Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 69 (31 Jul 2019)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Voltage-dependent P/Q-type calcium channel subunit alpha

Gene

Cacna1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent P/Q-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109482 Cacna1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei126 – 144HelicalSequence analysisAdd BLAST19
Transmembranei177 – 200HelicalSequence analysisAdd BLAST24
Transmembranei259 – 280HelicalSequence analysisAdd BLAST22
Transmembranei292 – 314HelicalSequence analysisAdd BLAST23
Transmembranei443 – 462HelicalSequence analysisAdd BLAST20
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Transmembranei569 – 591HelicalSequence analysisAdd BLAST23
Transmembranei645 – 669HelicalSequence analysisAdd BLAST25
Transmembranei1147 – 1166HelicalSequence analysisAdd BLAST20
Transmembranei1186 – 1207HelicalSequence analysisAdd BLAST22
Transmembranei1219 – 1236HelicalSequence analysisAdd BLAST18
Transmembranei1281 – 1303HelicalSequence analysisAdd BLAST23
Transmembranei1393 – 1418HelicalSequence analysisAdd BLAST26
Transmembranei1474 – 1492HelicalSequence analysisAdd BLAST19
Transmembranei1504 – 1527HelicalSequence analysisAdd BLAST24
Transmembranei1595 – 1613HelicalSequence analysisAdd BLAST19
Transmembranei1691 – 1715HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q1R5

PeptideAtlas

More...
PeptideAtlasi
E9Q1R5

PRoteomics IDEntifications database

More...
PRIDEi
E9Q1R5

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q1R5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034656 Expressed in 196 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q1R5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q1R5 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1852 – 1886Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni715 – 734DisorderedSequence analysisAdd BLAST20
Regioni776 – 1070DisorderedSequence analysisAdd BLAST295
Regioni1090 – 1124DisorderedSequence analysisAdd BLAST35
Regioni1893 – 2321DisorderedSequence analysisAdd BLAST429

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili322 – 342Sequence analysisAdd BLAST21
Coiled coili665 – 701Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi781 – 795PolarSequence analysisAdd BLAST15
Compositional biasi798 – 817PolyampholyteSequence analysisAdd BLAST20
Compositional biasi827 – 944PolyampholyteSequence analysisAdd BLAST118
Compositional biasi947 – 964PolarSequence analysisAdd BLAST18
Compositional biasi1005 – 1034PolarSequence analysisAdd BLAST30
Compositional biasi1045 – 1065PolarSequence analysisAdd BLAST21
Compositional biasi1097 – 1117PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1900 – 1915PolarSequence analysisAdd BLAST16
Compositional biasi1934 – 1948PolarSequence analysisAdd BLAST15
Compositional biasi1960 – 1974PolarSequence analysisAdd BLAST15
Compositional biasi2039 – 2058PolyampholyteSequence analysisAdd BLAST20
Compositional biasi2109 – 2126BasicSequence analysisAdd BLAST18
Compositional biasi2127 – 2163PolyampholyteSequence analysisAdd BLAST37
Compositional biasi2164 – 2198PolarSequence analysisAdd BLAST35
Compositional biasi2304 – 2321PolyampholyteSequence analysisAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156518

