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UniProtKB - E9PZQ0 (RYR1_MOUSE)

Protein

Ryanodine receptor 1

Gene

Ryr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:7515481, PubMed:7621815, PubMed:21156754). Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain (PubMed:22036948). Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481). Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481).6 Publications

Activity regulationi

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity (PubMed:7621815). Channel activity is regulated by calmodulin (CALM). The calcium release is activated by increased cytoplasmic calcium levels, by nitric oxyde (NO), caffeine and ATP (PubMed:7621815, PubMed:22036948, PubMed:21156754). Channel activity is inhibited by magnesium ions, possibly by competition for calcium binding sites.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3896CalciumBy similarity1
Metal bindingi3970CalciumBy similarity1
Binding sitei4714CaffeineBy similarity1
Metal bindingi4999Calcium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4214 – 4218ATPBy similarity5
Nucleotide bindingi4952 – 4957ATPBy similarity6
Nucleotide bindingi4977 – 4983ATPBy similarity7

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • calcium channel activity Source: UniProtKB
  • calcium-induced calcium release activity Source: MGI
  • calcium ion binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB-KW
  • enzyme binding Source: BHF-UCL
  • protease binding Source: UniProtKB
  • ryanodine-sensitive calcium-release channel activity Source: UniProtKB
  • voltage-gated calcium channel activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels
R-MMU-5578775 Ion homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Ryanodine receptor 1
Short name:
RYR-1
Short name:
RyR1
Alternative name(s):
Skeletal muscle calcium release channel
Skeletal muscle ryanodine receptor
Skeletal muscle-type ryanodine receptor
Type 1 ryanodine receptor
Gene namesi
Name:Ryr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99659 Ryr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4556CytoplasmicBy similarityAdd BLAST4556
Transmembranei4557 – 4577Helical; Name=1By similarityAdd BLAST21
Topological domaini4578 – 4638LumenalBy similarityAdd BLAST61
Transmembranei4639 – 4659Helical; Name=2By similarityAdd BLAST21
Topological domaini4660 – 4777CytoplasmicBy similarityAdd BLAST118
Transmembranei4778 – 4800Helical; Name=3By similarityAdd BLAST23
Topological domaini4801LumenalBy similarity1
Transmembranei4802 – 4818Helical; Name=4By similarityAdd BLAST17
Topological domaini4819 – 4833CytoplasmicBy similarityAdd BLAST15
Transmembranei4834 – 4854Helical; Name=5By similarityAdd BLAST21
Topological domaini4855 – 4877LumenalBy similarityAdd BLAST23
Intramembranei4878 – 4897Pore-formingBy similarityAdd BLAST20
Topological domaini4898 – 4917LumenalBy similarityAdd BLAST20
Transmembranei4918 – 4938Helical; Name=6By similarityAdd BLAST21
Topological domaini4939 – 5035CytoplasmicBy similarityAdd BLAST97

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Perinatal lethality, due to severe defects in skeletal muscle development. Neonates do not breathe and do not move. Mutant mice show defects in muscle fiber development. Their muscles do not show a contractile response to electrical stimulation. In addition, mice display abnormal curvature of the spine, thin limbs, and an abnormal rib cage.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi165R → C: Increased channel activity, leading to permanently increased cytoplasmic Ca(2+) levels. Increased activation by calcium, and increased ryanodine binding. 1 Publication1
Mutagenesisi4895I → T: Causes paralysis and perinatal death in homozygous mice, apparently due to asphyxia. Mutant mice have greatly reduced and amorphous skeletal muscle. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2133

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004155661 – 5035Ryanodine receptor 1Add BLAST5035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1339PhosphoserineBy similarity1
Modified residuei2346PhosphoserineBy similarity1
Modified residuei2844Phosphoserine; by PKA and PKGCombined sources2 Publications1
Modified residuei3636S-nitrosocysteineBy similarity1
Modified residuei4464PhosphothreonineBy similarity1
Modified residuei4468PhosphoserineBy similarity1
Modified residuei4861PhosphotyrosineBy similarity1
Modified residuei4864PhosphoserineBy similarity1

Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2844 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2844.2 Publications
Activated by reversible S-nitrosylation (PubMed:22036948). Repeated very high-level exercise increases S-nitrosylation.By similarity2 Publications

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

MaxQBiE9PZQ0
PaxDbiE9PZQ0
PeptideAtlasiE9PZQ0
PRIDEiE9PZQ0

PTM databases

iPTMnetiE9PZQ0
PhosphoSitePlusiE9PZQ0

Expressioni

Tissue specificityi

Detected in muscle and myotubes (at protein level) (PubMed:18003898). Ubiquitous. Detected in diaphragm, skeletal muscle, esophagus, spleen, submaxillary gland, adrenal gland, cerebellum, brain and in testis germ cells.5 Publications

Gene expression databases

BgeeiENSMUSG00000030592 Expressed in 142 organ(s), highest expression level in knee joint
ExpressionAtlasiE9PZQ0 baseline and differential
GenevisibleiE9PZQ0 MM

Interactioni

Subunit structurei

Homotetramer (PubMed:18003898). Can also form heterotetramers with RYR2 (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (PubMed:18268335). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1) (PubMed:18268335). Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity (By similarity). Interacts with S100A1 (By similarity). Interacts with FKBP1A; this stabilizes the closed conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity. Interacts with SELENON (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortaliCPX-3092 Ryanodine 1 complex
DIPiDIP-29705N
IntActiE9PZQ0, 29 interactors
MINTiE9PZQ0
STRINGi10090.ENSMUSP00000137123

Chemistry databases

BindingDBiE9PZQ0

Structurei

3D structure databases

ProteinModelPortaliE9PZQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 154MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini161 – 206MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini212 – 266MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini272 – 329MIR 4PROSITE-ProRule annotationAdd BLAST58
Domaini337 – 394MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini583 – 799B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST217
Repeati843 – 9561Add BLAST114
Repeati957 – 10702Add BLAST114
Domaini1015 – 1210B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST196
Repeati1346 – 13613; truncatedAdd BLAST16
Domaini1359 – 1572B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST214
Repeati1374 – 13894; truncatedAdd BLAST16
Repeati2727 – 28465Add BLAST120
Repeati2847 – 29606Add BLAST114
Domaini4078 – 4106EF-handPROSITE-ProRule annotationAdd BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni671 – 682Interaction with FKBP1ABy similarityAdd BLAST12
Regioni843 – 29606 X approximate repeatsAdd BLAST2118
Regioni3615 – 3644Interaction with CALMBy similarityAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi4892 – 4898Selectivity filterBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1869 – 2089Glu-richAdd BLAST221
Compositional biasi3683 – 3762Glu-richAdd BLAST80
Compositional biasi4459 – 4525Pro-richAdd BLAST67

Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum (SR) and the T-tubule (PubMed:7621815, PubMed:7724570). Pore opening is mediated via the cytoplasmic calcium-binding domains that mediate a small rotation of the channel-forming transmembrane regions that then leads to channel opening (By similarity).By similarity2 Publications

Sequence similaritiesi

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00760000119152
HOGENOMiHOG000231428
HOVERGENiHBG102939
InParanoidiE9PZQ0
KOiK04961
OrthoDBiEOG091G00T0
TreeFamiTF315244

