Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 76 (08 May 2019)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Contactin-associated protein-like 3

Gene

Cntnap3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Contactin-associated protein-like 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cntnap3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3588199 Cntnap3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1245 – 1267HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324302329 – 1287Sequence analysisAdd BLAST1259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi933 ↔ 960PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PY62

PRoteomics IDEntifications database

More...
PRIDEi
E9PY62

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PY62

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PY62

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033063 Expressed in 8 organ(s), highest expression level in cerebral cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000089140

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PY62

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 180F5/8 type CInterPro annotationAdd BLAST147
Domaini186 – 368LAM_G_DOMAINInterPro annotationAdd BLAST183
Domaini374 – 548LAM_G_DOMAINInterPro annotationAdd BLAST175
Domaini550 – 587EGF-likeInterPro annotationAdd BLAST38
Domaini586 – 638Fibrinogen C-terminalInterPro annotationAdd BLAST53
Domaini795 – 960LAM_G_DOMAINInterPro annotationAdd BLAST166
Domaini961 – 999EGF-likeInterPro annotationAdd BLAST39
Domaini1018 – 1204LAM_G_DOMAINInterPro annotationAdd BLAST187

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3516 Eukaryota
ENOG410XPHG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160228

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PY62

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHCQQEL

Database of Orthologous Groups

More...
OrthoDBi
338397at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PY62

TreeFam database of animal gene trees

More...
TreeFami
TF321823

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028873 CASPR3
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR15036:SF36 PTHR15036:SF36, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9PY62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARVNGAFLD ALLLLLLLSV QTLPLVAAGD PHNCDAPLAS SLPQLSFSSS
60 70 80 90 100
SQLSSSHGPG FARLNRRDGA GGWTPLVSNK YQWLQIDLGE RMEVTAVATQ
110 120 130 140 150
GGYGSSDWVT SYLLMFSDGG RNWKQYHQEE SISGFPGNTN ADSVVQYSLQ
160 170 180 190 200
PSFHTRFLRF LPLTWNPKGR IGMRIEVYGC SYKSEVVYFD GQSSLLYKFD
210 220 230 240 250
NGAIRPVREV ISLKFKAMQN SGIIFHGKGQ HGTHIVLELN KGKLVVYLNS
260 270 280 290 300
GDGNLPPVNS IMNFTLGSLL DDRHWHSVLI ELHNMHMNFT LDKYMHHVHV
310 320 330 340 350
NKETSYLDLN FEISFGEILM PGGRFLTFPH KNFHGCLENI YYNGVNIIKL
360 370 380 390 400
AKKHESQILI KGNVSFTCPQ PQTIPVTFLS SGSYLALPSS LREDKMSLAF
410 420 430 440 450
QLRTWNKAGH VFFSQVGHGS GSLVLFLKNG KLILNLSEPG QPLQSITTGA
460 470 480 490 500
VLNDGLWHSV SVSAKGSYLS LLVDGDTAQT LMSVEIHLGD TYYFGGCPNN
510 520 530 540 550
SSSFGCEHSF GGFQGCLRLI SVGDKVVDPI AVQQGVLGSF SDLQIDSCGI
560 570 580 590 600
IDRCLPSYCE HGSRCTQSWD TFSCDCEGTG YTGTTCHSSI YEQSCEAHRH
610 620 630 640 650
RGSPSGLYYI DVDGSGPLAP FLVYCNMTAD TAWTVVQHGG PDVVTVRGGP
660 670 680 690 700
EGHMHSATFS YAANAAQLHA VVNVAEHCEQ QVDLQCRTSG PSDTGDGTSL
710 720 730 740 750
SWWVGRSNET YTYWGGSLPN PQKCTCGFEG NCIDSQYHCN CDADRNEWTS
760 770 780 790 800
DTIVLSHKEH LPVTEMVVTD TGRPYSEAAY TLGPLLCQGD KSFWNSASFN
810 820 830 840 850
TEASYLHFPT FRGELTADVH FLFKTTISSG VFMENLGITD FIRIELRAPT
860 870 880 890 900
EVTFSFDVGN GPCELTIQSP TPFNDNRWHH VRAERNVKGA SLQVDQLPQK
910 920 930 940 950
TQSTPADGHV RLQLNSQLFI GGTASRQKGF LGCIRSLQVN GMALDLEERA
960 970 980 990 1000
VMTPGVEPGC SGHCSSYGHL CRNGGMCQEK HRGIACDCAF SAYDGPLCSY
1010 1020 1030 1040 1050
EISAYFETGS SVTYNFQEYS TLSANTSYLA SSLHGDVILS RETITLSFRT
1060 1070 1080 1090 1100
TQTPCLLLYV TSFYEEYLSI ILANNGSLQV RYKLDRHRNA DAFNFDLRNL
1110 1120 1130 1140 1150
ADGHFHQLTI NREEAVVSVE VNQSTKRQVI LSSGTEFNAV KSLVLGKVLE
1160 1170 1180 1190 1200
PLDADPETQQ AAAQGFTGCL SSVRFGLEVP LKAALNQNRA RVTIQGSVAA
1210 1220 1230 1240 1250
AAHCAEGPGS AERKLSPGPS MDAGHSGSAE DRQPLPNTDR SDPGVIGGIT
1260 1270 1280
AVVIFILLCV SAIAIRVHQQ RRLHQKNEST VSKTEEC
Length:1,287
Mass (Da):140,857
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E6B8E25BEE406CC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC101142 Genomic DNA No translation available.
AC156576 Genomic DNA No translation available.
AC159190 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074598.1, NM_001081129.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091554; ENSMUSP00000089140; ENSMUSG00000033063

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
238680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:238680

UCSC genome browser

More...
UCSCi
uc007qyz.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101142 Genomic DNA No translation available.
AC156576 Genomic DNA No translation available.
AC159190 Genomic DNA No translation available.
RefSeqiNP_001074598.1, NM_001081129.1

3D structure databases

SMRiE9PY62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089140

PTM databases

iPTMnetiE9PY62
PhosphoSitePlusiE9PY62

Proteomic databases

PaxDbiE9PY62
PRIDEiE9PY62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091554; ENSMUSP00000089140; ENSMUSG00000033063
GeneIDi238680
KEGGimmu:238680
UCSCiuc007qyz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79937
MGIiMGI:3588199 Cntnap3

Phylogenomic databases

eggNOGiKOG3516 Eukaryota
ENOG410XPHG LUCA
GeneTreeiENSGT00940000160228
InParanoidiE9PY62
OMAiDHCQQEL
OrthoDBi338397at2759
PhylomeDBiE9PY62
TreeFamiTF321823

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033063 Expressed in 8 organ(s), highest expression level in cerebral cortex

Family and domain databases

CDDicd00057 FA58C, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028873 CASPR3
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR000421 FA58C
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR008979 Galactose-bd-like_sf
IPR001791 Laminin_G
PANTHERiPTHR15036:SF36 PTHR15036:SF36, 1 hit
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00231 FA58C, 1 hit
SM00282 LamG, 4 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 4 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 1 hit
PS50022 FA58C_3, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50025 LAM_G_DOMAIN, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PY62_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PY62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again