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Protein
Submitted name:

KN motif and ankyrin repeat domains 1

Gene

Kank1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
KN motif and ankyrin repeat domains 1Imported
Gene namesi
Name:Kank1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147707 Kank1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9Q238
PaxDbiE9Q238
PeptideAtlasiE9Q238
PRIDEiE9Q238

PTM databases

iPTMnetiE9Q238
PhosphoSitePlusiE9Q238

Expressioni

Gene expression databases

BgeeiENSMUSG00000032702 Expressed in 298 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiE9Q238 baseline and differential
GenevisibleiE9Q238 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9Q238, 1 interactor
STRINGi10090.ENSMUSP00000042177

Structurei

3D structure databases

ProteinModelPortaliE9Q238
SMRiE9Q238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1163 – 1328ANK_REP_REGIONInterPro annotationAdd BLAST166
Repeati1169 – 1191ANKPROSITE-ProRule annotationAdd BLAST23
Repeati1241 – 1273ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1274 – 1295ANKPROSITE-ProRule annotationAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili260 – 280Sequence analysisAdd BLAST21
Coiled coili291 – 311Sequence analysisAdd BLAST21
Coiled coili367 – 394Sequence analysisAdd BLAST28
Coiled coili453 – 487Sequence analysisAdd BLAST35
Coiled coili829 – 849Sequence analysisAdd BLAST21

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0514 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063448
InParanoidiE9Q238
OMAiFMGSGNH
OrthoDBiEOG091G0D3F
TreeFamiTF324499

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF12075 KN_motif, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q238-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYTTKVNGC AAEKADGVLN GDHNKEKKDP YFVETPYGFQ LDLDFVKYVD
60 70 80 90 100
DIQKGNTIKK LNIQKRRKPS VPCPEVRAIP GHQGVWTSTE SLSSSNSDDS
110 120 130 140 150
KQCPSFLLAR SHVTSTPIPR PPAPLETSPT FAVSENRQLL PPPSPQLPRH
160 170 180 190 200
NLHVTKTLME TRRRLEQERV TMQMAPGDFR RPRLASFGGM GSTSSLPSFV
210 220 230 240 250
GSANHSSAIH QLQNGYQGNG DYNSYVPAAP TTSSMGSSVR HSPLSSGIST
260 270 280 290 300
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ
310 320 330 340 350
LASQLKSQRA SSQNEACGVR KRSYSAGNAS QLELLARARR GGGELYIDYE
360 370 380 390 400
EEEMESVEQS TQRIQEFRQL TADMQALERK IQDSSCEVAS ELRENGQCPS
410 420 430 440 450
RECKSVAVGS DENMNDVVVY HRDLRPCKDT AVGTVTETRN VGISVTEAML
460 470 480 490 500
GVITEADKEI ELQQQTIEAL KEKIYRLEVQ LKETTHDREM TKLKQELQAA
510 520 530 540 550
GSRKKVDKAT MAQPLVFSKL VEALVPTRDQ MVGSHVDTRE SCVGTSVQTS
560 570 580 590 600
SVGTSCHPDC KNQVVGSELP MNWWVVKERV AMHDQCVGRS VETCDRSVGV
610 620 630 640 650
EVSVCETGSN TEASGSDLTL LKTNLNLKDV RSIGCGDCSV DVIVCFPKEC
660 670 680 690 700
TSRSMNTEAV GQEEAAVMAV PHTTDQHTST NLERVDQCTN TEAATLVESC
710 720 730 740 750
TNTLLSTMDK QTSTQTVEMR TVAIGEGRVR DINPSTKTRS VGVGTVLSGN
760 770 780 790 800
SEFDRPCAVK TKESGVGQIN IQDNYLVGLK MRTIACGPPQ LTVGLMGSRR
810 820 830 840 850
SVGVGNEPVG ELPEESPQPR VASGMVTGLD HYIERVQRLL AEQQTLLAEN
860 870 880 890 900
YSELAEAFGE PHSQIGSLNS QLISTLSSIN SVMKSASTEE LRNSDFQKAS
910 920 930 940 950
LGKTTGNHLE YTCKCGGLRS GGLLNVQPSQ PEVEAETAEG KHSRGHEQFP
960 970 980 990 1000
MQGSTLPPVN LTDDQIATGL YVCPNNENTL KSIMKKSDGN KDSNGAKKNL
1010 1020 1030 1040 1050
QFIGINGGYE TTSSDESSSD GSSSSESDDE CDTIGYPPEE EEEEEEKDHD
1060 1070 1080 1090 1100
TRGMAEGHHA VNIEGFKSAR VEDEVQVPEC EPEKEEIRER YELSEKMLSA
1110 1120 1130 1140 1150
CNLLKYNIKD PKALASKDMR ICLNTLQHDW FRVSSQKSAV PAMVGDYIAA
1160 1170 1180 1190 1200
FEAVSPDVLR YIINMADGNG NTALHYSVSH SNFQIVKLLL DADVCNVDHQ
1210 1220 1230 1240 1250
NKAGYTPIML AALAAVEAEK DMQVVEELFS CGDVNAKASQ AGQTALMLAV
1260 1270 1280 1290 1300
SHGRIDMVKG LLACGADVNI QDDEGSTALM CASEHGHVEI VKLLLAQPGC
1310 1320 1330 1340 1350
NGHLEDNDGS TALSIALEAG HKDIAVLLYA HLNFSKAQSP STPRLGRKTS
1360
PGPTHRGSFD
Length:1,360
Mass (Da):148,254
Last modified:April 5, 2011 - v1
Checksum:i8A2F580524D8A61D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q944E9Q944_MOUSE
KN motif and ankyrin repeat domains...
Kank1
1,147Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126944 Genomic DNA No translation available.
AC132319 Genomic DNA No translation available.
RefSeqiNP_852069.4, NM_181404.6
XP_006526648.1, XM_006526585.3
XP_011245415.1, XM_011247113.2
UniGeneiMm.260722

Genome annotation databases

EnsembliENSMUST00000049400; ENSMUSP00000042177; ENSMUSG00000032702
GeneIDi107351
UCSCiuc008hbf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126944 Genomic DNA No translation available.
AC132319 Genomic DNA No translation available.
RefSeqiNP_852069.4, NM_181404.6
XP_006526648.1, XM_006526585.3
XP_011245415.1, XM_011247113.2
UniGeneiMm.260722

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YAYX-ray1.55A1088-1338[»]
5YAZX-ray1.90A1088-1338[»]
ProteinModelPortaliE9Q238
SMRiE9Q238
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q238, 1 interactor
STRINGi10090.ENSMUSP00000042177

PTM databases

iPTMnetiE9Q238
PhosphoSitePlusiE9Q238

Proteomic databases

MaxQBiE9Q238
PaxDbiE9Q238
PeptideAtlasiE9Q238
PRIDEiE9Q238

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049400; ENSMUSP00000042177; ENSMUSG00000032702
GeneIDi107351
UCSCiuc008hbf.1 mouse

Organism-specific databases

CTDi23189
MGIiMGI:2147707 Kank1

Phylogenomic databases

eggNOGiKOG0514 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063448
InParanoidiE9Q238
OMAiFMGSGNH
OrthoDBiEOG091G0D3F
TreeFamiTF324499

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032702 Expressed in 298 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiE9Q238 baseline and differential
GenevisibleiE9Q238 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF12075 KN_motif, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q238_MOUSE
AccessioniPrimary (citable) accession number: E9Q238
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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