762; ENSMUSP00000120085; ENSMUSG00000033671
GeneIDi74081
KEGGimmu:74081
UCSCiuc007dbs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120391 Genomic DNA No translation available.
AC121314 Genomic DNA No translation available.
AK044664 mRNA Translation: BAC32024.1
AK172956 mRNA Translation: BAD32234.1
CCDSiCCDS48400.1
RefSeqiNP_001034273.1, NM_001039184.1
UniGeneiMm.260247

3D structure databases

ProteinModelPortaliE9Q309
SMRiE9Q309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q309, 12 interactors
MINTiE9Q309
STRINGi10090.ENSMUSP00000120085

PTM databases

iPTMnetiE9Q309
PhosphoSitePlusiE9Q309

Proteomic databases

MaxQBiE9Q309
PaxDbiE9Q309
PeptideAtlasiE9Q309
PRIDEiE9Q309

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000138762; ENSMUSP00000120085; ENSMUSG00000033671
GeneIDi74081
KEGGimmu:74081
UCSCiuc007dbs.2 mouse

Organism-specific databases

CTDi9857
MGIiMGI:1921331 Cep350
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ISTJ Eukaryota
ENOG410YQD7 LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000111528
HOVERGENiHBG095435
InParanoidiE9Q309
KOiK16768
OMAiEKEFCAG
OrthoDBiEOG091G0038
TreeFamiTF329845

Miscellaneous databases

ChiTaRSiCep350 mouse
PROiPR:E9Q309
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033671 Expressed in 279 organ(s), highest expression level in placenta
GenevisibleiE9Q309 MM

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028750 CEP350
PANTHERiPTHR13958 PTHR13958, 1 hit
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE350_MOUSE
AccessioniPrimary (citable) accession number: E9Q309
Secondary accession number(s): A0A1D5RMJ4
, D3YTP2, Q6A062, Q8BXM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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