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Protein
Submitted name:

Dynein, axonemal, heavy chain 7A

Gene

Dnah7a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi2253 – 2264PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Dynein, axonemal, heavy chain 7AImported
Gene namesi
Name:Dnah7aImported
Synonyms:Dnahc7aImported, Dnahc7bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685838 Dnah7a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9Q0T8
PaxDbiE9Q0T8
PRIDEiE9Q0T8

PTM databases

iPTMnetiE9Q0T8
PhosphoSitePlusiE9Q0T8

Expressioni

Gene expression databases

BgeeiENSMUSG00000096141 Expressed in 64 organ(s), highest expression level in testis

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092571

Structurei

3D structure databases

ProteinModelPortaliE9Q0T8
SMRiE9Q0T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2240 – 2275EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili512 – 532Sequence analysisAdd BLAST21
Coiled coili722 – 742Sequence analysisAdd BLAST21
Coiled coili2831 – 2879Sequence analysisAdd BLAST49
Coiled coili3175 – 3195Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964
InParanoidiE9Q0T8
KOiK10408
OMAiCGMVYVQ
OrthoDBiEOG091G00FO
TreeFamiTF316836

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013602 Dynein_heavy_dom-2
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 5 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q0T8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKKDKLST KGKSKTPVRF LPQLPMDKLS SKEKVKLPTT VLPQLSLTGV
60 70 80 90 100
KPQWQQTAPS FHLNIKQENP VLEPYTVKNE QSFAEYMEHC QKKGKLLDQI
110 120 130 140 150
DDDRSAPSTS RSKIKSPQKE RENLRSTLAK VIMQKDGGLE SDVIDESGIP
160 170 180 190 200
KETTSATEKD ISRYYYYIRQ GLDTDHVAPM EDSWLEHVLQ LVPEHLKVLT
210 220 230 240 250
NSIKVLSDEI REDYLLSVKK SIVDFVLKDP REKDDDGKIT ELPPHRAEME
260 270 280 290 300
VLPKPWRRSF LSACSYIRDH LNAMNPMMLA VLDLWHSTFK KLRLVDIEEF
310 320 330 340 350
HSCQDALELS EFQNIVIKHM ESAKETLLKT WFPEVQNIFN QGNKKKQLPT
360 370 380 390 400
GKSTAKLDSF FNCAATLMTL QLQDLILVSM QDFTDLIAQP LESIRVFEHP
410 420 430 440 450
GFIMRLVLDK EAIKFEPEFN EYIDSLINIY EIMIKAVSFV PRVETKLYSQ
460 470 480 490 500
WESKSKPTTL KPIILNEIID THKEKIREVI LRESVAPTEH LKMYDKYQFL
510 520 530 540 550
ITGKAERDID ELLFQNQNYE RLIEEIRKYQ KLGEEIQYTS QKTVCLGMFE
560 570 580 590 600
MHCEELIRSL VKRADVICGK LIAKMFRDHQ EVNTMLCDEF EKIAEKALST
610 620 630 640 650
PLNTAELMEM KAHVQKLETT DMLELGQRLV DSKICLAFLI ECVNFSPADI
660 670 680 690 700
RLNKSVFQWY GRMGEIFDEH RKIIKEKTEL YQEFLKFRCE RFVEELESYA
710 720 730 740 750
KQVEEFHAFG DLLDVQRYLQ KAQVLNGKLD AAADKIDQFN AEEEAFGWVP
760 770 780 790 800
SAYPQRKKIQ DALNPYLHLY ETAVEFSTKH RGWTEGPYHK VNPDQVEADV
810 820 830 840 850
GNYWRGLYKL EKVFHDSPNA LAMTKKVHSM VEEFKQYIPL IQVFCNPGLR
