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Protein
Submitted name:

Rho GTPase-activating protein 5

Gene

Arhgap5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Submitted name:
Rho GTPase-activating protein 5Imported
Gene namesi
Name:Arhgap5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1332637 Arhgap5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000035133 Expressed in 307 organ(s), highest expression level in rostral migratory stream
GenevisibleiE9PYT0 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PYT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 325FFInterPro annotationAdd BLAST59
Domaini366 – 420FFInterPro annotationAdd BLAST55
Domaini427 – 481FFInterPro annotationAdd BLAST55
Domaini482 – 548FFInterPro annotationAdd BLAST67
Domaini590 – 763PG1 pseudoGTPaseInterPro annotationAdd BLAST174
Domaini779 – 944PG2 pseudoGTPaseInterPro annotationAdd BLAST166
Domaini1263 – 1450Rho-GAPInterPro annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili309 – 329Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4271 Eukaryota
ENOG410XR4E LUCA
GeneTreeiENSGT00930000150818
KOiK13709
OMAiFKYITEA
OrthoDBiEOG091G00ZO
TreeFamiTF324451

Family and domain databases

Gene3Di1.10.10.440, 3 hits
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR027417 P-loop_NTPase
IPR039007 pG1
IPR008936 Rho_GTPase_activation_prot
IPR032835 RhoGAP-FF1
IPR000198 RhoGAP_dom
IPR039006 RhoGAP_pG2
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF01846 FF, 1 hit
PF00071 Ras, 1 hit
PF00620 RhoGAP, 1 hit
PF16512 RhoGAP-FF1, 1 hit
SMARTiView protein in SMART
SM00441 FF, 4 hits
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit
SSF81698 SSF81698, 1 hit
PROSITEiView protein in PROSITE
PS51676 FF, 4 hits
PS51852 PG1, 1 hit
PS51853 PG2, 1 hit
PS50238 RHOGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PYT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAKNKEPRP PSYTVSVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY
60 70 80 90 100
PEHTSVLSTI DFGGRVVNND HFLYWGDITQ NGEDGVECKI HVIEQTEFID
110 120 130 140 150
DQTFLPHRST NLQPYIKRAA ASKLQSAEKL MYICTDQLGL EQDFEQKQMP
160 170 180 190 200
EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV NNLFVQLSKS KKPVIIAATK
210 220 230 240 250
CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT ALVQMLDKTR
260 270 280 290 300
GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH
310 320 330 340 350
PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIS TLPRAFNTLL
360 370 380 390 400
PDLEEIEHLN WLEALKLMEK RADFQLCFVV LEKTPWDETD HIDKINDRRI
410 420 430 440 450
PFDLLSTLEA EKVYQNHVQH LISEKRRIEM KEKFKKTLEK IQFISPGQPW
460 470 480 490 500
EEVMCFVMED EAFKYITEAD SKEVYGRHQR EIVEKAKEEF QEMLFEHSEL
510 520 530 540 550
FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES LLLKHIGFVY
560 570 580 590 600
HPTKETCLSG QYCTDIKVEN LLATSLLEMD HNRVRLYHDS TNIDKVNLFI
610 620 630 640 650
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYILSQLWT
660 670 680 690 700
AAFKPHGCFC VFNSIESLSF IGEFIGKIRT EASQIRKDKY MTNLPFTLIL
710 720 730 740 750
ANQRDSISKN LPILRHQGQQ LANKLQCPFV DVPTGTYPRK FNESQIKQAL
760 770 780 790 800
RGVLESVKHN LDVVSPVPIN KDVSEADLRI VMCAMCGDPF SVDLILSPFL
810 820 830 840 850
DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI GVRKDELVHG
860 870 880 890 900
YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL
910 920 930 940 950
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL
960 970 980 990 1000
SDNTRESTHQ SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL
1010 1020 1030 1040 1050
LPTPSDRSRY RLDLEGNEYP VHSTPNCHDH ERNHKVPPPI KPKPVVPKTN
1060 1070 1080 1090 1100
VKKLDPNLLK TIEAGIGKNP RKQTSRVPLA HPEDMDSSDN YVEPLDTIFK
1110 1120 1130 1140 1150
QKGYSDEIYV VPDDSQNRII KIRNSFVNNT QGDEENGFSD RTSKGHGERR
1160 1170 1180 1190 1200
PSKYKYKSKT LFSKAKSYYR RTHSDASDDE AFTTSKTKRK GRHRGSEEDP
1210 1220 1230 1240 1250
LLSPVETWKG GIDNPAITSD QEVDDKKIKK KTHKVKEDKK QKKKTKTFNP
1260 1270 1280 1290 1300
PTRRNWESNY FGMPLQDLVT AEKPIPLFVE KCVEFIEDTG LCTEGLYRVS
1310 1320 1330 1340 1350
GNKTDQDNIQ KQFDQDHNIN LASMEVTVNA VAGALKAFFA DLPDPLIPYS
1360 1370 1380 1390 1400
LHPELLEAAK IPDKTERFHA LKEIVKKFHP VNYDVFRYVI THLNRVSQQN
1410 1420 1430 1440 1450
KINLMTADNL SICFWPTLMR PDFENREFLS TTKIHQSVVE TFIQQCQFFF
1460 1470 1480 1490 1500
YNGEIVETAN TVAPPPTSNP GQLVESMVPL QLPPPLQPQL IQPQLQTDPL

