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Protein
Submitted name:

Integrin, alpha 10

Gene

Itga10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin, alpha 10Imported
Gene namesi
Name:Itga10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2153482 Itga10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1120 – 1144HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_500142426723 – 1166UniRule annotationAdd BLAST1144

Proteomic databases

PeptideAtlasiE9PXZ3
PRIDEiE9PXZ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000090210 Expressed in 97 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiE9PXZ3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PXZ3
SMRiE9PXZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 85FG-GAPPROSITE-ProRule annotationAdd BLAST62
Repeati95 – 154FG-GAPPROSITE-ProRule annotationAdd BLAST60
Domaini167 – 350VWFAInterPro annotationAdd BLAST184
Repeati361 – 412FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati417 – 470FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati472 – 534FG-GAPPROSITE-ProRule annotationAdd BLAST63
Repeati535 – 593FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati597 – 657FG-GAPPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00760000118782
KOiK06586

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PXZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLSIPHLL LPLALLTGLC SSFNLDEHHP RLFTGPPEAE FGYSVLQHVG
60 70 80 90 100
GGQRWMLVGA PWDGPSGDRR GDVYRCSIGG FHSAPCTKGH LGDYQLGNSS
110 120 130 140 150
QPAVNMHLGM SLLETDADGG FMACAPLWSR ACGSSVFSSG ICARVDASFR
160 170 180 190 200
PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP WSEVQTFLRR LVGRLFIDPE
210 220 230 240 250
QIQVGLVQYG ENPVHEWSLG DFRTKEEVVR AARNLSRREG RETRTAQAIM
260 270 280 290 300
VACTEGFSQS RGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
310 320 330 340 350
GIAVLGHYLR RQRDPSSFLR EIRAIASDPD ERFFFNVTDE AALTDIVDAL
360 370 380 390 400
GDRIFGLEGS RGENESSFGL EMSEIGFSIH RLQDGILFGM VGAYDWGGSV
410 420 430 440 450
LWLEEGRRLF PPQAALEDEF PPALQNHAAY LGYSVSSMLL PGGRRLFLSG
460 470 480 490 500
APRFRHRGKV IAFQLKKDGV VRVAQSLQGD QIGSYFGSEL CPLDTDKDGI
510 520 530 540 550
TNILLVAAPM FLGPQNKETG RVYVYMVGQQ NLLMLQGTLQ PDRSQDSRFG
560 570 580 590 600
FAMAALPDLN HDGFTDVAVG APLEDGHRGA LYLYHGTQTG IRPHPTQRIA
610 620 630 640 650
AVSMPQALRY FGRSVDGRLD LDGDDLVDVA VGAHGAAVLF SSQPIIHLIP
660 670 680 690 700
TLDVMPPHIS VVQKDCKRRG QEAACLTAAL CFQVVSQTPG RWDRRFYIRF
710 720 730 740 750
SASLDEWTAG ARAVFDGSGQ RLSPRQLQLS VGNVTCEQLH FHALDTSDYL
760 770 780 790 800
RPVALTVTFA LDNTTKPGPV LAEGSSTTIR KLIPFSKDCG PDNECVTDLV
810 820 830 840 850
LQADMDIRGS RKSPFVVQGG RQKVLVSATL ENKKENAYNT SLSLSFSRNL
860 870 880 890 900
HLASLTPQAK SVKVECAVPS PHTRLCTVGH PVFQTGAKVS FLLEFEFSCT
910 920 930 940 950
FLLSQVFVRL TASSSSLEMN ETLQDNTAQT SAYIRYEPHL VFSSESTLHR
960 970 980 990 1000
YEVHPYRTLP MGPGPEFKTT LRVQNLGCHV VSGLVISALL PAVAHGGNYF
1010 1020 1030 1040 1050
LSLSQVISGN ASCTVQNLTE PPGFPVHPEE LQHASRLNGS NSRCQVVRCH
1060 1070 1080 1090 1100
LGLLAKGTEI SVRLLRLVHN EFFRRAKFKS VTVVSTFKLG TEEGSVLLLN
1110 1120 1130 1140 1150
EASRSSESHL EVIQTHPTLI SLWILVGSVL GGLLLLALLV FCLWKLGFFT
1160
RKKIPKEEES EEKLEQ
Length:1,166
Mass (Da):127,764
Last modified:April 5, 2011 - v1
Checksum:iF921BF67850BFD72
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6R1E9Q6R1_MOUSE
Integrin, alpha 10
Itga10
1,167Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112261 Genomic DNA No translation available.
AC122037 Genomic DNA No translation available.
RefSeqiNP_001289400.1, NM_001302471.1
UniGeneiMm.32741

Genome annotation databases

EnsembliENSMUST00000119365; ENSMUSP00000112393; ENSMUSG00000090210
GeneIDi213119
KEGGimmu:213119
UCSCiuc012ctz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112261 Genomic DNA No translation available.
AC122037 Genomic DNA No translation available.
RefSeqiNP_001289400.1, NM_001302471.1
UniGeneiMm.32741

3D structure databases

ProteinModelPortaliE9PXZ3
SMRiE9PXZ3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PXZ3
PRIDEiE9PXZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119365; ENSMUSP00000112393; ENSMUSG00000090210
GeneIDi213119
KEGGimmu:213119
UCSCiuc012ctz.1 mouse

Organism-specific databases

CTDi8515
MGIiMGI:2153482 Itga10

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00760000118782
KOiK06586

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090210 Expressed in 97 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiE9PXZ3 baseline and differential

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PXZ3_MOUSE
AccessioniPrimary (citable) accession number: E9PXZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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