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Protein
Submitted name:

Tensin 1

Gene

Tns1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: MGI

GO - Biological processi

  • cell-substrate junction assembly Source: MGI
  • fibroblast migration Source: MGI
  • intracellular signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Submitted name:
Tensin 1Imported
Gene namesi
Name:Tns1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104552 Tns1

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9Q0S6
PaxDbiE9Q0S6
PeptideAtlasiE9Q0S6
PRIDEiE9Q0S6

PTM databases

iPTMnetiE9Q0S6
PhosphoSitePlusiE9Q0S6

Expressioni

Gene expression databases

BgeeiENSMUSG00000055322 Expressed in 259 organ(s), highest expression level in ascending aorta
ExpressionAtlasiE9Q0S6 baseline and differential
GenevisibleiE9Q0S6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9Q0S6, 4 interactors
STRINGi10090.ENSMUSP00000127715

Structurei

3D structure databases

ProteinModelPortaliE9Q0S6
SMRiE9Q0S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 108Phorbol-ester/DAG-typeInterPro annotationAdd BLAST48
Domaini175 – 347Phosphatase tensin-typeInterPro annotationAdd BLAST173
Domaini352 – 478C2 tensin-typeInterPro annotationAdd BLAST127
Domaini1616 – 1725SH2InterPro annotationAdd BLAST110

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
InParanoidiE9Q0S6
OrthoDBiEOG091G0G8Y
TreeFamiTF315996

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

E9Q0S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCTVSLVCC EALEPLPSCG PQPPGTPPGP ARPERCEPGG AAPDPRRRLL
60 70 80 90 100
LQPEDLEAPK THHFKVKAFK KVKPCGICRQ AITREGCVCK VCSFSCHRKC
110 120 130 140 150
QAKVAAPCVP PSSHELVPIT TETVPKNVVD VGEGDCRVGS SPKNLEEGGS
160 170 180 190 200
MRVSPSIQPQ PQSQPTSLSR NTSVSRAMED SCELDLVYVT ERIIAVSFPS
210 220 230 240 250
TANEENFRSN LREVAQMLKS KHGGNYLLFN LSEQRPDITK LHAKVLEFGW
260 270 280 290 300
PDLHTPALEK ICSVCKAMDT WLNADPHNVV VLHNKGNRGR IGVVIAAYLH
310 320 330 340 350
YSNISASADQ ALDRFAMKRF YEDKIVPIGQ PSQRRYVHYF SGLLSGSIKM
360 370 380 390 400
NNKPLFLHHV IMHGIPNFES KGGCRPFLRI YQAMQPVYTS GIYNIPGDSQ
410 420 430 440 450
ASICITIEPG LLLKGDILLK CYHKKFRSPA RDVIFRVQFH TCAIHDLGVV
460 470 480 490 500
FGKEDLDEAF KDDRFPDYGK VEFVFSYGPE KIQGMEHLEN GPSVSVDYNT
510 520 530 540 550
SDPLIRWDSY DNFSGHREDG MEEVVGHTQG PLDGSLYAKV KKKDSLNGSS
560 570 580 590 600
GPVTTARPAL SATPNHVEHT LSVSSDSGNS TASTKTDKTD EPVSGATTAP
610 620 630 640 650
AALSPQEKKE LDRLLSGFGV DREKQGAMYR AQQLRSHPGG GPTVPSPGRH
660 670 680 690 700
IVPAQVHVNG GALASERETD ILDDELPIQD GQSGGSMGTL SSLDGVTNTS
710 720 730 740 750
ESGYPETLSP LTNGLDKPYS TEPVLNGGGY PYEAANRVIP VHSSHSAPIR
760 770 780 790 800
PSYSAQEGLA GYQREGPHPA WSQQVTSAHC GCDPSGLFRS QSFPDVEPQL
810 820 830 840 850
PQAPTRGGSS REAVQRGLNS WQQQQPHPPP RQQERSPLQS LARSKPSPQL
860 870 880 890 900
SAETPVAALP EFPRAASQQE IEQSIETLNM LMLDLEPASA AAPLHKSQSV
910 920 930 940 950
PGAWPGASPL SSQPLLGSSR QSHPLTQSRS GYIPSGHSLG TPELVSSGRP
960 970 980 990 1000
YSPYDYQLHP AGSNQSFHPK SPASSTFLPS PHSSAGPQEP PASLPGLIAQ
1010 1020 1030 1040 1050
PQLPPKETTS DPSRTPEEEP LNLEGLVAHR VAGVQARERQ PAEPPGPLRR
1060 1070 1080 1090 1100
RAASDGQYEN QSPEATSPRS PGVRSPVQCV SPELALTIAL NPGGRPKEPH
1110 1120 1130 1140 1150
LHSYKEAFEE MEGTSPSSPP HSVARSPPGL AKTPLSALGL KPHNPADILL
1160 1170 1180 1190 1200
HPTGVARRLI QPEEDEGEEV TKPPEEPRSY VESVARTAVA GPRAQDVEPK
1210 1220 1230 1240 1250
SFSAPAAHAY GHETPLRNGT PGGSFVSPSP LSTSSPILSA DSTSVGSFPS
1260 1270 1280 1290 1300
VVSSDQGPRT PFQPMLDSSI RSGSLGQPSP AALSYQSSSP VPVGGSSYNS
1310 1320 1330 1340 1350
PDYSLQPFSS SPESQGQPQY SAASVHMVPG SPQARHRTVG TNTPPSPGFG
1360 1370 1380 1390 1400
RRAVNPTMAA PGSPSLSHRQ VMGPSGPGFH GNVVSGHPAS AATTPGSPSL
1410 1420 1430 1440 1450
GRHPVGSHQV PGLHSSVVTT PGSPSLGRHP GAHQGNLASS LHSNAVISPG
1460 1470 1480 1490 1500
SPSLGRHLGG SGSVVPGSPS LDRHAAYGGY STPEDRRPTL SRQSSASGYQ
1510 1520 1530 1540 1550
APSTPSFPVS PAYYPGLSSP ATSPSPDSAA FRQGSPTPAL PEKRRMSVGD
1560 1570 1580 1590 1600
RAGSLPNYAT INGKVSSSPV ANGMASGSST VSFSHTLPDF SKYSMPDNSP
1610 1620 1630 1640 1650
ETRAKVKFVQ DTSKYWYKPE ISREQAIALL KDQEPGAFII RDSHSFRGAY
1660 1670 1680 1690 1700
GLAMKVSSPP PTITQQGKKG DMTHELVRHF LIETGPRGVK LKGCPNEPNF
1710 1720 1730 1740 1750
GSLSALVYQH SVIPLALPCK LVIPSRDPTD ESKDSSGPAN STTDLLKQGA
1760 1770 1780 1790 1800
ACNVLFVNSV DMESLTGPQA ISKATSETLA ADPTPAATIV HFKVSAQGIT
1810 1820 1830 1840 1850
LTDNQRKLFF RRHYPLNTVT FCDLDPQERK WMKTEGGAPA KLFGFVARKQ
1860 1870 1880
GSTTDNACHL FAELDPNQPA SAIVNFVSKV MLSAGQKR
Length:1,888
Mass (Da):201,383
Last modified:April 5, 2011 - v1
Checksum:i8143843A1BFC2494
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQS0A0A087WQS0_MOUSE
Tensin 1
Tns1
1,867Annotation score:
A0A087WQM0A0A087WQM0_MOUSE
Tensin 1
Tns1
1,823Annotation score:
A0A1D5RM59A0A1D5RM59_MOUSE
Tensin 1
Tns1
1,880Annotation score:
A0A087WRZ8A0A087WRZ8_MOUSE
Tensin 1
Tns1
118Annotation score:
A0A087WS32A0A087WS32_MOUSE
Tensin 1
Tns1
172Annotation score:
Q9DBT6Q9DBT6_MOUSE
Tensin 1
Tns1 Tns
624Annotation score:
A0A087WQ94A0A087WQ94_MOUSE
Tensin 1
Tns1
1,719Annotation score:
A0A087WRU0A0A087WRU0_MOUSE
Tensin 1
Tns1
1,705Annotation score:
A0A087WR29A0A087WR29_MOUSE
Tensin 1
Tns1
142Annotation score:
A0A087WP40A0A087WP40_MOUSE
Tensin 1
Tns1
196Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116419 Genomic DNA No translation available.
AC117757 Genomic DNA No translation available.
RefSeqiNP_082160.3, NM_027884.3
UniGeneiMm.309975

