UniProtKB - E9Q236 (E9Q236_MOUSE)
Protein
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Gene
Abcc4
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 445 – 452 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1075 – 1082 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
- drug transmembrane transporter activity Source: MGI
- prostaglandin transmembrane transporter activity Source: MGI
GO - Biological processi
- cilium assembly Source: MGI
- drug transmembrane transport Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- prostaglandin secretion Source: MGI
- response to organic cyclic compound Source: Ensembl
- response to organonitrogen compound Source: Ensembl
- transmembrane transport Source: GO_Central
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-114608 Platelet degranulation R-MMU-382556 ABC-family proteins mediated transport |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4Imported |
Gene namesi | Name:Abcc4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443111 Abcc4 |
Subcellular locationi
Plasma Membrane
- basolateral plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
- platelet dense granule membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 134 – 157 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 208 – 227 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 233 – 254 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 321 – 342 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 348 – 369 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 704 – 728 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 767 – 791 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 835 – 857 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 863 – 882 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 948 – 970 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
jPOSTi | E9Q236 |
MaxQBi | E9Q236 |
PaxDbi | E9Q236 |
PRIDEi | E9Q236 |
PTM databases
SwissPalmi | E9Q236 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032849 Expressed in 244 organ(s), highest expression level in brain blood vessel |
ExpressionAtlasi | E9Q236 baseline and differential |
Genevisiblei | E9Q236 MM |
Structurei
3D structure databases
ProteinModelPortali | E9Q236 |
SMRi | E9Q236 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 93 – 377 | ABC transmembrane type-1InterPro annotationAdd BLAST | 285 | |
Domaini | 410 – 633 | ABC transporterInterPro annotationAdd BLAST | 224 | |
Domaini | 715 – 1005 | ABC transmembrane type-1InterPro annotationAdd BLAST | 291 | |
Domaini | 1041 – 1274 | ABC transporterInterPro annotationAdd BLAST | 234 |
Keywords - Domaini
RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG0054 Eukaryota COG1132 LUCA |
GeneTreei | ENSGT00940000153931 |
InParanoidi | E9Q236 |
KOi | K05673 |
OrthoDBi | 138195at2759 |
PhylomeDBi | E9Q236 |
TreeFami | TF105202 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR030240 ABCC4 IPR027417 P-loop_NTPase |
PANTHERi | PTHR24223:SF237 PTHR24223:SF237, 1 hit |
Pfami | View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382 AAA, 2 hits |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
E9Q236-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPVHTEVKP NPLQDANLCS RVFFWWLNPL FKTGHKRRLE EDDMFSVLPE
60 70 80 90 100
DRSKHLGEEL QRYWDKELLR AKKDSRKPSL TKAIIKCYWK SYLILGIFTL
110 120 130 140 150
IEEGTRVVQP LFLGKIIEYF EKYDPDDSVA LHTAYGYAAV LSMCTLILAI
160 170 180 190 200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNSAMGKTT TGQIVNLLSN
210 220 230 240 250
DVNKFDQVTI FLHFLWAGPL QAIAVTVLLW VEIGISCLAG LAVLVILLPL
260 270 280 290 300
QSCIGKLFSS LRSKTAAFTD ARIRTMNEVI TGMRIIKMYA WEKSFADLIA
310 320 330 340 350
NLRKKEISKI LGSSYLRGMN MASFFIANKV ILFVTFTSYV LLGNEITASH
360 370 380 390 400
VFVAMTLYGA VRLTVTLFFP SAIERGSEAI VSIRRIKNFL LLDELPQRKA
