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Entry version 77 (02 Jun 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Nebulin

Gene

Neb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-390522, Striated Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NebulinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NebImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97292, Neb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q1W3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q1W3

PRoteomics IDEntifications database

More...
PRIDEi
E9Q1W3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
361959

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q1W3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q1W3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026950, Expressed in quadriceps femoris and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q1W3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q1W3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047763

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q1W3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q1W3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7093 – 7152SH3InterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 64DisorderedSequence analysisAdd BLAST32
Regioni7010 – 7042DisorderedSequence analysisAdd BLAST33
Regioni7065 – 7089DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 52Polar residuesSequence analysisAdd BLAST20
Compositional biasi7010 – 7030Polar residuesSequence analysisAdd BLAST21

Keywords - Domaini

RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1702, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000024_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q1W3

Database of Orthologous Groups

More...
OrthoDBi
1549538at2759

TreeFam database of animal gene trees

More...
TreeFami
TF319104

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11933, SH3_Nebulin_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013998, Nebulin-like
IPR000900, Nebulin_repeat
IPR035629, Nebulin_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00880, Nebulin, 81 hits
PF14604, SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00510, NEBULIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00227, NEBU, 195 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51216, NEBULIN, 197 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

E9Q1W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEEEYEEV IEYYTEETVY EEVPGETITE VYETTTTRTS DYGQSETATP
60 70 80 90 100
ALAQPQPAKP VERKKVIRKK VDSSKFMTPY IQHSQKMQDL FSSNKYKENY
110 120 130 140 150
EKAKGQPYAI TSDTPELRRI KKVQDQLSEV KYRMDGDVAK TICHVDEKAK
160 170 180 190 200
DIEHAKKVSQ QVSKVLYKQN WEDTKDKYLL PPDAPELVQA VKNTAMFSKK
