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Entry version 66 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Intraflagellar transport protein 140 homolog

Gene

Ift140

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22282595). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (PubMed:24619649).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intraflagellar transport protein 140 homolog
Alternative name(s):
WD and tetratricopeptide repeats protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ift140Imported
Synonyms:WDTC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2146906 Ift140

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Ift140 are the cause of cauliflower (cauli) phenotype, a mouse model for human asphyxiating thoracic dystrophy (Jeune syndrome). Embryos die at E13.5 and exhibit exencephaly, anophthalmia, severely disorganized ribs with extensive exostoses, vertebral and palatal defects, agenesis/hypoplasia of the craniofacial skeleton, and polydactyly of the hindlimbs. Cilia morphology in limb buds is severely disrupted with a broader and bulbous appearance.1 Publication

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice exhibit pronounced postnatal renal cyst formation and renal failure. Significant increases in expression of canonical Wnt pathway genes and mediators of Hedgehog and tissue fibrosis seen in highly cystic, but not precystic kidneys. Disrupted cilia assembly in postnatal day 5 (P5) kidneys (PubMed:22282595). Mice exhibit cone cell degeneration and opsin accumulation in the plasma membrane of the inner segments of photoreceptor cells (PubMed:24619649).2 Publications

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004410171 – 1464Intraflagellar transport protein 140 homologAdd BLAST1464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1445PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PY46

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PY46

PRoteomics IDEntifications database

More...
PRIDEi
E9PY46

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PY46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PY46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024169 Expressed in 264 organ(s), highest expression level in fetal liver hematopoietic progenitor cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PY46 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PY46 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex A (IFT-A). Interacts with TTC25.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000024983

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PY46

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 48WD 1Add BLAST45
Repeati51 – 90WD 2Add BLAST40
Repeati93 – 132WD 3Add BLAST40
Repeati139 – 188WD 4Add BLAST50
Repeati221 – 259WD 5Add BLAST39
Repeati266 – 305WD 6Add BLAST40
Repeati322 – 361WD 7Add BLAST40
Repeati772 – 808TPR 1Sequence analysisAdd BLAST37
Repeati863 – 896TPR 2Sequence analysisAdd BLAST34
Repeati902 – 935TPR 3Sequence analysisAdd BLAST34
Repeati956 – 989TPR 4Sequence analysisAdd BLAST34
Repeati1011 – 1044TPR 5Sequence analysisAdd BLAST34
Repeati1079 – 1112TPR 6Sequence analysisAdd BLAST34
Repeati1124 – 1157TPR 7Sequence analysisAdd BLAST34
Repeati1190 – 1223TPR 8Sequence analysisAdd BLAST34

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3617 Eukaryota
ENOG410XSS4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153417

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230867

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055589

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PY46

KEGG Orthology (KO)

More...
KOi
K19672

Database of Orthologous Groups

More...
OrthoDBi
41516at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105851