860 870 880 890 900
PRHWEAMSTI VGYPLQPSDD STVFSFIDMN LEPFLDRFGS ISEAASKEYS
910 920 930 940 950
LEKAMDKMMT EWDSMEFVIL PYRESGTYIL SSVDDIQMLL DDHIIKTQTM
960 970 980 990 1000
RGSPFIKPYE KQMREWEGKL LLLQEILDEW LKVQATWLYL EPIFSSRDIM
1010 1020 1030 1040 1050
SQMPEEGRRF TAVDKTWRDV MKTVVQDKQV LAVVTIERML ERLKKSNELL
1060 1070 1080 1090 1100
ELILKGLNEY LEKKRLFFPR FFFLSNDELL EILSETKDPT RVQPHLKKCF
1110 1120 1130 1140 1150
EGIAKVEFTE TLDITHMKSS EGEVVELVDT ISTAKARGQV EKWLVELERT
1160 1170 1180 1190 1200
MIKSIHKVIR DAIVAYTKTS RISWVRDWPG QTVLCVSQTF WTVEVQIAIP
1210 1220 1230 1240 1250
EGHRALEGYL AKCNHQIDDI VTLVRGKLSK QNRVTLGALV VLDVHARDVL
1260 1270 1280 1290 1300
ASLVDKKISD DSDFQWLSQL RYYWQENNLE TKMINAGLRY GYEYLGNSPR
1310 1320 1330 1340 1350
LVITPLTDRC YRTLFGALHL HLGGAPEGPA GTGKTETTKD LAKAVAKQCV
1360 1370 1380 1390 1400
VFNCSDGLDY LALGKFFKGL LSCGAWACFD EFNRIDLEVL SVVAQQILTI
1410 1420 1430 1440 1450
QRGINAGTDL LVFEGTELKL DPTCAVFITM NPGYAGRSEL PDNLKALFRT
1460 1470 1480 1490 1500
VAMMVPDYAM IAEIVLYSCG FVTARPLSIK IVATYRLCSE QLSSQHHYDY
1510 1520 1530 1540 1550
GMRAVKSVLT AAGNLKLKYP NENEEILLLR SIIDVNLPKF LSHDLPLFEG
1560 1570 1580 1590 1600
ITSDLFPGVK LPKPDYNDLL AAIRDNCHSM NLQMTDFFSE KILQIYEMMI
1610 1620 1630 1640 1650
VRHGFMIVGE PFGGKTSAYR VLAGALNDIC EKGLMEENKV QITVLNPKSV
1660 1670 1680 1690 1700
TMGQLYGQFD LVSHEWSDGV LAVSFRAFAA SSTPDRKWLI FDGPVDAVWI
1710 1720 1730 1740 1750
ENMNTVLDDN KKLCLMSGEI IQMSPQMNLI FEPMDLEVAS PATVSRCGMI
1760 1770 1780 1790 1800
YMEPHMLGWR PLMVSWINTL PQSVSIIQKE FIEGLFDRMV PLSVEFIRRH
1810 1820 1830 1840 1850
TKELSPTSDT NLVRSLMNLI DCFMDDFADE NKQKERNDRE SFSLLEGIFL
1860 1870 1880 1890 1900
FSLIWSVGAT CTDDDRLKFD KILRELLEGP ISNLTRNKFK LLSGTEQTSS
1910 1920 1930 1940 1950
KVFIVPFPEK GTIYDYQFIP EGLGRWDKWI KDLADTPPIP KDVQFNEIIV
1960 1970 1980 1990 2000
PTLDTIRYSA LMNLLTTHQK PSIFVGPTGT GKSVYIINFL LNQLNKDIYK
2010 2020 2030 2040 2050
PLIVNFSAQT TAAQTQNIIM SKLDKRRKGV FGPPLGKRMI VFVDDVNMPA
2060 2070 2080 2090 2100
REVYGAQPPI ELLRQWLDHW NWYDLKDCSV IKLVDIQIMC AMGPPGGGRN
2110 2120 2130 2140 2150
PITPRYMRHF NIVTINEFSN KSMFTIFSRI LAWHLRTCYK FPDDFLDLTT
2160 2170 2180 2190 2200
QIVNGTMALY KDAMKNLLPT PAKSHYLFNL RDFSRVIQGV CLSRPETAEN
2210 2220 2230 2240 2250
KEAIKRLWVH EVLRVYYDRL VDNADRSWLI NYIQEILKNY MQEDFHDLFK
2260 2270 2280 2290 2300
NLDFNHDGTV EEDDLRSLMF CDFHDPKRED FGYREIANVD ALRMIVEGHL
2310 2320 2330 2340 2350
DEYNNMSKKP MNLVLFRFAI EHISRISRIL KQPRSHALLV GVGGSGRQSV
2360 2370 2380 2390 2400
TRLAAHMADY SLFQVEISKG YGSHEWHEDL KVILRKCAES DMQGVFLFTD
2410 2420 2430 2440 2450
TQIKRESFLE DVNNLLNAGE VPNLFALDEK QEICEKMRQI DRQRDKSKQT
2460 2470 2480 2490 2500
DGSPIALFNM FIDCCRNQLH VVLAMSPIGD AFRIRLRKFP ALVNCCTIDW
2510 2520 2530 2540 2550
FQSWPEDALE AVASRFLEDI EMSEEIREGC IDMCKRFHTS TINLSTSFHN
2560 2570 2580 2590 2600
