UniProtKB - E9PZZ1 (PRD13_MOUSE)
Protein
PR domain zinc finger protein 13
Gene
Prdm13
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 185 – 207 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 620 – 642 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 648 – 670 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 677 – 700 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin binding Source: MGI
- chromatin DNA binding Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
- histone methyltransferase activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: MGI
- neurogenesis Source: MGI
Keywordsi
Molecular function | DNA-binding, Methyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: PR domain zinc finger protein 13 (EC:2.1.1.-)Alternative name(s): PR domain-containing protein 13 |
Gene namesi | Name:Prdm13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2448528 Prdm13 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416115 | 1 – 754 | PR domain zinc finger protein 13Add BLAST | 754 |
Proteomic databases
PaxDbi | E9PZZ1 |
PeptideAtlasi | E9PZZ1 |
PRIDEi | E9PZZ1 |
PTM databases
PhosphoSitePlusi | E9PZZ1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040478 Expressed in 8 organ(s), highest expression level in neural tube ventricular layer |
Structurei
3D structure databases
ProteinModelPortali | E9PZZ1 |
SMRi | E9PZZ1 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 160 | SETPROSITE-ProRule annotationAdd BLAST | 122 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 312 – 383 | Gly-richAdd BLAST | 72 | |
Compositional biasi | 384 – 398 | His-richAdd BLAST | 15 | |
Compositional biasi | 482 – 487 | Poly-Gly | 6 | |
Compositional biasi | 538 – 557 | Ala-richAdd BLAST | 20 | |
Compositional biasi | 602 – 610 | Poly-Gly | 9 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 185 – 207 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 620 – 642 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 648 – 670 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 677 – 700 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000160200 |
HOGENOMi | HOG000049198 |
HOVERGENi | HBG053667 |
InParanoidi | E9PZZ1 |
OrthoDBi | 1318335at2759 |
TreeFami | TF106398 |
Family and domain databases
InterProi | View protein in InterPro IPR001214 SET_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF00096 zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667 SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50280 SET, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: E9PZZ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPAHVTPRTE DARRGAGPSS ACGCSWFCHL RPVEDPASPS VCLAAVATMH
60 70 80 90 100
GTSRTSATSV NADCCIPAGL RLGPVPGTFK LGKYLSDRRE PGPKKKVRMV
110 120 130 140 150
RGELVDESGG SPLEWIGLIR AARNPQEQTL EAIADLPGGQ IFYRALRDVQ
160 170 180 190 200
PGEELTVWYS NSLAQWFDIP TTATPTHDEK GEERYICWYC WRTFRYPNSL
210 220 230 240 250
KAHLRFHCVL SGGGGRAFLP QEHAARPGAS PVAEGLGLPP KPTVPDLTAP
260 270 280 290 300
VQAIALRPQA PAAQLAQACG ARESIKREAS LAPLATSPPP GKWGTPKKGK
310 320 330 340 350
EQPDRAHSQF LGIVGGSSGG GGGLPFYPGV RSAFKPAGLA RAAAQSDPYR
360 370 380 390 400
EEGGGKGPGL ALGRLLGGGR AGGRPGSGES PAGHHHHHHH AHHHHHHHPK
410 420 430 440 450
CLLAGEPPPA GLPCPGALRA FPLLAGHPEE ASAFKHVERA PPAAATTSLP
460 470 480 490 500
SARYAALPAP GLPVERCALQ PLDGGSLKAY PGGGGGGECS PLPAVMPAFT
510 520 530 540 550
VYSGDLLYGP PAAYYPLKLH LGGLLKYPES ISYLSGPAAA AAAAAAAAAA
560 570 580 590 600
AAAIGPAELG SLASIDREIA MHTQQLSEMA AGKSRARLDS GTLPPAVVAA
610 620 630 640 650
TGPGGGGGGG SAAGKPKTGH LCLYCGKLYS RKYGLKIHMR THTGYKPLKC
660 670 680 690 700
KVCLRPFGDP SNLNKHIRLH AEGNTPYRCE FCGKVLVRRR DLERHVKSRH
710 720 730 740 750
PGQSLMAKAG DGPGPEPSYA LEPGDPKSED SDVDVCFTDD QSDPEAGGRG
EHDS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042506 | 1 – 48 | Missing in isoform 2. CuratedAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672159 Genomic DNA No translation available. |
CCDSi | CCDS38699.1 [E9PZZ1-1] |
RefSeqi | NP_001074240.1, NM_001080771.1 [E9PZZ1-1] |
UniGenei | Mm.208541 |
Genome annotation databases
Ensembli | ENSMUST00000076206; ENSMUSP00000075562; ENSMUSG00000040478 [E9PZZ1-2] ENSMUST00000095141; ENSMUSP00000092761; ENSMUSG00000040478 [E9PZZ1-1] |
GeneIDi | 230025 |
KEGGi | mmu:230025 |
UCSCi | uc008sco.1 mouse [E9PZZ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672159 Genomic DNA No translation available. |
CCDSi | CCDS38699.1 [E9PZZ1-1] |
RefSeqi | NP_001074240.1, NM_001080771.1 [E9PZZ1-1] |
UniGenei | Mm.208541 |
3D structure databases
ProteinModelPortali | E9PZZ1 |
SMRi | E9PZZ1 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000092761 |
PTM databases
PhosphoSitePlusi | E9PZZ1 |
Proteomic databases
PaxDbi | E9PZZ1 |
PeptideAtlasi | E9PZZ1 |
PRIDEi | E9PZZ1 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000076206; ENSMUSP00000075562; ENSMUSG00000040478 [E9PZZ1-2] ENSMUST00000095141; ENSMUSP00000092761; ENSMUSG00000040478 [E9PZZ1-1] |
GeneIDi | 230025 |
KEGGi | mmu:230025 |
UCSCi | uc008sco.1 mouse [E9PZZ1-1] |
Organism-specific databases
CTDi | 59336 |
MGIi | MGI:2448528 Prdm13 |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000160200 |
HOGENOMi | HOG000049198 |
HOVERGENi | HBG053667 |
InParanoidi | E9PZZ1 |
OrthoDBi | 1318335at2759 |
TreeFami | TF106398 |
Miscellaneous databases
PROi | PR:E9PZZ1 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040478 Expressed in 8 organ(s), highest expression level in neural tube ventricular layer |
Family and domain databases
InterProi | View protein in InterPro IPR001214 SET_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF00096 zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667 SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50280 SET, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | PRD13_MOUSE | |
Accessioni | E9PZZ1Primary (citable) accession number: E9PZZ1 Secondary accession number(s): B1AV74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2012 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 16, 2019 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot