UniProtKB - E9PYX7 (E9PYX7_MOUSE)
Protein
Submitted name:
Afadin
Gene
Afdn
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- signal transduction Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: AfadinImported |
Gene namesi | Name:AfdnImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1314653, Afdn |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000068036, Expressed in dorsal pancreas and 277 other tissues |
ExpressionAtlasi | E9PYX7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 133 | Ras-associatingInterPro annotationAdd BLAST | 95 | |
Domaini | 246 – 348 | Ras-associatingInterPro annotationAdd BLAST | 103 | |
Domaini | 668 – 908 | DiluteInterPro annotationAdd BLAST | 241 | |
Domaini | 1007 – 1093 | PDZInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 196 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 356 – 377 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 538 – 569 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1107 – 1194 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 1203 – 1222 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1235 – 1278 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 1308 – 1527 | DisorderedSequence analysisAdd BLAST | 220 | |
Regioni | 1567 – 1587 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1616 – 1663 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 196 | PolyampholyteSequence analysisAdd BLAST | 54 | |
Compositional biasi | 545 – 568 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1130 – 1147 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1154 – 1169 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1171 – 1194 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1308 – 1340 | PolarSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1360 – 1376 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1406 – 1441 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 1442 – 1490 | PolarSequence analysisAdd BLAST | 49 | |
Compositional biasi | 1512 – 1527 | PolyampholyteSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
HOGENOMi | CLU_000594_1_0_1 |
OMAi | VTPRNID |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
E9PYX7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
60 70 80 90 100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
110 120 130 140 150
ERRLDIDEKP LVVQLNWNKD DREGRFVLKN ENDAIPAKKA QSNGPEKQEK
160 170 180 190 200
EGVIQNFKRT LSKKEKKEKK KKEKEALRQA SDKEERPSQG DDSENSRLAA
210 220 230 240 250
EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS DGRPDSGGTL
260 270 280 290 300
RIYADSLKPN IPYKTILLST TDTADFAVAE SLEKYGLEKE NPKDYCIARV
310 320 330 340 350
MLPPGAQHSD ERGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDY
360 370 380 390 400
IPKKMKKHVE GKSLKGKDRA DGSGYGSALP PEKLPYLVEL SPGRRNHFAY
410 420 430 440 450
YSYHTYEDGS DSRDKPKLYR LQLSVTEVGT EKFDDNSIQL FGPGIQPHHC
460 470 480 490 500
DLTNMDGVVT VTPRSMDAET YVDGQRISET TMLQSGMRLQ FGTSHVFKFV
510 520 530 540 550
DPIQDHVLSK RSVDGGLMVK GPRHKPGAVQ ETTFELGGDV HSGTALPASR
560 570 580 590 600
STTRLDSDRV SSASSTAERG MVKPMIRLDQ EQEYRRRENR TQDATGPELI
610 620 630 640 650
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSSQH
660 670 680 690 700
RPDISPTERT HKAIAVVNKM VSMMEGVIQK QKNIAGALAF WMANASELLN
710 720 730 740 750
FIKQDRDLSR ITLDAQDVLA HLVQMAFKYL VHCLQSELNN YMPAFLDDPE
760 770 780 790 800
ENSLQRPKID DVLHTLTGAM SLLRRCRVNA ALTIQLFSQL FHFINMWLFN
810 820 830 840 850
RLVTDPDSGL CSHYWGAIIR QQLGHIEAWA EKQGLELAAD CHLSRIVQAT
860 870 880 890 900
TLLTMDKYVP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE
910 920 930 940 950
NVVAVAENTA DELARSDGRD VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN
960 970 980 990 1000
GLQEFLDPLC QRGFCRLVPH TRSPGTWTIY FEGADYESHL MRENAELAQP
1010 1020 1030 1040 1050
LRKEPEIITV TLKKQNGMGL SIVAAKGAGQ DKLGIYVKSV VKGGAADVDG
1060 1070 1080 1090 1100
RLAAGDQLLS VDGRSLVGLS QERAAELMTR TSSVVTLEVA KQGAIYHGLA
1110 1120 1130 1140 1150
TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSAQNGS PESPQMPWTE
1160 1170 1180 1190 1200
YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKGPYT SGTAAKITSV
1210 1220 1230 1240 1250
STGNLCTEEQ SPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQSQWP
1260 1270 1280 1290 1300
NYEEKPHVHT ESNHSSIAIQ RVTRSQEELR EEKVYQLERH RVEAGMDRKC
1310 1320 1330 1340 1350
DSDMWINQSS SVESSTSSQE HLNHSSKSVT PASTLTKSGP GRWKTPAAVL
1360 1370 1380 1390 1400
PTPVAVSQPI RTDLPPPPPP PPVHYTSEFD GIPMDLPLPP PPANQAGPQS
1410 1420 1430 1440 1450
AQVAAAEWKK REEHQRWYEK EKARLEEERE RKRREQERKL GQMRSQTLNP
1460 1470 1480 1490 1500
ASFSPLATQA KPEKPSTLQR PQETVIRELQ PQQQPRTIER KDLQYITISK
1510 1520 1530 1540 1550
EELSSGDSLS PDPWKRDARE KLEKQQQMHI VDMLSKEIHE LQNKVDRTAE
1560 1570 1580 1590 1600
ESDRLRKLML EWQFQKRLQE SKQKDEDDDE EEDDDVDTML IMQRLEAERR
1610 1620 1630 1640 1650
ARQTAMPAIS VLDLMQDEER RRQQQLEEMR KREAEDRVRQ EEDGRHQEEE
1660
RVKRDAEEKV MVL
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9QZQ1 | AFAD_MOUSE | Afadin | Afdn Af6, Mllt4 | 1,820 | Annotation score: | ||
E9Q9C3 | E9Q9C3_MOUSE | Afadin | Afdn | 1,827 | Annotation score: | ||
E9Q852 | E9Q852_MOUSE | Afadin | Afdn | 1,805 | Annotation score: | ||
D3YUD2 | D3YUD2_MOUSE | Afadin | Afdn | 229 | Annotation score: | ||
D3Z7L2 | D3Z7L2_MOUSE | Afadin | Afdn | 221 | Annotation score: | ||
F7C3I9 | F7C3I9_MOUSE | Afadin | Afdn | 380 | Annotation score: | ||
A0A668KLE6 | A0A668KLE6_MOUSE | Afadin | Afdn | 87 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC155253 Genomic DNA No translation available. AC174800 Genomic DNA No translation available. CT030652 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000137708; ENSMUSP00000114485; ENSMUSG00000068036 |
UCSCi | uc008ams.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC155253 Genomic DNA No translation available. AC174800 Genomic DNA No translation available. CT030652 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PYX7 |
ModBasei | Search... |
Proteomic databases
jPOSTi | E9PYX7 |
MaxQBi | E9PYX7 |
PeptideAtlasi | E9PYX7 |
PRIDEi | E9PYX7 |
Protocols and materials databases
Antibodypediai | 4608, 260 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000137708; ENSMUSP00000114485; ENSMUSG00000068036 |
UCSCi | uc008ams.1, mouse |
Organism-specific databases
MGIi | MGI:1314653, Afdn |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
HOGENOMi | CLU_000594_1_0_1 |
OMAi | VTPRNID |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068036, Expressed in dorsal pancreas and 277 other tissues |
ExpressionAtlasi | E9PYX7, baseline and differential |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PYX7_MOUSE | |
Accessioni | E9PYX7Primary (citable) accession number: E9PYX7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | October 7, 2020 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |