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Protein
Submitted name:

Signal-induced proliferation-associated protein 1

Gene

Sipa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-392517 Rap1 signalling

Names & Taxonomyi

Protein namesi
Submitted name:
Signal-induced proliferation-associated protein 1Imported
Gene namesi
Name:Sipa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:107576 Sipa1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSMUSG00000056917 Expressed in 186 organ(s), highest expression level in spleen

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 535Rap-GAPInterPro annotationAdd BLAST219
Domaini683 – 759PDZInterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili981 – 1015Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
KOiK08013
OMAiMAPAPTD
OrthoDBiEOG091G016P
TreeFamiTF318626

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF02145 Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q0Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWAGGVGSPR RGMAPAPTDD LFARKLRQPA RPPLTPHTFE PRPARGPLLR
60 70 80 90 100
SGSDAGEVRP PTPASPRARA HSHEDASRPA ATPTRLFTDP LALLGLPAEE
110 120 130 140 150
PEPTFPPVLE PRWFAHYDVQ SLLFDWAPRP RGTGSHIEAN SGTLAEGQTT
160 170 180 190 200
TSDLLLGAPG FVSELGGEGE LGLGGPISPP VPPALPNAAV SVLEEPQTRT
210 220 230 240 250
TAYSLEHADL GAGYYRKYFY GKEHQNFFGL DEALGPVAVS LRREEKEGSG
260 270 280 290 300
GGTLHSYRVI VRTTQLRTLR GTISEDALPP GPPRGLSPRK LLEHVAPRLS
310 320 330 340 350
PTCLRLGSAS PKVPRTLLTL DEQVLSFQRK VGILYCRAGQ GSEEEMYNNQ
360 370 380 390 400
EAGAAFMQFL TLLGDVVRLK GFESYRAQLD TKTDSTGTHS LYTTYQDHEI
410 420 430 440 450
MFHVSTMLPY TPNNQQQLLR KRHIGNDIVT IVFQEPGSKP FCPTTIRSHF
460 470 480 490 500
QHVFLVVRAH APCTPHTSYR VAVSRTQDTP AFGPALPEGG GPFAANADFR
510 520 530 540 550
AFLLAKALNG EQAAGHARQF HAMATRTRQQ YLQDLATNEV TTTSLDSASR
560 570 580 590 600
FGLPSLGGRR RATPRSPGAE LQAAGALMWG VRAAPGARVA AGAETSGPED
610 620 630 640 650
AEVPCLLGIS AETLVLVAPR DGRVVFNCAC RDVLAWTFSE HQLDLYHGRG
660 670 680 690 700
EAITLRLDGA PGQAVGEVVA RLQLVSRGCE TRELALPRDG QGRLGFEVDA
710 720 730 740 750
EGFITHVERF TFAETTGLRP GARLLRVCGQ TLPKLGPEAA AQMLRSAPKV
760 770 780 790 800
CVTVLPPDES GRPRRSFSEL YMLSLKEPSR RGGPEPVQDE TGKLVILPPT
810 820 830 840 850
KQLLHFCLKD SSSPPGPGDL TEERTEFLRS HNSLSSGSSL SDEAPVLPNT
860 870 880 890 900
TPDLLLVTTA NPSAPGTDRE TPPSQDQSGS PSSHEDTSDS GPELRASILP
910 920 930 940 950
RTLSLRNSIS KIMSEAGSET LEDEWQSISE IASTCNTILE SLSREGQPIS
960 970 980 990 1000
ESGDPKEALK CDSEPEPGSL SEKVSHLESM LWKLQEDLQR EKADRAALEE
1010 1020 1030
EVRSLRHNNQ RLLAESESAA TRLLLASKHL GAPTTDLA
Length:1,038
Mass (Da):112,224
Last modified:April 5, 2011 - v1
Checksum:i9F7929E21B856968
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P46062SIPA1_MOUSE
Signal-induced proliferation-associ...
Sipa1 Spa-1, Spa1
1,037Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134563 Genomic DNA No translation available.
RefSeqiNP_001157952.1, NM_001164480.1
NP_001157953.1, NM_001164481.1
NP_001157954.1, NM_001164482.1
NP_001158040.1, NM_001164568.1
NP_035509.4, NM_011379.4
UniGeneiMm.3072

Genome annotation databases

EnsembliENSMUST00000071857; ENSMUSP00000073618; ENSMUSG00000056917
ENSMUST00000080824; ENSMUSP00000079637; ENSMUSG00000056917
ENSMUST00000164304; ENSMUSP00000128208; ENSMUSG00000056917
ENSMUST00000169854; ENSMUSP00000132345; ENSMUSG00000056917
GeneIDi20469
KEGGimmu:20469
UCSCiuc008geg.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134563 Genomic DNA No translation available.
RefSeqiNP_001157952.1, NM_001164480.1
NP_001157953.1, NM_001164481.1
NP_001157954.1, NM_001164482.1
NP_001158040.1, NM_001164568.1
NP_035509.4, NM_011379.4
UniGeneiMm.3072

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071857; ENSMUSP00000073618; ENSMUSG00000056917
ENSMUST00000080824; ENSMUSP00000079637; ENSMUSG00000056917
ENSMUST00000164304; ENSMUSP00000128208; ENSMUSG00000056917
ENSMUST00000169854; ENSMUSP00000132345; ENSMUSG00000056917
GeneIDi20469
KEGGimmu:20469
UCSCiuc008geg.3 mouse

Organism-specific databases

CTDi6494
MGIiMGI:107576 Sipa1

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
KOiK08013
OMAiMAPAPTD
OrthoDBiEOG091G016P
TreeFamiTF318626

Enzyme and pathway databases

ReactomeiR-MMU-392517 Rap1 signalling

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056917 Expressed in 186 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF02145 Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q0Y4_MOUSE
AccessioniPrimary (citable) accession number: E9Q0Y4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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