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Entry version 78 (12 Aug 2020)
Sequence version 2 (03 Oct 2012)
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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 1B

Gene

Lrp1b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 1BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrp1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2151136, Lrp1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 55PROSITE-ProRule annotation
Disulfide bondi731 ↔ 743PROSITE-ProRule annotation
Disulfide bondi738 ↔ 756PROSITE-ProRule annotation
Disulfide bondi772 ↔ 784PROSITE-ProRule annotation
Disulfide bondi779 ↔ 797PROSITE-ProRule annotation
Disulfide bondi813 ↔ 825PROSITE-ProRule annotation
Disulfide bondi820 ↔ 838PROSITE-ProRule annotation
Disulfide bondi861 ↔ 879PROSITE-ProRule annotation
Disulfide bondi873 ↔ 888PROSITE-ProRule annotation
Disulfide bondi892 ↔ 904PROSITE-ProRule annotation
Disulfide bondi899 ↔ 917PROSITE-ProRule annotation
Disulfide bondi959 ↔ 974PROSITE-ProRule annotation
Disulfide bondi1002 ↔ 1017PROSITE-ProRule annotation
Disulfide bondi2404 ↔ 2422PROSITE-ProRule annotation
Disulfide bondi2438 ↔ 2450PROSITE-ProRule annotation
Disulfide bondi2445 ↔ 2463PROSITE-ProRule annotation
Disulfide bondi2457 ↔ 2472PROSITE-ProRule annotation
Disulfide bondi2477 ↔ 2489PROSITE-ProRule annotation
Disulfide bondi2484 ↔ 2502PROSITE-ProRule annotation
Disulfide bondi2496 ↔ 2511PROSITE-ProRule annotation
Disulfide bondi2545 ↔ 2560PROSITE-ProRule annotation
Disulfide bondi2568 ↔ 2580PROSITE-ProRule annotation
Disulfide bondi2575 ↔ 2593PROSITE-ProRule annotation
Disulfide bondi2587 ↔ 2602PROSITE-ProRule annotation
Disulfide bondi2606 ↔ 2618PROSITE-ProRule annotation
Disulfide bondi2613 ↔ 2631PROSITE-ProRule annotation
Disulfide bondi2691 ↔ 2703PROSITE-ProRule annotation
Disulfide bondi2698 ↔ 2716PROSITE-ProRule annotation
Disulfide bondi2731 ↔ 2743PROSITE-ProRule annotation
Disulfide bondi2777 ↔ 2789PROSITE-ProRule annotation
Disulfide bondi2784 ↔ 2802PROSITE-ProRule annotation
Disulfide bondi2796 ↔ 2811PROSITE-ProRule annotation
Disulfide bondi2858 ↔ 2868PROSITE-ProRule annotation
Disulfide bondi3203 ↔ 3215PROSITE-ProRule annotation
Disulfide bondi3210 ↔ 3228PROSITE-ProRule annotation
Disulfide bondi3243 ↔ 3255PROSITE-ProRule annotation
Disulfide bondi3250 ↔ 3268PROSITE-ProRule annotation
Disulfide bondi3262 ↔ 3277PROSITE-ProRule annotation
Disulfide bondi3302 ↔ 3317PROSITE-ProRule annotation
Disulfide bondi3342 ↔ 3357PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E9Q202

