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Entry version 71 (31 Jul 2019)
Sequence version 2 (03 Oct 2012)
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Protein
Submitted name:

HECT domain E3 ubiquitin protein ligase 4

Gene

Hectd4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation EC:2.3.2.26

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4386Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HECT domain E3 ubiquitin protein ligase 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hectd4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3647820 Hectd4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9Q2E4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q2E4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q2E4

PeptideAtlas

More...
PeptideAtlasi
E9Q2E4

PRoteomics IDEntifications database

More...
PRIDEi
E9Q2E4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q2E4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q2E4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q2E4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042744 Expressed in 242 organ(s), highest expression level in Ammon's horn

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q2E4 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048345

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4060 – 4418HECTInterPro annotationAdd BLAST359

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1917 – 1948DisorderedSequence analysisAdd BLAST32
Regioni2039 – 2062DisorderedSequence analysisAdd BLAST24
Regioni2642 – 2668DisorderedSequence analysisAdd BLAST27
Regioni3279 – 3342DisorderedSequence analysisAdd BLAST64
Regioni3439 – 3460DisorderedSequence analysisAdd BLAST22
Regioni3750 – 3826DisorderedSequence analysisAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1374 – 1394Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1917 – 1932PolarSequence analysisAdd BLAST16
Compositional biasi1933 – 1948PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2039 – 2053PolarSequence analysisAdd BLAST15
Compositional biasi3279 – 3310PolarSequence analysisAdd BLAST32
Compositional biasi3328 – 3342PolarSequence analysisAdd BLAST15
Compositional biasi3439 – 3457PolyampholyteSequence analysisAdd BLAST19
Compositional biasi3750 – 3767PolyampholyteSequence analysisAdd BLAST18
Compositional biasi3796 – 3826PolyampholyteSequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1426 Eukaryota
COG5184 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00910000144226

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q2E4

KEGG Orthology (KO)

More...
KOi
K17849

Identification of Orthologs from Complete Genome Data

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OMAi
SLKSACY

Database of Orthologous Groups

More...
OrthoDBi
1868at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331621

