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Entry version 94 (29 Sep 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Basement membrane-specific heparan sulfate proteoglycan core protein

Gene

Hspg2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Basement membrane-specific heparan sulfate proteoglycan core proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hspg2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96257, Hspg2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000028763

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Basement membraneARBA annotation, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324303526 – 4383Sequence analysisAdd BLAST4358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi219 ↔ 234PROSITE-ProRule annotation
Disulfide bondi285 ↔ 297PROSITE-ProRule annotation
Disulfide bondi292 ↔ 310PROSITE-ProRule annotation
Disulfide bondi304 ↔ 319PROSITE-ProRule annotation
Disulfide bondi325 ↔ 337PROSITE-ProRule annotation
Disulfide bondi332 ↔ 350PROSITE-ProRule annotation
Disulfide bondi344 ↔ 359PROSITE-ProRule annotation
Disulfide bondi388 ↔ 403PROSITE-ProRule annotation
Disulfide bondi783 ↔ 792PROSITE-ProRule annotation
Disulfide bondi1178 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1237 ↔ 1246PROSITE-ProRule annotation
Disulfide bondi1249 ↔ 1263PROSITE-ProRule annotation
Disulfide bondi1275 ↔ 1287PROSITE-ProRule annotation
Disulfide bondi1295 ↔ 1304PROSITE-ProRule annotation
Disulfide bondi1582 ↔ 1591PROSITE-ProRule annotation
Disulfide bondi1641 ↔ 1650PROSITE-ProRule annotation
Disulfide bondi3864 ↔ 3873PROSITE-ProRule annotation
Disulfide bondi3886 ↔ 3903PROSITE-ProRule annotation
Disulfide bondi3905 ↔ 3914PROSITE-ProRule annotation
Disulfide bondi4124 ↔ 4133PROSITE-ProRule annotation
Disulfide bondi4159 ↔ 4168PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, Glycoprotein, Heparan sulfateARBA annotation, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PZ16

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PZ16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PZ16

PeptideAtlas

More...
PeptideAtlasi
E9PZ16

PRoteomics IDEntifications database

More...
PRIDEi
E9PZ16

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
314446

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PZ16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028763, Expressed in heart and 302 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PZ16, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PZ16, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000131316

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 191SEAInterPro annotationAdd BLAST112
Domaini406 – 484Ig-likeInterPro annotationAdd BLAST79
Domaini545 – 730Laminin IV type AInterPro annotationAdd BLAST186
Domaini764 – 813Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini948 – 1125Laminin IV type AInterPro annotationAdd BLAST178
Domaini1159 – 1208Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1209 – 1265Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1275 – 1324Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1351 – 1529Laminin IV type AInterPro annotationAdd BLAST179
Domaini1563 – 1612Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1613 – 1670Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini1670 – 1763Ig-likeInterPro annotationAdd BLAST94
Domaini1769 – 1859Ig-likeInterPro annotationAdd BLAST91
Domaini1865 – 1948Ig-likeInterPro annotationAdd BLAST84
Domaini1955 – 2038Ig-likeInterPro annotationAdd BLAST84
Domaini2051 – 2132Ig-likeInterPro annotationAdd BLAST82
Domaini2145 – 2231Ig-likeInterPro annotationAdd BLAST87
Domaini2245 – 2322Ig-likeInterPro annotationAdd BLAST78
Domaini2336 – 2423Ig-likeInterPro annotationAdd BLAST88
Domaini2435 – 2517Ig-likeInterPro annotationAdd BLAST83
Domaini2524 – 2614Ig-likeInterPro annotationAdd BLAST91
Domaini2624 – 2710Ig-likeInterPro annotationAdd BLAST87
Domaini2724 – 2807Ig-likeInterPro annotationAdd BLAST84
Domaini2824 – 2906Ig-likeInterPro annotationAdd BLAST83
Domaini2912 – 3005Ig-likeInterPro annotationAdd BLAST94
Domaini3019 – 3104Ig-likeInterPro annotationAdd BLAST86
Domaini3109 – 3197Ig-likeInterPro annotationAdd BLAST89
Domaini3208 – 3288Ig-likeInterPro annotationAdd BLAST81
Domaini3295 – 3379Ig-likeInterPro annotationAdd BLAST85
Domaini3396 – 3480Ig-likeInterPro annotationAdd BLAST85
Domaini3483 – 3567Ig-likeInterPro annotationAdd BLAST85
Domaini3572 – 3653Ig-likeInterPro annotationAdd BLAST82
Domaini3659 – 3841LAM_G_DOMAINInterPro annotationAdd BLAST183
Domaini3839 – 3874EGF-likeInterPro annotationAdd BLAST36
Domaini3877 – 3915EGF-likeInterPro annotationAdd BLAST39
Domaini3921 – 4101LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini4097 – 4134EGF-likeInterPro annotationAdd BLAST38
Domaini4136 – 4169EGF-likeInterPro annotationAdd BLAST34
Domaini4194 – 4381LAM_G_DOMAINInterPro annotationAdd BLAST188