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049252, Expressed in secondary oocyte and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q202, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q202, MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 80EGF-likeInterPro annotationAdd BLAST40
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati181 – 223LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati224 – 267LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati268 – 311LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati454 – 496LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati497 – 542LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati543 – 592LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati593 – 636LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1186 – 1232LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati1233 – 1275LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1276 – 1322LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati1323 – 1367LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1368 – 1408LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati1504 – 1546LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1547 – 1590LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1591 – 1630LDL-receptor class BPROSITE-ProRule annotationAdd BLAST40
Repeati1631 – 1673LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1674 – 1716LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1808 – 1850LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1851 – 1893LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1894 – 1937LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1938 – 1981LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2125 – 2166LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati2167 – 2215LDL-receptor class BPROSITE-ProRule annotationAdd BLAST49
Repeati2216 – 2260LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati2261 – 2303LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati2304 – 2345LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini2854 – 2886EGF-likeInterPro annotationAdd BLAST33
Repeati2941 – 2984LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2985 – 3027LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3028 – 3071LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati3072 – 3112LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati3113 – 3153LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000085_2_1_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 20 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 7 hits
4.10.400.10, 22 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 21 hits
PF00058, Ldl_recept_b, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 13 hits
SM00179, EGF_CA, 3 hits
SM00192, LDLa, 22 hits
SM00135, LY, 33 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 22 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 2 hits
PS01209, LDLRA_1, 11 hits
PS50068, LDLRA_2, 22 hits
PS51120, LDLRB, 31 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E9Q202-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ELLPSCQQLN CQFKCAMVRN ATRCYCEDGF EVAEDGRSCK DQDECSIYGI
60 70 80 90 100
CSQTCKNTYG SYACSCVEGY IMQSDNRSCK VKHEPTDKAP MLLISSLETI
110 120 130 140 150
ELFYINGSKM TTLSSANRNE IHTLDFIYSE EMICWIESRE SSNQLKCGQI
160 170 180 190 200
TKAGRLTDQR IINSLQSFQN VEQMAFDWLT RNIYFVDHVS DRIFVCNFNG
210 220 230 240 250
SVCVTLIESE LHNPKAIAAD PIAGKLFFTD YGNVPKIERC DLDGMNRTRI
260 270 280 290 300
VYSKAEQPSA LALDLVNRLV YWVDLYLDYV GVVDYQGKNR HTIVQGRQVK
310 320 330 340 350
HLYGITVFED YLYATSSDNF NIIRINRFNG TDIHSIIKME SARGIRTYQK
360 370 380 390 400
RTQPTVRSHA CEVDAYGMPG GCSHICLLSS SYKTRTCRCR TGFNMGSDGR
410 420 430 440 450
SCKRPKNELF LFYGKGRPGI VRGMDLNTKI ADECMIPIEN LVNPRALDFH
460 470 480 490 500
AEANYIYFAD TTSFLIGRQK IDGTERETIL KDDLDNVEGI AVDWIGNNLY
510 520 530 540 550
WTNDGHRKTI NVARLEKASQ SRKTLLEGGM SHPRAIVVDP VNGWMYWTDW
560 570 580 590 600
KEDKIDDSVG RIEKAWMDGV NRQVFVTSKM LWPNGLTLDF HTSTLYWCDA
610 620 630 640 650
YYDHIEKVFL NGTHRKVVYS GKELNHPFGL SHHGNYVFWT DYMNGSIFQL
660 670 680 690 700
DLMTNEVTLL RHERAPLFGL QIYDPRKQQG DNMCRINNGG CGTLCLAIPA
710 720 730 740 750
