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UniProtKB - E9Q2H1 (E9Q2H1_MOUSE)

Entry version 87 (02 Dec 2020)
Sequence version 2 (28 Feb 2018)
Previous versions | rss
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Protein
Submitted name:

E3 ubiquitin-protein ligase UBR5

Gene

Ubr5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2761Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1171 – 1239UBR-typePROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase UBR5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubr5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1918040, Ubr5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		E9Q2H1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9Q2H1

PeptideAtlas

More...PeptideAtlasi		E9Q2H1

PRoteomics IDEntifications database

More...PRIDEi		E9Q2H1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000037487, Expressed in testis and 305 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9Q2H1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9Q2H1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		E9Q2H1, 26 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9Q2H1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1171 – 1239UBR-typeInterPro annotationAdd BLAST69
Domaini2371 – 2448PABCInterPro annotationAdd BLAST78
Domaini2497 – 2792HECTInterPro annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 175DisorderedSequence analysisAdd BLAST99
Regioni322 – 347DisorderedSequence analysisAdd BLAST26
Regioni577 – 642DisorderedSequence analysisAdd BLAST66
Regioni993 – 1029DisorderedSequence analysisAdd BLAST37
Regioni1046 – 1069DisorderedSequence analysisAdd BLAST24
Regioni1293 – 1312DisorderedSequence analysisAdd BLAST20
Regioni1509 – 1734DisorderedSequence analysisAdd BLAST226
Regioni1853 – 1886DisorderedSequence analysisAdd BLAST34
Regioni1978 – 2015DisorderedSequence analysisAdd BLAST38
Regioni2111 – 2137DisorderedSequence analysisAdd BLAST27
Regioni2317 – 2387DisorderedSequence analysisAdd BLAST71
Regioni2467 – 2494DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 35Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 151PolarSequence analysisAdd BLAST65
Compositional biasi322 – 338PolyampholyteSequence analysisAdd BLAST17
Compositional biasi577 – 596PolyampholyteSequence analysisAdd BLAST20
Compositional biasi605 – 626PolarSequence analysisAdd BLAST22
Compositional biasi1011 – 1025Pro-richSequence analysisAdd BLAST15
Compositional biasi1046 – 1066PolarSequence analysisAdd BLAST21
Compositional biasi1516 – 1545PolarSequence analysisAdd BLAST30
Compositional biasi1557 – 1571AcidicSequence analysisAdd BLAST15
Compositional biasi1572 – 1602PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1616 – 1645PolarSequence analysisAdd BLAST30
Compositional biasi1654 – 1679PolarSequence analysisAdd BLAST26
Compositional biasi1687 – 1734PolarSequence analysisAdd BLAST48
Compositional biasi1870 – 1886PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1990 – 2008PolyampholyteSequence analysisAdd BLAST19
Compositional biasi2323 – 2364PolyampholyteSequence analysisAdd BLAST42
Compositional biasi2467 – 2484PolyampholyteSequence analysisAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1171 – 1239UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156357

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000257_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		EAKFRRD

Database of Orthologous Groups

More...OrthoDBi		717at2759

TreeFam database of animal gene trees

More...TreeFami		TF314406

Family and domain databases

Conserved Domains Database

More...CDDi		cd14423, CUE_UBR5, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024725, E3_UbLigase_EDD_UBA
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR036053, PABP-dom
IPR002004, PABP_HYD
IPR009091, RCC1/BLIP-II
IPR003126, Znf_UBR

