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UniProtKB - E9Q0E2 (E9Q0E2_MOUSE)

Entry version 63 (02 Dec 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

RIKEN cDNA 2700049A03 gene

Gene

2700049A03Rik

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RIKEN cDNA 2700049A03 geneImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:2700049A03RikImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1924217, 2700049A03Rik

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		E9Q0E2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9Q0E2

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9Q0E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000034601, Expressed in oocyte and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9Q0E2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9Q0E2, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9Q0E2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni322 – 370DisorderedSequence analysisAdd BLAST49
Regioni568 – 632DisorderedSequence analysisAdd BLAST65
Regioni759 – 793DisorderedSequence analysisAdd BLAST35
Regioni826 – 848DisorderedSequence analysisAdd BLAST23
Regioni1060 – 1093DisorderedSequence analysisAdd BLAST34
Regioni1145 – 1170DisorderedSequence analysisAdd BLAST26
Regioni1184 – 1230DisorderedSequence analysisAdd BLAST47
Regioni1412 – 1432DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili487 – 514Sequence analysisAdd BLAST28
Coiled coili928 – 948Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi351 – 370PolyampholyteSequence analysisAdd BLAST20
Compositional biasi582 – 620PolarSequence analysisAdd BLAST39
Compositional biasi1193 – 1207Pro-richSequence analysisAdd BLAST15
Compositional biasi1214 – 1230PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012397

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004577_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029246, TALPID3

The PANTHER Classification System

More...PANTHERi		PTHR15721, PTHR15721, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15324, TALPID3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q0E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNVEFSLER GQRLKMPARK LREIVSPNQG NKLAVVEDEL PRVPPALAAN 
        60         70         80         90        100
KRLAVETRTS SNGTLCGSLD LTSARLYHQP LLESPPASKK SDFSKDAVVR 
       110        120        130        140        150
QLPLNKTEEN NAPKANDIFI SQYTMGQKDA LRTVLKQKAQ SMPVFKAVKV 
       160        170        180        190        200
HLFEDTSTEK NTVAQETETP PNRIDSATTV AAATAAAIAT AAPLIKVQSD 
       210        220        230        240        250
LEAKVNCVGE LLTKLQETDK QLQRVTEHQA SVQSKQEKVH CHDHDKQMNA 
       260        270        280        290        300
FMEQHIRHLE KLQQQQIDIQ THFIDAALKA SSLQLGMSTS RAVGKYSGKL 
       310        320        330        340        350
GSPSVGSSVF SHNTFVSKRV PLSEDTDFDG QKSPLETPAP RRFAPVPVSR 
       360        370        380        390        400
DGKITKRESP TEEKENMEMN SPKGNVRLLE QVLNSNECLT RKTESSDITS 
       410        420        430        440        450
LTQPKMGWNL EKRDSTETLH SQIFPSSEER GTAQVPVPKY NDVVHDLGQK 
       460        470        480        490        500
KQASDMLQIK QSPVTLRLSD HPHNPALLQT TNTRSVLKDA AKILRGVQNN 
       510        520        530        540        550
KKVLEENLEA IVRAKDGAAM YSFINALATN REMSEKIRIR KQVDEWIKII 
       560        570        580        590        600
SAEIQDELMR KDYEQKRFDP KNQRNKKALT MSRDIKANNQ EKTVNRSVIP 
       610        620        630        640        650
RSHYQKQTQE QFTSPPVRNL PASGPQKERS GLLKSATTLQ DEDYMLQIYG 
       660        670        680        690        700
KPVYQGHRST LKKGPYLRFS SPSPKAKPQR PRVIELVKGT KVKSAKTQTD 
       710        720        730        740        750
FHAASRMKMD SKIQHPITAL PHADQQYMVS PSREMPTVSG TLEGHLIPMA 
       760        770        780        790        800
ILLGQTQSNS DSMPPAGVTV NKPRPVTVTT SIPPASRKGN AGVKKPNVAI 
       810        820        830        840        850
VEMKSEKKDP PQLSVQILPS VDIDSVSYSS TDGASSPPSP KEASLPPLHT 
       860        870        880        890        900
WIQTPDFMKV DEEEVPLPGT NFDEVIDVIQ EEEKRDEIPE CSAPMLEFNR 
       910        920        930        940        950
SVKVVPTKYN GPSFPPVVSA YHPTTDILDK VIERKETLEN SLIQWVEQEI 
       960        970        980        990       1000
MSRIISGLFP LQQQARLDAS VSVSEASEPS ASDIVAGTSS GALQRMVDAR 
      1010       1020       1030       1040       1050
VPVNSDMVSH FVNEALTETI AVMLADREAE RQRAAATSVP GDLSGTETNL 
      1060       1070       1080       1090       1100
LARVCAPVAT PQPTPPCSPS PVREHVRVKT PDSSPCESDP DAASSIKEIR 
      1110       1120       1130       1140       1150
VEKGSDMPAV MLVSTPTRTP VATPPPAAAL TPTLSETSID KLKLSSPELP 
      1160       1170       1180       1190       1200
KPWDSGDLPL DEENPNSLQE LPHPRAVVMS VANEEPESVD FSAQPAPPEP 
      1210       1220       1230       1240       1250
APSAPLPEGT KAPSLQRVPS SGSSTLENTL STVTETETLD RHISEGEILF 
      1260       1270       1280       1290       1300
SCGQNLATKR PGDLFLMNIN DSLSSTLQDA LEMEDDPPSE GQVIRRPHKK 
      1310       1320       1330       1340       1350
RHEDAIVALL TKQQRELLVS QQEEDLDNSV GELSEGQRLV LKAAEDISAG 
      1360       1370       1380       1390       1400
PSGQMLPPTS PAEPSYQHAD PRLVLQQSDM ASGGPADLLL IAHVSPARMS 
      1410       1420       1430 
VTLPSANLED CSQSLSTSSM HGGTESSGTD TF
Length:1,432
Mass (Da):156,906
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE94286C9D51385C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV87TALD3_MOUSE
Protein TALPID3
Talpid3
1,520Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZIY2F6ZIY2_MOUSE
RIKEN cDNA 2700049A03 gene
2700049A03Rik
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC159620 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_084094.1, NM_029818.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000045907; ENSMUSP00000044701; ENSMUSG00000034601

Database of genes from NCBI RefSeq genomes

More...GeneIDi		76967

UCSC genome browser

More...UCSCi		uc007nuo.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159620 Genomic DNA No translation available.
RefSeqiNP_084094.1, NM_029818.1

3D structure databases

SMRiE9Q0E2
ModBaseiSearch...

Proteomic databases

EPDiE9Q0E2
jPOSTiE9Q0E2
MaxQBiE9Q0E2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		21, 13 antibodies

Genome annotation databases

EnsembliENSMUST00000045907; ENSMUSP00000044701; ENSMUSG00000034601
GeneIDi76967
UCSCiuc007nuo.2, mouse

Organism-specific databases

MGIiMGI:1924217, 2700049A03Rik

Phylogenomic databases

GeneTreeiENSGT00390000012397
HOGENOMiCLU_004577_0_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		76967, 3 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		2700049A03Rik, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000034601, Expressed in oocyte and 195 other tissues
ExpressionAtlasiE9Q0E2, baseline and differential
GenevisibleiE9Q0E2, MM

Family and domain databases

InterProiView protein in InterPro
IPR029246, TALPID3
PANTHERiPTHR15721, PTHR15721, 2 hits
PfamiView protein in Pfam
PF15324, TALPID3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q0E2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q0E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 2, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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