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715 PTHR13715, 1 hit
PTHR13715:SF15 PTHR13715:SF15, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PZQ0-1 [UniParc]FASTAAdd to basket
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        10         20         30         40         50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL 
        60         70         80         90        100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR 
       110        120        130        140        150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT 
       160        170        180        190        200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL 
       210        220        230        240        250
WNMNPICSGC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG 
       260        270        280        290        300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLGLTEDQGL 
       310        320        330        340        350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ 
       360        370        380        390        400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ 
       410        420        430        440        450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI 
       460        470        480        490        500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT 
       510        520        530        540        550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS 
       560        570        580        590        600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV 
       610        620        630        640        650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF 
       660        670        680        690        700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG 
       710        720        730        740        750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLA PEDVVSCCLD 
       760        770        780        790        800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE 
       810        820        830        840        850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL 
       860        870        880        890        900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD 
       910        920        930        940        950
NKRLHPCLVN FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN 
       960        970        980        990       1000
LKKTKLPKTY MMSNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD 
      1010       1020       1030       1040       1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY 
      1060       1070       1080       1090       1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGE 
      1110       1120       1130       1140       1150
MRVGWARPEL RPDVELGADD LAYVFNGHRG QRWHLGSEPF GRPWQSGDVV 
      1160       1170       1180       1190       1200
GCMIDLTENT IIFTLNGEVL MSDSGSETAF RDIEIGDGFL PVCSLGPGQV 
      1210       1220       1230       1240       1250
GHLNLGQDVS SLRFFAICGL QEGFEPFAIN MQRPVTTWFS KSLPQFEPVP 
      1260       1270       1280       1290       1300
LEHPHYEVAR MDGTVDTPPC LRLTHRTWGS QNSLVEMLFL RLSLPVQFHQ 
      1310       1320       1330       1340       1350
HFRCTAGATP LASPGLQPPA EDEARAAEPD TDYENLRRSA GGWGEAEGGK 
      1360       1370       1380       1390       1400
DGTAKEGTPG GTAQAGVEAQ PARAENEKDA TTEKNKKRGF LFKAKKVAMM 
      1410       1420       1430       1440       1450
TQPPSTPALP RLPRDVVPAD NRDDPEIILN TTTYYYSVRV FAGQEPSCVW 
      1460       1470       1480       1490       1500
VGWVTPDYHQ HDMSFDLSKV RAVTVTMGDE QGNVHSSLKC SNCYMVWGGD 
      1510       1520       1530       1540       1550
FVSPGQQGRI SHTDLVIGCL VDLATGLMTF TANGKESNTF FQVEPNTKLF 
      1560       1570       1580       1590       1600
PAVFVLPTHQ NVVQFELGKQ KNIMPLSAAM FLSERKNPAP QCPPRLEVQM 
      1610       1620       1630       1640       1650
LMPVSWSRMP NHFLQVDTRR AGERLGWAVQ CQEPLMMMAL HIPEENRCMD 
      1660       1670       1680       1690       1700
ILELSERLDL QRFHSHTLSL YRSVCALGNN RVAHALCSHV DQAQLLHALE 
      1710       1720       1730       1740       1750
DARLPGPLRA GYYDLLISIH LESACRSRRS MLSEYIVPLT PETRAITLFP 
      1760       1770       1780       1790       1800
PGRSAEDGPR RHGLPGVGVT TSLRPPHHFS PPCFVVALPA AGATEAPARL 
      1810       1820       1830       1840       1850
