UniProtKB - E9PZQ0 (RYR1_MOUSE)
Ryanodine receptor 1
Ryr1
Functioni
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:7515481, PubMed:7621815, PubMed:21156754).
Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm (PubMed:18268335).
Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain (PubMed:22036948).
Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481).
Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481).
6 PublicationsActivity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 3896 | CalciumBy similarity | 1 | |
Metal bindingi | 3970 | CalciumBy similarity | 1 | |
Binding sitei | 4714 | CaffeineBy similarity | 1 | |
Metal bindingi | 4999 | Calcium; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 4214 – 4218 | ATPBy similarity | 5 | |
Nucleotide bindingi | 4952 – 4957 | ATPBy similarity | 6 | |
Nucleotide bindingi | 4977 – 4983 | ATPBy similarity | 7 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- calcium channel activity Source: UniProtKB
- calcium-induced calcium release activity Source: MGI
- calcium ion binding Source: UniProtKB
- calmodulin binding Source: UniProtKB-KW
- enzyme binding Source: BHF-UCL
- protease binding Source: UniProtKB
- ryanodine-sensitive calcium-release channel activity Source: UniProtKB
- voltage-gated calcium channel activity Source: UniProtKB
GO - Biological processi
- calcium ion transport Source: MGI
- cellular response to ATP Source: MGI
- cellular response to caffeine Source: UniProtKB
- cellular response to calcium ion Source: UniProtKB
- muscle contraction Source: MGI
- ossification involved in bone maturation Source: UniProtKB
- outflow tract morphogenesis Source: UniProtKB
- protein homotetramerization Source: UniProtKB
- regulation of cytosolic calcium ion concentration Source: MGI
- regulation of muscle contraction Source: MGI
- release of sequestered calcium ion into cytosol Source: MGI
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
- response to caffeine Source: MGI
- response to hypoxia Source: MGI
- sarcoplasmic reticulum calcium ion transport Source: MGI
- skeletal muscle fiber development Source: UniProtKB
- skin development Source: UniProtKB
Keywordsi
Molecular function | Calcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels R-MMU-5578775, Ion homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: Ryanodine receptor 1Short name: RYR-1 Short name: RyR1 Alternative name(s): Skeletal muscle calcium release channel Skeletal muscle ryanodine receptor Skeletal muscle-type ryanodine receptor Type 1 ryanodine receptor |
Gene namesi | Name:Ryr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99659, Ryr1 |
VEuPathDBi | HostDB:ENSMUSG00000030592 |
Subcellular locationi
Other locations
- Sarcoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 1 Publication
- Membrane Curated; Multi-pass membrane protein Curated
- Sarcoplasmic reticulum By similarity
Note: The number of predicted transmembrane domains varies between orthologs, but the 3D-structures show the presence of six transmembrane regions. Both N-terminus and C-terminus are cytoplasmic.By similarity
Endoplasmic reticulum
- ryanodine receptor complex Source: UniProtKB
- sarcoplasmic reticulum Source: MGI
- sarcoplasmic reticulum membrane Source: UniProtKB
- smooth endoplasmic reticulum Source: MGI
- terminal cisterna Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: MGI
- plasma membrane Source: MGI
- ryanodine receptor complex Source: UniProtKB
- sarcolemma Source: MGI