210 220 230 240 250
LYTEDWEADK ALFYPYNDSP ELRRVAQAQK ALSDIAYKKG LTEQQTQFTS
260 270 280 290 300
LPDPPEVEFA KKVTNQVSKQ KYKEDYEKKV KGKWSETPCF EIATARMNAD
310 320 330 340 350
NLSSRKYQED FENMKDQIYF MQTETPEYKM NKQAGVAASK VKYKQDYEKN
360 370 380 390 400
KGKADYNVLP ASENPLLRQL KTAGNVLSDK LYKENYEKTK ARSINYCETP
410 420 430 440 450
KFQLDTVLQN FSSDTKYKDS YLKNILGHYV GSFEDPYHTH CMKVTAQNSD
460 470 480 490 500
KNYKAEYEED RGKGFFPQTI TQEYEAIKKL DQCKDHAYKV HPDKTKFTQV
510 520 530 540 550
TDSPVLVQAQ VNSKQLSDLN YKAKHESEKF KCHIPPDAPA FIQHRVNAYN
560 570 580 590 600
LSDNVYKQDW EKSKAKKFDI KVDAIPLLAA KANSKNASDV MYKKDYEKSK
610 620 630 640 650
GKMIGALSIN DDPKMLHSLK TAKNQSDRLY RENYEKTKAK SMNYCETPKY
660 670 680 690 700
QLDTLLKNFS EAKYKDSYVK NMLGHYVGSF EDPYHTHCMK VSAQNSDKSY
710 720 730 740 750
KAEYEEDKGK CYFPQTITQE YESIKKLDQC KDHTYKVHPD KTRFTAVTDT
760 770 780 790 800
PVLLQAQLNT KQLSDLNYKA KHEGEKFKCS VPADAPEFIQ HRVNAYNLSD
810 820 830 840 850
NVYKHDWEKS KAKKFDIKVD AIPLLAAKAN SKNASDVMYK KDYEKSKGKM
860 870 880 890 900
IGALSINDDP KMLHSLKTAK NQSDREYRKD YEKSKTIYTA PLDMIQVTQA
910 920 930 940 950
KKSQAIASDV DYKHVLHNYS YPPDSINVDL AKKAYALQSD VEYKADYNSW
960 970 980 990 1000
MKGCGWVPFG SLEMEKAKRA SEILNEKKYR QHPDTLKFTS IEDAPITVQS
1010 1020 1030 1040 1050
KINQAQRSDI AYKAKGEEIL HKYNLPADLP QFIQAKVNAY NISENMYKAD
1060 1070 1080 1090 1100
LKDLSKKGYD LRIDAIPIKA AKAARQAASD IHYKKDYEKA KGKMVGFQSL
1110 1120 1130 1140 1150
QDDPKLVHYM NVAKIQSDRE YKKDYEKTKT KYNTPHDMFD VVAAKKAQDV
1160 1170 1180 1190 1200
ISNTNYKHSL HHYTYLPDAM DLELSKNMMH IQSDNAYKED YNTWMKGIGW
1210 1220 1230 1240 1250
IPIGSLDQEK VKKAGDALSE KKYRQHPDTL KFTSIVDSPV MVQAKQNTQQ
1260 1270 1280 1290 1300
ASDILYKAKG EDVKHKYTLN PDLPQFLQAK CNAYNISDVC YKRDWHDLIA
1310 1320 1330 1340 1350
KGNNVLADAI PITAAKSSRN IASDYKYKEA YEKAKGKHVG FRSLQDDPKL
1360 1370 1380 1390 1400
VHYMNVAKLQ SDREYKKNYE NTKTSYHTPG DMVSITAARM AQDVATNVNY
1410 1420 1430 1440 1450
KQPLHHYTYL PDALSLEHTR NANQIQSDNV YKDEYNSFFK GIGWIPIGSL
1460 1470 1480 1490 1500
EVEKAKKAGE ALNERKYRQH PDTIKFTSVP DSMGMVLAQQ NTKQLSDLNY
1510 1520 1530 1540 1550
KVEGEKMKHK YTMDPELPQF IQAKVNAINM SDAHYKADWK KTLAKGYDLR
1560 1570 1580 1590 1600
PDAIPIVAAK SSRNIASDCK YKEAYEKARG KQIGFLSLQD DPKLVHYMNV
1610 1620 1630 1640 1650
AKIQSDREYK KGYEASKTRY HTPLDMFSVT AAKKSQEVAT NSNYRQPYHN
1660 1670 1680 1690 1700
YTLLPDALNV EHSRNAMQIQ SDNLYKSDFT HWMKGIGWVP IDSLEVEKAK
1710 1720 1730 1740 1750
KAGEILSERK YRQHPEKLKF TYSMDTMEQA LNKSNKLTMD KRLYTEKWNK
1760 1770 1780 1790 1800
DKTSIHVMPD TPDILLSRVN QITMSDKLYK AGWEEEKTKG YDLKPDAIAI
1810 1820 1830 1840 1850
KAAKASRDIA SDYKYKQAYE QSKGKHIGFR SLEDDPKLVH FMQVAKIQSD
1860 1870 1880 1890 1900
REYKKGYEKS KTSFHTPVDM FSVVAAKKSQ EVATNANYRN IIHTYNMLPD
1910 1920 1930 1940 1950
AMSFELAKNM MQIQSDNQYK ADYADFMKGI GWLPLGSLEA EKNKKAMEII
1960 1970 1980 1990 2000