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13735 SPRY_HECT_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR035781 SPRY_HECTD4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632 HECT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q2E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSAAAAAA AAAAAAAADS AQWLSVKEET IFLHDGLIRV TDLAELPSEI
60 70 80 90 100
LGAPEAADTD LEILTFETKN PTELAERLRS VCGNQSNAYA RLLEYRLNAL
110 120 130 140 150
RGLWNAQRQL ALEEQHEREG SGDEETLALL KRQGLLQQPE QAPFTSRVGL
160 170 180 190 200
LLVFPLIQSQ SRTDPSLCNI TAEVLLNCLR DCQPLSLTKE PADCLNGIET
210 220 230 240 250
LLCSWLEETS DTGRHIPHKQ KENAAAALVA LACARGSLKT FVHTVHLLQR
260 270 280 290 300
QTELGSLPVA DVLYRLLLLE GGPGSPSCLL GGKHIVSWGY EDMLPAPDSN
310 320 330 340 350
TGSSSENKDA DLGRCLTADG HYLYTTNSAG RGVSKLGSGL HGTLRGFVYC
360 370 380 390 400
RNEELEPGWV AYGNGHLLHR PVSFDNKPHS LFQVIDQNTL QVCQTVPMPA
410 420 430 440 450
SPLPVGSTMS TVHLSSDGTY FYWIWSPASL NEKTPKGHSV FMDIFELVVE
460 470 480 490 500
NGVFVANPLQ ERTILMRKEG ESAKSINEML LSRLSRYRAS PSATLAALTG
510 520 530 540 550
STISNTLKED QAANTSCGLP LKMLRKTPMY TCGTYLVMLV PPPGGSGSSA
560 570 580 590 600
TRSLFGGTSG LSSLKILASS LVYNISDGQF ASRADLIDAA GSSLGRGALV
610 620 630 640 650
PGLGACYDTM NNMLWTCSND YIDQWCNPGN QAFHYVCQRL GVSHIITEPK
660 670 680 690 700
EEAISTNEVI NQLLHHVGAM CIHQLNLLAT NPNLPITSVL GKQHPIEARH
710 720 730 740 750
LSSICDIMEK AMVNGDTCIV RCILVVFQVV FKFFFSPQTE RNRDIIRRSG
760 770 780 790 800
LLLWQLLMAP KDQICPEIQK EVCLAISSGL NILYPGETEI NNLLKLVLTE
810 820 830 840 850
GERNSGLSQL RDVILTNLAE QLQNNRFGSD EDDHYRLNDE LLHYILKIVV
860 870 880 890 900
RESCILITKC QTVSKDDFQK LLSTVPAASS CLRYLMAVQN HLLSNTVLIK
910 920 930 940 950
PDENEDSDSS LQGETLKELK TSILALATQI LTGCDEVLEM LQQVTTALIN
960 970 980 990 1000
SDIPDREQRL KGLEQVTKAT MLGHLLPVLL TSLMHPNLQT LTMADALMPQ
1010 1020 1030 1040 1050
LVQLVLYTSQ TALLLKTQCP AFAEMSCSPC GTSDQKCRLF PDERMLEEKE
1060 1070 1080 1090 1100
EPGFLTGLKI PAPWAAGKTV ETVHPVRDNY KFKETVHIPG ARCLYLRFDT
1110 1120 1130 1140 1150
RCSSQYDYDK LVIYAGPNTN SRKVAEYGGN TLGYGSRSVL GTGWPKDLVK
1160 1170 1180 1190 1200
VEGDTVTFSF EMRSGREHNT PDKAMWGFAC TVRAQESSED VSGGLPFLVD
1210 1220 1230 1240 1250
LALGLSVLAC SMLRILYNGP EITKEEEACQ DLLRSKLLQR CQWQVEANGV
1260 1270 1280 1290 1300
ISPALTPSPS PLPLTIEEDR EFTYPADVLV PPVGNYFDLP RIRLPPGIMI
1310 1320 1330 1340 1350
KLREISGRAR PQFRPSIKEV IQPDVMEEMV VSCVIKHLNL VDALQSLINF
1360 1370 1380 1390 1400
QYQEEHAEEY DLLCKIMGET FKKLNAMERQ LQSVAELEQK WQSEAEDAMQ
1410 1420 1430 1440 1450
GKLENNMPFF YDYHFNENKM KELELLCSMK EVSFDGNDLE NMVLSLREKF
1460 1470 1480 1490 1500
LQEVNSLAQK PSHPLAKTKT LVRSLMNRAE LLLHVTIAAQ AGLTRSISGT
1510 1520 1530 1540 1550
PAETPACKSA SETKVASHAV RQPVFLRSMS APSDLEMIGN EDLEFTRANQ
1560 1570 1580 1590 1600
RRRHVTSHRS SSFTLLQSLA IEDSRDKPTY SVLLGQLFAF IGTNPDQAVS
1610 1620 1630 1640 1650
SSSFLLAAQT RWRRGNTRKQ ALVHMRELLT AAVRVGGVTH LVGPVTMVLQ
1660 1670 1680 1690 1700
GGPRIEELTC GGMVEQVQEA FGETMTSVVS LCARYPIACA NSIGLLCTIP
1710 1720 1730 1740 1750
YTRSEEKCLV RSGLVQLMDR LCSLSSQTES SSSEKQTKKQ KVATMAWAAF
1760 1770 1780 1790 1800
QVLANRCVEW EKEEGGSTEA VHSGLARQVS SLLTNHLARA TECCGNQAAG
1810 1820 1830 1840 1850
NDALQDVLSL LNDLSRSHIG KAILSQPACV SKLLSLLLDQ RPSPKLVLII
1860 1870 1880 1890 1900
LQLCRAALPL MSVEDCGNVE LPPWSYSVPS LNSEQEDPSD PASKIASLLL
1910 1920 1930 1940 1950
AKLADYVVPG CQTVLSPTAS EPDTTLTKTS PKNSLKGDKD PGEESEAVDG
1960 1970 1980 1990 2000
KLSIFIHKRE DQSSHEVLQP LLSSSEGRPF RLGTGANMEK VVKMDRDMTK
2010 2020 2030 2040 2050
GGCCEVITEE ASAALRKATK WAQSGLIVSV GPPVESINPE TVSGLSTGDK
2060 2070 2080 2090 2100
KKTAQTSICR ERNSELARTD PVRPFISGHV ANSMAAEVIA LLHSLLMAPE
2110 2120 2130 2140 2150
SNAAQIWTTT AEKVLSRALM YIPQLGKYAE SILENGSSSG RKLAKLQRIA
2160 2170 2180 2190 2200
RQAVAALCAL GGFKETIKIG SEVQVLGRGI SGSIGVVASI NEQEGIATVR
2210 2220 2230 2240 2250
FPPVDCRRTS QAADTLTIPL SRLCVPRSEA LPLHKLSITE KVVQAVQSML
2260 2270 2280 2290 2300
LPQEGSLSIH TSLPATGDGS APVMAVVRLL AEIRTRACLV MAQLLEDSLF
2310 2320 2330 2340 2350
CEEFIQQCPA AVEVLNLVAQ ECSAGERLAV VEMQCERLRM LYRDCARPPP
2360 2370 2380 2390 2400