Genome annotation databases

EnsembliENSMUST00000169786; ENSMUSP00000127715; ENSMUSG00000055322
GeneIDi21961
UCSCiuc011wmx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116419 Genomic DNA No translation available.
AC117757 Genomic DNA No translation available.
RefSeqiNP_082160.3, NM_027884.3
UniGeneiMm.309975

3D structure databases

ProteinModelPortaliE9Q0S6
SMRiE9Q0S6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q0S6, 4 interactors
STRINGi10090.ENSMUSP00000127715

PTM databases

iPTMnetiE9Q0S6
PhosphoSitePlusiE9Q0S6

Proteomic databases

MaxQBiE9Q0S6
PaxDbiE9Q0S6
PeptideAtlasiE9Q0S6
PRIDEiE9Q0S6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169786; ENSMUSP00000127715; ENSMUSG00000055322
GeneIDi21961
UCSCiuc011wmx.2 mouse

Organism-specific databases

CTDi7145
MGIiMGI:104552 Tns1

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
InParanoidiE9Q0S6
OrthoDBiEOG091G0G8Y
TreeFamiTF315996

Miscellaneous databases

ChiTaRSiTns1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055322 Expressed in 259 organ(s), highest expression level in ascending aorta
ExpressionAtlasiE9Q0S6 baseline and differential
GenevisibleiE9Q0S6 MM

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q0S6_MOUSE
AccessioniPrimary (citable) accession number: E9Q0S6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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