SEKKYRQHPD TLKYSTLMDS MNMVLAQNNA KIMNKNLYKQ AWEADKTKIH
2010 2020 2030 2040 2050
IMPDIPEIVL AKANAINMSD KLYKLSLEES RKKGYDLRTD AIPIKAAKAS
2060 2070 2080 2090 2100
RDIASDYKYK HSYEKEKGKM VGFRSLEDDP KLVHSMQVAK MQSDREYKKN
2110 2120 2130 2140 2150
YEKTKTSYHT PADMLSVTAA KDAQANITNT NYKRLIHKYI LLPDAMNIEL
2160 2170 2180 2190 2200
TRNMNHIQSD NEYKQDYREW YRGLGWSPAG SLEVEKAKKA TEYASDQKYR
2210 2220 2230 2240 2250
QHPSTFQFKK LTDSMDMVLA KQNAHTMNKH LYTIDWNKDK TKIHVMPDTP
2260 2270 2280 2290 2300
DILQAKQNQT LYSQKSYRLG WEEALKKGYD LPVDAISVQL AKTSRDIASD
2310 2320 2330 2340 2350
FKYKQGYRKQ LGHHIGFLSV QDDPKLVLSM NVAKMQSDRE YKKDFEKWKT
2360 2370 2380 2390 2400
KYTSPVDMLG VVLAKKCQAL VSDADYRNYL HQWTCLPDQN DVIQAKKVYE
2410 2420 2430 2440 2450
LQSENMYKSD LEWLRGIGWS PLGSLEAEKN KRASEIISEK KYRQPPDRNK
2460 2470 2480 2490 2500
FTSIPDAMDI VLAKTNAKNR SDRLYREAWD KDKTQIHIMP DTPDIILAKA
2510 2520 2530 2540 2550
NLINTSDKLY KMGYEELKKK GYDLPVDAIP IKAAKASREI ASEYKYKEGF
2560 2570 2580 2590 2600
RKQLGHHIGA RNIKDDPKMM WSMHVAKIQS DREYKKDFEK WKTKYSSPVD
2610 2620 2630 2640 2650
MLGVVLAKKC QTLVSDADYR NYLHQWTCLP DQNDVIHARQ AYDLQSDNVY
2660 2670 2680 2690 2700
KADLQWLKGI GWIPSGSLED EKNKRATQIL SDHVYRQHPN KFKFSSLMDS
2710 2720 2730 2740 2750
MPMVLAKNNA ITMNHHLYTE AWNKDKTTVH IMPDTPEVIL AKQNKVNYSE
2760 2770 2780 2790 2800
KLYKLGLEEA KRKGYDMRLD AIPIKTAKAS RDIASDFKYK EGYRKQLGHH
2810 2820 2830 2840 2850
IGARGIHDDP KMMWSMHVAK IQSDREYKKD FEKWKTKYSS PVDMLGVVLA
2860 2870 2880 2890 2900
KKCQTLVSDA DYRNYLHQWT CLPDQNDVIH ARQAYDLQSD NMYKSDLQWM
2910 2920 2930 2940 2950
RGIGWVPIGS LDVEKCKRAT EILSDKIYRQ PPDKFKFTSV TDSLEQVLAK
2960 2970 2980 2990 3000
NNAITMNKRL YTEAWDKDKT QIHIMPDTPE IMLARMNKVN YSESLYKLAN
3010 3020 3030 3040 3050
EEAKKKGYDL RSDAIPIVAA KASRDIASDY KYKDGYRKQL GHHIGARNIK
3060 3070 3080 3090 3100
DDPKMMWSMH VAKIQSDREY KKDFEKWKTK YSSPVDMLGV VLAKKCQILV
3110 3120 3130 3140 3150
SDIDYKHPLH EWTCLPDQND VIHARQAYDL QSDNVYKSDL QWMRGIGWVP
3160 3170 3180 3190 3200
IGSLDVVKCK RAAEILSDNI YRQPPNKFKF TSVTDSLEQV LAKSNALNMN
3210 3220 3230 3240 3250
KRLYTEAWDK DKIQIHVMPD TPEIMLARQN RINYSESLYK LANEEAKKKG
3260 3270 3280 3290 3300
YDLRVDAIPI VAAKASRDIA SDYKYKVGYR KQLGHHIGAR NIEDDPKMMW
3310 3320 3330 3340 3350
SMHVAKIQSD REYKKDFEKW KTKYSSPVDM LGVVLAKKCQ TLVSDVDYRN
3360 3370 3380 3390 3400
YLHQWTCLPD QNDVIHARQA YDLQSDNVYK SDLQWMRGIG WVPIGSLDVV
3410 3420 3430 3440 3450
KCKRAAEILS DNIYRQPPNK FKFTSVTDSL EQVLAKSNAL NMNKRLYTEA
3460 3470 3480 3490 3500
WDKDKTQIHI MPDTPEIMLA RQNKINYSES LYRQAMEEAK KEGYDLRSDA
3510 3520 3530 3540 3550
IPIVAAKASR DIASDYKYKE AYRKQLGHHI GARAIHDDPK MMWSLHIAKV
3560 3570 3580 3590 3600
QSDREYKKEF EKYKTRYSSP VDMLGIVLAK KCQTLVSDVD YKHPLHEWTC
3610 3620 3630 3640 3650
LPDQNDVIQA RKAYDLQSDN LYKADLEWMK GIGWVPIGSL EVVKAKRATE
3660 3670 3680 3690 3700
ILSDNIYRQR PDTLKFTSIT DSLEQVLAKN NAITMNKRLY TEAWDNDKKT
