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Protein
Submitted name:

Desmoplakin

Gene

Dsp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DesmoplakinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DspImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109611 Dsp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PZW0

PeptideAtlas

More...
PeptideAtlasi
E9PZW0

PRoteomics IDEntifications database

More...
PRIDEi
E9PZW0

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9PZW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054889 Expressed in 270 organ(s), highest expression level in skin epidermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PZW0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PZW0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PZW0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini470 – 527SH3InterPro annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili147 – 167Sequence analysisAdd BLAST21
Coiled coili331 – 351Sequence analysisAdd BLAST21
Coiled coili423 – 453Sequence analysisAdd BLAST31
Coiled coili721 – 741Sequence analysisAdd BLAST21
Coiled coili1039 – 1059Sequence analysisAdd BLAST21
Coiled coili1067 – 1108Sequence analysisAdd BLAST42
Coiled coili1116 – 1164Sequence analysisAdd BLAST49
Coiled coili1183 – 1332Sequence analysisAdd BLAST150

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154843

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028462 Desmoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR44773 PTHR44773, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681 Plectin, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250 PLEC, 18 hits
SM00150 SPEC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399 SSF75399, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PZW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT
60 70 80 90 100
FYSHSRRCTV NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI
110 120 130 140 150
AQPELKFGEG MQLAWNRELD EYFTQANDQM EIIDGLIREM RQMGQPCDAY
160 170 180 190 200
QKRLLQLQEQ MRALYKAISV PRVRRASSKG AGGYTCQSGS GWDEFTKRLT
210 220 230 240 250
GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI GDYRWQLDKI
260 270 280 290 300
KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND
310 320 330 340 350
CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL
360 370 380 390 400
NQHPASDKIE AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST
410 420 430 440 450
EAYLKGLQDS IRKKYPCDKN MPLQHLLEQI KELEKEREKI IEYKRQVQNL
460 470 480 490 500
VNKSKKIVQL KPRNPDYRSN KPIILRALCD YKQDQKIVHK GDECILKDNN
510 520 530 540 550
ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ YYEAILALWN
560 570 580 590 600
QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ
610 620 630 640 650
DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT
660 670 680 690 700
EITHLGTCQD VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL
710 720 730 740 750
KNLLLAEQGS THHITVKINE LKSVQNDSQA LAEVLNQLKD MLANFRGSEK
760 770 780 790 800
YCYLQNEIFG LFQKLENING VSDGYLNSLC SVRALLQAIL QTEDMLKVYE
810 820 830 840 850
ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM KTELQKAQQI
860 870 880 890 900
HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL
910 920 930 940 950
RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS
960 970 980 990 1000
GKRDKSEEVH KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP
1010 1020 1030 1040 1050
SGVILQEAAD IHARYIELLT RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE
1060 1070 1080 1090 1100
EELRLARDAN SENCNKNKFL DQNLQKYQAE CSQFKAKLVS LEELKRQAEL
1110 1120 1130 1140 1150
DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV EDRFDQQKND
1160 1170 1180 1190 1200
YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY
1210 1220 1230 1240 1250
ENELAKASNR IQESKSQCTQ VVQERESLLV KIKVLEQDKA RLQRLEDELN
1260 1270 1280 1290 1300
RAKATLEAES RVKQRLECEK QQIQNDLNQW KTQYSRKEET IRKIESEREK
1310 1320 1330 1340 1350
SEREKNSLRS EIERLQAEIK RIEERCRRKL EDSSRETQSQ LESERCRLQK
1360 1370 1380 1390 1400
EIEKLRQRPY GSHRETQTEY EWTVDSSKLV FDGLRKKVTA MQLYECQLID
1410 1420 1430 1440 1450
KTTLDKLLKG KKSVEEVASE IQPFLRGAGA IAGASASPKE KYSLVEAKRK
1460 1470 1480 1490 1500
KFITPESTVM LLEAQAATGG IIDPHRNEKL TVDNAVARDL IDFDDRQQIY
1510 1520 1530 1540 1550
TAEKAITGFD DPFSGKTVSV SEAIKKNLID RETGMRLLEA QLASGGVVDP
1560 1570 1580 1590 1600
VNSVFLPKDV ALARGLIDRD LYRSLNDPRD SQKNFVDPIT KKKVSYMQLR
1610 1620 1630 1640 1650
ERCRIEPHTG LLLLSVQKRS MSFQGIRQPV TVTELVDSGI LRPSTVNELE
1660 1670 1680 1690 1700
SGQISYDEVG ERIKDFLQGS SCIAGIYNET TKQKLGIYEA MKIGLVRPGT
1710 1720 1730 1740 1750
ALELLEAQAA TGFIVDPVSN LRLPVEEAYK RGLVGIEFKE KLLSAERAVT
1760 1770 1780 1790 1800
GYNDPETGNI ISLFQAMNKE LIEKGHGIRL LEAQIATGGI IDPKESHRLP
1810 1820 1830 1840 1850
VDMAYKRGYF NEELSEILSD PSDDTKGFFD PNTEENLTYL QLKERCIKDE
1860 1870 1880 1890 1900
ETGLCLLPLK EKKKQVQTSQ KNTLRKRRVV IVDPETNKEM SVQEAYKKGL
1910 1920 1930 1940 1950
IDYDTFKELC EQECEWEEIT ITGSDGSTRV VLVDRKTGSQ YDIQDAIDKG
1960 1970 1980 1990 2000
LVDRKFFDQY RSGSLSLTQF ADMISLKNGV GNSSGLGGSV NDDVFSSSRH
2010 2020 2030 2040 2050
DSVSKISTIS SVRNLTIRSS SLSDPLEESS PIAAIFDTEN LEKISIAEGI
2060 2070 2080 2090 2100
ERGIVDSITG QRLLEAQACT GGIIHPTTGQ KLSLQDAVNQ GLIDQDMATR
2110 2120 2130 2140 2150
LKPAQKAFIG FEGVKGKKKM SAAEAVKEKW LPYEAGQRFL EFQFLTGGLV
2160 2170 2180 2190 2200
DPEVHGRIST EEAIRKGFID GRAAQRLQDI SSYAKILTCP KTKLKISYKD
2210 2220 2230 2240 2250
AMNRSMVEDI TGLRLLEAAS VSSKGLPSPY NMSAPGSRSG SRSGSRSGSR
2260 2270 2280
SGSRSGSRRG SFDATGNSSY SYSYSFSSSS IGGY
Length:2,284
Mass (Da):261,420
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C5DB16985159434
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q557DESP_MOUSE
Desmoplakin
Dsp
2,883Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC140331 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006516595.1, XM_006516532.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.355327

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000127906; ENSMUSP00000117252; ENSMUSG00000054889

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109620

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140331 Genomic DNA No translation available.
RefSeqiXP_006516595.1, XM_006516532.3
UniGeneiMm.355327

3D structure databases

ProteinModelPortaliE9PZW0
SMRiE9PZW0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiE9PZW0

Proteomic databases

MaxQBiE9PZW0
PeptideAtlasiE9PZW0
PRIDEiE9PZW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000127906; ENSMUSP00000117252; ENSMUSG00000054889
GeneIDi109620

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1832
MGIiMGI:109611 Dsp

Phylogenomic databases

GeneTreeiENSGT00940000154843

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dsp mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054889 Expressed in 270 organ(s), highest expression level in skin epidermis
ExpressionAtlasiE9PZW0 baseline and differential

Family and domain databases

Gene3Di3.90.1290.10, 3 hits
InterProiView protein in InterPro
IPR028462 Desmoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR44773 PTHR44773, 2 hits
PfamiView protein in Pfam
PF00681 Plectin, 8 hits
SMARTiView protein in SMART
SM00250 PLEC, 18 hits
SM00150 SPEC, 2 hits
SUPFAMiSSF75399 SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PZW0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PZW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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