GRVCACADNQ LLDENGTTCT FNPEEIRFHI CKPGEFRCKN KHCIQARWKC
760 770 780 790 800
DGDDDCLDGS DEDSVTCFNH SCPDDQFKCQ NNRCIPKRWL CDGANDCGSN
810 820 830 840 850
EDESNQTCTA RTCQADQFSC GNGRCIPTAW LCDREDDCGD QTDEVASCEF
860 870 880 890 900
PTCEPLTQFI CKSGRCISNK WHCDTDDDCG DRSDEVGCVH SCLDDQFRCS
910 920 930 940 950
SGRCIPGHWA CDGDNDCGDF SDETHINCTK EEARSPAGCI GNEFQCRPDG
960 970 980 990 1000
NCIPDLWRCD GEKDCEDGSD EKGCNGTIRL CDHKTKFSCR STGRCINNAW
1010 1020 1030 1040 1050
VCDGDVDCED QSDEEDCDSF LCGPPKYPCA NDTSVCLQPE KLCNGRKDCP
1060 1070 1080 1090 1100
DGSDEGDLCD ECSLNNGGCS NHCSVVPGRG IVCSCPEGHQ LKKDNRTCEI
1110 1120 1130 1140 1150
VDYCASHLRC SQVCEQQKHM VKCSCYEGWA LGTDGESCTS VDSFEAFIIF
1160 1170 1180 1190 1200
SIRHEIRRID LHKGDYSLLV PGLRNTIALD FHFNQSLLYW TDVVEDRIYR
1210 1220 1230 1240 1250
GKLSESGGVS AIEVVVEHGL ATPEGLTVDW IAGNIYWIDS NLDQIEVSKL
1260 1270 1280 1290 1300
DGSLRATLIA GAMEHPRAIA LDPRYGILFW TDWDANFPRI ESASMSGAGR
1310 1320 1330 1340 1350
KTIYKDMKTG AWPNGLTVDH FERRIVWTDA RSDAIYSAFY DGTNMIEIIR
1360 1370 1380 1390 1400
GHEYLSHPFA VSLYGSEVYW TDWRTNTLAK ANKWTGQNVS VIQKTSAQPF
1410 1420 1430 1440 1450
DLQIYHPSRQ PQAPNPCAAN EGRGPCSHLC LINHNRSAAC ACPHLMKLSS
1460 1470 1480 1490 1500
DKKTCYEMKK FLLYARRSEI RGVDIDNPYV NFITAFTVPD IDDVAVIDFD
1510 1520 1530 1540 1550
ASEERLYWTD IKTQTITRAF INGTGLETVI SRDIQSIRGL AVDWVSRNLY
1560 1570 1580 1590 1600
WISSEFDETQ INVARLDGSL KTSIIHGIDK PQCLAAHPVR GKLYWTDGNT
1610 1620 1630 1640 1650
INMANMDGSN SKILFQNQKE PVGLSIDYVE NKLYWISSGN GTINRCNLDG
1660 1670 1680 1690 1700
GNLEVIESMK EELTKATALT IMDKKLWWAD QNLAQLGTCN KRDGRNPSIL
1710 1720 1730 1740 1750
RNKTSGVVHM KVYDKEAQQG SNSCQVNNGG CSQLCLPTSE TTRTCMCTVG
1760 1770 1780 1790 1800
YYLQKNRMSC QGIESFLMYS VHEGIRGIPL EPRDKVDALM PISGAAFAVG
1810 1820 1830 1840 1850
IDFHAENDTI YWTDMGLNKI SRAKRDQTWK EDVVTNGLGR VEGIAVDWIA
1860 1870 1880 1890 1900
GNIYWTDHGF NLIEVARLNG SFRYVIISQG LDQPRSIAVH PEKGFLFWTE
1910 1920 1930 1940 1950
WGQVPCIGKA RLDGSEKVMI VSVGITWPNG ISIDYEENKL YWCDARSDKI
1960 1970 1980 1990 2000
ERIDLDTGAN REVLLSGSNV DLFSVAVFGA YIYWSDRAHA NGSVRRGHKN
2010 2020 2030 2040 2050
DATETVTMRT GLGVNLKEIK IFNRVREKGT NVCAKENGGC QQLCLYRGNS
2060 2070 2080 2090 2100
RRTCACAHGY LAGDGVTCLR HEGYLLYSGR TILKSIHLSD ETNLNSPVRP
2110 2120 2130 2140 2150
YENPNYFKNI IALAFDYNQR REGTNRIFYS DAHFGNIQLI KDNWEDRQVI
2160 2170 2180 2190 2200
VENVGSVEGL AYHRAWDTLY WTSSSTSSIT RHTVDQTRPG AIDREAVITM
2210 2220 2230 2240 2250
SEDDHPHVLA LDECQNLMFW TNWNEQHPSI MRATLTGKNA HVVVSTDILT
2260 2270 2280 2290 2300
PNGLTIDHRA EKLYFSDGSL GKIERCEYDG SQRHVIVKSG PGTFLSLAVY
2310 2320 2330 2340 2350
DSYIFWSDWG RRAILRSNKY TGGETKILRS DIPHQPMGII AVANDTNSCE
2360 2370 2380 2390 2400
LSPCALLNGG CHDLCLLTPD GRVNCSCRGD RVLLANNRCV TKNSSCNIYS
2410 2420 2430 2440 2450
EFECGNGDCV DYVLTCDGIP HCKDKSDEKL LYCENRSCRS GFKPCYNRRC
2460 2470 2480 2490 2500
VPHGKLCDGT NDCGDSSDEL DCKVSTCSTV EFRCADGTCI PRSARCNQNM
2510 2520 2530 2540 2550
DCSDASDEKG CNNTDCTHFY KLGVKSTGFI RCNSTSLCVL PSWICDGSND
2560 2570 2580 2590 2600
CGDYSDELKC PVQNKHKCEE NYFGCPSGRC ILNTWVCDGQ KDCEDGLDEL
2610 2620 2630 2640 2650
HCDSSCSWNQ FACSVKKCIS KHWICDGEDD CGDSLDESDS ICGAVTCAAD
2660 2670 2680 2690 2700
MFSCQGSHAC VPQHWLCDGE RDCPDGSDEL SSAGCAPNNT CDENAFMCHN
2710 2720 2730 2740 2750
KVCIPKQFVC DHDDDCGDGS DEFLQCGYRQ CGPEEFRCAD GRCLVNTLWQ
2760 2770 2780 2790 2800
CDGDFDCPDS SDEAPINPRC RSAEHSCNSS FFMCKNGRCI PSDGLCDIRD
2810 2820 2830 2840 2850
DCGDGSDETN CHINECLSKK ISGCSQDCQD LPVSYKCKCW PGFQLKDDGK
2860 2870 2880 2890 2900
TCVDIDECSS GFPCSQQCIN TYGTYKCHCA EGYETQPDNP NGCRSLSDEE
2910 2920 2930 2940 2950
PFLILADQHE IRKISTDGSN YTLLKQGLNN VIALDFDYRE EFIYWIDSSR
2960 2970 2980 2990 3000
PNGSRINRMC LNGSDIKVVH NTAVPNALAV DWIGKNLYWS DTEKRIIEVS
3010 3020 3030 3040 3050
KLNGLYPTVL VSKRLKFPRD LSLDPRAGNL YWIDCCEYPH IGRVGMDGTN
3060 3070 3080 3090 3100
QSVVIETKIS RPMALTIDYV NHRLYWADEN HIEFSNMDGS HRHKVPNQDI
3110 3120 3130 3140 3150
PGVIALTLFE DYIYWTDGKT KSLSRVHKTS GADRLSLINS WHAITDIQVY
3160 3170 3180 3190 3200
HSYRQPDVSK HLCTVNNGGC SHLCLLGPGK THTCACPTNF YLAADNRTCL
3210 3220 3230 3240 3250
SNCTASQFRC KTDKCIPFWW KCDTVDDCGD GSDEPDDCPE FKCQPGRFQC
3260 3270 3280 3290 3300
GTGLCALPAF ICDGENDCGD NSDELNCDTH VCLAGQFKCT KNKKCIPVNL
3310 3320 3330 3340 3350
RCNGQDDCGD EEDEKDCPEN SCSPDYFQCK TTKHCISKLW VCDEDPDCAD

