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Protein
Submitted name:

Pappalysin 2

Gene

Pappa2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • bone morphogenesis Source: MGI
  • proteolysis Source: MGI
  • response to salt stress Source: Ensembl

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Submitted name:
Pappalysin 2Imported
Gene namesi
Name:Pappa2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3051647 Pappa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500324303719 – 1789Sequence analysisAdd BLAST1771

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiE9PZ87
PeptideAtlasiE9PZ87
PRIDEiE9PZ87

PTM databases

iPTMnetiE9PZ87
PhosphoSitePlusiE9PZ87

Expressioni

Gene expression databases

BgeeiENSMUSG00000073530 Expressed in 120 organ(s), highest expression level in placenta
ExpressionAtlasiE9PZ87 baseline and differential
GenevisibleiE9PZ87 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124022

Structurei

3D structure databases

ProteinModelPortaliE9PZ87
SMRiE9PZ87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1521 – 1590SushiInterPro annotationAdd BLAST70
Domaini1591 – 1646SushiInterPro annotationAdd BLAST56

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KDUG Eukaryota
ENOG410YRGU LUCA
GeneTreeiENSGT00390000009007
InParanoidiE9PZ87
KOiK08647
OMAiECTCRDP
OrthoDBiEOG091G026Y
PhylomeDBiE9PZ87
TreeFamiTF331636

Family and domain databases

CDDicd00033 CCP, 1 hit
cd04275 ZnMc_pappalysin_like, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR036116 FN3_sf
IPR006558 LamG-like
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR026918 PAPPA2
IPR008754 Peptidase_M43
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF1 PTHR19325:SF1, 1 hit
PfamiView protein in Pfam
PF00066 Notch, 1 hit
PF05572 Peptidase_M43, 1 hit
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00560 LamGL, 1 hit
SM00004 NL, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF57535 SSF57535, 3 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PZ87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMCWKVLRIS LVVLTGWALS TTNSEQGWTR KKFLAQKEHL NQVLLEGERC
60 70 80 90 100
WLGYKVRRPR TAPQHHLFGV YPSRLENYPR SYPVGTQQQT LYAEWSQRSP
110 120 130 140 150
ERQAPSGIPR DLTENPAGAR RESQQPAAPW VGDGPIGQSQ LLRNDDTYLG
160 170 180 190 200
EGGSKEALGE PAIQGSSEIA VSTIATFAYQ KGPTAETQRK GQSKSRLPRQ
210 220 230 240 250
VQKRQAEDMT GDPQNTPQGF QLWPKEPLKH GDSDSPLEGT IQNGGGASLR
260 270 280 290 300
RVETFNSQGG LPVLYFTGKR ERLLLRPEVL AEIPREAFTV EAWVRPEGGQ
310 320 330 340 350
SNPAIIAGVF DNCSHTVNDK GWALGIRSGK DKGWRDARFF FSLRTDRMKK
360 370 380 390 400
ATIVTGHSRY QPGMWTHVAA TYDGQHTALY VDGTRVASSR DQFGPLNSPF
410 420 430 440 450
MASCRSLILG GDSSEDGHYF RGYLGTLVIW STALSQTHLQ HSPLHPSAAD
460 470 480 490 500
ELTTLILTAT FDPLMEQWAP FRDDLYPRLE VLQDSESQPE ILSPLQPPPC
510 520 530 540 550
GQTACDNVEL ISQYNKHGPL RREKVIRYQV VNIYDDEGLH PIVSDHQIRR
560 570 580 590 600
QHEALNQAFS RYNISWQLSV HRVHNSTLRH RVVLVNCEPS KIGNDHCDPE
610 620 630 640 650
CEHPLTGFDG GDCRLQGRCY SWNRRDGLCH VECNNMLNDF DDGDCCDPEV
660 670 680 690 700
TDVRKTCFDP DSPKRAYMSV KELKEALQLN STHFLNVYFA SSVREDLAGS
710 720 730 740 750
ATWPWDKEAL SHLGGVVLNP TYYGMLGHTN IMIHEVGHVL GLYHVFKGVS
760 770 780 790 800
ERESCDDPCR ETVPSMETGD LCADTAPTPK SKLCRDPEPA NDTCGFTLFP
810 820 830 840 850
GAPFNNYMSY TDDECTDNFT PNQVARMHCY LDLVYQQWSE SQKPTPIPIP
860 870 880 890 900
PMVIGQTHKS LTIHWLPPIS GVVYDRAPDS MCSACTEDGT FRQYVYKASS
910 920 930 940 950
GRVCDSSGYW TPEEAVGPPD VDQPCEPSLQ AWSPELHLNH MNMTVPCPAE
960 970 980 990 1000
GCSLELLFQY PVQADTLTLW VTYLSMNSSK AFFDIEILLE HKKSMHLGPL
1010 1020 1030 1040 1050
NTFCDIPLTI KLHMDEKVMG AKVYTFDERM EIDAALLTSR PNSSLCSGCK
1060 1070 1080 1090 1100
PMSYQVLREP PFSSGLPMVV THPHRKFTDT EVIPGQMYQY QVQAEAVGEL
1110 1120 1130 1140 1150
GEASPPLSHI HGGPYCGDGK VERSIGEMCD DGDLLNGDGC SRACELEEGF
1160 1170 1180 1190 1200
NCAGEPSLCY RYEGDGVCED FEKESIITDC GLHTPEGYLD QWASQAYSYH
1210 1220 1230 1240 1250
EDKEKCPVSL VTGEPHSMIC TSWHPDSSPY HSFPGWFPCV FSLKKDQDAG
1260 1270 1280 1290 1300
SEQAKDSLQK DNEIWLEVCF NRPGVAVAIY IFLASDGVTP GEHQQATVTL
1310 1320 1330 1340 1350
YLIDVSGSNH SLGTYGLSCQ QNPLVINVSH HVNVYPQHTS SMLLNFSSPL
1360 1370 1380 1390 1400
VGISAVALRT SSQTSSSAPS NCIPEQNYEG KSCAQRPCGE QGRCAPLLLD
1410 1420 1430 1440 1450
HTDMVNCTSS SPGHMECAIT CQRGYVLQTS SGQYLRNMQK EILLTCSSGH
1460 1470 1480 1490 1500
WDKDVICKRL DCGVPDSSLV NYANFSCLEG TDFLKQCSIS CVPPAKLQGL
1510 1520 1530 1540 1550
NPWLTCLEDG LWSLPEVYCK LECEAPPVIP NANLLLPHFL EGNHDVGTIC
1560 1570 1580 1590 1600
KYECKPGYYV KETSGSQGKN KFLKIQCLDD GSWEQGSCVP VVCEPPPPVF
1610 1620 1630 1640 1650
EGMYECTDGF KLDSQCVLNC NQETEGIPIL CTKEGLWTQE FKLCENLQGE
1660 1670 1680 1690 1700
CPPPTSELNS VEYKCGQGYG IGAVCSPSCV IPPSDPVILP ENVTTDTLEH
1710 1720 1730 1740 1750
WMEPVKVQSI VCTGRRQWHP DPSLVHCIQS CEPFQADGWC DTINNRAYCN
1760 1770 1780
YDGGDCCSST LSSKKVIPFA ADCDLDECTC RDPKAEENQ
Length:1,789
Mass (Da):198,825
Last modified:April 5, 2011 - v1
Checksum:i50A18CD29E1C00C4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TFC9F6TFC9_MOUSE
Pappalysin 2
Pappa2
246Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115116 Genomic DNA No translation available.
AC158910 Genomic DNA No translation available.
AC162173 Genomic DNA No translation available.
RefSeqiNP_001078845.1, NM_001085376.2
XP_006496886.1, XM_006496823.3
XP_006496887.1, XM_006496824.3
XP_011237108.1, XM_011238806.2
UniGeneiMm.458621

