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Protein
Submitted name:

Alpha-actinin-4

Gene

Actn4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-actinin-4Imported
Gene namesi
Name:Actn4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1890773 Actn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9Q2W9
PeptideAtlasiE9Q2W9
PRIDEiE9Q2W9

Expressioni

Gene expression databases

BgeeiENSMUSG00000054808
ExpressionAtlasiE9Q2W9 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiE9Q2W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 155Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini164 – 270Calponin-homology (CH)InterPro annotationAdd BLAST107

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 484Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR029637 ACTN4
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR43947:SF7 PTHR43947:SF7, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 2 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits

Sequencei

Sequence statusi: Fragment.

E9Q2W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYHAANQA YQYGPNSGGG NGAGGGGSMG DYMAQEDDWD RDLLLDPAWE
60 70 80 90 100
KQQRKTFTAW CNSHLRKAGT QIENIDEDFR DGLKLMLLLE VISGERLPKP
110 120 130 140 150
ERGKMRVHKI NNVNKALDFI ASKGVKLVSI GAEEIVDGNA KMTLGMIWTI
160 170 180 190 200
ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNVQNFH ISWKDGLAFN
210 220 230 240 250
ALIHRHRPEL IEYDKLRKDD PVTNLNNAFE VAEKYLDIPK MLDAEDIVGT
260 270 280 290 300
LRPDEKAIMT YVSCFYHAFS GAQKAETAAN RICKVLAVNQ ENEHLMEDYE
310 320 330 340 350
RLASDLLEWI RRTIPWLEDR VPQKTIQEMQ QKLEDFRDYR RVHKPPKVQE
360 370 380 390 400
KCQLEINFNT LQTKLRLSNR PAFMPSEGRM VSDINNGWQH LEQAEKGYEE
410 420 430 440 450
WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLKQR DYETATLSDI
460 470 480 490 500
KALIRKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYYDSH NVNTRCQKIC
510
DQWDNLGSLT HSRREALE
Length:518
Mass (Da):59,898
Last modified:April 5, 2011 - v1
Checksum:i56F8D4DAAE61C767
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei518Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166357 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000127210; ENSMUSP00000115436; ENSMUSG00000054808

Similar proteinsi

Entry informationi

Entry nameiE9Q2W9_MOUSE
AccessioniPrimary (citable) accession number: E9Q2W9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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