SPAIPLEALR DKALRMLGEA VRDGGQHARD PVGGSVEFQF VPVLKLVSTL 
      1860       1870       1880       1890       1900
LVMGVFSDED VKQILKMIEP EVFREEEEVE EEGEEEEEDE EEKEEDEEEE 
      1910       1920       1930       1940       1950
AHEKEDEEKE EAEDAAEEEK EELEEGLLQM KLPESVKLQM CHLLEYFCDQ 
      1960       1970       1980       1990       2000
ELQHRVESLA AFAECYVDKM QGNQRGRYGL LMKAFTMSAA ETARRTREFR 
      2010       2020       2030       2040       2050
SPPQEQINML LHFKNGADEE ECPLPEEIRQ ELVNFHQDLL AHCGIQLEGE 
      2060       2070       2080       2090       2100
EEEPEEESTL GSRLMSLLEK VKLVKKTEEK PEEEPAPEEH KPQSLQELVS 
      2110       2120       2130       2140       2150
HTVVRWAQED FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISVSSV 
      2160       2170       2180       2190       2200
EDTMSLLECL GQIRSLLIVQ MGPQEENLMI QSIGNIMNNK VFYQHPNLMR 
      2210       2220       2230       2240       2250
ALGMHETVME VMVNVLGGGE SKEIRFPKMV TSCCRFLCYF CRISRQNQRS 
      2260       2270       2280       2290       2300
MFDHLSYLLE NSGIGLGMQG STPLDVAAAS VIDNNELALA LQEQDLEKVV 
      2310       2320       2330       2340       2350
SYLAGCGLQS CPMLLAKGYP DIGWNPCGGE RYLDFLRFAV FVNGESVEEN 
      2360       2370       2380       2390       2400
ANVVVRLLIR KPECFGPALR GEGGSGLLAA IEEAIRISED PARDGPGVRR 
      2410       2420       2430       2440       2450
DRRREHFGEE PPEENRVHLG HAIMSFYAAL IDLLGRCAPE THLIQAGKGE 
      2460       2470       2480       2490       2500
ALRIRAILRS LVPLDDLVGI ISLPLQIPTL GKDGALVQPK MSASFVPDHK 
      2510       2520       2530       2540       2550
ASMVLFLDRV YGIENQDFLL HVLDVGFLPD MRAAASLDTA TFSTTEMALA 
      2560       2570       2580       2590       2600
LNRYLCLAVL PLITKCAPLF AGTEHRAIMV DSMLHTVYRL SRGRSLTKAQ 
      2610       2620       2630       2640       2650
RDVIEDCLMA LCRYIRPSML QHLLRRLVFD VPILNEFAKM PLKLLTNHYE 
      2660       2670       2680       2690       2700
RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDQELYRIA 
      2710       2720       2730       2740       2750
MPCLCAIAGA LPPDYVDASY SSKTEKKATV DAEGNFDPRP VETLNVIIPE 
      2760       2770       2780       2790       2800
KLDSFINKFA EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE 
      2810       2820       2830       2840       2850
KDKEIYRWPI KESLKAMIAW EWTVEKAREG EEEKTEKKKT RKISQTAQTY 
      2860       2870       2880       2890       2900
DPREGYNPQP PDLSVVTLSR ELQAMAEQLA ENYHNTWGRK KKQELEAKGG 
      2910       2920       2930       2940       2950
GSHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR GLKDMELDTS 
      2960       2970       2980       2990       3000
SIEKRFAFGF LQQLLRWMDI SQEFIAHLEA VVSSGRVEKS PHEQEIKFFA 
      3010       3020       3030       3040       3050
KILLPLINQY FTNHCLYFLS TPAKVLGSGG HASNKEKEMI TSLFCKLAAL 
      3060       3070       3080       3090       3100
VRHRVSLFGT DAPAVVNCLH ILARSLDART VMKSGPEIVK AGLRSFFESA 
      3110       3120       3130       3140       3150
SEDIEKMVEN LRLGKVSQAR TQVKGVGQNL TYTTVALLPV LTTLFQHIAQ 
      3160       3170       3180       3190       3200
HQFGDDVILD DVQVSCYRTL CSIYSLGTTR NPYVEKLRPA LGECLARLAA 
      3210       3220       3230       3240       3250
AMPVAFLEPE LNEYNACSVY TTKSPRERAI LGLPNSVEEM CPDIPVLERL 
      3260       3270       3280       3290       3300
MAEIGGLAES GARYTEMPHV IEITLPMLCS YLPRWWERGP EAPPPALPAG 
      3310       3320       3330       3340       3350
APPPCTAVTS DHLNSLLGNI LRIIVNNLGI DEASWMKRLA VFAQPIVSRA 
      3360       3370       3380       3390       3400
RPELLRSHFI PTIGRLRKRA GKVVAEEEQL RLEAKAEAEE GELLVRDEFS 
      3410       3420       3430       3440       3450
VLCRDLYALY PLLIRYVDNN RAHWLTEPNP NAEELFRMVG EIFIYWSKSH 
      3460       3470       3480       3490       3500
NFKREEQNFV VQNEINNMSF LTADNKSKMA KAGDVQSGGS DQERTKKKRR 
      3510       3520       3530       3540       3550
GDRYSVQTSL IVATLKKMLP IGLNMCAPTD QDLIVLAKAR YALKDTDEEV 
      3560       3570       3580       3590       3600
REFLQNNLNL QGKVEGSPSL RWQMALYRGV PGREEDADDP EKIVRRVQEV 
      3610       3620       3630       3640       3650
SAVLYHLDQT EHPYKSKKAV WHKLLSKQRR RAVVACFRMT PLYNLPTHRA 
      3660       3670       3680       3690       3700
CNMFLESYKA SWILTEDHSF EDRMIDDLSK AGEQEEEEEE VEEKKPDPLH 
      3710       3720       3730       3740       3750