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1713 – 1733DisorderedSequence analysisAdd BLAST21
Regioni2619 – 2639DisorderedSequence analysisAdd BLAST21
Regioni2712 – 2734DisorderedSequence analysisAdd BLAST23
Regioni4356 – 4383DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1716 – 1733Polar residuesSequence analysisAdd BLAST18

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3509, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156670

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDERGSM

Database of Orthologous Groups

More...
OrthoDBi
414294at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PZ16

TreeFam database of animal gene trees

More...
TreeFami
TF326548

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 22 hits
4.10.400.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000082, SEA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 2 hits
PF07679, I-set, 11 hits
PF00052, Laminin_B, 3 hits
PF00053, Laminin_EGF, 9 hits
PF00054, Laminin_G_1, 3 hits
PF00057, Ldl_recept_a, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 10 hits
SM00179, EGF_CA, 5 hits
SM00180, EGF_Lam, 9 hits
SM00409, IG, 22 hits
SM00408, IGc2, 22 hits
SM00406, IGv, 8 hits
SM00281, LamB, 3 hits
SM00282, LamG, 3 hits
SM00192, LDLa, 4 hits
SM00200, SEA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 22 hits
SSF49899, SSF49899, 3 hits
SSF57424, SSF57424, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 4 hits
PS01248, EGF_LAM_1, 7 hits
PS50027, EGF_LAM_2, 6 hits
PS50835, IG_LIKE, 22 hits
PS50025, LAM_G_DOMAIN, 3 hits
PS51115, LAMININ_IVA, 3 hits
PS01209, LDLRA_1, 3 hits
PS50068, LDLRA_2, 4 hits
PS50024, SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PZ16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQRAVGSLL LGLLLHARLL AVTHGLRAYD GLSLPEDTET VTASRYGWTY
60 70 80 90 100
SYLSDDEDLL ADDASGDGLG SGDVGSGDFQ MVYFRALVNF TRSIEYSPQL
110 120 130 140 150
EDASAKEFRE VSEAVVEKLE PEYRKIPGDQ IVSVVFIKEL DGWVFVELDV
160 170 180 190 200
GSEGNADGSQ IQEVLHTVVS SGSIGPYVTS PWGFKFRRLG TVPQFPRVCT
210 220 230 240 250
ETEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVPE LSSSTPAVGK
260 270 280 290 300
VSPLPLWPEA ATTPPPPVTH GPQFLLPSVP GPSACGPQEA SCHSGHCIPR
310 320 330 340 350
DYLCDGQEDC RDGSDELGCA SPPPCEPNEF ACENGHCALK LWRCDGDFDC
360 370 380 390 400
EDRTDEANCS VKQPGEVCGP THFQCVSTNR CIPASFHCDE ESDCPDRSDE