3710 3720 3730 3740 3750
IHVMPDTPEI MLAKLNRINY SDKLYKVSLE EARRQGYDLR VDAIPIRSAK
3760 3770 3780 3790 3800
ASREIASDYK YKEGYRKQLG HHIGARNIKD DPKMMWSMHV AKIQSDREYK
3810 3820 3830 3840 3850
KDFEKWKTKY SSPVDMLGVV LAKKCQILVS DIDYKHPLHE WTCLPDQNDV
3860 3870 3880 3890 3900
IQARKAYDLQ SDAVYKADLE WLRGIGWVPI GSVEVEKVKR AGEILSDRKY
3910 3920 3930 3940 3950
RQPADQLKFT CITDTPEIVL AKSNAITMSK HLYTEAWDAD KASIHVMPDT
3960 3970 3980 3990 4000
PEILLAKSNS ANISHKLYTK GWDESKMKDY DLREDAISIK SAKASRDIAS
4010 4020 4030 4040 4050
DYKYKEAYEK QKGHHIGAQS VEDDPRILCA MHAGKIYSDR EYKKEFQKWK
4060 4070 4080 4090 4100
TKFSSPVDML GVVLAKKCQT LVSDVDYRNY LHNWTCLPDQ NDIIQAKKAY
4110 4120 4130 4140 4150
ELQSDSVYKA DLEWLRGIGW MPEGSIEMTR VKGAQDLVNE RLYRTRPEAL
4160 4170 4180 4190 4200
KFTSIVDTPE VVLAKANSLQ MSERLYQEAW NKDKTNISLP LDTPAMLQAQ
4210 4220 4230 4240 4250
INALQISNKL YQKDWDEAKQ KGYDLRADAI EIKHAKASRE IASEYKYKEG
4260 4270 4280 4290 4300
YRKQLGHHVG FRSLQDDPKL VWSIHAAKIQ SDREYKKAYE KSKGIYNTPL
4310 4320 4330 4340 4350
DMMSIVQAKK CQVLVSDVDY RNYLHQWTCL PDQNDVIQAK KAYELQSDAI
4360 4370 4380 4390 4400
YKADLEWLRG IGWMPEGSPE VLRVKNAQEI LCDSVYRTPV VKLKYTSIVD
4410 4420 4430 4440 4450
TPEVVLAKSN AENISIPKYR EVWDKDKTSI HIMPDTPEIN LARANALNVS
4460 4470 4480 4490 4500
NKLYREGWDE VKMSCDVRLD AIPIQAAKAS REIASDYKYK LDHEKQKGHY
4510 4520 4530 4540 4550
VGTLTARDDN KIRWALIAGK IQNEREYRLQ WAKWKTKFQS PVDMLSILHS
4560 4570 4580 4590 4600
KKCQTLVSDI DYRNYLHEWT CMPDQNDVIQ AKKAYELQSD AVYKADLEWL
4610 4620 4630 4640 4650
RGIGWMPNDS VSVNHAKHAA DIFSEKKYRT KIETLNFTPV DDRVDYVTAK
4660 4670 4680 4690 4700
QSSEIRDDIK YRKDWNAIKS KYTLTETPLL HTAQEAARIL DQYLYKEGWE
4710 4720 4730 4740 4750
KQKATGYILP PDAVPFVHAH HSSDVQSELK YKAEHVKQRG HYVGVPTMRD
4760 4770 4780 4790 4800
DPKLVWFEHA GQIQNDRLYK ESYHKSKAKI NIPADMVSVV AAKEGQNLVS
4810 4820 4830 4840 4850
DIDYRQYLHQ WTCHPDQNDV IQAKIAYDLQ SDNVYKADLE WLRGIGWIPL
4860 4870 4880 4890 4900
DSVDHVRVTK NQEMVNQIKY KKDALANYPN FTSVEDPPEI VLAKINSVNQ
4910 4920 4930 4940 4950
SDVKYKETFN KAKGKYIFSP DTPYISHSKD MGKLYSTILY KGAWEGTKAY
4960 4970 4980 4990 5000
GYTLDERYIP IVGAKHADLV NSELKYKETY EKQKGHYLAG KEISEFPGVV
5010 5020 5030 5040 5050
HCLDFQQMRS ALNYRRDYED TKANVHIPND MMNHVLAKRC QYILSDLEYR
5060 5070 5080 5090 5100
HYFHQWTSLP EEPNVIRARN AQEILSDNVY KDDLNWLKGI GCYVWDTPQI
5110 5120 5130 5140 5150
LHAKKSYDLQ SQLQYTAASK ENLQNYNLVT DTPVYVTALQ SGINASEVKY
5160 5170 5180 5190 5200
KENYHQIKDK YTTVLETADY DRTKHLKSLY SSNIYKEAWD KVKATSYNLP
5210 5220 5230 5240 5250
TSTLSLTHAK NQKHLASHIK YREEYEKFKA LYTLPKSVDD DPNTARCLRV
5260 5270 5280 5290 5300
GKLNIDRLYR SVYEKNKMKI NIVPDMVEMV TAKDSQKKVS EIDYRLHLHE
5310 5320 5330 5340 5350
WICHPDLQVN SHVRKVTDQI SDIVYKDDLT WLKGIGCYVW DTPEILHAKH
5360 5370 5380 5390 5400
AYDLRNDIKY KAHVQKTRND YKLVTDTPVY VQAVKSGKQL SDAVYHYDYV
5410 5420 5430 5440 5450
HSVRGKVAPT TKTVDLDRAL HAYKLQSENL YKKGLRFLPT GYRLPVDTPH
5460 5470 5480 5490 5500
FNHTKDTRYM SSYFKYKEAY EHIKANGYTL GPKDVPFVHV RRVNNVTSER
5510 5520 5530 5540 5550
LYRELYHKLK DKIHTTPDTP EIRQVKKTQE AVSELIYKSD FFKMQGHMIS
5560 5570 5580 5590 5600
LPYTPQVLHC RYVGDITSDI KYKEDLQILK GLGCFLYDTP DMVRSRHLRK
5610 5620 5630 5640 5650
LWSNYLYTDN ARKMRDKYKV VLDTPEYRKV QELKTHLSEL VYRASGKKQK
5660 5670 5680 5690 5700
SIFTSVPDTP DLLRAKRGQK LQSQYLYVEL ATKERPHHHA GNQTTALQHA
5710 5720 5730 5740 5750
KDVKDMVSEK KYKIQYEKMK DKYTPVADTP ILIRAKRAYW NASDLRYKET
5760 5770 5780 5790 5800
FQKTKGRYHT VKDALDIVYH RKVTDDISKV KYKENYMSQL GIWSSIPDRP
5810 5820 5830 5840 5850
EHFHHRAVTD AVSDVKYKED LTWLKGIGCY AYDTPDLTLA EQNKTLYSKY
5860 5870 5880 5890 5900
KYKEVFERTK SNFKYVADCP INRHFKYATQ LMNEKKYRAD YEQRKDKYHL
5910 5920 5930 5940 5950
VVDEPRHLLA KTAGDQISQI KYRKKYEKSK DKFTSVVDTP EHLRTTKVNK
5960 5970 5980 5990 6000
QISDILYKLE YNKARPRGYT TIHDTPMLLH VRKVKDEVSD LKYKEVYQRN
6010 6020 6030 6040 6050
KSNCTIKPDA VHIKAAKDAY KVNTNLDYKK QYEANKAYWK WTPDRPDFIQ
6060 6070 6080 6090 6100
AAKSSLQQSD FEYKLDREFL KGCKLSVTDD KDMVLALRNS LIESDLKYKE
6110 6120 6130 6140 6150
KHVKERGSCH AVPDTPQILL AKTVSNLVSE NKYKDHVKKH LAQGSYTTLP
6160 6170 6180 6190 6200
ETRDTVHVKA VTKHVSDTNY KKKFVKEKGK SNYSIMQEPP EVKHAMEVAK
6210 6220 6230 6240 6250
KQSDVAYKKD AKENLHYTTV ADRPDIKKAT QAAKQASEVE YRAKHRKEGS
6260 6270 6280 6290 6300
HGLSMLGRPD IEMAKKAAKL SSQVKYRENF DKEKGKTPKY NPKDSQLYKT
6310 6320 6330 6340 6350
MKDANNLASE VKYKADLKKL HKPVTDMKES LIMHHVLNTS QLASSYQYKK
6360 6370 6380 6390 6400
NYEKSKGHYH TIPDNLEQLH HREATELQSI VKYKEKYEKE RGKPMLDFET
6410 6420 6430 6440 6450
PTYITAKESQ QMQSGKEYRK DYEESIKGRN LTGLEVTPAL LHVRHATKIA
6460 6470 6480 6490 6500
SEKEYRKDLE ESIRGRGLTE MEDTPDMLRA KNATQILNEK EYKRDLELEV
6510 6520 6530 6540 6550
KGRGLNAMAN ETPDFMRARN ATDIASQIKY KQSAEMEKAN FTSVVDTPEI
6560 6570 6580 6590 6600
IHAQQVKNLS SQKKYKEDAE KSMSYYETVL DTPEMQRVRE NQKNFSLLQY
6610 6620 6630 6640 6650
QCDLKNSKGK ITVVQDTPEI LRVKENQKNF SSVLYKEDVS PGTAIGKTPE
6660 6670 6680 6690 6700
MLRVKQTQDH ISSVKYKEAI GQGTPIPDLP EVKRVKETQK HISSVMYKEN
6710 6720 6730 6740 6750
PGTGIPTTVT PEIERVKRNQ ENFSSVLYKE SLGKGTPTAI TPEMERVKRN
6760 6770 6780 6790 6800
QENFSSVLYK ENMGKGTPLP VTPEMERVKH NQENISSVLY KENVGKATPT
6810 6820 6830 6840 6850
PVTPEMQRVK RNQENISSVL YKENMGKATP TPFTPEMERV KRNQENFSSV
6860 6870 6880 6890 6900
LYKENMRKAT PTPVTPDMER AKRNQENISS VLYSDSFRKQ IQGKAAYVLD
6910 6920 6930 6940 6950
TPEMRRVRET QRHISTVKYH EDFEKHKGCF TPVVTDPITE RVKKNTQDFS
6960 6970 6980 6990 7000
DINYRGIQRK VVEMEQKRND QDQDTITGLR VWRTNPGSVF DYDPAEDNIQ
7010 7020 7030 7040 7050
SRSLHMINVQ AQRRSRDQSR SASALSISGG EEKSEHSEAA DQRLSTYSDG
7060 7070 7080 7090 7100
GAFFSATSTA YKHVKTTQLP QQRSSSVATQ QTTLSSIPSH PSTAGKIFRA
7110 7120 7130 7140 7150
IYDYIAADAD EVSFKDGDAI VNAQAIDEGW MYGTVQRTGR TGMLPANYVE

