Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Roundabout homolog 2

Gene

Robo2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-376176 Signaling by ROBO receptors
R-MMU-428542 Regulation of commissural axon pathfinding by SLIT and ROBO

Names & Taxonomyi

Protein namesi
Submitted name:
Roundabout homolog 2Imported
Gene namesi
Name:Robo2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1890110 Robo2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiE9PYK2
PeptideAtlasiE9PYK2
PRIDEiE9PYK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000052516 Expressed in 206 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiE9PYK2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PYK2
SMRiE9PYK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00910000144011

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR032985 Robo2
PANTHERiPTHR44096:SF2 PTHR44096:SF2, 2 hits
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

E9PYK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XFTTKTTYNS SSQITQATPY ATTQILHSNS IHELAVDLPD PQWKSSVQQK
60 70 80 90 100
TDLMGFGYSL PDQNKGNNGG KGGKKKKTKN SSKAQKNNGS TWANVPLPPP
110 120 130 140 150
PVQPLPGTEL GHYAAEQENG YDSDSWCPPL PVQTYLHQGM EDELEEDEDR
160 170 180 190 200
VPTPPVRGVA SSPAISFGQQ STATLTPSPR EEMQPMLQAH LDELTRAYQF

DIAKQTW
Length:207
Mass (Da):22,779
Last modified:October 10, 2018 - v2
Checksum:i06CBB7108DB8D14E
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TPD3ROBO2_MOUSE
Roundabout homolog 2
Robo2 Kiaa1568
1,470Annotation score:
Q19AB2Q19AB2_MOUSE
ROBO2 isoform b
Robo2
1,508Annotation score:
E9Q6A0E9Q6A0_MOUSE
Roundabout homolog 2
Robo2
1,377Annotation score:
A0A2I3BR72A0A2I3BR72_MOUSE
Roundabout homolog 2
Robo2
1,512Annotation score:
A0A2I3BQB9A0A2I3BQB9_MOUSE
Roundabout homolog 2
Robo2
1,065Annotation score:
A0A338P7C8A0A338P7C8_MOUSE
Roundabout homolog 2
Robo2
149Annotation score:
A0A338P6W2A0A338P6W2_MOUSE
Roundabout homolog 2
Robo2
219Annotation score:
A0A338P6R3A0A338P6R3_MOUSE
Roundabout homolog 2
Robo2
178Annotation score:
A0A338P6D2A0A338P6D2_MOUSE
Roundabout homolog 2
Robo2
793Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112155 Genomic DNA No translation available.
AC122049 Genomic DNA No translation available.
AC129203 Genomic DNA No translation available.
AC134452 Genomic DNA No translation available.
AC158234 Genomic DNA No translation available.
AC162374 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000116586; ENSMUSP00000112285; ENSMUSG00000052516

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112155 Genomic DNA No translation available.
AC122049 Genomic DNA No translation available.
AC129203 Genomic DNA No translation available.
AC134452 Genomic DNA No translation available.
AC158234 Genomic DNA No translation available.
AC162374 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PYK2
SMRiE9PYK2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9PYK2
PeptideAtlasiE9PYK2
PRIDEiE9PYK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116586; ENSMUSP00000112285; ENSMUSG00000052516

Organism-specific databases

MGIiMGI:1890110 Robo2

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00910000144011

Enzyme and pathway databases

ReactomeiR-MMU-376176 Signaling by ROBO receptors
R-MMU-428542 Regulation of commissural axon pathfinding by SLIT and ROBO

Miscellaneous databases

ChiTaRSiRobo2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052516 Expressed in 206 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiE9PYK2 baseline and differential

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR032985 Robo2
PANTHERiPTHR44096:SF2 PTHR44096:SF2, 2 hits
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PYK2_MOUSE
AccessioniPrimary (citable) accession number: E9PYK2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 10, 2018
Last modified: October 10, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again