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11547, E3_UbLigase_EDD, 1 hit
PF00632, HECT, 1 hit
PF00658, PABP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00119, HECTc, 1 hit
SM00517, PolyA, 1 hit
SM00396, ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
SSF63570, SSF63570, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50237, HECT, 1 hit
PS51309, PABC, 1 hit
PS51157, ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q2H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ 
        60         70         80         90        100
CVVGPNHAAF LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR 
       110        120        130        140        150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG 
       160        170        180        190        200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK 
       210        220        230        240        250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS 
       260        270        280        290        300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRERDSE 
       310        320        330        340        350
LLRERESVLR LRERRWLDGA SFDNERGSTS KEGESNPDKK NTPVQSPVSL 
       360        370        380        390        400
GEDLQWWPDK DGTKFTCIGA LYSELLAVSS KGELYQWKWS ESEPYRNAQN 
       410        420        430        440        450
PSLHHPRATF LGLTNEKIVL LSANSIRATV ATENNKVATW VDETLSSVAS 
       460        470        480        490        500
KLEHTAQTYS ELQGERIVSL HCCALYTCAQ LENNLYWWGV VPFSQRKKML 
       510        520        530        540        550
EKARAKNKKP KSSAGISSMP NITVGTQVCL RNNPLYHAGA VAFSISAGIP 
       560        570        580        590        600
KVGVLMESVW NMNDSCRFQL RSPESLKSME KASKTLETKP ESKQEPVKTE 
       610        620        630        640        650
MGPPPSPAST CSDASSIASS ASMPYKRRRS TPAPREEEKV NEEQWPLREV 
       660        670        680        690        700
VFVEDVKNVP VGKVLKVDGA YVAVKFPGTS TNTTCQNSSG PDADPSSLLQ 
       710        720        730        740        750
DCRLLRIDEL QVVKTGGTPK VPDCFQRTPK KLCIPEKTEI LAVNVDSKGV 
       760        770        780        790        800
HAVLKTGSWV RYCVFDLATG KAEQENNFPT SSVAFLGQDE RSVAIFTAGQ 
       810        820        830        840        850
ESPIVLRDGN GTIYPMAKDC MGGIRDPDWL DLPPISSLGM GVHSLINLPA 
       860        870        880        890        900
NSTIKKKAAI IIMAVEKQTL MQHILRCDYE ACRQYLVNLE QAVVLEQNLQ 
       910        920        930        940        950
MLQTFISHRC DGNRNILHAC VSVCFPTSNK ETKEEEEAER SERNTFAERL 
       960        970        980        990       1000
SAVEAIANAI SVVSSNGPGN RAGSSNSRSL RLREMMRRSL RAAGLGRHEA 
      1010       1020       1030       1040       1050
GASSSDHQDP VSPPIAPPSW VPDPPSMDPD GDIDFILAPA VGSLTTAATG 
      1060       1070       1080       1090       1100
SGQGPSTSTI PGPSTEPSVV ESKDRKANAH FILKLLCDSA VLQPYLRELL 
      1110       1120       1130       1140       1150
SAKDARGMTP FMSAVSGRAY PAAITILETA QKIAKAEVSA SEKEEDVFMG 
      1160       1170       1180       1190       1200
MVCPSGTNPD DSPLYVLCCN DTCSFTWTGA EHINQDIFEC RTCGLLESLC 
      1210       1220       1230       1240       1250
CCTECARVCH KGHDCKLKRT SPTAYCDCWE KCKCKTLIAG QKSARLDLLY 
      1260       1270       1280       1290       1300
RLLTATNLVT LPNSRGEHLL LFLVQTVARQ TVEHCQYRPP RIREDRNRKT 
      1310       1320       1330       1340       1350
ASPEDSDMPD HDLEPPRFAQ LALERVLQDW NALRSMIMFG SQENKDPLSA 
      1360       1370       1380       1390       1400
SSRIGHLLPE EQVYLNQQSG TIRLDCFTHC LIVKCTADIL LLDTLLGTLV 
      1410       1420       1430       1440       1450
KELQNKYTPG RREEAIAVTM RFLRSVARVF VILSVEMASS KKKNNFIPQP 
      1460       1470       1480       1490       1500
IGKCKRVFQA LLPYAVEELC NVAESLIVPV RMGIARPTAP FTLASTSIDA 
      1510       1520       1530       1540       1550
MQGSEELFSV EPLPPRPSSD QASSSSQSQS SYIIRNPQQR RISQSQPVRG 
      1560       1570       1580       1590       1600
RDEEQDDIVS ADVEEVEVVE GVAGEEDHHD EQEEHGEENA EAEGHHDEHD 
      1610       1620       1630       1640       1650
EDGSDMELDL LAAAETESDS ESNHSNQDNA SGRRSVVTAA TAGSEAGASS 
      1660       1670       1680       1690       1700
VPAFFSEDDS QSNDSSDSDS SSSQSDDIEQ ETFMLDEPLE RTTNSSHANG 
      1710       1720       1730       1740       1750
AAQAPRSMQW AVRNPQHQRA ASTAPSSTST PAASSAGLIY IDPSNLRRSG 
      1760       1770       1780       1790       1800
TISTSAAAAA AALEASNASS YLTSASSLAR AYSIVIRQIS DLMGLIPKYN 
      1810       1820       1830       1840       1850
HLVYSQIPAA VKLTYQDAVN LQNYVEEKLI PTWNWMVSVM DSTEAQLRYG 
      1860       1870       1880       1890       1900
SALASAGDPG HPNHPLHASQ NSARRERMTA REEASLRTLE GRRRATLLSA 
      1910       1920       1930       1940       1950
RQGMMSARGD FLNYALSLMR SHNDEHSDVL PVLDVCSLKH VAYVFQALIY 
      1960       1970       1980       1990       2000
WIKAMNQQTT LDTPQLERKR TRELLELGID NEDSEHENDD DTSQSATLND 
      2010       2020       2030       2040       2050
KDDDSLPAET GQNHPFFRRS DSMTFLGCIP PNPFEVPLAE AIPLADQPHL 
      2060       2070       2080       2090       2100
LQPNARKEDL FGRPSQGLYS SSAGSGKCIV EVTMDRNCLE VLPTKMSYAA 
      2110       2120       2130       2140       2150
NLKNVMNMQN RQKKEGEEQS LLAEEADSSK PGPSAPDVAA QLKSSLLAEI 
      2160       2170       2180       2190       2200
GLTESEGPPL TSFRPQCSFM GMVISHDMLL GRWRLSLELF GRVFMEDVGA 
      2210       2220       2230       2240       2250
EPGSILTELG GFEVKESKFR REMEKLRNQQ SRDLSLEVDR DRDLLIQQTM 
      2260       2270       2280       2290       2300
RQLNNHFGRR CATTPMAVHR VKVTFKDEPG EGSGVARSFY TAIAQAFLSN 
      2310       2320       2330       2340       2350
EKLPNLDCIQ NANKGTHTSL MQRLRNRGER DREREREREM RRSSGLRAGS 
      2360       2370       2380       2390       2400
RRDRDRDFRR QLSIDTRPFR PASEGNPSDD PDPLPAHRQA LGERLYPRVQ 
      2410       2420       2430       2440       2450
AMQPAFASKI TGMLLELSPA QLLLLLASED SLRARVDEAM ELIIAHGREN 
      2460       2470       2480       2490       2500
GADSILDLGL LDSSEKVQEN RKRHGSSRSV VDMDLEDTDD GDDNAPLFYQ 
      2510       2520       2530       2540       2550
PGKRGFYTPR PGKNTEARLN CFRNIGRILG LCLLQNELCP ITLNRHVIKV 
      2560       2570       2580       2590       2600
LLGRKVNWHD FAFFDPVMYE SLRQLILASQ SSDADAVFSA MDLAFAIDLC 
      2610       2620       2630       2640       2650
KEEGGGQVEL IPNGVNIPVT PQNVYEYVRK YAEHRMLVVA EQPLHAMRKG 
      2660       2670       2680       2690       2700
LLDVLPKNSL EDLTAEDFRL LVNGCGEVNV QMLISFTSFN DESGENAEKL 
      2710       2720       2730       2740       2750
LQFKRWFWSI VEKMSMTERQ DLVYFWTSSP SLPASEEGFQ PMPSITIRPP 
      2760       2770       2780       2790 
DDQHLPTANT CISRLYVPLY SSKQILKQKL LLAIKTKNFG FV
Length:2,792
Mass (Da):308,319
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8EB1C31F45E620B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80TP3UBR5_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5 Edd, Edd1, Kiaa0896
2,792Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQS6A0A2I3BQS6_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
2,798Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPG8A0A2I3BPG8_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQC1A0A2I3BQC1_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC122035 Genomic DNA No translation available.
AC122291 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001106192.1, NM_001112721.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000110336; ENSMUSP00000105965; ENSMUSG00000037487