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005448 CACNA1A
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01632 PQVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q1R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARFGDEMPG RYGAGGGGSG PAAGVVVGAA GGRGAGGSRQ GGQPGAQRMY
60 70 80 90 100
KQSMAQRART MALYNPIPVR QNCLTVNRSL FLFSEDNVDD TEPYFIGIFC
110 120 130 140 150
FEAGIKIVAL GFAFHKGSYL RNGWNVMDFV VVLTGILATV GTEFDLRTLR
160 170 180 190 200
AVRVLRPLKL VSGIPSLQVV LKSIMKAMIP LLQIGLLLFF AILIFAIIGL
210 220 230 240 250
EFYMGKFHTT CFEEGTDDIQ GESPAPCGTE EPARTCPNGT KCQPYWEGPN
260 270 280 290 300
NGITQFDNIL FAVLTVFQCI TMEGWTDLLY NSNDASGNTW NWLYFIPLII
310 320 330 340 350
IGSFFMLNLV LGVLSGEFAK ERERVENRRA FLKLRRQQQI ERELNGYMEW
360 370 380 390 400
ISKAEEVILA EDETDVEQRH PFDGALRRAT LKKSKTDLLN PEEAEDQLAD
410 420 430 440 450
IASVGSPFAR ASIKSAKLEN STFFHKKERR MRFYIRRMVK TQAFYWTVLS
460 470 480 490 500
LVALNTLCVA IVHYNQPEWL SDFLYYAEFI FLGLFMSEMF IKMYGLGTRP
510 520 530 540 550
YFHSSFNCFD CGVIIGSIFE VIWAVIKPGT SFGISVLRAL RLLRIFKVTK
560 570 580 590 600
YWASLRNLVV SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFDEG
610 620 630 640 650
TPPTNFDTFP AAIMTVFQIL TGEDWNEVMY DGIKSQGGVQ GGMVFSIYFI
660 670 680 690 700
VLTLFGNYTL LNVFLAIAVD NLANAQELTK DEQEEEEAAN QKLALQKAKE
710 720 730 740 750
VAEVSPLSAA NMSIAVKEQQ KNQKPTKSVW EQRTSEMRKQ NLLASREALY
760 770 780 790 800
GDAAERWPTP YARPLRPDVK THLDRPLVVD PQENRNNNTN KSRAPEALRP
810 820 830 840 850
TARPRESARD PDARRAWPGS PERAPGREGP YGRESEPQQR EHAPPREHAP
860 870 880 890 900
WDADTERAKA GDAPRRHTHR PVAEGEPRRH RARRRPGDEP DDRPERRPRP
910 920 930 940 950
RDATRPARAA DGEGDDGERK RRHRHGPPAH DDRERRHRRR KENQGSGVPV
960 970 980 990 1000
SGPNLSTTRP IQQDLGRQDL PLAEDLDNMK NNKLATGEPA SPHDSLGHSG
1010 1020 1030 1040 1050
LPPSPAKIGN STNPGPALAT NPQNAASRRT PNNPGNPSNP GPPKTPENSL
1060 1070 1080 1090 1100
IVTNPSSTQP NSAKTARKPE HMAVEIPPAC PPLNHTVVQV NKNANPDPLP
1110 1120 1130 1140 1150
KKEEEKKEEE EADPGEDGPK PMPPYSSMFI LSTTNPLRRL CHYILNLRYF
1160 1170 1180 1190 1200
EMCILMVIAM SSIALAAEDP VQPNAPRNNV LRYFDYVFTG VFTFEMVIKM
1210 1220 1230 1240 1250
IDLGLVLHQG AYFRDLWNIL DFIVVSGALV AFAFTGNSKG KDINTIKSLR
1260 1270 1280 1290 1300
VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VFNILIVYML FMFIFAVVAV
1310 1320 1330 1340 1350
QLFKGKFFHC TDESKEFERD CRGKYLLYEK NEVKARDREW KKYEFHYDNV
1360 1370 1380 1390 1400
LWALLTLFTV STGEGWPQVL KHSVDATFEN QGPSPGYRME MSIFYVVYFV
1410 1420 1430 1440 1450
VFPFFFVNIF VALIIITFQE QGDKMMEEYS LEKNERACID FAISAKPLTR
1460 1470 1480 1490 1500
HMPQNKQSFQ YRMWQFVVSP PFEYTIMAMI ALNTIVLMMK FYGASVAYEN
1510 1520 1530 1540 1550
ALRVFNIVFT SLFSLECVLK VMAFGILNYF RDAWNIFDFV TVLGSITDIL
1560 1570 1580 1590 1600
VTEFGNNFIN LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC
1610 1620 1630 1640 1650
LLIAMLFFIY AIIGMQVFGN IGIDGEDEDS DEDEFQITEH NNFRTFFQAL
1660 1670 1680 1690 1700
MLLFRSATGE AWHNIMLSCL SGKPCDKNSG ILTADCGNEF AYFYFVSFIF
1710 1720 1730 1740 1750
LCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEYVRVW AEYDPAACGR
1760 1770 1780 1790 1800
IHYKDMYSLL RVISPPLGLG KKCPHRVACK RLLRMDLPVA DDNTVHFNST
1810 1820 1830 1840 1850
LMALIRTALD IKIAKGGADK QQMDAELRKE MMAIWPNLSQ KTLDLLVTPH
1860 1870 1880 1890 1900
KSTDLTVGKI YAAMMIMEYY RQSKAKKLQA MREEQNRTPL MFQRMEPPSP