PPLQADRRQP KEITWSPSRV FPPVRACMFS SHLTSVTFLA DPSAGGGLPR
2410 2420 2430 2440 2450
GTFIYATSPL PVQAPSFYWE IEIVSYGDTD DDTGPIVSFG FATEAEKRDG
2460 2470 2480 2490 2500
AWTNPVGTCL FHNNGRAVHY NGSSLLQWKS VRLDVTLSPG DVAGIGWERT
2510 2520 2530 2540 2550
EGTPPPPGQP AKGRVYFTYC GQRLTPYLED VSGGMWPVVH IQKKNTKTRA
2560 2570 2580 2590 2600
NFGSRPFAYA EGQAHRNAAD LCTDLAEEIS ANFEALPFAM ASDSDNDAGT
2610 2620 2630 2640 2650
SIASDPGTHG PPCRIAAVAT AQQQYDSDTS CHYKVELSYE NFITSGPDPH
2660 2670 2680 2690 2700
PPPIADDESD DDDDDDIPQE DHYALLVKAW ETKVFPTIRR RFRNEAERKS
2710 2720 2730 2740 2750
GLDQIKGALQ LGMVDIARQT VEFLYEENGG IPRDLYLPTI EDIKDEANKF
2760 2770 2780 2790 2800
TIDKVRKGLT VVTRSPDSSN VASSTVGTAL PKFAIRGMLK TFSLHGVVLD
2810 2820 2830 2840 2850
VDSVNELVQV ETYLRSEGVL VRYWYPIDML ERPPAGYRRT ATNGLVTLDN
2860 2870 2880 2890 2900
TNLQIHRELL RCEAALARLY CRMALLNIFA PKLPHLFTRL FHIPAIRDIT
2910 2920 2930 2940 2950
LEHLQLLSNQ LLAPPLPDGT ISSSSILLAQ SLQHCIHSQS CSATDLFYQG
2960 2970 2980 2990 3000
SSQTLREWLS VAITRTLHQG EDSLLELTKQ ICAFLQTAPE QFPSEEFPVS
3010 3020 3030 3040 3050
ESKVSMDVNF PGAAFVVVSC KESQSGFRKD SSLYKAPWAR VLVYGLGHKV
3060 3070 3080 3090 3100
KRTGQLNLIE AACYPRDASP ANTGLAPPPT ADQYPSVVLS TDKVHIKLGV
3110 3120 3130 3140 3150
SPPPGAVLVL HSLPLEFPLA MAFAEQLLSW KSEDSDGKSE DEPDSIPASV
3160 3170 3180 3190 3200
LLHVVELLGN FLWTTDMAAC VKELVFHLLA ELLRTVHTLE QRKHPAGLSS
3210 3220 3230 3240 3250
SIALQLNPCL AMLMALQSEL HKLYDEETQS WVSSSACGGS GAAAVGDQGR
3260 3270 3280 3290 3300
FSTYFHALME GCLAVAEVTL PTNISVTASG VTSTTTPNLS DSSSSSSSSP
3310 3320 3330 3340 3350
GQTPQSPSLL SKRKKVKMKR EKASSSNKRQ SSRASDADST VLSIGGSKPE
3360 3370 3380 3390 3400
DMLWFHRALT LLIILRHLTK KDPQGLGVTS DAIADACQAL VGPTAHSRLL
3410 3420 3430 3440 3450
VISGIPTHLD EAVVRGAIRK ACNAHGGVFK DEIYIPLQDE DPKKPKDKAE
3460 3470 3480 3490 3500
GSDSKVESEK LLGFPSVDSL EGSTSSSLAP AMSISASAST SQASVCSSQC
3510 3520 3530 3540 3550
VSQTASDLSV DPLPSGLELP VPPVLLEPHV VSSQESLDIS LCSTGSLGSL
3560 3570 3580 3590 3600
GSLGEPLDNP ETASVSDVGS MYTVTSLDTQ PLATRPIKGF AVVEIRSRAK
3610 3620 3630 3640 3650
IEKIRASLFN NNDLIGLSSL DGEDELMEMS TEEILTVSVV NQSLFDTQGS
3660 3670 3680 3690 3700
PGLEDYFSDK SIKGEKLVPG AREVLTEIFK SCAHSEQTLS LTPAKPIRVS
3710 3720 3730 3740 3750
DIYLSKEQIN SQTPGNLLHL FFTNVRPPKK VLEDQLTQIL RKYGVPKPKL
3760 3770 3780 3790 3800
DKSKYSKAGK EQHPVKVVST KRPVTKPPAK DKAVLSSLSR TALSEKKPTV
3810 3820 3830 3840 3850
KPKSPEKSKP DEKDPEKSPT KKQEVPEEKY LTLEGFHKFV IDRAKQDIRS
3860 3870 3880 3890 3900
VWRAILSCGY DLHFERCACI DVRHAQKASR KWTLEMDVAL VQYINRLCRH
3910 3920 3930 3940 3950
LAITPARLHP HEVYLDPADA ADPRMACLSN VPIESLRLRF ALLQSLNTTL
3960 3970 3980 3990 4000
ETFFLPLVEL RQTPMYAHSI AALLKEAKGL IFYDTKVTVM NRVLNATVQR
4010 4020 4030 4040 4050
TADHAAPEIT LDPLEIVGGE IRASENSYFC QAARQLASVP SSQLCVKLAS
4060 4070 4080 4090 4100
GGDPTYAFNI RFTGEEVHGT SGSFRHFLWQ VCKELQSSSL SLLLLCPSSA
4110 4120 4130 4140 4150
VNKNKGKYIL TPSPITYGEE QLLHFLGQLL GIAIRADVPL PLDLLPSFWK
4160 4170 4180 4190 4200
TLVGEPLDPD QDLQEADILT YNYVKKFESI NDESELEALC AEIASQHLAT
4210 4220 4230 4240 4250
ESPEGPKPCC RFTYLTMTGE EVELCSRGRH IPVAWENKDI YAAAIRSLRL
4260 4270 4280 4290 4300
RELQNMECVT AVRAGLGSII PLQLLTTLSP LEMELRTCGL PYINLEFLKA
4310 4320 4330 4340 4350
HTMYQVGLME TDQHIELFWG ALEMFTQEEL CKFIKFACNQ ERIPFTCPCK
4360 4370 4380 4390 4400
DGGPDTAHVP PYPMKIAPPD GTAGPPDSRY IRVETCMFMI KLPQYSSLET
4410
MLEKLRCAIH YREDPLSG
Length:4,418
Mass (Da):484,128
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDB6D77DC5C6D46C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6GQX8Q6GQX8_MOUSE
AU042671 protein
Hectd4 AU042671, Gm15800
1,014Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XXX5F6XXX5_MOUSE
HECT domain E3 ubiquitin protein li...
Hectd4
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUS1A0A0J9YUS1_MOUSE
HECT domain E3 ubiquitin protein li...
Hectd4
678Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC110037 Genomic DNA No translation available.
AC126938 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_852086.3, NM_181421.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000042614; ENSMUSP00000048345; ENSMUSG00000042744