410 420 430 440 450
FGCMPPQVVT PPQQSIQASR GQTVTFTCVA TGVPTPIINW RLNWGHIPAH
460 470 480 490 500
PRVTMTSEGG RGTLIIRDVK EADQGAYTCE AMNSRGMVFG IPDGVLELVP
510 520 530 540 550
QRGPCPDGHF YLEDSASCLP CFCFGVTNVC QSSLRFRDQI RLSFDQPNDF
560 570 580 590 600
KGVNVTMPSQ PGVPPLSSTQ LQIDPALQEF QLVDLSRRFL VHDAFWALPK
610 620 630 640 650
QFLGNKVDSY GGFLRYKVRY ELARGMLEPV QKPDVILVGA GYRLHSRGHT
660 670 680 690 700
PTHPGTLNQR QVQLSEEHWV HESGRPVQRA EMLQALASLE AVLLQTVYNT
710 720 730 740 750
KMASVGLSDI VMDTTVTHTT IHGRAHSVEE CRCPIGYSGL SCESCDAHFT
760 770 780 790 800
RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC LNCQHNTEGP QCDKCKPGFF
810 820 830 840 850
GDATKATATA CRPCPCPYID ASRRFSDTCF LDTDGQATCD ACAPGYTGRR
860 870 880 890 900
CESCAPGYEG NPIQPGGKCR PTTQEIVRCD ERGSLGTSGE TCRCKNNVVG
910 920 930 940 950
RLCNECSDGS FHLSKQNPDG CLKCFCMGVS RQCSSSSWSR AQVLGASEQP
960 970 980 990 1000
SQFSLSNAAG THTTSEGVSS PAPGELSFSS FHNLLSEPYF WSLPASFRGD
1010 1020 1030 1040 1050
KVTSYGGELR FTVTQRPRPS SAPLHRQPLV VLQGNNIVLE HHASRDPSPG
1060 1070 1080 1090 1100
QPSNFIVPFQ EQAWQRPDGQ PATREHLLMA LAGIDALLIQ ASYTQQPAES
1110 1120 1130 1140 1150
RVSGISMDVA VPENTGQDSA REVEQCTCPP GYRGPSCQDC DTGYTRVPSG
1160 1170 1180 1190 1200
LYLGTCERCN CHGHSETCEP ETGACQSCQH HTEGASCEQC QPGYYGDAQR
1210 1220 1230 1240 1250
GTPQDCQPCP CYGAPAAGQA AHTCFLDTDG HPTCDSCSPG HSGRHCERCA
1260 1270 1280 1290 1300
PGYYGNPSQG QPCHRDGQVP EVLGCGCDPH GSISSQCDAA GQCQCKAQVE
1310 1320 1330 1340 1350
GRTCSHCRPH HFHLSASNPE GCLPCFCMGV TQQCASSSYS RQLISTHFAP
1360 1370 1380 1390 1400
GDFQGFALVN PQRNSQLTGG FTVEPVHDGA RLSFSNFAHL GQESFYWQLP
1410 1420 1430 1440 1450
EIYQGDKVAA YGGKLRYTLS YTAGPQGSPL LDPDIQITGN NIMLVASQPA
1460 1470 1480 1490 1500
LQGPERRSYE IIFREEFWRR PDGQPATREH LLMALADLDE LLVRATFSSV
1510 1520 1530 1540 1550
PRAASISAVS LEVAQPGPSS GPRALEVEEC RCPPGYVGLS CQDCAPGYTR
1560 1570 1580 1590 1600
TGSGLYLGQC ELCECNGHSD LCHPETGACS RCQHNTAGEF CELCATGYYG
1610 1620 1630 1640 1650
DATAGTPEDC QPCACPLTNP ENMFSRTCES LGAGGYRCTA CEPGYTGQYC
1660 1670 1680 1690 1700
EQCAPGYEGD PNVQGGRCQP LTKESLEVQI HPSRSVVPQG GPHSLRCQVS
1710 1720 1730 1740 1750
GSPPHYFYWS REDGRPLPSS AQQRHQGSEL HFPSVQPSDA GVYICTCRNL
1760 1770 1780 1790 1800
IHTSNSRAEL LVAEAPSKPI TVTVEEQRSQ SVRPGADVTF ICTAKSKSPA
1810 1820 1830 1840 1850
YTLVWTRLHN GKLPSRAMDF NGILTIRNVQ PSDAGTYVCT GSNMFAMDQG
1860 1870 1880 1890 1900
