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UniProtKB - E9PYS0 (E9PYS0_MOUSE)
Protein
Submitted name:
Vomeronasal 2, receptor 108
Gene
Vmn2r108
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Vomeronasal 2, receptor 108Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3643822, Vmn2r108 |
VEuPathDBi | HostDB:ENSMUSG00000091805 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 584 – 609 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 621 – 642 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 654 – 678 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 698 – 717 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 743 – 766 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 778 – 798 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 810 – 833 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5003243033 | 20 – 855 | Sequence analysisAdd BLAST | 836 |
Proteomic databases
PaxDbi | E9PYS0 |
PeptideAtlasi | E9PYS0 |
PTM databases
iPTMneti | E9PYS0 |
PhosphoSitePlusi | E9PYS0 |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000130373 |
Miscellaneous databases
RNActi | E9PYS0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 584 – 848 | G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST | 265 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00950000183069 |
HOGENOMi | CLU_005389_5_0_1 |
OMAi | FTICANI |
OrthoDBi | 546292at2759 |
PhylomeDBi | E9PYS0 |
TreeFami | TF340115 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR004073, GPCR_3_vmron_rcpt_2 IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01535, VOMERONASL2R |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9PYS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSCIFISSL LLIAKFVLTF MHVNISKCFY KITEDFHHEG DVVIGAFFPL
60 70 80 90 100
HTYYTKNKIP HSYLPYYYKD NYLQYNFKNY QYILALVFAI EEINDNPNLL
110 120 130 140 150
PNISLGFDFY NVRFIEKDTL MNVCFWLTGQ GQKNILPNYN CGKSNFATAL
160 170 180 190 200
TGTAWTTSAQ IGTLLQLFKF PQLSFGPYDS ILSDRGQYSS LYQMASKYTS
210 220 230 240 250
ISLGIVSLMV HFRWSWVGLI LPDNHKGNKI LSEFREDMER KGVCIAFVKM
260 270 280 290 300
IPMTWNAYYN KFWENMDETN VIIIYGDIDS LTGLMRNIGQ RLLTAKVWIM
310 320 330 340 350
NTEPHITDYA DYFMLDSFHG SLIFTHNYRK SFKISNFIQT VNPYKYPEDI
360 370 380 390 400
YLPKLWHLFF KCSFSDVDCR LLANCQPNAS LDVLPSHILD MVISEESNNI
410 420 430 440 450
YNAVYAVAHS LHQMHLQEVQ IKPHENGEAI AFFPWQLNIF LKDINERDNM
460 470 480 490 500
SFGGRQKLNA EYDILNLWNL PKGLGQKVKI GSFSANAPEG QQLSLSEQMI
510 520 530 540 550
QWAEGFSEIP QSVCSESCGP GFRKVTLEGK AICCYNCTPC ADNEISNETD
560 570 580 590 600
VDQCVKCPES HYSNTEKNHC LQKTVIFLAY EDPLGMTLAC IALCLSALTA
610 620 630 640 650
FVIGVFVKYR DTPIVKANNR GLSYTLLITI TFCLLCSLNF IGQPNTASCI
660 670 680 690 700
LQQNIFGVAF TVALATVLAK AITVVLAFKA TFPGRMVRWL MTSRAPNYII
710 720 730 740 750
PLCTLIQLFI CGIWMTMSPP FIHQDNHAEH GHILLLCNKG SSVAFHCVLG
760 770 780 790 800
YLCSLAFGGY TMAFLSRNLP DTFNESKFLS FSMVVFFCVW VTFLPVYHST
810 820 830 840 850
KGKVMVAVEV FSILASSTAL LGFIFAPKCY IILFRPEKNS FHRIKDKTYS
RWNKI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2WAK9 | A0A3B2WAK9_MOUSE | Vomeronasal 2, receptor 108 | Vmn2r108 | 819 | Annotation score: | ||
A0A3B2WD17 | A0A3B2WD17_MOUSE | Vomeronasal 2, receptor 108 | Vmn2r108 | 783 | Annotation score: | ||
A0A3B2WAT0 | A0A3B2WAT0_MOUSE | Vomeronasal 2, receptor 108 | Vmn2r108 | 497 | Annotation score: | ||
A0A3B2WB20 | A0A3B2WB20_MOUSE | Vomeronasal 2, receptor 108 | Vmn2r108 | 533 | Annotation score: | ||
A0A3B2WCR1 | A0A3B2WCR1_MOUSE | Vomeronasal 2, receptor 108 | Vmn2r108 | 173 | Annotation score: |
Sequence databases
RefSeqi | NP_001098040.1, NM_001104570.1 |
Genome annotation databases
Ensembli | ENSMUST00000167314; ENSMUSP00000130373; ENSMUSG00000091805 |
GeneIDi | 627805 |
KEGGi | mmu:627805 |
UCSCi | uc009vbl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001098040.1, NM_001104570.1 |
3D structure databases
SMRi | E9PYS0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000130373 |
PTM databases
iPTMneti | E9PYS0 |
PhosphoSitePlusi | E9PYS0 |
Proteomic databases
PaxDbi | E9PYS0 |
PeptideAtlasi | E9PYS0 |
Genome annotation databases
Ensembli | ENSMUST00000167314; ENSMUSP00000130373; ENSMUSG00000091805 |
GeneIDi | 627805 |
KEGGi | mmu:627805 |
UCSCi | uc009vbl.1, mouse |
Organism-specific databases
CTDi | 627805 |
MGIi | MGI:3643822, Vmn2r108 |
VEuPathDBi | HostDB:ENSMUSG00000091805 |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00950000183069 |
HOGENOMi | CLU_005389_5_0_1 |
OMAi | FTICANI |
OrthoDBi | 546292at2759 |
PhylomeDBi | E9PYS0 |
TreeFami | TF340115 |
Miscellaneous databases
BioGRID-ORCSi | 627805, 2 hits in 59 CRISPR screens |
RNActi | E9PYS0, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | E9PYS0, baseline and differential |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR004073, GPCR_3_vmron_rcpt_2 IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01535, VOMERONASL2R |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PYS0_MOUSE | |
Accessioni | E9PYS0Primary (citable) accession number: E9PYS0 Secondary accession number(s): E9Q6V2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | January 9, 2013 | |
Last modified: | January 19, 2022 | |
This is version 76 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |