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Protein
Submitted name:

Centromere protein F

Gene

Cenpf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Submitted name:
Centromere protein FImported
Gene namesi
Name:CenpfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1313302 Cenpf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9PY14
PeptideAtlasiE9PY14
PRIDEiE9PY14

Expressioni

Gene expression databases

BgeeiENSMUSG00000026605 Expressed in 206 organ(s), highest expression level in primary oocyte
ExpressionAtlasiE9PY14 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PY14
SMRiE9PY14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 292CENP-F_NInterPro annotationAdd BLAST292

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 131Sequence analysisAdd BLAST119
Coiled coili159 – 186Sequence analysisAdd BLAST28
Coiled coili263 – 318Sequence analysisAdd BLAST56
Coiled coili326 – 378Sequence analysisAdd BLAST53
Coiled coili408 – 466Sequence analysisAdd BLAST59
Coiled coili499 – 595Sequence analysisAdd BLAST97
Coiled coili606 – 626Sequence analysisAdd BLAST21
Coiled coili640 – 660Sequence analysisAdd BLAST21
Coiled coili693 – 720Sequence analysisAdd BLAST28
Coiled coili814 – 862Sequence analysisAdd BLAST49
Coiled coili888 – 922Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IGJF Eukaryota
ENOG410XS5F LUCA
GeneTreeiENSGT00730000111187
OMAiHHEREIL

Family and domain databases

InterProiView protein in InterPro
IPR018463 Centromere_CenpF_N
PfamiView protein in Pfam
PF10481 CENP-F_N, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PY14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK
60 70 80 90 100
QKQKVEDGKT EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ
110 120 130 140 150
ESQLSSCKKQ IEKLEQELKR CKSEFERSQQ VAQSADVSLN PCSTPQKLFA
160 170 180 190 200
TPLTPSSTYE DLKEKYNKEV EERKRLEEEV KALHAKKVSL PVSQATMNHR
210 220 230 240 250
DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH FLGEEVSPNK
260 270 280 290 300
SSMKTGRGDC SSLPDLKSKM TELELRLQGQ EKEMRSQVNK CQDLQLQLEK
310 320 330 340 350
TKVELIEKER ILNKTRDEVV RSTAQYDQAA AKCTTLEQKL KTLTEELSCH
360 370 380 390 400
RQNAESAKRS LEQRIKEKEK ELQEELSRQH QSFQALDSEY TQMKTRLTQE
410 420 430 440 450
LQQVKHLHST LQLELEKVTS VKQQLERNLE EIRLKLSRAE QALQASQVAE
460 470 480 490 500
NELRRSSEEM KKENSLIRSQ SEQRTREVCH LEEELGKVKV SLSKSQNFAE
510 520 530 540 550
EMKAKNTSQE IMLRDLQEKL NQQENSLTLE KLKLALADLE RQRNCSQDLL
560 570 580 590 600
KKREHHIDQL NNKLNKIEKE FETLLSALEL KKKECEELKE EKNQISFWKI
610 620 630 640 650
DSEKLINQIE SEKEILLGKI NHLETSLKTQ QVSPDSNERI RTLEMERENF
660 670 680 690 700
TVEIKNLQSM LDSKMVEIKT QKQAYLELQQ KSESSDQKHQ KEIENMCLKA
710 720 730 740 750
NKLTGQVESL ECKLQLLSSE VVTKDQQYQD LRMEYETLRD LLKSRGSSLV
760 770 780 790 800
TNEDNQRSSE DNQRSSEDNQ RGSLAFEQQP AVSDSFANVM GRKGSINSER
810 820 830 840 850
SDCSVDGGRS PEHIAILQNR VTSLESSLES QNQMNSDLQM RCEELLQIKG
860 870 880 890 900
EVEENLSKAE QIHQNFVAET NQCISKLQED AAVHQNIVAE TLATLESKEK
910 920 930 940 950
ELQLLKEKLE AQQTEVQKLN KNNCLLEGTL KELQLLSDTL SSEKKEMNSI

IS
Length:952
Mass (Da):110,020
Last modified:April 5, 2011 - v1
Checksum:i132EA3CD20C50D03
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3P4E9Q3P4_MOUSE
Centromere protein F
Cenpf
2,997Annotation score:
E9Q776E9Q776_MOUSE
Centromere protein F
Cenpf
88Annotation score:
F6V6F0F6V6F0_MOUSE
Centromere protein F
Cenpf
119Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei952Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140679 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000165962; ENSMUSP00000132759; ENSMUSG00000026605

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140679 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PY14
SMRiE9PY14
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9PY14
PeptideAtlasiE9PY14
PRIDEiE9PY14

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165962; ENSMUSP00000132759; ENSMUSG00000026605

Organism-specific databases

MGIiMGI:1313302 Cenpf

Phylogenomic databases

eggNOGiENOG410IGJF Eukaryota
ENOG410XS5F LUCA
GeneTreeiENSGT00730000111187
OMAiHHEREIL

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiCenpf mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026605 Expressed in 206 organ(s), highest expression level in primary oocyte
ExpressionAtlasiE9PY14 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR018463 Centromere_CenpF_N
PfamiView protein in Pfam
PF10481 CENP-F_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PY14_MOUSE
AccessioniPrimary (citable) accession number: E9PY14
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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