TATLHVQVSG TSTAPVASIH PPQLTVQPGQ QAEFRCSATG NPTPMLEWIG
1910 1920 1930 1940 1950
GPSGQLPAKA QIHNGILRLP AIEPSDQGQY LCRALSSAGQ HVARAMLQVH
1960 1970 1980 1990 2000
GGSGPRVQVS PERTQVHEGR TVRLYCRAAG VPSASITWRK EGGSLPPQAR
2010 2020 2030 2040 2050
SENTDIPTLL IPAITAADAG FYLCVATSPT GTAQARIQVV VLSASGANSV
2060 2070 2080 2090 2100
PVRIESSSPS VTEGQTLDLN CAVMGLTYTQ VTWYKRGGSL PPHAQVHGSR
2110 2120 2130 2140 2150
LRLPQVSPAD SGDYVCRVES DVGPKEASIV VSVLHSPHSG PSYTPATSIT
2160 2170 2180 2190 2200
PPIRIESSSS HVAEGQTLDL NCVVPGQAQV TWRKRGGSLP ARHQTHGSLL
2210 2220 2230 2240 2250
RLHQVSPADS GEYVCHVVLG SEHTETSVLV TIEPAESIPA PGPAPPVRIE
2260 2270 2280 2290 2300
ASSSTVTEGH MLDLNCVVAG QAHAQVTWYK RGGSLPARHQ VRGSRLYILQ
2310 2320 2330 2340 2350
ASPADAGEYV CRAGNGQEAT ITVTVTRNHG ANLAYPPGST SPIRIESSSS
2360 2370 2380 2390 2400
HVAEGQTLDL NCVVQGQAHA QVTWHKRGGS LPARHQTHGS LLRLHQVSPV
2410 2420 2430 2440 2450
DSGEYVCRVE GGAVPLESSV LVTIEPAGTA PGVIPPVRIE SSSSHVSEGQ
2460 2470 2480 2490 2500
SLDLNCLVSG QTHPQISWHK RGGSLPARHQ VHGSRLRLLQ VTPTDSGEYV
2510 2520 2530 2540 2550
CRVVSGSGTQ EASILVTIQQ TLSPSHSQSV VHPVRIESSS PSLANGHTLD
2560 2570 2580 2590 2600
LNCLVASLTP HTITWYKRGG SLPSRHQIVG SRLRIPQVTP ADSGEYVCHV
2610 2620 2630 2640 2650
SNGAGSQETS LIVTIESRGP SHVPSVSPPM RIETSSPTVT EGQTLDLNCV
2660 2670 2680 2690 2700
VVGRPQATIT WYKRGGSLPF RHQAHGSRLR LHHMSVADSG EYVCRANNNI
2710 2720 2730 2740 2750
DAQETSIMIS VSPSTNSPPA PASPAPIRIE SSSSRVAEGQ TLDLNCVVPG
2760 2770 2780 2790 2800
HAHAQVTWHK RGGSLPTHHQ THGSRLRLYQ VSSADSGEYV CSVLSSSGPL
2810 2820 2830 2840 2850
EASVLVSITP AAANVHIPGE VPFPPIRIET SSSRVAEGQT LDLSCVVPGQ
2860 2870 2880 2890 2900
AHAQVTWHKR GGSLPAGHQV HGHMLRLNRV SPADSGEYSC QVTGSSGTLE
2910 2920 2930 2940 2950
ASVLVTIEAS EPSPIPAPGL AQPVYIESSS SHLTEGQTVD LKCVVPGQAH
2960 2970 2980 2990 3000
AQVTWHKRGS SLPARHQTHG SLLRLYQLSP ADSGEYVCQV AGSSHPEHEA
3010 3020 3030 3040 3050
SFKLTVPSSQ NSSFRLRSPV ISIEPPSSTV QQGQDASFKC LIHEGATPIK
3060 3070 3080 3090 3100
VEWKIRDQEL EDNVHISPNG SIITIVGTRP SNHGAYRCVA SNVYGMAQSV
3110 3120 3130 3140 3150
VNLSVHGPPT VSVLPEGPVH VKMGKDITLE CISSGEPRSS PRWTRLGIPV
3160 3170 3180 3190 3200
KLEPRMFGLM NSHAMLKIAS VKPSDAGTYV CQAQNALGTA QKQVELIVDT
3210 3220 3230 3240 3250
GTVAPGAPQV QVEESELTLE AGHTATLHCS ATGNPPPTIH WSKLRAPLPW
3260 3270 3280 3290 3300
QHRIEGNTLV IPRVAQQDSG QYICNATNSA GHTEATVVLH VESPPYATII
3310 3320 3330 3340 3350