ASDEANC
Length:3,357
Mass (Da):376,338
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16C69D489B7C952B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JI18LRP1B_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b Lrpdit
4,599Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2API5A2API5_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
4,599Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YDG9F6YDG9_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVX0A0A0N4SVX0_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
781Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVE4A0A0N4SVE4_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVC8A0A0N4SVC8_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPQ4A0A087WPQ4_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SV53A0A0N4SV53_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL805948 Genomic DNA No translation available.
AL840626 Genomic DNA No translation available.
AL844225 Genomic DNA No translation available.
AL844515 Genomic DNA No translation available.
AL844533 Genomic DNA No translation available.
AL844553 Genomic DNA No translation available.
AL845293 Genomic DNA No translation available.
AL928732 Genomic DNA No translation available.
BX000439 Genomic DNA No translation available.
BX649304 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000167270; ENSMUSP00000129192; ENSMUSG00000049252

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805948 Genomic DNA No translation available.
AL840626 Genomic DNA No translation available.
AL844225 Genomic DNA No translation available.
AL844515 Genomic DNA No translation available.
AL844533 Genomic DNA No translation available.
AL844553 Genomic DNA No translation available.
AL845293 Genomic DNA No translation available.
AL928732 Genomic DNA No translation available.
BX000439 Genomic DNA No translation available.
BX649304 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiE9Q202

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33599, 51 antibodies

Genome annotation databases

EnsembliENSMUST00000167270; ENSMUSP00000129192; ENSMUSG00000049252

Organism-specific databases

MGIiMGI:2151136, Lrp1b

Phylogenomic databases

GeneTreeiENSGT00940000157521
HOGENOMiCLU_000085_2_1_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrp1b, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049252, Expressed in secondary oocyte and 111 other tissues
ExpressionAtlasiE9Q202, baseline and differential
GenevisibleiE9Q202, MM

Family and domain databases

CDDicd00112, LDLa, 20 hits
Gene3Di2.120.10.30, 7 hits
4.10.400.10, 22 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 21 hits
PF00058, Ldl_recept_b, 9 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 13 hits
SM00179, EGF_CA, 3 hits
SM00192, LDLa, 22 hits
SM00135, LY, 33 hits
SUPFAMiSSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 22 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 2 hits
PS01209, LDLRA_1, 11 hits
PS50068, LDLRA_2, 22 hits
PS51120, LDLRB, 31 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q202_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q202
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 3, 2012
Last modified: August 12, 2020
This is version 78 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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