ELQRYNYVTP TSYLELISTF KLLLEKKRNE VMKMKRRYEV GLDKLDSASS
2610 2620 2630 2640 2650
QVATMQSELE ALHPQLKVAS REVDEMMIII ERESMEVAKT EKIVKADETV
2660 2670 2680 2690 2700
ANDQAMAAKA IKDECDADLA GALPILESAL AALDTLTAQD ITVVKSMKSP
2710 2720 2730 2740 2750
PAGVKLVMEA VCILKGIKAD KIPDPTGSGK KTEDFWGPAK RLLGDIRFLQ
2760 2770 2780 2790 2800
SLHEYDKDNI PPAYMNIIRK SYIPNPDFVP EKIRNASTAA EGLCKWVIAM
2810 2820 2830 2840 2850
DSYDKVAKIV APKKIKLAAA EGKLKVAMEG LRKKQAALHE VQDKLAKLQD
2860 2870 2880 2890 2900
TLELNKQKKA DLEHQVDLCS KKLERAEQLI GGLGGEKTRW SNSALELGHL
2910 2920 2930 2940 2950
YINLTGDILI SSGVVAYLGA FTSNYRQNQT KQWSQSCKER DIPCSDDYSL
2960 2970 2980 2990 3000
MGTLGEAVTI RAWNIAGLPS DSFSIDNGII IMNARRWPLM IDPQGQANKW
3010 3020 3030 3040 3050
IKNMEKTNSL QLIKLSDPSY VRTLENCIQF GTPVLLENVG EELDPILEPL
3060 3070 3080 3090 3100
LLKQTFKQGG STCIRLGDST IEYSPDFRFY ITTKLRNPHY LPETSVKVTL
3110 3120 3130 3140 3150
LNFMITPEGM QDQLLGIVVA RERPDLEEEK QALILQGADN KRQLKEIEDK
3160 3170 3180 3190 3200
ILEVLSLSEG NILEDETAIK ILSSSKSLAN EISQKQEVAE ETEKKIDITR
3210 3220 3230 3240 3250
MGYRPIAIHS SILFFSIADL ANIEPMYQYS LTWFINLFIL SIENSEKSDI
3260 3270 3280 3290 3300
LSKRLQILRD HFTYSLYVNI CRSLFEKDKL LFSFCLTVNL LIHDNAINKT
3310 3320 3330 3340 3350
EWRFLLTGGI GLDNPYTNPC TWLPQKSWDE ICRLDDLPAF KTIREEFMRL
3360 3370 3380 3390 3400
KDGWKKVYDS MEPHHEMFPE DWGNKANDFQ RMLIIRCLRP DKVIPMLQEF
3410 3420 3430 3440 3450
IIKKLGRSFI EPPPFDLAKA FGDSNCCAPL IFVLSPGADP MNALLKFADD
3460 3470 3480 3490 3500
QGYGGSKLSS LSLGQGQGPI AMKMLEKAVK DGTWVVLQNC HLATSWMPTL
3510 3520 3530 3540 3550
EKVCEELSAE STHPDFRIWL TSYPSPNFPV SVLQNGVKMT NEAPKGLRAN
3560 3570 3580 3590 3600
IIRSYLMDPI SDPEFFGSCK KPEEFKKLLY GLCFFHALVQ ERRKFGPLGW
3610 3620 3630 3640 3650
NIPYEFNETD LRISVQQLHM FLDQYEELPY DALRYMTGEC NYGGRVTDDW
3660 3670 3680 3690 3700
DRRTLRSILN KFFCTELVEN PQYKFDSSGI YFVPPSGDHK SYIDYTKTLP
3710 3720 3730 3740 3750
LIPAPEVFGM NANADITKDQ SETQLLFDNI LLTQSHSSGS GTKSSDEVVN
3760 3770 3780 3790 3800
EVAGDILGKL PNNFDVEAAM RRYPTTYTQS MNTVLVQEMG RFNKLLITIR
3810 3820 3830 3840 3850
ESCINIQKAV KGLVVMSTEL EEVVSSILNV KIPAMWMGKS YPSLKPLGSY
3860 3870 3880 3890 3900
VNDFLERLKF LQQWYEVGPP PVFWLSGFFF TQAFLTGAQQ NYARKFTIPI
3910 3920 3930 3940 3950
DLLGFDYEVM DDKEYKKAPE DGVYIHGLFL DGASWDRKTK KLAESHPKVL
3960 3970 3980 3990 4000
YDTVPVMWLK PCKKSDIPRR PSYVAPLYKT SERRGTLSTT GHSTNFVIAM
4010 4020
ILPSVHPKEH WIGRGVALLC QLNS
Length:4,024
Mass (Da):460,904
Last modified:October 3, 2012 - v2
Checksum:i3858F36FCA18A3F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100561 Genomic DNA No translation available.
AC122925 Genomic DNA No translation available.
AC138328 Genomic DNA No translation available.
AC153650 Genomic DNA No translation available.
RefSeqiNP_001238999.1, NM_001252070.1
UniGeneiMm.184692