QLVLHFSRTA LTEKSKLDED YLYMAYADIM AKSCHLEEGG ENGEEGGEEE 
      3760       3770       3780       3790       3800
EVEVSFEEKE MEKQRLLYQQ SRLHNRGAAE MVLQMISACK GETGAMVSST 
      3810       3820       3830       3840       3850
LKLGISILNG GNAEVQQKML DYLKDKKEVG FFQSIQALMQ TCSVLDLNAF 
      3860       3870       3880       3890       3900
ERQNKAEGLG MVNEDGTVIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN 
      3910       3920       3930       3940       3950
DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG 
      3960       3970       3980       3990       4000
KRNFSKAMSV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA 
      4010       4020       4030       4040       4050
HMMMKLAQDS SQIELLKELL DLQKDMVVML LSLLEGNVVN GMIARQMVDM 
      4060       4070       4080       4090       4100
LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL ISKKDFQKAM 
      4110       4120       4130       4140       4150
DSQKQFTGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL 
      4160       4170       4180       4190       4200
TNLSEHVPHD PRLRNFLELA ESILEYFRPY LGRIEIMGAS RRIERIYFEI 
      4210       4220       4230       4240       4250
SETNRAQWEM PQVKESKRQF IFDVVNEGGE SEKMEMFVSF CEDTIFEMQI 
      4260       4270       4280       4290       4300
AAQISEPEGE PEEDEDEGAE EAEEGAAGSD GSGSAAAAGV WVWLAATAGR 
      4310       4320       4330       4340       4350
TLRGLSYRSL RRRVRRLRRL TAREAATAVA ALLWALVTRA GGAGAGAAAG 
      4360       4370       4380       4390       4400
ALRLLWGSLF GGGLVDSAKK VTVTELLAGM PDPTGDEVHG QQPSGAGSDA 
      4410       4420       4430       4440       4450
EGEGEGEGEG DAADGAGDEE AAADQAGTGG ADGAVAVADG SPFRPEGAGG 
      4460       4470       4480       4490       4500
LGDMGDTTPV EPPTPEGSPI LKRKLGVDGE EEEPPPEPEP EPEPEPEKAD 
      4510       4520       4530       4540       4550
TENGEKEVPE PPPEPPKKTP PPPPPKKEEA GGAGLEEFWG ELEVQRVKFL 
      4560       4570       4580       4590       4600
NYLSRNFYTL RFLALFLAFA INFILLFYKV SDSPPGEDDI EGSGAGDMSG 
      4610       4620       4630       4640       4650
AGSGDGSGWG SRAGEEVEGD EDENMVYYFL EESTGYMEPA LRCLSLLHTL 
      4660       4670       4680       4690       4700
VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD 
      4710       4720       4730       4740       4750
RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG MDLASLEITA 
      4760       4770       4780       4790       4800
HNERKPDPPP GLLTWIMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG 
      4810       4820       4830       4840       4850
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT 
      4860       4870       4880       4890       4900
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE 
      4910       4920       4930       4940       4950
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE 
      4960       4970       4980       4990       5000
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE 
      5010       5020       5030 
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
Length:5,035
Mass (Da):565,039
Last modified:April 5, 2011 - v1
Checksum:iD15D2E764B445573
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4M2K3W4M2_MOUSE
Ryanodine receptor 1
Ryr1
5,033Annotation score:
A0A1L1SQG7A0A1L1SQG7_MOUSE
Ryanodine receptor 1
Ryr1
5,061Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti616R → C in CAC34624 (Ref. 4) Curated1
Sequence conflicti1380A → S in AAP29981 (PubMed:18003898).Curated1
Sequence conflicti3484D → V in AAP29981 (PubMed:18003898).Curated1
Sequence conflicti4766I → L in AAA64955 (PubMed:7635066).Curated1
Sequence conflicti4821L → V in CAA58784 (PubMed:7876312).Curated1
Sequence conflicti4888G → A in CAA58784 (PubMed:7876312).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268935 mRNA Translation: AAP29981.1
AC164564 Genomic DNA No translation available.
AC165142 Genomic DNA No translation available.
D21798 Genomic DNA Translation: BAA21010.1
D21796 mRNA Translation: BAA04821.1
D21797 Genomic DNA Translation: BAA04822.1
AJ308737 Genomic DNA Translation: CAC34624.1
BC051248 mRNA Translation: AAH51248.1
BC055487 mRNA Translation: AAH55487.1
X83932 mRNA Translation: CAA58784.1
U23754 mRNA Translation: AAA64955.1
D38216 mRNA Translation: BAA07391.1
CCDSiCCDS39866.1
PIRiI48741
I58087
I78376
I78377
S56105
RefSeqiNP_033135.2, NM_009109.2
UniGeneiMm.439745