Database of genes from NCBI RefSeq genomes

More...GeneIDi		70790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:70790

UCSC genome browser

More...UCSCi		uc007vno.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122035 Genomic DNA No translation available.
AC122291 Genomic DNA No translation available.
RefSeqiNP_001106192.1, NM_001112721.2

3D structure databases

SMRiE9Q2H1
ModBaseiSearch...

Protein-protein interaction databases

IntActiE9Q2H1, 26 interactors

Proteomic databases

EPDiE9Q2H1
jPOSTiE9Q2H1
PeptideAtlasiE9Q2H1
PRIDEiE9Q2H1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13236, 277 antibodies

Genome annotation databases

EnsembliENSMUST00000110336; ENSMUSP00000105965; ENSMUSG00000037487
GeneIDi70790
KEGGimmu:70790
UCSCiuc007vno.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51366
MGIiMGI:1918040, Ubr5

Phylogenomic databases

GeneTreeiENSGT00940000156357
HOGENOMiCLU_000257_0_0_1
OMAiEAKFRRD
OrthoDBi717at2759
TreeFamiTF314406

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		70790, 9 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ubr5, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000037487, Expressed in testis and 305 other tissues
ExpressionAtlasiE9Q2H1, baseline and differential
GenevisibleiE9Q2H1, MM

Family and domain databases

CDDicd14423, CUE_UBR5, 1 hit
InterProiView protein in InterPro
IPR024725, E3_UbLigase_EDD_UBA
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR036053, PABP-dom
IPR002004, PABP_HYD
IPR009091, RCC1/BLIP-II
IPR003126, Znf_UBR
PfamiView protein in Pfam
PF11547, E3_UbLigase_EDD, 1 hit
PF00632, HECT, 1 hit
PF00658, PABP, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00517, PolyA, 1 hit
SM00396, ZnF_UBR1, 1 hit
SUPFAMiSSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
SSF63570, SSF63570, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS51309, PABC, 1 hit
PS51157, ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q2H1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q2H1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 28, 2018
Last modified: December 2, 2020
This is version 87 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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