PEHTSAQPGN LVQLQCLAHG TPPLTYQWSL VGGVLPEKAV ARNQVLRLEP
3360 3370 3380 3390 3400
TVPEDSGRYR CQVSNRVGSA EAFAQVLVQG SSSNLPDTSI PGGSTPTVQV
3410 3420 3430 3440 3450
TPQLETRNIG ASVEFHCAVP NERGTHLRWL KEGGQLPPGH SVQDGVLRIQ
3460 3470 3480 3490 3500
NLDQSCQGTY VCQAHGPWGQ AQATAQLIVQ ALPSVLINVR TSVHSVVVGH
3510 3520 3530 3540 3550
SVEFECLALG DPKPQVTWSK VGGHLRPGIV QSGSIIRIAH VELADAGQYR
3560 3570 3580 3590 3600
CAATNAAGTT QSHVLLLVQA LPQISTPPEI RVPAGSAAVF PCMASGYPTP
3610 3620 3630 3640 3650
AITWSKVDGD LPPDSRLENN MLMLPSVRPE DAGTYVCTAT NRQGKVKAFA
3660 3670 3680 3690 3700
YLQVPERVIP YFTQTPYSFL PLPTIKDAYR KFEIKITFRP DSADGMLLYN
3710 3720 3730 3740 3750
GQKRSPTNLA NRQPDFISFG LVGGRPEFRF DAGSGMATIR HPTPLALGQF
3760 3770 3780 3790 3800
HTVTLLRSLT QGSLIVGNLA PVNGTSQGKF QGLDLNEELY LGGYPDYGAI
3810 3820 3830 3840 3850
PKAGLSSGFV GCVRELRIQG EEVVFHDVNL TTHGISHCPT CQDRPCQNGG
3860 3870 3880 3890 3900
QCQDSESSSY TCVCPAGFTG SRCEHSQALH CHPEACGPDA TCVNRPDGRG
3910 3920 3930 3940 3950
YTCRCHLGRS GVRCEEGVTV TTPSMSGAGS YLALPALTNM HHELRLDVEF
3960 3970 3980 3990 4000
KPLEPNGILL FSGGKSGPVE DFVSLAMVGG HLEFRYELGS GLAVLRSHEP
4010 4020 4030 4040 4050
LTLGRWHRVS AERLNKDGSL RVDGGRPVLR SSPGKSQGLN LHTLLYLGGV
4060 4070 4080 4090 4100
EPSVQLSPAT NMSAHFHGCV GEVSVNGKRL DLTYSFLGSQ GVGQCYDSSP
4110 4120 4130 4140 4150
CERQPCQNGA TCMPAGEYEF QCLCQDGFKG DLCEHEENPC QLHEPCLNGG
4160 4170 4180 4190 4200
TCRGARCLCL PGFSGPRCQQ GAGYGVVESD WHPEGSGGND APGQYGAYFY
4210 4220 4230 4240 4250
DNGFLGLPGN SFSRSLPEVP ETIEFEVRTS TADGLLLWQG VVREASRSKD
4260 4270 4280 4290 4300
FISLGLQDGH LVFSYQLGSG EARLVSEDPI NDGEWHRITA LREGQRGSIQ
4310 4320 4330 4340 4350
VDGEDLVTGR SPGPNVAVNT KDIIYIGGAP DVATLTRGKF SSGITGCIKN
4360 4370 4380
LVLHTARPGA PPPQPLDLQH RAQAGANTRP CPS
Length:4,383
Mass (Da):469,785
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1EC661296F39FEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q05793PGBM_MOUSE
Basement membrane-specific heparan ...
Hspg2
3,707Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B0C7B1B0C7_MOUSE
Basement membrane-specific heparan ...
Hspg2
4,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BD72A0A571BD72_MOUSE
Basement membrane-specific heparan ...
Hspg2
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_032331.2, NM_008305.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000171332; ENSMUSP00000131316; ENSMUSG00000028763