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PY46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALYFDHRIK APDTPSSPSH ITWHPTHPFL AVASISPSSG GNVDIYLEQG
60 70 80 90 100
EPVPDTHIER SFQATSLCWH PTRLILAIGW ETGEVIMFNK QDKEQHTVPL
110 120 130 140 150
PHTTDIAILS WSTSGSCLVS GDKLGVLLLW RLDQRGRVQG TPLLKHEYGK
160 170 180 190 200
ALTHCIFRLP PPGEDLVQLA KAAVSGDEKA LDMFNWRKSS FGSFLKTGSQ
210 220 230 240 250
EGLSFFVSLM DGTVHYVDEK GKTAQVASTD SSIQTLFYIE RREALVVVTE
260 270 280 290 300
NLLLSLYVVT PEGEAEEVMK VKLSGKTGCR ADITLIEGSL LVTAIGEPVL
310 320 330 340 350
RFWDLERGEN YILSLQEKFG FEKGESINCV CFCKAKGLLA AGTNKGRVAM
360 370 380 390 400
WKKVPSFPNG RGAEGKDMWA LQTPTELEGN ITQIKWGSRK NLLAVSSTES
410 420 430 440 450
VSILSEQAMS SHFHQQVAAV QISPSLVNVS FLSTGGTHSL HTDMHISGVF
460 470 480 490 500
ATKDAVAVWN GKQVAIFEPS GSTLRNAGTF LCETSVLAMH EESIYTVEPN
510 520 530 540 550
RLQVRTWQGT VKQLLLFSET EGSPCFLDVC GTFLVAGTDL AHFKSFDLSR
560 570 580 590 600
REAKVHCSCK NLAQLVPDVG SITSLRCNAN GNKISILLSK VNNSPDSKIY
610 620 630 640 650
IYDVEMDTVN VFNFTTGQIG QIQTLPFNEP PTNETRSFMD KSLAGYTPVN
660 670 680 690 700
HFWDQSEPRL FVCEALQEAP GAQPQAVDKQ PRVEEGTCHK EEVLILSFFA
710 720 730 740 750
SEEHGFLLHD SFPRPSTYQS LLGMEVPHYY FTKKPGEADK EDRVDSGYYH
760 770 780 790 800
IPQMVAKRPL RDFVGLEDCD KSTRDAMLNF SFFVTIGDMD EAFKSIKLIK
810 820 830 840 850
SEAVWENMAR MCVKTQRLDV AKVCLGNMGH ARGARALREA EQEPELEARV
860 870 880 890 900
AMLAIQLGML EEAEQLYKKC KRYDLLNKFY QASDQWQKAV EVAELHDRVH
910 920 930 940 950
LRTTYYNYAK HLEASADCGQ ALSYYEKSDT HRFEVPRMLS EDLQSLELYI
960 970 980 990 1000
NRMKDKTLWR WWAQYLESQA EMDTALRYYE LAQDYFSLVR IHCFQGNIQK
1010 1020 1030 1040 1050
AAEIANETGD WAASYHLARQ YESQDEVKQA VHFYTRAQAF NNAIRLCKEN
1060 1070 1080 1090 1100
GLDDQLMNLA LLSSPEDMIE AARYYEEKGE QMDRAVMLYH KAGHFSKALE
1110 1120 1130 1140 1150
LAFTTQQFAA LQLIAEDLDE KSDPALLARC SDFCIEHRQF EKAVELLLAA
1160 1170 1180 1190 1200
KKYHEALQLC LEQNMTITED MAEKMTVSKD SKDMSEESRR ELLEQIANCC
1210 1220 1230 1240 1250
MRQGNYHLAT KKYTQAGNKL KAMRALLKSG DTEKIVFFAG VSRQKEIYIM
1260 1270 1280 1290 1300
AANYLQSLDW RKEPEIMKSI ISFYTKGRAL DLLAGFYDAC AQVEIDEYQN
1310 1320 1330 1340 1350
YDKAHGALTE AYKCLSKAKT KNPLDQETKL AQLQSKMTLV KRFIQARRTY
1360 1370 1380 1390 1400
TEDPKESLRQ CELLLEEPDL DSTIRVGDVY GFLVEHHVQM EEYQMAYKYL
1410 1420 1430 1440 1450
EEMRKRLPSA NMSYYVDQRT VDTVHQGLGL LPPSRIMPER VRHNSMEDHK
1460
EVYEEVIEEV DNDP
Length:1,464
Mass (Da):165,875
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE564F9AD816950C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q682E9Q682_MOUSE
Intraflagellar transport protein 14...
Ift140
1,232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W3F6A0A3B2W3F6_MOUSE
Intraflagellar transport protein 14...
Ift140
1,421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198G → R in ABB72790 (Ref. 1) Curated1
Sequence conflicti508Q → E in ABB72790 (Ref. 1) Curated1
Sequence conflicti624T → A in ABB72790 (Ref. 1) Curated1
Sequence conflicti1051G → S in AAI39006 (PubMed:15489334).Curated1
Sequence conflicti1051G → S in ABB72790 (Ref. 1) Curated1
Sequence conflicti1304A → V in ABB72790 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti855I → K in cauli. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ266093 mRNA Translation: ABB72790.1
AC130711 Genomic DNA No translation available.
AC154229 Genomic DNA No translation available.
BC139005 mRNA Translation: AAI39006.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28505.1

NCBI Reference Sequences

More...
RefSeqi
NP_598887.3, NM_134126.3
XP_006523465.1, XM_006523402.3
XP_006523466.1, XM_006523403.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.32802

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000024983; ENSMUSP00000024983; ENSMUSG00000024169

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:106633

UCSC genome browser

More...
UCSCi
uc008azm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ266093 mRNA Translation: ABB72790.1
AC130711 Genomic DNA No translation available.
AC154229 Genomic DNA No translation available.
BC139005 mRNA Translation: AAI39006.1
CCDSiCCDS28505.1
RefSeqiNP_598887.3, NM_134126.3
XP_006523465.1, XM_006523402.3
XP_006523466.1, XM_006523403.3
UniGeneiMm.32802

3D structure databases

ProteinModelPortaliE9PY46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024983

PTM databases

iPTMnetiE9PY46
PhosphoSitePlusiE9PY46

Proteomic databases

MaxQBiE9PY46
PaxDbiE9PY46
PRIDEiE9PY46

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024983; ENSMUSP00000024983; ENSMUSG00000024169
GeneIDi106633
KEGGimmu:106633
UCSCiuc008azm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9742
MGIiMGI:2146906 Ift140

Phylogenomic databases

eggNOGiKOG3617 Eukaryota
ENOG410XSS4 LUCA
GeneTreeiENSGT00940000153417
HOGENOMiHOG000230867
HOVERGENiHBG055589
InParanoidiE9PY46
KOiK19672
OrthoDBi41516at2759
TreeFamiTF105851

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ift140 mouse

Protein Ontology

More...
PROi
PR:E9PY46

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024169 Expressed in 264 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
ExpressionAtlasiE9PY46 baseline and differential
GenevisibleiE9PY46 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF140_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PY46
Secondary accession number(s): B2RSU5, Q2XQY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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