- T-tubule Source: MGI
Other locations
- calcium channel complex Source: GO_Central
- cell cortex Source: MGI
- cytoplasm Source: MGI
- cytoplasmic vesicle membrane Source: GO_Central
- I band Source: MGI
- integral component of organelle membrane Source: UniProtKB
- junctional membrane complex Source: MGI
- membrane Source: MGI
- protein-containing complex Source: UniProtKB
- Z disc Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4556 | CytoplasmicBy similarityAdd BLAST | 4556 | |
Transmembranei | 4557 – 4577 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 4578 – 4638 | LumenalBy similarityAdd BLAST | 61 | |
Transmembranei | 4639 – 4659 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 4660 – 4777 | CytoplasmicBy similarityAdd BLAST | 118 | |
Transmembranei | 4778 – 4800 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 4801 | LumenalBy similarity | 1 | |
Transmembranei | 4802 – 4818 | Helical; Name=4By similarityAdd BLAST | 17 | |
Topological domaini | 4819 – 4833 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 4834 – 4854 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 4855 – 4877 | LumenalBy similarityAdd BLAST | 23 | |
Intramembranei | 4878 – 4897 | Pore-formingBy similarityAdd BLAST | 20 | |
Topological domaini | 4898 – 4917 | LumenalBy similarityAdd BLAST | 20 | |
Transmembranei | 4918 – 4938 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 4939 – 5035 | CytoplasmicBy similarityAdd BLAST | 97 |
Keywords - Cellular componenti
Membrane, Sarcoplasmic reticulumPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 165 | R → C: Increased channel activity, leading to permanently increased cytoplasmic Ca(2+) levels. Increased activation by calcium, and increased ryanodine binding. 1 Publication | 1 | |
Mutagenesisi | 4895 | I → T: Causes paralysis and perinatal death in homozygous mice, apparently due to asphyxia. Mutant mice have greatly reduced and amorphous skeletal muscle. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL2133 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000415566 | 1 – 5035 | Ryanodine receptor 1Add BLAST | 5035 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1339 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2346 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2844 | Phosphoserine; by PKA and PKGCombined sources2 Publications | 1 | |
Modified residuei | 3636 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 4464 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 4468 | PhosphoserineBy similarity | 1 | |
Modified residuei | 4861 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 4864 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, S-nitrosylationProteomic databases
MaxQBi | E9PZQ0 |
PaxDbi | E9PZQ0 |
PeptideAtlasi | E9PZQ0 |
PRIDEi | E9PZQ0 |
ProteomicsDBi | 256854 |
PTM databases
iPTMneti | E9PZQ0 |
PhosphoSitePlusi | E9PZQ0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000030592, Expressed in knee joint and 175 other tissues |
Genevisiblei | E9PZQ0, MM |
Interactioni
Subunit structurei
Homotetramer (PubMed:18003898). Can also form heterotetramers with RYR2 (By similarity).
Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (PubMed:18268335). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1) (PubMed:18268335).
Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity (By similarity).
Interacts with S100A1 (By similarity).
Interacts with FKBP1A; this stabilizes the closed conformation of the channel.
Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel.
Interacts with CACNB1.
Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity.
Interacts with SELENON (By similarity).
Interacts with scorpion calcins (AC P0DPT1; AC P0DM30; AC A0A1L4BJ42; AC P59868; AC P60254; AC B8QG00; AC L0GBR1; AC P60252; AC P60253) (By similarity).
By similarity2 PublicationsBinary interactionsi
E9PZQ0
With | #Exp. | IntAct |
---|---|---|
Bsg [O55108] | 3 | EBI-642079,EBI-643315 |
Camlg [P49070] | 3 | EBI-642079,EBI-309114 |
Fkbp1a [P26883] | 2 | EBI-642079,EBI-6379901 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- enzyme binding Source: BHF-UCL
- protease binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 203045, 9 interactors |
ComplexPortali | CPX-3092, Ryanodine 1 complex |
DIPi | DIP-29705N |
IntActi | E9PZQ0, 29 interactors |
MINTi | E9PZQ0 |
STRINGi | 10090.ENSMUSP00000137123 |
Chemistry databases
BindingDBi | E9PZQ0 |
Miscellaneous databases
RNActi | E9PZQ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 154 | MIR 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 161 – 206 | MIR 2PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 212 – 266 | MIR 3PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 272 – 329 | MIR 4PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 337 – 394 | MIR 5PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 583 – 799 | B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST | 217 | |
Repeati | 843 – 956 | 1Add BLAST | 114 | |
Repeati | 957 – 1070 | 2Add BLAST | 114 | |
Domaini | 1015 – 1210 | B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST | 196 | |
Repeati | 1346 – 1361 | 3; truncatedAdd BLAST | 16 | |
Domaini | 1359 – 1572 | B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST | 214 | |
Repeati | 1374 – 1389 | 4; truncatedAdd BLAST | 16 | |
Repeati | 2727 – 2846 | 5Add BLAST | 120 | |
Repeati | 2847 – 2960 | 6Add BLAST | 114 | |
Domaini | 4078 – 4106 | EF-handPROSITE-ProRule annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 671 – 682 | Interaction with FKBP1ABy similarityAdd BLAST | 12 | |
Regioni | 843 – 2960 | 6 X approximate repeatsAdd BLAST | 2118 | |
Regioni | 1309 – 1387 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 1873 – 1928 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 2391 – 2414 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 2828 – 2859 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 3479 – 3502 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 3615 – 3644 | Interaction with CALMBy similarityAdd BLAST | 30 | |
Regioni | 4255 – 4283 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 4378 – 4531 | DisorderedSequence analysisAdd BLAST | 154 | |
Regioni | 4586 – 4618 | DisorderedSequence analysisAdd BLAST | 33 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 4892 – 4898 | Selectivity filterBy similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1372 – 1387 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1874 – 1923 | Acidic residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 2828 – 2844 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 4257 – 4274 | Acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 4402 – 4418 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 4482 – 4496 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 4497 – 4513 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 4514 – 4528 | Pro residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2243, Eukaryota |