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
15530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15530

UCSC genome browser

More...
UCSCi
uc008vjc.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_032331.2, NM_008305.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131316

PTM databases

iPTMnetiE9PZ16

Proteomic databases

jPOSTiE9PZ16
MaxQBiE9PZ16
PaxDbiE9PZ16
PeptideAtlasiE9PZ16
PRIDEiE9PZ16
ProteomicsDBi314446

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
980, 481 antibodies

Genome annotation databases

EnsembliENSMUST00000171332; ENSMUSP00000131316; ENSMUSG00000028763
GeneIDi15530
KEGGimmu:15530
UCSCiuc008vjc.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3339
MGIiMGI:96257, Hspg2
VEuPathDBiHostDB:ENSMUSG00000028763

Phylogenomic databases

eggNOGiKOG3509, Eukaryota
GeneTreeiENSGT00940000156670
OMAiCDERGSM
OrthoDBi414294at2759
PhylomeDBiE9PZ16
TreeFamiTF326548

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
15530, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hspg2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028763, Expressed in heart and 302 other tissues
ExpressionAtlasiE9PZ16, baseline and differential
GenevisibleiE9PZ16, MM

Family and domain databases

CDDicd00112, LDLa, 4 hits
Gene3Di2.60.40.10, 22 hits
4.10.400.10, 4 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000082, SEA_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF07679, I-set, 11 hits
PF00052, Laminin_B, 3 hits
PF00053, Laminin_EGF, 9 hits
PF00054, Laminin_G_1, 3 hits
PF00057, Ldl_recept_a, 4 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 10 hits
SM00179, EGF_CA, 5 hits
SM00180, EGF_Lam, 9 hits
SM00409, IG, 22 hits
SM00408, IGc2, 22 hits
SM00406, IGv, 8 hits
SM00281, LamB, 3 hits
SM00282, LamG, 3 hits
SM00192, LDLa, 4 hits
SM00200, SEA, 1 hit
SUPFAMiSSF48726, SSF48726, 22 hits
SSF49899, SSF49899, 3 hits
SSF57424, SSF57424, 4 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 4 hits
PS01248, EGF_LAM_1, 7 hits
PS50027, EGF_LAM_2, 6 hits
PS50835, IG_LIKE, 22 hits
PS50025, LAM_G_DOMAIN, 3 hits
PS51115, LAMININ_IVA, 3 hits
PS01209, LDLRA_1, 3 hits
PS50068, LDLRA_2, 4 hits
PS50024, SEA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PZ16_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PZ16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 29, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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