ATP-binding cassette, sub-family C (CFTR/MRP), member 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity, coupled to transmembrane movement of substances Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• ATP binding Source: UniProtKB-UniRule
• drug transmembrane transporter activity Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 12499391
• prostaglandin transmembrane transporter activity Source: MGIInferred from sequence orthologyⁱ
  • 25173977

GO - Biological processⁱ

• cilium assembly Source: MGIInferred from sequence orthologyⁱ
  • 25173977
• drug transmembrane transport Source: MGITraceable author statementⁱ
  • 12499391
• positive regulation of smooth muscle cell proliferation Source: MGI
• prostaglandin secretion Source: MGIInferred from sequence orthologyⁱ
  • 25173977
• response to organic cyclic compound Source: Ensembl
• response to organonitrogen compound Source: Ensembl
• transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MLPVHTEVKP NPLQDANLCS RVFFWWLNPL FKTGHKRRLE EDDMFSVLPE 
        60         70         80         90        100
DRSKHLGEEL QRYWDKELLR AKKDSRKPSL TKAIIKCYWK SYLILGIFTL 
       110        120        130        140        150
IEEGTRVVQP LFLGKIIEYF EKYDPDDSVA LHTAYGYAAV LSMCTLILAI 
       160        170        180        190        200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNSAMGKTT TGQIVNLLSN 
       210        220        230        240        250
DVNKFDQVTI FLHFLWAGPL QAIAVTVLLW VEIGISCLAG LAVLVILLPL 
       260        270        280        290        300
QSCIGKLFSS LRSKTAAFTD ARIRTMNEVI TGMRIIKMYA WEKSFADLIA 
       310        320        330        340        350
NLRKKEISKI LGSSYLRGMN MASFFIANKV ILFVTFTSYV LLGNEITASH 
       360        370        380        390        400
VFVAMTLYGA VRLTVTLFFP SAIERGSEAI VSIRRIKNFL LLDELPQRKA 
       410        420        430        440        450
HVPSDGKAIV HVQDFTAFWD KALDSPTLQG LSFIARPGEL LAVVGPVGAG 
       460        470        480        490        500
KSSLLSAVLG ELPPASGLVS VHGRIAYVSQ QPWVFSGTVR SNILFGKKYE 
       510        520        530        540        550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGATLSGGQK ARVNLARAVY 
       560        570        580        590        600
QDADIYLLDD PLSAVDAEVG KHLFQLCICQ ALHEKITILV THQLQYLKAA 
       610        620        630        640        650
SHILILKDGE MVQKGTYTEF LKSGVDFGSL LKKENEEAEP STAPGTPTLR 
       660        670        680        690        700
KRTFSEASIW SQQSSRPSLK DGAPEGQDAE NTQAVQPEES RSEGRIGFKA 
       710        720        730        740        750
YKNYFSAGAS WFFIIFLVLL NMVGQVFYVL QDWWLSHWAN KQGALNNTRN 
       760        770        780        790        800
ANGNITETLD LSWYLGIYAG LTAVTVLFGI ARSLLVFYIL VNASQTLHNR 
       810        820        830        840        850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HMDDLLPLTF LDFIQTLLLV 
       860        870        880        890        900
VSVIAVAAAV IPWILIPLVP LSVVFLVLRR YFLETSRDVK RLESTTRSPV 
       910        920        930        940        950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV 
       960        970        980        990       1000
RLDAICAIFV IVVAFGSLVL AKTLNAGQVG LALSYALTLM GMFQWSVRQS 
      1010       1020       1030       1040       1050
AEVENMMISV ERVIEYTDLE KEAPWECKKR PPPGWPHEGV IVFDNVNFTY 
      1060       1070       1080       1090       1100
SLDGPLVLKH LTALIKSREK VGIVGRTGAG KSSLISALFR LSEPEGKIWI 
      1110       1120       1130       1140       1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWRAL 
      1160       1170       1180       1190       1200
EEVQLKEAIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILKNNRILII 
      1210       1220       1230       1240       1250
DEATANVDPR TDELIQQKIR EKFAQCTVLT IAHRLNTIID SDKIMVLDSG 
      1260       1270       1280       1290       1300
RLKEYDEPYV LLQNPESLFY KMVQQLGKGE AAALTETAKQ VYFRRNYPDI 
      1310       1320 
TFTSPAVMNT SNGQPSALTI FETAL                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