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Protein
Submitted name:

Keratin 78

Gene

Krt78

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Keratin 78Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Krt78Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917529 Krt78

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filamentPROSITE-ProRule annotationSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q0F0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q0F0

PRoteomics IDEntifications database

More...
PRIDEi
E9Q0F0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050463 Expressed in 72 organ(s), highest expression level in stomach

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q0F0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000126197

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9Q0F0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q0F0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 418IF rodInterPro annotationAdd BLAST314

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili109 – 129Sequence analysisAdd BLAST21
Coiled coili160 – 194Sequence analysisAdd BLAST35
Coiled coili316 – 396Sequence analysisAdd BLAST81

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHY4 Eukaryota
ENOG4111DA8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162461

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q0F0

KEGG Orthology (KO)

More...
KOi
K07605

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVTMPGR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0BSH

TreeFam database of animal gene trees

More...
TreeFami
TF317854

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01276 TYPE2KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q0F0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSPCRAQR GFSAHSACSA FSGARGRTGF SSRSLSSSRR CRGSSCGRAW
60 70 80 90 100
GAETRQGIRF GQGKGGPGFS QCPPGGIQAV TVDQSLLTPL KIEVDPQFQV
110 120 130 140 150
VKTQETREIR SLNNQFASFI DKVRFLEQQN KVLETKWELL QQLQGNRSPQ
160 170 180 190 200
GLECIFETCL ARLRQQLEEL QRERRALDSE LKTYQDQEDE YKSKYDQEAY
210 220 230 240 250
KHASVQNDFV VLKKDVDEVF QSKMDLEGNL ESLKEHVCFL TRLYEEELGQ
260 270 280 290 300
LKTQADDMSV VLSMDNNRCL DFSDIIAEVR ARYEEITRTS KAEAEAVFQT
310 320 330 340 350
KYQELQESAQ LQGNSMKEAQ VQISQLRQAI HRLQSQIGSL RKQNDSLQSA
360 370 380 390 400
IADAEQQGEM AVRDAQAKLD ELEAALRTAK QDMAQMLRDY QELMGTKLSL
410 420 430 440 450
DVEIAMYRRL LESEECRIST EHTSQVTVSI TEGSIVPGRT CGGQVVVPGR
460 470 480 490 500
IGTGQVVMPG RECGGHVVMP GRGSGGQVTI PGRGSGGQVT VPRGECGGQV
510 520 530 540 550
TMPGRGSGGQ VTMPGRGSGG QVTIPGRGSG GQVTVPGRGS GGQVTIPGRG
560 570 580 590 600
SGGQVTIPGR GSGGQVTVPG RGSGGQVTIP GRGSGGQVTI PGRESGGQVT
610 620 630 640 650
IPGRESGGQV TMPGREYGGQ VTIPGRESGG QVTMPGRGSG GQVTMPGRGS
660 670 680 690 700
GGQVTVPGRE YGGQVTVPGR GSGGQVTVPG REYGGQVTVP RGECGGQVTV
710 720 730 740 750
PGREYGGQVT MPRGECGGQV TMPGREYGGQ VTMPGRESGG QVTVPGREYG
760 770 780 790 800
GQVTMPRGEC GGQVTVPGRE YGGQVTMPRG ECGGQVTMPG REYGGQVTVP
810 820 830 840 850
RRECGGQVTV PGREYGGQVT MPGRESGGQV TVPGREYGGQ VTVPRGECGG
860 870 880 890 900
QVTVPGREYG GQVTVPRGEC GGQVTVPGRE YGGQVTMPRG ECGGQVTVPR
910 920 930 940 950
GECGGQVTMP GREYGGQVTV PGREYGGQMT MPGRECGGQE VIPRGECGGQ
960 970 980 990 1000
VVMPGQECGG QAVIPRGDCG SQVVIPREEC GGQVSMPRGE CGGQVGTCGH
1010 1020 1030 1040 1050
RGWQGSFGSG GCSSIVTGGF EIPQGSGYSP TMGSCSVSGS GFSSGSGSSC
1060
RTILKKTVES SRKMSVIY
Length:1,068
Mass (Da):112,265
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEB2FD1589A00F9C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC139844 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_997652.4, NM_212487.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.325105

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000164932; ENSMUSP00000126197; ENSMUSG00000050463

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
332131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:332131

UCSC genome browser

More...
UCSCi
uc007xuh.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139844 Genomic DNA No translation available.
RefSeqiNP_997652.4, NM_212487.4
UniGeneiMm.325105

3D structure databases

ProteinModelPortaliE9Q0F0
SMRiE9Q0F0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126197

Proteomic databases

MaxQBiE9Q0F0
PaxDbiE9Q0F0
PRIDEiE9Q0F0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164932; ENSMUSP00000126197; ENSMUSG00000050463
GeneIDi332131
KEGGimmu:332131
UCSCiuc007xuh.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196374
MGIiMGI:1917529 Krt78

Phylogenomic databases

eggNOGiENOG410IHY4 Eukaryota
ENOG4111DA8 LUCA
GeneTreeiENSGT00940000162461
InParanoidiE9Q0F0
KOiK07605
OMAiQVTMPGR
OrthoDBiEOG091G0BSH
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050463 Expressed in 72 organ(s), highest expression level in stomach
GenevisibleiE9Q0F0 MM

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q0F0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q0F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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