AI
Length:7,152
Mass (Da):828,662
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFEEE21BECA3644F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AQA9A2AQA9_MOUSE
Nebulin
Neb
6,909Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AQB2A2AQB2_MOUSE
Nebulin
Neb
3,044Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X9B6F6X9B6_MOUSE
Nebulin
Neb
768Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BF58A0A571BF58_MOUSE
Nebulin
Neb
7,523Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSI0A0A1B0GSI0_MOUSE
Nebulin
Neb
269Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BF46A0A571BF46_MOUSE
Nebulin
Neb
7,488Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSF5A0A1B0GSF5_MOUSE
Nebulin
Neb
529Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RDH3F6RDH3_MOUSE
Nebulin
Neb
1,190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWS1G3UWS1_MOUSE
Nebulin
Neb
342Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_035019.1, NM_010889.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000036934; ENSMUSP00000047763; ENSMUSG00000026950

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17996

UCSC genome browser

More...
UCSCi
uc008jqv.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_035019.1, NM_010889.1

3D structure databases

SMRiE9Q1W3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047763

PTM databases

iPTMnetiE9Q1W3
PhosphoSitePlusiE9Q1W3

Proteomic databases

MaxQBiE9Q1W3
PaxDbiE9Q1W3
PRIDEiE9Q1W3
ProteomicsDBi361959

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1171, 121 antibodies

Genome annotation databases

EnsembliENSMUST00000036934; ENSMUSP00000047763; ENSMUSG00000026950
GeneIDi17996
KEGGimmu:17996
UCSCiuc008jqv.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4703
MGIiMGI:97292, Neb

Phylogenomic databases

eggNOGiKOG1702, Eukaryota
GeneTreeiENSGT00940000154533
HOGENOMiCLU_000024_0_0_1
InParanoidiE9Q1W3
OrthoDBi1549538at2759
TreeFamiTF319104

Enzyme and pathway databases

ReactomeiR-MMU-390522, Striated Muscle Contraction

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
17996, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Neb, mouse
RNActiE9Q1W3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026950, Expressed in quadriceps femoris and 134 other tissues
ExpressionAtlasiE9Q1W3, baseline and differential
GenevisibleiE9Q1W3, MM

Family and domain databases

CDDicd11933, SH3_Nebulin_C, 1 hit
InterProiView protein in InterPro
IPR013998, Nebulin-like
IPR000900, Nebulin_repeat
IPR035629, Nebulin_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00880, Nebulin, 81 hits
PF14604, SH3_9, 1 hit
PRINTSiPR00510, NEBULIN
SMARTiView protein in SMART
SM00227, NEBU, 195 hits
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51216, NEBULIN, 197 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q1W3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q1W3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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