GeneTreei | ENSGT00940000155288 |
InParanoidi | E9PZQ0 |
PhylomeDBi | E9PZQ0 |
TreeFami | TF315244 |
Family and domain databases
CDDi | cd12877, SPRY1_RyR, 1 hit cd12878, SPRY2_RyR, 1 hit cd12879, SPRY3_RyR, 1 hit |
Gene3Di | 2.60.120.920, 3 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR011992, EF-hand-dom_pair IPR014821, Ins145_P3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR013333, Ryan_recept IPR003032, Ryanodine_rcpt IPR009460, Ryanrecept_TM4-6 IPR035910, RyR/IP3R_RIH_dom_sf IPR033215, RyR1 IPR035761, SPRY1_RyR IPR035764, SPRY2_RyR IPR035762, SPRY3_RyR IPR003877, SPRY_dom |
PANTHERi | PTHR13715:SF15, PTHR13715:SF15, 1 hit |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF06459, RR_TM4-6, 1 hit PF01365, RYDR_ITPR, 2 hits PF02026, RyR, 4 hits PF00622, SPRY, 3 hits |
PRINTSi | PR00795, RYANODINER |
SMARTi | View protein in SMART SM00472, MIR, 4 hits SM00449, SPRY, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF47473, SSF47473, 1 hit SSF49899, SSF49899, 3 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 3 hits PS50919, MIR, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL
60 70 80 90 100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR
110 120 130 140 150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT
160 170 180 190 200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL
210 220 230 240 250
WNMNPICSGC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG
260 270 280 290 300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLGLTEDQGL
310 320 330 340 350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ
360 370 380 390 400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ
410 420 430 440 450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI
460 470 480 490 500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT
510 520 530 540 550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS
560 570 580 590 600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV
610 620 630 640 650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF
660 670 680 690 700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG
710 720 730 740 750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLA PEDVVSCCLD
760 770 780 790 800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE
810 820 830 840 850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL
860 870 880 890 900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD
910 920 930 940 950
NKRLHPCLVN FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN
960 970 980 990 1000
LKKTKLPKTY MMSNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD
1010 1020 1030 1040 1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY
1060 1070 1080 1090 1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGE
1110 1120 1130 1140 1150
MRVGWARPEL RPDVELGADD LAYVFNGHRG QRWHLGSEPF GRPWQSGDVV
1160 1170 1180 1190 1200
GCMIDLTENT IIFTLNGEVL MSDSGSETAF RDIEIGDGFL PVCSLGPGQV
1210 1220 1230 1240 1250
GHLNLGQDVS SLRFFAICGL QEGFEPFAIN MQRPVTTWFS KSLPQFEPVP
1260 1270 1280 1290 1300
LEHPHYEVAR MDGTVDTPPC LRLTHRTWGS QNSLVEMLFL RLSLPVQFHQ
1310 1320 1330 1340 1350
HFRCTAGATP LASPGLQPPA EDEARAAEPD TDYENLRRSA GGWGEAEGGK
1360 1370 1380 1390 1400
DGTAKEGTPG GTAQAGVEAQ PARAENEKDA TTEKNKKRGF LFKAKKVAMM
1410 1420 1430 1440 1450
TQPPSTPALP RLPRDVVPAD NRDDPEIILN TTTYYYSVRV FAGQEPSCVW
1460 1470 1480 1490 1500
VGWVTPDYHQ HDMSFDLSKV RAVTVTMGDE QGNVHSSLKC SNCYMVWGGD
1510 1520 1530 1540 1550
FVSPGQQGRI SHTDLVIGCL VDLATGLMTF TANGKESNTF FQVEPNTKLF
1560 1570 1580 1590 1600
PAVFVLPTHQ NVVQFELGKQ KNIMPLSAAM FLSERKNPAP QCPPRLEVQM
1610 1620 1630 1640 1650
LMPVSWSRMP NHFLQVDTRR AGERLGWAVQ CQEPLMMMAL HIPEENRCMD
1660 1670 1680 1690 1700
ILELSERLDL QRFHSHTLSL YRSVCALGNN RVAHALCSHV DQAQLLHALE
1710 1720 1730 1740 1750
DARLPGPLRA GYYDLLISIH LESACRSRRS MLSEYIVPLT PETRAITLFP
1760 1770 1780 1790 1800
PGRSAEDGPR RHGLPGVGVT TSLRPPHHFS PPCFVVALPA AGATEAPARL
1810 1820 1830 1840 1850
SPAIPLEALR DKALRMLGEA VRDGGQHARD PVGGSVEFQF VPVLKLVSTL
1860 1870 1880 1890 1900
LVMGVFSDED VKQILKMIEP EVFREEEEVE EEGEEEEEDE EEKEEDEEEE
1910 1920 1930 1940 1950
AHEKEDEEKE EAEDAAEEEK EELEEGLLQM KLPESVKLQM CHLLEYFCDQ
1960 1970 1980 1990 2000
ELQHRVESLA AFAECYVDKM QGNQRGRYGL LMKAFTMSAA ETARRTREFR
2010 2020 2030 2040 2050
SPPQEQINML LHFKNGADEE ECPLPEEIRQ ELVNFHQDLL AHCGIQLEGE
2060 2070 2080 2090 2100
EEEPEEESTL GSRLMSLLEK VKLVKKTEEK PEEEPAPEEH KPQSLQELVS
2110 2120 2130 2140 2150
HTVVRWAQED FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISVSSV
2160 2170 2180 2190 2200
EDTMSLLECL GQIRSLLIVQ MGPQEENLMI QSIGNIMNNK VFYQHPNLMR
2210 2220 2230 2240 2250
ALGMHETVME VMVNVLGGGE SKEIRFPKMV TSCCRFLCYF CRISRQNQRS
2260 2270 2280 2290 2300
MFDHLSYLLE NSGIGLGMQG STPLDVAAAS VIDNNELALA LQEQDLEKVV
2310 2320 2330 2340 2350
SYLAGCGLQS CPMLLAKGYP DIGWNPCGGE RYLDFLRFAV FVNGESVEEN
2360 2370 2380 2390 2400
ANVVVRLLIR KPECFGPALR GEGGSGLLAA IEEAIRISED PARDGPGVRR
2410 2420 2430 2440 2450
DRRREHFGEE PPEENRVHLG HAIMSFYAAL IDLLGRCAPE THLIQAGKGE
2460 2470 2480 2490 2500
ALRIRAILRS LVPLDDLVGI ISLPLQIPTL GKDGALVQPK MSASFVPDHK
2510 2520 2530 2540 2550
ASMVLFLDRV YGIENQDFLL HVLDVGFLPD MRAAASLDTA TFSTTEMALA
2560 2570 2580 2590 2600
LNRYLCLAVL PLITKCAPLF AGTEHRAIMV DSMLHTVYRL SRGRSLTKAQ
2610 2620 2630 2640 2650
RDVIEDCLMA LCRYIRPSML QHLLRRLVFD VPILNEFAKM PLKLLTNHYE
2660 2670 2680 2690 2700
RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDQELYRIA
2710 2720 2730 2740 2750
MPCLCAIAGA LPPDYVDASY SSKTEKKATV DAEGNFDPRP VETLNVIIPE
2760 2770 2780 2790 2800
KLDSFINKFA EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE
2810 2820 2830 2840 2850
KDKEIYRWPI KESLKAMIAW EWTVEKAREG EEEKTEKKKT RKISQTAQTY
2860 2870 2880 2890 2900
DPREGYNPQP PDLSVVTLSR ELQAMAEQLA ENYHNTWGRK KKQELEAKGG
2910 2920 2930 2940 2950
GSHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR GLKDMELDTS
2960 2970 2980 2990 3000
SIEKRFAFGF LQQLLRWMDI SQEFIAHLEA VVSSGRVEKS PHEQEIKFFA
3010 3020 3030 3040 3050
KILLPLINQY FTNHCLYFLS TPAKVLGSGG HASNKEKEMI TSLFCKLAAL
3060 3070 3080 3090 3100
VRHRVSLFGT DAPAVVNCLH ILARSLDART VMKSGPEIVK AGLRSFFESA
3110 3120 3130 3140 3150
SEDIEKMVEN LRLGKVSQAR TQVKGVGQNL TYTTVALLPV LTTLFQHIAQ
3160 3170 3180 3190 3200
HQFGDDVILD DVQVSCYRTL CSIYSLGTTR NPYVEKLRPA LGECLARLAA
3210 3220 3230 3240 3250
AMPVAFLEPE LNEYNACSVY TTKSPRERAI LGLPNSVEEM CPDIPVLERL
3260 3270 3280 3290 3300
MAEIGGLAES GARYTEMPHV IEITLPMLCS YLPRWWERGP EAPPPALPAG
3310 3320 3330 3340 3350
APPPCTAVTS DHLNSLLGNI LRIIVNNLGI DEASWMKRLA VFAQPIVSRA
3360 3370 3380 3390 3400
RPELLRSHFI PTIGRLRKRA GKVVAEEEQL RLEAKAEAEE GELLVRDEFS
3410 3420 3430 3440 3450
VLCRDLYALY PLLIRYVDNN RAHWLTEPNP NAEELFRMVG EIFIYWSKSH
3460 3470 3480 3490 3500
NFKREEQNFV VQNEINNMSF LTADNKSKMA KAGDVQSGGS DQERTKKKRR
3510 3520 3530 3540 3550
GDRYSVQTSL IVATLKKMLP IGLNMCAPTD QDLIVLAKAR YALKDTDEEV
3560 3570 3580 3590 3600
REFLQNNLNL QGKVEGSPSL RWQMALYRGV PGREEDADDP EKIVRRVQEV
3610 3620 3630 3640 3650
SAVLYHLDQT EHPYKSKKAV WHKLLSKQRR RAVVACFRMT PLYNLPTHRA
3660 3670 3680 3690 3700
CNMFLESYKA SWILTEDHSF EDRMIDDLSK AGEQEEEEEE VEEKKPDPLH
3710 3720 3730 3740 3750