Genome annotation databases

EnsembliENSMUST00000179893; ENSMUSP00000137123; ENSMUSG00000030592
GeneIDi20190
KEGGimmu:20190
UCSCiuc009gao.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268935 mRNA Translation: AAP29981.1
AC164564 Genomic DNA No translation available.
AC165142 Genomic DNA No translation available.
D21798 Genomic DNA Translation: BAA21010.1
D21796 mRNA Translation: BAA04821.1
D21797 Genomic DNA Translation: BAA04822.1
AJ308737 Genomic DNA Translation: CAC34624.1
BC051248 mRNA Translation: AAH51248.1
BC055487 mRNA Translation: AAH55487.1
X83932 mRNA Translation: CAA58784.1
U23754 mRNA Translation: AAA64955.1
D38216 mRNA Translation: BAA07391.1
CCDSiCCDS39866.1
PIRiI48741
I58087
I78376
I78377
S56105
RefSeqiNP_033135.2, NM_009109.2
UniGeneiMm.439745

3D structure databases

ProteinModelPortaliE9PZQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3092 Ryanodine 1 complex
DIPiDIP-29705N
IntActiE9PZQ0, 29 interactors
MINTiE9PZQ0
STRINGi10090.ENSMUSP00000137123

Chemistry databases

BindingDBiE9PZQ0
ChEMBLiCHEMBL2133

PTM databases

iPTMnetiE9PZQ0
PhosphoSitePlusiE9PZQ0

Proteomic databases

MaxQBiE9PZQ0
PaxDbiE9PZQ0
PeptideAtlasiE9PZQ0
PRIDEiE9PZQ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179893; ENSMUSP00000137123; ENSMUSG00000030592
GeneIDi20190
KEGGimmu:20190
UCSCiuc009gao.1 mouse

Organism-specific databases

CTDi6261
MGIiMGI:99659 Ryr1

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00760000119152
HOGENOMiHOG000231428
HOVERGENiHBG102939
InParanoidiE9PZQ0
KOiK04961
OrthoDBiEOG091G00T0
TreeFamiTF315244

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels
R-MMU-5578775 Ion homeostasis

Miscellaneous databases

PROiPR:E9PZQ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030592 Expressed in 142 organ(s), highest expression level in knee joint
ExpressionAtlasiE9PZQ0 baseline and differential
GenevisibleiE9PZQ0 MM

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR015925 Ryanodine_recept-rel
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715 PTHR13715, 1 hit
PTHR13715:SF15 PTHR13715:SF15, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRYR1_MOUSE
AccessioniPrimary (citable) accession number: E9PZQ0
Secondary accession number(s): Q60834
, Q61779, Q61780, Q62173, Q62196, Q62235, Q78EJ6, Q7TNG1, Q80UQ5, Q80X16, Q99JF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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