410 420 430 440 450
HVPSDGKAIV HVQDFTAFWD KALDSPTLQG LSFIARPGEL LAVVGPVGAG
460 470 480 490 500
KSSLLSAVLG ELPPASGLVS VHGRIAYVSQ QPWVFSGTVR SNILFGKKYE
510 520 530 540 550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGATLSGGQK ARVNLARAVY
560 570 580 590 600
QDADIYLLDD PLSAVDAEVG KHLFQLCICQ ALHEKITILV THQLQYLKAA
610 620 630 640 650
SHILILKDGE MVQKGTYTEF LKSGVDFGSL LKKENEEAEP STAPGTPTLR
660 670 680 690 700
KRTFSEASIW SQQSSRPSLK DGAPEGQDAE NTQAVQPEES RSEGRIGFKA
710 720 730 740 750
YKNYFSAGAS WFFIIFLVLL NMVGQVFYVL QDWWLSHWAN KQGALNNTRN
760 770 780 790 800
ANGNITETLD LSWYLGIYAG LTAVTVLFGI ARSLLVFYIL VNASQTLHNR
810 820 830 840 850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HMDDLLPLTF LDFIQTLLLV
860 870 880 890 900
VSVIAVAAAV IPWILIPLVP LSVVFLVLRR YFLETSRDVK RLESTTRSPV
910 920 930 940 950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV
960 970 980 990 1000
RLDAICAIFV IVVAFGSLVL AKTLNAGQVG LALSYALTLM GMFQWSVRQS
1010 1020 1030 1040 1050
AEVENMMISV ERVIEYTDLE KEAPWECKKR PPPGWPHEGV IVFDNVNFTY
1060 1070 1080 1090 1100
SLDGPLVLKH LTALIKSREK VGIVGRTGAG KSSLISALFR LSEPEGKIWI
1110 1120 1130 1140 1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWRAL
1160 1170 1180 1190 1200
EEVQLKEAIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILKNNRILII
1210 1220 1230 1240 1250
DEATANVDPR TDELIQQKIR EKFAQCTVLT IAHRLNTIID SDKIMVLDSG
1260 1270 1280 1290 1300
RLKEYDEPYV LLQNPESLFY KMVQQLGKGE AAALTETAKQ VYFRRNYPDI
1310 1320
TFTSPAVMNT SNGQPSALTI FETAL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q467 | E9Q467_MOUSE | ATP-binding cassette, sub-family C ... | Abcc4 | 1,250 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC154419 Genomic DNA No translation available. AC167668 Genomic DNA No translation available. CT025694 Genomic DNA No translation available. |
RefSeqi | NP_001028508.2, NM_001033336.3 |
UniGenei | Mm.40537 |
Genome annotation databases
Ensembli | ENSMUST00000036554; ENSMUSP00000042186; ENSMUSG00000032849 |
GeneIDi | 239273 |
KEGGi | mmu:239273 |
UCSCi | uc007uyv.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC154419 Genomic DNA No translation available. AC167668 Genomic DNA No translation available. CT025694 Genomic DNA No translation available. |
RefSeqi | NP_001028508.2, NM_001033336.3 |
UniGenei | Mm.40537 |
3D structure databases
ProteinModelPortali | E9Q236 |
SMRi | E9Q236 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000042186 |
PTM databases
SwissPalmi | E9Q236 |
Proteomic databases
jPOSTi | E9Q236 |
MaxQBi | E9Q236 |
PaxDbi | E9Q236 |
PRIDEi | E9Q236 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000036554; ENSMUSP00000042186; ENSMUSG00000032849 |
GeneIDi | 239273 |
KEGGi | mmu:239273 |
UCSCi | uc007uyv.2 mouse |
Organism-specific databases
CTDi | 10257 |
MGIi | MGI:2443111 Abcc4 |
Phylogenomic databases
eggNOGi | KOG0054 Eukaryota COG1132 LUCA |
GeneTreei | ENSGT00940000153931 |
InParanoidi | E9Q236 |
KOi | K05673 |
OrthoDBi | 138195at2759 |
PhylomeDBi | E9Q236 |
TreeFami | TF105202 |
Enzyme and pathway databases
Reactomei | R-MMU-114608 Platelet degranulation R-MMU-382556 ABC-family proteins mediated transport |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032849 Expressed in 244 organ(s), highest expression level in brain blood vessel |
ExpressionAtlasi | E9Q236 baseline and differential |
Genevisiblei | E9Q236 MM |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR030240 ABCC4 IPR027417 P-loop_NTPase |
PANTHERi | PTHR24223:SF237 PTHR24223:SF237, 1 hit |
Pfami | View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382 AAA, 2 hits |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | E9Q236_MOUSE | |
Accessioni | E9Q236Primary (citable) accession number: E9Q236 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 16, 2019 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |