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Protein
Submitted name:

KN motif and ankyrin repeat domains 1

Gene

Kank1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
KN motif and ankyrin repeat domains 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kank1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147707 Kank1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q238

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q238

PeptideAtlas

More...
PeptideAtlasi
E9Q238

PRoteomics IDEntifications database

More...
PRIDEi
E9Q238

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q238

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q238

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032702 Expressed in 298 organ(s), highest expression level in humerus cartilage element

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q238 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q238 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
E9Q238, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042177

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9Q238

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q238

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1163 – 1328ANK_REP_REGIONInterPro annotationAdd BLAST166
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1169 – 1191ANKPROSITE-ProRule annotationAdd BLAST23
Repeati1241 – 1273ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1274 – 1295ANKPROSITE-ProRule annotationAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili260 – 280Sequence analysisAdd BLAST21
Coiled coili291 – 311Sequence analysisAdd BLAST21
Coiled coili367 – 394Sequence analysisAdd BLAST28
Coiled coili453 – 487Sequence analysisAdd BLAST35
Coiled coili829 – 849Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0514 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154886

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q238

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMGSGNH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0D3F

TreeFam database of animal gene trees

More...
TreeFami
TF324499

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF12075 KN_motif, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q238-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYTTKVNGC AAEKADGVLN GDHNKEKKDP YFVETPYGFQ LDLDFVKYVD
60 70 80 90 100
DIQKGNTIKK LNIQKRRKPS VPCPEVRAIP GHQGVWTSTE SLSSSNSDDS
110 120 130 140 150
KQCPSFLLAR SHVTSTPIPR PPAPLETSPT FAVSENRQLL PPPSPQLPRH
160 170 180 190 200
NLHVTKTLME TRRRLEQERV TMQMAPGDFR RPRLASFGGM GSTSSLPSFV
210 220 230 240 250
GSANHSSAIH QLQNGYQGNG DYNSYVPAAP TTSSMGSSVR HSPLSSGIST
260 270 280 290 300
PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ
310 320 330 340 350
LASQLKSQRA SSQNEACGVR KRSYSAGNAS QLELLARARR GGGELYIDYE
360 370 380 390 400
EEEMESVEQS TQRIQEFRQL TADMQALERK IQDSSCEVAS ELRENGQCPS
410 420 430 440 450
RECKSVAVGS DENMNDVVVY HRDLRPCKDT AVGTVTETRN VGISVTEAML
460 470 480 490 500
GVITEADKEI ELQQQTIEAL KEKIYRLEVQ LKETTHDREM TKLKQELQAA
510 520 530 540 550
GSRKKVDKAT MAQPLVFSKL VEALVPTRDQ MVGSHVDTRE SCVGTSVQTS
560 570 580 590 600
SVGTSCHPDC KNQVVGSELP MNWWVVKERV AMHDQCVGRS VETCDRSVGV
610 620 630 640 650
EVSVCETGSN TEASGSDLTL LKTNLNLKDV RSIGCGDCSV DVIVCFPKEC
660 670 680 690 700
TSRSMNTEAV GQEEAAVMAV PHTTDQHTST NLERVDQCTN TEAATLVESC
710 720 730 740 750
TNTLLSTMDK QTSTQTVEMR TVAIGEGRVR DINPSTKTRS VGVGTVLSGN
760 770 780 790 800
SEFDRPCAVK TKESGVGQIN IQDNYLVGLK MRTIACGPPQ LTVGLMGSRR
810 820 830 840 850
SVGVGNEPVG ELPEESPQPR VASGMVTGLD HYIERVQRLL AEQQTLLAEN
860 870 880 890 900
YSELAEAFGE PHSQIGSLNS QLISTLSSIN SVMKSASTEE LRNSDFQKAS
910 920 930 940 950
LGKTTGNHLE YTCKCGGLRS GGLLNVQPSQ PEVEAETAEG KHSRGHEQFP
960 970 980 990 1000
MQGSTLPPVN LTDDQIATGL YVCPNNENTL KSIMKKSDGN KDSNGAKKNL
1010 1020 1030 1040 1050
QFIGINGGYE TTSSDESSSD GSSSSESDDE CDTIGYPPEE EEEEEEKDHD
1060 1070 1080 1090 1100
TRGMAEGHHA VNIEGFKSAR VEDEVQVPEC EPEKEEIRER YELSEKMLSA
1110 1120 1130 1140 1150
CNLLKYNIKD PKALASKDMR ICLNTLQHDW FRVSSQKSAV PAMVGDYIAA
1160 1170 1180 1190 1200
FEAVSPDVLR YIINMADGNG NTALHYSVSH SNFQIVKLLL DADVCNVDHQ
1210 1220 1230 1240 1250
NKAGYTPIML AALAAVEAEK DMQVVEELFS CGDVNAKASQ AGQTALMLAV
1260 1270 1280 1290 1300
SHGRIDMVKG LLACGADVNI QDDEGSTALM CASEHGHVEI VKLLLAQPGC
1310 1320 1330 1340 1350
NGHLEDNDGS TALSIALEAG HKDIAVLLYA HLNFSKAQSP STPRLGRKTS
1360
PGPTHRGSFD
Length:1,360
Mass (Da):148,254
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A2F580524D8A61D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q944E9Q944_MOUSE
KN motif and ankyrin repeat domains...
Kank1
1,147Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC126944 Genomic DNA No translation available.
AC132319 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_852069.4, NM_181404.6
XP_006526648.1, XM_006526585.3
XP_011245415.1, XM_011247113.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.260722

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049400; ENSMUSP00000042177; ENSMUSG00000032702

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107351

UCSC genome browser

More...
UCSCi
uc008hbf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126944 Genomic DNA No translation available.
AC132319 Genomic DNA No translation available.
RefSeqiNP_852069.4, NM_181404.6
XP_006526648.1, XM_006526585.3
XP_011245415.1, XM_011247113.2
UniGeneiMm.260722

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YAYX-ray1.55A1088-1338[»]
5YAZX-ray1.90A1088-1338[»]
ProteinModelPortaliE9Q238
SMRiE9Q238
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q238, 1 interactor
STRINGi10090.ENSMUSP00000042177

PTM databases

iPTMnetiE9Q238
PhosphoSitePlusiE9Q238

Proteomic databases

MaxQBiE9Q238
PaxDbiE9Q238
PeptideAtlasiE9Q238
PRIDEiE9Q238

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049400; ENSMUSP00000042177; ENSMUSG00000032702
GeneIDi107351
UCSCiuc008hbf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23189
MGIiMGI:2147707 Kank1

Phylogenomic databases

eggNOGiKOG0514 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000154886
InParanoidiE9Q238
OMAiFMGSGNH
OrthoDBiEOG091G0D3F
TreeFamiTF324499

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032702 Expressed in 298 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiE9Q238 baseline and differential
GenevisibleiE9Q238 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF12075 KN_motif, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q238_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q238
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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