Database of genes from NCBI RefSeq genomes

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GeneIDi
269700

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:269700

UCSC genome browser

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UCSCi
uc008ziv.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110037 Genomic DNA No translation available.
AC126938 Genomic DNA No translation available.
RefSeqiNP_852086.3, NM_181421.4

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048345

PTM databases

iPTMnetiE9Q2E4
PhosphoSitePlusiE9Q2E4
SwissPalmiE9Q2E4

Proteomic databases

EPDiE9Q2E4
MaxQBiE9Q2E4
PaxDbiE9Q2E4
PeptideAtlasiE9Q2E4
PRIDEiE9Q2E4

Genome annotation databases

EnsembliENSMUST00000042614; ENSMUSP00000048345; ENSMUSG00000042744
GeneIDi269700
KEGGimmu:269700
UCSCiuc008ziv.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
283450
MGIiMGI:3647820 Hectd4

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00910000144226
InParanoidiE9Q2E4
KOiK17849
OMAiSLKSACY
OrthoDBi1868at2759
TreeFamiTF331621

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000042744 Expressed in 242 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiE9Q2E4 baseline and differential

Family and domain databases

CDDicd13735 SPRY_HECT_like, 1 hit
InterProiView protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR035781 SPRY_HECTD4
PfamiView protein in Pfam
PF00632 HECT, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q2E4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q2E4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 3, 2012
Last modified: July 31, 2019
This is version 71 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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