Genome annotation databases

EnsembliENSMUST00000159861; ENSMUSP00000124022; ENSMUSG00000073530
GeneIDi23850
KEGGimmu:23850
UCSCiuc007ddv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115116 Genomic DNA No translation available.
AC158910 Genomic DNA No translation available.
AC162173 Genomic DNA No translation available.
RefSeqiNP_001078845.1, NM_001085376.2
XP_006496886.1, XM_006496823.3
XP_006496887.1, XM_006496824.3
XP_011237108.1, XM_011238806.2
UniGeneiMm.458621

3D structure databases

ProteinModelPortaliE9PZ87
SMRiE9PZ87
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124022

PTM databases

iPTMnetiE9PZ87
PhosphoSitePlusiE9PZ87

Proteomic databases

PaxDbiE9PZ87
PeptideAtlasiE9PZ87
PRIDEiE9PZ87

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159861; ENSMUSP00000124022; ENSMUSG00000073530
GeneIDi23850
KEGGimmu:23850
UCSCiuc007ddv.1 mouse

Organism-specific databases

CTDi60676
MGIiMGI:3051647 Pappa2

Phylogenomic databases

eggNOGiENOG410KDUG Eukaryota
ENOG410YRGU LUCA
GeneTreeiENSGT00390000009007
InParanoidiE9PZ87
KOiK08647
OMAiECTCRDP
OrthoDBiEOG091G026Y
PhylomeDBiE9PZ87
TreeFamiTF331636

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

ChiTaRSiPappa2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073530 Expressed in 120 organ(s), highest expression level in placenta
ExpressionAtlasiE9PZ87 baseline and differential
GenevisibleiE9PZ87 MM

Family and domain databases

CDDicd00033 CCP, 1 hit
cd04275 ZnMc_pappalysin_like, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR036116 FN3_sf
IPR006558 LamG-like
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR026918 PAPPA2
IPR008754 Peptidase_M43
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF1 PTHR19325:SF1, 1 hit
PfamiView protein in Pfam
PF00066 Notch, 1 hit
PF05572 Peptidase_M43, 1 hit
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00560 LamGL, 1 hit
SM00004 NL, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF57535 SSF57535, 3 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PZ87_MOUSE
AccessioniPrimary (citable) accession number: E9PZ87
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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