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Protein
Submitted name:

G protein-coupled receptor 179

Gene

Gpr179

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • protein localization to plasma membrane Source: MGI
  • visual perception Source: MGI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
G protein-coupled receptor 179Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gpr179Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443409 Gpr179

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei378 – 403HelicalSequence analysisAdd BLAST26
Transmembranei415 – 438HelicalSequence analysisAdd BLAST24
Transmembranei450 – 469HelicalSequence analysisAdd BLAST20
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324569828 – 2293Sequence analysisAdd BLAST2266

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PY61

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PY61

PRoteomics IDEntifications database

More...
PRIDEi
E9PY61

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PY61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PY61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000070337 Expressed in 95 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PY61 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091474

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PY61

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini380 – 650G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST271

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4418 Eukaryota
ENOG410XXEC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160776

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PY61

KEGG Orthology (KO)

More...
KOi
K22961

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAHTSRM

Database of Orthologous Groups

More...
OrthoDBi
63351at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PY61

TreeFam database of animal gene trees

More...
TreeFami
TF319114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017978 GPCR_3_C
IPR032964 GPR179

The PANTHER Classification System

More...
PANTHERi
PTHR32546:SF7 PTHR32546:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9PY61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGARAVVISS LAWGLLSCCF LCSGALGSQR PLRSLPPLPS QAKPRSEPMW
60 70 80 90 100
MPPKGAEAAL AFLYSGDVQR LSGANCSEKY EVRGAEGKAG VPPVLQRAAG
110 120 130 140 150
TLAQAANFLN MLLQANDIRE SSVEEDVEWY QALVRSVAEG DPKAYRALLT
160 170 180 190 200
FNPAPGASHL QLALQATRMG DETVLQDLSG NKVQEETPGE DLDRPVLQKR
210 220 230 240 250
VLTNDLRSLD SPKWPRGDGY VGDIQQVKLS PPFLECHEGQ LRPGWLVTVS
260 270 280 290 300
ATFYGLKPDL TPEVRGQVQM DIDLQSVDIN QCASGPGWYS NTHLCDLNST
310 320 330 340 350
QCVPLESQGF VLGRYLCRCR PGFYGASGSG GLEESATQAA GQFGSPQDSL
360 370 380 390 400
GKLLRCQPCP EGCTSCLDAT PCLVEEALAL RTAVLACQAC CMLAVFLSML
410 420 430 440 450
VAYRCRGSKR IRASGIVLLE TILFGSLLLY FPVFILYFKP SVFRCVALRW
460 470 480 490 500
VRLLGFAVVY GTIILKLYRV LQLFLSRTAQ RVPHPSSGQL LRRLGQLLLL
510 520 530 540 550
VLGFLVVWTA GALEPGTQHT ALVTRGHTPT GRHFYLCHHD HWDYIMVVAE
560 570 580 590 600
MLLLCWGSFL CYATRAVPSA FHEPRYMSIA LHNELLLSTA FHTARFVLVP
610 620 630 640 650
SLHPDWTLLL FFLHTHSTVT ATLALIFIPK FWKPGAPPRE EILDEVYEDE
660 670 680 690 700
LDLQRSGSYL NSSIASAWSE RSLEPGDIRD ELKKLYAQLE IRKTKEMAAN
710 720 730 740 750
NPHLPKKRGS SHQGLGRSFM RYLAEFPEAL ARQHSRDSGS LGLGSLPGSS
760 770 780 790 800
RRRLLSSSLQ ETEKPPALRK TRSTYDHHRE HNTLPFDSTL RRTLSKKASP
810 820 830 840 850
TDGRESLADG PPALGFRSAS AHNLTVGERL PRARPISLQK SLSVAAGSRE
860 870 880 890 900
KALLVASQAY LEETYRQAKE REERKKAEAA MVSPVRRPST RRLEWPLRAP
910 920 930 940 950
LSAPPSPGKS SSMDSSQTTA RPHEEAGRRL PHPPIRHQVS TPVLALSGIC
960 970 980 990 1000
LGEPRMLSPT PASTLAPILL PAPAPAPAPV LAPVSKPPQS PTLLTFICPW
1010 1020 1030 1040 1050
ENAELPGKKE NVVQEDPAGP ERSGHSPASA RTKIWRALSV AVEKRGTGES
1060 1070 1080 1090 1100
EALTEGGHVQ GEADDTDEEK PKVFSKSHSL KTPLQQGSVR SLGLAIKALT
1110 1120 1130 1140 1150
RSRSTYKEKD GGEGTPETEK GKPTEVSTGA PLRSPRLGRP KAVSKQVALA
1160 1170 1180 1190 1200
PCEDEESLQN QQNAHTSRML HVCQKEGSRE QEDRNKRVAP GPGERKVERT
1210 1220 1230 1240 1250
GKITMTTLRQ VFGEKNAEQA KESPAGYQEV PNPALQSLGS ADHRVAEVCP
1260 1270 1280 1290 1300
WEVTEPESGM DPPESVNKAK VYSWERTEGG SLEKKPSRQV LSRSWEEREK
1310 1320 1330 1340 1350
VLAESETEGV GAIPRKKPER LVRSQEAVCP WESPDSGGLS PQLVHQESDR
1360 1370 1380 1390 1400
TGGRFVVVSK GDAHPEALPS HAAKAELCLW EMSDVGEGTS TQRVQELPEE
1410 1420 1430 1440 1450
RQKSPKKATF WGERNLGGDL VSLCPWESTD FRGPSAVSLQ APGSSGSLGS
1460 1470 1480 1490 1500
GIAEVCPWEA ENIANDKKAE VCPWELGEEL AGSDGLNPGA DGKSLPGKET
1510 1520 1530 1540 1550
PSRKGCLAES GEQTVRAKPT VPQGQESVCP WEDEAPERSS PQPDKASSKA
1560 1570 1580 1590 1600
GEKLLSHGGS QVLQVCPWEA VKPEEKQATL STAEICPWEV DGQPETRTSE
1610 1620 1630 1640 1650
HPSKGEVHKD EEKMPGRARI KAQEEAEGRI QKQEAICPWE SMAPGSTPQR
1660 1670 1680 1690 1700
DTEKAQASLQ RQGSVAGRAA EICPWEVGTE VGEERTIGAE ASEARPNDAG
1710 1720 1730 1740 1750
HASTDSGSRQ VAASAPKKSE RLGSEKEVVC PWDSLSPGDS SQQPDTPNTE
1760 1770 1780 1790 1800
KLKDELQEHG SSRPIEVCPW EAEEVPTGEK AKICPWELNE GTVGKGLERE
1810 1820 1830 1840 1850
PGCEPERQRR QNLEEAGLPF QEEGTSKGDT KLCREQEGEA ICPWKPPAQV
1860 1870 1880 1890 1900
PKVSDLPLST VGQGVEGQSL EASDRASEKG ELRQDLKMGS LPEYITQVVP
1910 1920 1930 1940 1950
VDGGGASSEL QPISLQEGMV LAGSSSHPHI QCPDQPRVSS QPLVSTGDGT
1960 1970 1980 1990 2000
AEVCPWDAPD SDSDTKVEPC AQKVTGRVTE TEMSRQDEKE KSQEEKERAP
2010 2020 2030 2040 2050
ETRDHEGVAV QKMPQTSNFG KQEAVCPRES QDFGVQAATD ASDGSKGGSE
2060 2070 2080 2090 2100
KVCPWEVEEV PSIKEAEICP WEASPGAVGE GALDLGQDGE SQGEGRAERH
2110 2120 2130 2140 2150
LLKAAETVCP LEGTMSSGLF TQEDVVDTDL PKVGLHGASS PGKGLAELCV
2160 2170 2180 2190 2200
WEVTDPEGNK IKGTMADICP WEETRAQSDE SGPLALPVTQ AGVPAAPEKS
2210 2220 2230 2240 2250
VCLSVHGPLE SFLPESKSVR PDISKPPGSS RPEGVREQEP LELETGAKSV
2260 2270 2280 2290
PKPSPTETEA PESFTLTDDQ GLMASEGEAG ELSPPPDYPW DCE
Length:2,293
Mass (Da):248,715
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB9EB2BA17CD6785
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL596088 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074689.1, NM_001081220.1
XP_006533087.1, XM_006533024.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.32622