QLVLHFSRTA LTEKSKLDED YLYMAYADIM AKSCHLEEGG ENGEEGGEEE
3760 3770 3780 3790 3800
EVEVSFEEKE MEKQRLLYQQ SRLHNRGAAE MVLQMISACK GETGAMVSST
3810 3820 3830 3840 3850
LKLGISILNG GNAEVQQKML DYLKDKKEVG FFQSIQALMQ TCSVLDLNAF
3860 3870 3880 3890 3900
ERQNKAEGLG MVNEDGTVIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN
3910 3920 3930 3940 3950
DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG
3960 3970 3980 3990 4000
KRNFSKAMSV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA
4010 4020 4030 4040 4050
HMMMKLAQDS SQIELLKELL DLQKDMVVML LSLLEGNVVN GMIARQMVDM
4060 4070 4080 4090 4100
LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL ISKKDFQKAM
4110 4120 4130 4140 4150
DSQKQFTGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL
4160 4170 4180 4190 4200
TNLSEHVPHD PRLRNFLELA ESILEYFRPY LGRIEIMGAS RRIERIYFEI
4210 4220 4230 4240 4250
SETNRAQWEM PQVKESKRQF IFDVVNEGGE SEKMEMFVSF CEDTIFEMQI
4260 4270 4280 4290 4300
AAQISEPEGE PEEDEDEGAE EAEEGAAGSD GSGSAAAAGV WVWLAATAGR
4310 4320 4330 4340 4350
TLRGLSYRSL RRRVRRLRRL TAREAATAVA ALLWALVTRA GGAGAGAAAG
4360 4370 4380 4390 4400
ALRLLWGSLF GGGLVDSAKK VTVTELLAGM PDPTGDEVHG QQPSGAGSDA
4410 4420 4430 4440 4450
EGEGEGEGEG DAADGAGDEE AAADQAGTGG ADGAVAVADG SPFRPEGAGG
4460 4470 4480 4490 4500
LGDMGDTTPV EPPTPEGSPI LKRKLGVDGE EEEPPPEPEP EPEPEPEKAD
4510 4520 4530 4540 4550
TENGEKEVPE PPPEPPKKTP PPPPPKKEEA GGAGLEEFWG ELEVQRVKFL
4560 4570 4580 4590 4600
NYLSRNFYTL RFLALFLAFA INFILLFYKV SDSPPGEDDI EGSGAGDMSG
4610 4620 4630 4640 4650
AGSGDGSGWG SRAGEEVEGD EDENMVYYFL EESTGYMEPA LRCLSLLHTL
4660 4670 4680 4690 4700
VAFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYITEQP EDDDVKGQWD
4710 4720 4730 4740 4750
RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG MDLASLEITA
4760 4770 4780 4790 4800
HNERKPDPPP GLLTWIMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG
4810 4820 4830 4840 4850
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT
4860 4870 4880 4890 4900
VVAFNFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
4910 4920 4930 4940 4950
DPAGDEYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE
4960 4970 4980 4990 5000
DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE
5010 5020 5030
HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SQG7 | A0A1L1SQG7_MOUSE | Ryanodine receptor 1 | Ryr1 | 5,061 | Annotation score: | ||
K3W4M2 | K3W4M2_MOUSE | Ryanodine receptor 1 | Ryr1 | 5,033 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 616 | R → C in CAC34624 (Ref. 5) Curated | 1 | |
Sequence conflicti | 1380 | A → S in AAP29981 (PubMed:18003898).Curated | 1 | |
Sequence conflicti | 3484 | D → V in AAP29981 (PubMed:18003898).Curated | 1 | |
Sequence conflicti | 4766 | I → L in AAA64955 (PubMed:7635066).Curated | 1 | |
Sequence conflicti | 4821 | L → V in CAA58784 (PubMed:7876312).Curated | 1 | |
Sequence conflicti | 4888 | G → A in CAA58784 (PubMed:7876312).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY268935 mRNA Translation: AAP29981.1 AC164564 Genomic DNA No translation available. AC165142 Genomic DNA No translation available. D21798 Genomic DNA Translation: BAA21010.1 D21796 mRNA Translation: BAA04821.1 D21797 Genomic DNA Translation: BAA04822.1 AJ308737 Genomic DNA Translation: CAC34624.1 BC051248 mRNA Translation: AAH51248.1 BC055487 mRNA Translation: AAH55487.1 X83932 mRNA Translation: CAA58784.1 U23754 mRNA Translation: AAA64955.1 D38216 mRNA Translation: BAA07391.1 |
CCDSi | CCDS39866.1 |
PIRi | I48741 I58087 I78376 I78377 S56105 |
RefSeqi | NP_033135.2, NM_009109.2 |
Genome annotation databases
Ensembli | ENSMUST00000179893; ENSMUSP00000137123; ENSMUSG00000030592 |
GeneIDi | 20190 |
KEGGi | mmu:20190 |
UCSCi | uc009gao.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY268935 mRNA Translation: AAP29981.1 AC164564 Genomic DNA No translation available. AC165142 Genomic DNA No translation available. D21798 Genomic DNA Translation: BAA21010.1 D21796 mRNA Translation: BAA04821.1 D21797 Genomic DNA Translation: BAA04822.1 AJ308737 Genomic DNA Translation: CAC34624.1 BC051248 mRNA Translation: AAH51248.1 BC055487 mRNA Translation: AAH55487.1 X83932 mRNA Translation: CAA58784.1 U23754 mRNA Translation: AAA64955.1 D38216 mRNA Translation: BAA07391.1 |
CCDSi | CCDS39866.1 |
PIRi | I48741 I58087 I78376 I78377 S56105 |
RefSeqi | NP_033135.2, NM_009109.2 |
3D structure databases
SMRi | E9PZQ0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203045, 9 interactors |
ComplexPortali | CPX-3092, Ryanodine 1 complex |
DIPi | DIP-29705N |
IntActi | E9PZQ0, 29 interactors |
MINTi | E9PZQ0 |
STRINGi | 10090.ENSMUSP00000137123 |
Chemistry databases
BindingDBi | E9PZQ0 |
ChEMBLi | CHEMBL2133 |
PTM databases
iPTMneti | E9PZQ0 |
PhosphoSitePlusi | E9PZQ0 |
Proteomic databases
MaxQBi | E9PZQ0 |
PaxDbi | E9PZQ0 |
PeptideAtlasi | E9PZQ0 |
PRIDEi | E9PZQ0 |
ProteomicsDBi | 256854 |
Protocols and materials databases
Antibodypediai | 44914, 174 antibodies from 24 providers |
DNASUi | 20190 |
Genome annotation databases
Ensembli | ENSMUST00000179893; ENSMUSP00000137123; ENSMUSG00000030592 |
GeneIDi | 20190 |
KEGGi | mmu:20190 |
UCSCi | uc009gao.1, mouse |
Organism-specific databases
CTDi | 6261 |
MGIi | MGI:99659, Ryr1 |
VEuPathDBi | HostDB:ENSMUSG00000030592 |
Phylogenomic databases
eggNOGi | KOG2243, Eukaryota |
GeneTreei | ENSGT00940000155288 |
InParanoidi | E9PZQ0 |
PhylomeDBi | E9PZQ0 |
TreeFami | TF315244 |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels R-MMU-5578775, Ion homeostasis |
Miscellaneous databases
BioGRID-ORCSi | 20190, 2 hits in 64 CRISPR screens |
ChiTaRSi | Ryr1, mouse |
PROi | PR:E9PZQ0 |
RNActi | E9PZQ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030592, Expressed in knee joint and 175 other tissues |
Genevisiblei | E9PZQ0, MM |
Family and domain databases
CDDi | cd12877, SPRY1_RyR, 1 hit cd12878, SPRY2_RyR, 1 hit cd12879, SPRY3_RyR, 1 hit |
Gene3Di | 2.60.120.920, 3 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR011992, EF-hand-dom_pair IPR014821, Ins145_P3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR013333, Ryan_recept IPR003032, Ryanodine_rcpt IPR009460, Ryanrecept_TM4-6 IPR035910, RyR/IP3R_RIH_dom_sf IPR033215, RyR1 IPR035761, SPRY1_RyR IPR035764, SPRY2_RyR IPR035762, SPRY3_RyR IPR003877, SPRY_dom |
PANTHERi | PTHR13715:SF15, PTHR13715:SF15, 1 hit |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF06459, RR_TM4-6, 1 hit PF01365, RYDR_ITPR, 2 hits PF02026, RyR, 4 hits PF00622, SPRY, 3 hits |
PRINTSi | PR00795, RYANODINER |
SMARTi | View protein in SMART SM00472, MIR, 4 hits SM00449, SPRY, 3 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF47473, SSF47473, 1 hit SSF49899, SSF49899, 3 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 3 hits PS50919, MIR, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RYR1_MOUSE | |
Accessioni | E9PZQ0Primary (citable) accession number: E9PZQ0 Secondary accession number(s): Q60834 Q99JF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 23, 2022 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families