Genome annotation databases

EnsembliENSMUST00000094964; ENSMUSP00000092571; ENSMUSG00000096141
GeneIDi627872
KEGGimmu:627872
UCSCiuc029qom.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100561 Genomic DNA No translation available.
AC122925 Genomic DNA No translation available.
AC138328 Genomic DNA No translation available.
AC153650 Genomic DNA No translation available.
RefSeqiNP_001238999.1, NM_001252070.1
UniGeneiMm.184692

3D structure databases

ProteinModelPortaliE9Q0T8
SMRiE9Q0T8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092571

PTM databases

iPTMnetiE9Q0T8
PhosphoSitePlusiE9Q0T8

Proteomic databases

MaxQBiE9Q0T8
PaxDbiE9Q0T8
PRIDEiE9Q0T8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094964; ENSMUSP00000092571; ENSMUSG00000096141
GeneIDi627872
KEGGimmu:627872
UCSCiuc029qom.1 mouse

Organism-specific databases

CTDi627872
MGIiMGI:2685838 Dnah7a

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00760000118964
InParanoidiE9Q0T8
KOiK10408
OMAiCGMVYVQ
OrthoDBiEOG091G00FO
TreeFamiTF316836

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000096141 Expressed in 64 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013602 Dynein_heavy_dom-2
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 5 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q0T8_MOUSE
AccessioniPrimary (citable) accession number: E9Q0T8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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