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093942; ENSMUSP00000091474; ENSMUSG00000070337

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217143

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217143

UCSC genome browser

More...
UCSCi
uc007ldy.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596088 Genomic DNA No translation available.
RefSeqiNP_001074689.1, NM_001081220.1
XP_006533087.1, XM_006533024.1
UniGeneiMm.32622

3D structure databases

ProteinModelPortaliE9PY61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091474

PTM databases

iPTMnetiE9PY61
PhosphoSitePlusiE9PY61

Proteomic databases

jPOSTiE9PY61
PaxDbiE9PY61
PRIDEiE9PY61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093942; ENSMUSP00000091474; ENSMUSG00000070337
GeneIDi217143
KEGGimmu:217143
UCSCiuc007ldy.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440435
MGIiMGI:2443409 Gpr179

Phylogenomic databases

eggNOGiKOG4418 Eukaryota
ENOG410XXEC LUCA
GeneTreeiENSGT00940000160776
InParanoidiE9PY61
KOiK22961
OMAiNAHTSRM
OrthoDBi63351at2759
PhylomeDBiE9PY61
TreeFamiTF319114

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000070337 Expressed in 95 organ(s), highest expression level in placenta
GenevisibleiE9PY61 MM

Family and domain databases

InterProiView protein in InterPro
IPR017978 GPCR_3_C
IPR032964 GPR179
PANTHERiPTHR32546:SF7 PTHR32546:SF7, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PY61_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PY61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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