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UniProtKB - E9PYS0 (E9PYS0_MOUSE)

Entry version 76 (19 Jan 2022)
Sequence version 2 (09 Jan 2013)
Previous versions | rss
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Protein
Submitted name:

Vomeronasal 2, receptor 108

Gene

Vmn2r108

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorARBA annotation, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Vomeronasal 2, receptor 108Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vmn2r108Imported
Synonyms:Vmn2r109Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3643822, Vmn2r108

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000091805

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei584 – 609HelicalSequence analysisAdd BLAST26
Transmembranei621 – 642HelicalSequence analysisAdd BLAST22
Transmembranei654 – 678HelicalSequence analysisAdd BLAST25
Transmembranei698 – 717HelicalSequence analysisAdd BLAST20
Transmembranei743 – 766HelicalSequence analysisAdd BLAST24
Transmembranei778 – 798HelicalSequence analysisAdd BLAST21
Transmembranei810 – 833HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324303320 – 855Sequence analysisAdd BLAST836

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9PYS0

PeptideAtlas

More...PeptideAtlasi		E9PYS0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		E9PYS0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E9PYS0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9PYS0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000130373

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		E9PYS0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9PYS0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini584 – 848G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST265

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1056, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183069

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005389_5_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		FTICANI

Database of Orthologous Groups

More...OrthoDBi		546292at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E9PYS0

TreeFam database of animal gene trees

More...TreeFami		TF340115

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR004073, GPCR_3_vmron_rcpt_2
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...PANTHERi		PTHR24061, PTHR24061, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00248, GPCRMGR
PR01535, VOMERONASL2R

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9PYS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSCIFISSL LLIAKFVLTF MHVNISKCFY KITEDFHHEG DVVIGAFFPL 
        60         70         80         90        100
HTYYTKNKIP HSYLPYYYKD NYLQYNFKNY QYILALVFAI EEINDNPNLL 
       110        120        130        140        150
PNISLGFDFY NVRFIEKDTL MNVCFWLTGQ GQKNILPNYN CGKSNFATAL 
       160        170        180        190        200
TGTAWTTSAQ IGTLLQLFKF PQLSFGPYDS ILSDRGQYSS LYQMASKYTS 
       210        220        230        240        250
ISLGIVSLMV HFRWSWVGLI LPDNHKGNKI LSEFREDMER KGVCIAFVKM 
       260        270        280        290        300
IPMTWNAYYN KFWENMDETN VIIIYGDIDS LTGLMRNIGQ RLLTAKVWIM 
       310        320        330        340        350
NTEPHITDYA DYFMLDSFHG SLIFTHNYRK SFKISNFIQT VNPYKYPEDI 
       360        370        380        390        400
YLPKLWHLFF KCSFSDVDCR LLANCQPNAS LDVLPSHILD MVISEESNNI 
       410        420        430        440        450
YNAVYAVAHS LHQMHLQEVQ IKPHENGEAI AFFPWQLNIF LKDINERDNM 
       460        470        480        490        500
SFGGRQKLNA EYDILNLWNL PKGLGQKVKI GSFSANAPEG QQLSLSEQMI 
       510        520        530        540        550
QWAEGFSEIP QSVCSESCGP GFRKVTLEGK AICCYNCTPC ADNEISNETD 
       560        570        580        590        600
VDQCVKCPES HYSNTEKNHC LQKTVIFLAY EDPLGMTLAC IALCLSALTA 
       610        620        630        640        650
FVIGVFVKYR DTPIVKANNR GLSYTLLITI TFCLLCSLNF IGQPNTASCI 
       660        670        680        690        700
LQQNIFGVAF TVALATVLAK AITVVLAFKA TFPGRMVRWL MTSRAPNYII 
       710        720        730        740        750
PLCTLIQLFI CGIWMTMSPP FIHQDNHAEH GHILLLCNKG SSVAFHCVLG 
       760        770        780        790        800
YLCSLAFGGY TMAFLSRNLP DTFNESKFLS FSMVVFFCVW VTFLPVYHST 
       810        820        830        840        850
KGKVMVAVEV FSILASSTAL LGFIFAPKCY IILFRPEKNS FHRIKDKTYS 

RWNKI
Length:855
Mass (Da):97,535
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8681E4AB1196AB98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2WAK9A0A3B2WAK9_MOUSE
Vomeronasal 2, receptor 108
Vmn2r108
819Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WD17A0A3B2WD17_MOUSE
Vomeronasal 2, receptor 108
Vmn2r108
783Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WAT0A0A3B2WAT0_MOUSE
Vomeronasal 2, receptor 108
Vmn2r108
497Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WB20A0A3B2WB20_MOUSE
Vomeronasal 2, receptor 108
Vmn2r108
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WCR1A0A3B2WCR1_MOUSE
Vomeronasal 2, receptor 108
Vmn2r108
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_001098040.1, NM_001104570.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000167314; ENSMUSP00000130373; ENSMUSG00000091805

Database of genes from NCBI RefSeq genomes

More...GeneIDi		627805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:627805

UCSC genome browser

More...UCSCi		uc009vbl.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001098040.1, NM_001104570.1

3D structure databases

SMRiE9PYS0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130373

PTM databases

iPTMnetiE9PYS0
PhosphoSitePlusiE9PYS0

Proteomic databases

PaxDbiE9PYS0
PeptideAtlasiE9PYS0

Genome annotation databases

EnsembliENSMUST00000167314; ENSMUSP00000130373; ENSMUSG00000091805
GeneIDi627805
KEGGimmu:627805
UCSCiuc009vbl.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		627805
MGIiMGI:3643822, Vmn2r108
VEuPathDBiHostDB:ENSMUSG00000091805

Phylogenomic databases

eggNOGiKOG1056, Eukaryota
GeneTreeiENSGT00950000183069
HOGENOMiCLU_005389_5_0_1
OMAiFTICANI
OrthoDBi546292at2759
PhylomeDBiE9PYS0
TreeFamiTF340115

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		627805, 2 hits in 59 CRISPR screens
RNActiE9PYS0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

ExpressionAtlasiE9PYS0, baseline and differential

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR004073, GPCR_3_vmron_rcpt_2
IPR028082, Peripla_BP_I
PANTHERiPTHR24061, PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit
PRINTSiPR00248, GPCRMGR
PR01535, VOMERONASL2R
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PYS0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PYS0
Secondary accession number(s): E9Q6V2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: January 9, 2013
Last modified: January 19, 2022
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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