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Protein
Submitted name:

SR-related CTD-associated factor 11

Gene

Scaf11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SR-related CTD-associated factor 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scaf11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919443 Scaf11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PZM7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PZM7

PeptideAtlas

More...
PeptideAtlasi
E9PZM7

PRoteomics IDEntifications database

More...
PRIDEi
E9PZM7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PZM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PZM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033228 Expressed in 286 organ(s), highest expression level in maxillary prominence

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PZM7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044898

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PZM7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PZM7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 82RING-typeInterPro annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili450 – 470Sequence analysisAdd BLAST21
Coiled coili1011 – 1031Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0825 Eukaryota
ENOG4111NG4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154168

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PZM7

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05JH

TreeFam database of animal gene trees

More...
TreeFami
TF332183

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9PZM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKKSVYNQN VGDQECDDME GEENSNTADA SGLLYSEADR CPICLSCLLG
60 70 80 90 100
KEVGFPESCN HVFCMACILK WAEILASCPI DRKPFQAVFE LSAFEGCAKI
110 120 130 140 150
QVKRRLRETE DKENQRSFKK QLFYHESSKG NKRKRNTIRE DLLCERSDGL
160 170 180 190 200
KVLYRNISNK MDGKKNATVK TNKVQRSNQC TDSCIRNEMS SVFSCGSHSW
210 220 230 240 250
GPRTHRASCT ESIEVNEISA LIRQKRQELE LSWFPNTLPG NGRVGSVPWS
260 270 280 290 300
VETAFLSLAS SGLPRTVFPA STTSLEHFGT SHKGYALAHT QGGGEKKQTS
310 320 330 340 350
GTSNTRGSRR KPAATAPTRR STRNTRAETV SQSQKSPVSN YSECDAPGNS
360 370 380 390 400
NSSVSISPPA ESEKQTRQAP KRKSVRRGRK PPLLKKKLRR SVPPAEKSSS
410 420 430 440 450
DSVEEETVDS DTPPVLEKEQ QSCVESSSIC SVQTDEENHL HLESCSEQTE
460 470 480 490 500
ENEQANNHEI EEQTESLNSE SCTQDPPGLV GEDTGIEAKE FCADHDISPD
510 520 530 540 550
TSLRGRDSAE HQEQLSGSSE SEVQALVCTE SPPEGSPTCP PSDIEHQPVS
560 570 580 590 600
SPLGEVSDNT TPVVSDERAE ESLTVESTDL NDERTGESLT VESTDLNDSA
610 620 630 640 650
VNIEAFVESP KMESCEGETA QGLDRHCVPS SDSELPEHIQ TENTEIIPAC
660 670 680 690 700
EHIQTENTEI IPACEHIQTE NTEIIPVCGT LENENSDAVQ DCEDNLLKHN
710 720 730 740 750
LDNSQSDKFL EETTESLVEH PIHAELPHKE VDQSEKHFSE DNNESVPMEC
760 770 780 790 800
DSFCSDQNES EVESSANTDS KQLSENSVPH SSEDKLSSDP AVEKVETVAQ
810 820 830 840 850
PAESLVDKAP KPRTRRSRFH SPSTTWSPNK DAAQEKRRAQ SPSPKRETVV
860 870 880 890 900
ESQSSQSPSP KRESARGRRK SRSLSPKKDV ARERRQSRSP KRENAREAKR
910 920 930 940 950
SESGSPRRDT SRENQRSQSR VKDSSSREKS RSRSRERESD REAQRRERDR
960 970 980 990 1000
ERRARRWSRS RSRSRSPSRL RTKSKSSSFG RNERDNYSPR WKERWTNDGW
1010 1020 1030 1040 1050
RCPRGNDRYR RNDSEKQNEN TRNEKNDITA DSNDPSSTDK HRSDCPSWVT
1060 1070 1080 1090 1100
EKINSGPDPR TRNPEKLKDS HWEENRNENS GNSWTKNFGP GWMSSRGRGG
1110 1120 1130 1140 1150
RGKGAYRGNF ACNDQSENRW QSRTPLSGSD SFKSAEQQPS KRKSEQELSF
1160 1170 1180 1190 1200
GTAADRSGWT SASSWAVRKT LPADVQSYYS RRGRNSSGPQ SGWMRQEEET
1210 1220 1230 1240 1250
PEQDSNLKDQ TNQVDGSQLP VNMMQPHMSV MQPPVNAPHP PVGVFPYPVG
1260 1270 1280 1290 1300
LPAPMMNMQR NPFTMHPPMP LHLHTGVPLM QVAAPASIPQ GPPPPPPPPP
1310 1320 1330 1340 1350
SQQVSYVASQ PDGKQVQGLS SASHVSNNMN TQVLPAPSAA PANTGSVQGP
1360 1370 1380 1390 1400
SSGNTSSSSH VQASNAAVKL AESKKLQIQE KAAQEVKLAI KPFYQNKDIT
1410 1420 1430 1440 1450
KEEYKEIVRK AVDKVCHSKS GEVNSTKVAN LVKAYVDKYR YSRKKALEEP

GSTEKT
Length:1,456
Mass (Da):162,100
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78737750DD33C0D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQU5A0A2I3BQU5_MOUSE
SR-related CTD-associated factor 11
Scaf11
1,389Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRQ7A0A2I3BRQ7_MOUSE
SR-related CTD-associated factor 11
Scaf11
476Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ68A0A2I3BQ68_MOUSE
SR-related CTD-associated factor 11
Scaf11
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQX1A0A2I3BQX1_MOUSE
SR-related CTD-associated factor 11
Scaf11
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC133578 Genomic DNA No translation available.
AC158769 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_082424.2, NM_028148.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.324474
Mm.472183

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047835; ENSMUSP00000044898; ENSMUSG00000033228

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72193

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72193

UCSC genome browser

More...
UCSCi
uc007xkf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133578 Genomic DNA No translation available.
AC158769 Genomic DNA No translation available.
RefSeqiNP_082424.2, NM_028148.2
UniGeneiMm.324474
Mm.472183

3D structure databases

ProteinModelPortaliE9PZM7
SMRiE9PZM7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044898

PTM databases

iPTMnetiE9PZM7
PhosphoSitePlusiE9PZM7

Proteomic databases

MaxQBiE9PZM7
PaxDbiE9PZM7
PeptideAtlasiE9PZM7
PRIDEiE9PZM7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047835; ENSMUSP00000044898; ENSMUSG00000033228
GeneIDi72193
KEGGimmu:72193
UCSCiuc007xkf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9169
MGIiMGI:1919443 Scaf11

Phylogenomic databases

eggNOGiKOG0825 Eukaryota
ENOG4111NG4 LUCA
GeneTreeiENSGT00940000154168
InParanoidiE9PZM7
OrthoDBiEOG091G05JH
TreeFamiTF332183

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Scaf11 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033228 Expressed in 286 organ(s), highest expression level in maxillary prominence
GenevisibleiE9PZM7 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PZM7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PZM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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