1910 1920 1930 1940 1950
TQEGGPSQNA LPSTQLDPGG GLMAHEGGMK ESPSWVTQRA QEMFQKTGTW
1960 1970 1980 1990 2000
SPERGPPIDM PNSQPNSQSV EMREMGTDGY SDSEHYLPME GQTRAASMPR
2010 2020 2030 2040 2050
LPAENQRRRG RPRGNDLSTI SDTSPMKRSA SVLGPKARRL DDYSLERVPP
2060 2070 2080 2090 2100
EENQRYHQRR RDRGHRTSER SLGRYTDVDT GLGTDLSMTT QSGDLPSKDR
2110 2120 2130 2140 2150
DQDRGRPKDR KHRPHHHHHH HHHHPPAPDR DRYAQERPDT GRARAREQRW
2160 2170 2180 2190 2200
SRSPSEGREH TTHRQGSSSV SGSPAPSTSG TSTPRRGRRQ LPQTPCTPRP
2210 2220 2230 2240 2250
LVSYSPAPRR PAARRMAGPA APPGGSPRGC RRAPRWPAHA PEGPRPRGAD
2260 2270 2280 2290 2300
YTEPDSPREP PGGAHDPAPR SPRTPRAAGC ASPRHGRRLP NGYYAGHGAP
2310 2320
RPRTARRGAH DAYSESEDDW C
Length:2,321
Mass (Da):262,163
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80712954B0C225AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97445CAC1A_MOUSE
Voltage-dependent P/Q-type calcium ...
Cacna1a Caca1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
2,368Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SQZ2A0A1L1SQZ2_MOUSE
Voltage-dependent P/Q-type calcium ...
Cacna1a
2,321Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BE75A0A571BE75_MOUSE
Voltage-dependent P/Q-type calcium ...
Cacna1a
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEF0A0A571BEF0_MOUSE
Voltage-dependent P/Q-type calcium ...
Cacna1a
776Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BET0A0A571BET0_MOUSE
Voltage-dependent P/Q-type calcium ...
Cacna1a
2,457Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC131189 Genomic DNA No translation available.
AC145556 Genomic DNA No translation available.
AC146603 Genomic DNA No translation available.
AC164557 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001238988.1, NM_001252059.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000122053; ENSMUSP00000114055; ENSMUSG00000034656

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12286

UCSC genome browser

More...
UCSCi
uc029wud.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131189 Genomic DNA No translation available.
AC145556 Genomic DNA No translation available.
AC146603 Genomic DNA No translation available.
AC164557 Genomic DNA No translation available.
RefSeqiNP_001238988.1, NM_001252059.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiE9Q1R5

Proteomic databases

MaxQBiE9Q1R5
PeptideAtlasiE9Q1R5
PRIDEiE9Q1R5

Genome annotation databases

EnsembliENSMUST00000122053; ENSMUSP00000114055; ENSMUSG00000034656
GeneIDi12286
UCSCiuc029wud.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
773
MGIiMGI:109482 Cacna1a

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00940000156518
OrthoDBi172471at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cacna1a mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034656 Expressed in 196 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9Q1R5 baseline and differential
GenevisibleiE9Q1R5 MM

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005448 CACNA1A
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01632 PQVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q1R5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q1R5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 31, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again