GII
Length:1,503
Mass (Da):172,472
Last modified:April 5, 2011 - v1
Checksum:i8F7B5F8206CD9C59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97393RHG05_MOUSE
Rho GTPase-activating protein 5
Arhgap5 Rhogap5
1,501Annotation score:
A0A1W2P6H9A0A1W2P6H9_MOUSE
Rho GTPase-activating protein 5
Arhgap5
241Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114002 Genomic DNA No translation available.
AC155819 Genomic DNA No translation available.
RefSeqiNP_033836.2, NM_009706.2
XP_006515501.1, XM_006515438.3
XP_011242291.1, XM_011243989.1
XP_011242292.1, XM_011243990.1
UniGeneiMm.35059
Mm.466962
Mm.474991

Genome annotation databases

EnsembliENSMUST00000110725; ENSMUSP00000106353; ENSMUSG00000035133
ENSMUST00000219443; ENSMUSP00000151809; ENSMUSG00000035133
GeneIDi11855
KEGGimmu:11855
UCSCiuc007nni.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114002 Genomic DNA No translation available.
AC155819 Genomic DNA No translation available.
RefSeqiNP_033836.2, NM_009706.2
XP_006515501.1, XM_006515438.3
XP_011242291.1, XM_011243989.1
XP_011242292.1, XM_011243990.1
UniGeneiMm.35059
Mm.466962
Mm.474991

3D structure databases

ProteinModelPortaliE9PYT0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110725; ENSMUSP00000106353; ENSMUSG00000035133
ENSMUST00000219443; ENSMUSP00000151809; ENSMUSG00000035133
GeneIDi11855
KEGGimmu:11855
UCSCiuc007nni.1 mouse

Organism-specific databases

CTDi394
MGIiMGI:1332637 Arhgap5

Phylogenomic databases

eggNOGiKOG4271 Eukaryota
ENOG410XR4E LUCA
GeneTreeiENSGT00930000150818
KOiK13709
OMAiFKYITEA
OrthoDBiEOG091G00ZO
TreeFamiTF324451

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiArhgap5 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035133 Expressed in 307 organ(s), highest expression level in rostral migratory stream
GenevisibleiE9PYT0 MM

Family and domain databases

Gene3Di1.10.10.440, 3 hits
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR027417 P-loop_NTPase
IPR039007 pG1
IPR008936 Rho_GTPase_activation_prot
IPR032835 RhoGAP-FF1
IPR000198 RhoGAP_dom
IPR039006 RhoGAP_pG2
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF01846 FF, 1 hit
PF00071 Ras, 1 hit
PF00620 RhoGAP, 1 hit
PF16512 RhoGAP-FF1, 1 hit
SMARTiView protein in SMART
SM00441 FF, 4 hits
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit
SSF81698 SSF81698, 1 hit
PROSITEiView protein in PROSITE
PS51676 FF, 4 hits
PS51852 PG1, 1 hit
PS51853 PG2, 1 hit
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PYT0_MOUSE
AccessioniPrimary (citable) accession number: E9PYT0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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