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Protein

Sodium/nucleoside cotransporter

Gene

Slc28a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/nucleoside cotransporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc28a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3605073 Slc28a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Transmembranei110 – 128HelicalUniRule annotationAdd BLAST19
Transmembranei148 – 167HelicalUniRule annotationAdd BLAST20
Transmembranei179 – 195HelicalUniRule annotationAdd BLAST17
Transmembranei202 – 222HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 283HelicalUniRule annotationAdd BLAST22
Transmembranei338 – 360HelicalUniRule annotationAdd BLAST23
Transmembranei424 – 446HelicalUniRule annotationAdd BLAST23
Transmembranei533 – 556HelicalUniRule annotationAdd BLAST24
Transmembranei568 – 592HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025726 Expressed in 15 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026820

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 255Nucleos_tra2_NInterPro annotationAdd BLAST72
Domaini264 – 360GateInterPro annotationAdd BLAST97
Domaini367 – 590Nucleos_tra2_CInterPro annotationAdd BLAST224

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3747 Eukaryota
COG1972 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016025

KEGG Orthology (KO)

More...
KOi
K11536

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRWIVQT

Database of Orthologous Groups

More...
OrthoDBi
471043at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10590 PTHR10590, 1 hit
PTHR10590:SF16 PTHR10590:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00804 nupC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9PXX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDTPRQRE SISLTPVAHG LENMGAEFLE IMEEGQLPHR HSSLPEGGGS
60 70 80 90 100
RSKAVWKPFS RWRSLQPTVQ ARSLCREHWQ LFEWISKGLL STAYIGFLIV
110 120 130 140 150
ACLLDFPRAL ALFVITCVVL VFLAYNLLKR LLGSKLKKCV KFQGHSCLSL
160 170 180 190 200
WLKRGLALAA GLGVILWLSL DTAQRPEQLV SFAGICVFLV LLFAGSKHHR
210 220 230 240 250
AVSWRAVSWG LGLQFVLGLF VIRTEPGFVA FQWLGDQIRV FLSYTEAGSS
260 270 280 290 300
FVFGEALVKD VFAFQVLPII VFFSCVMSVL YYLGLMQWVI LKIAWLMQVT
310 320 330 340 350
MGTSATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA
360 370 380 390 400
GSLLGAYISF GIDASSLIAA SVMAAPCALA LSKLVYPEVE ESKFRSEEGV
410 420 430 440 450
KLTYGDAQNL VEAASAGAAI SVKVVANIAA NLIAFLAVLA FINAALSWLG
460 470 480 490 500
DMVDIQGLSF QLICSYVLRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA
510 520 530 540 550
YQELSQYKQR RLAGAEEWLG DKKQWISVRA EILTTYALCG FANFSSIGIM
560 570 580 590 600
LGGLTSMVPQ RRSDFSQIVL RALITGAFVS LVNACVAGIL YVPRGVEVDC
610 620 630 640
MSLLNQTVSS SSFEVYLCCR QVFQNTSLEF GQEALHNCCR FYNHTVCT
Length:648
Mass (Da):71,174
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC32DCEA9133147E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC109220 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001004184.2, NM_001004184.3
XP_006541039.1, XM_006540976.3
XP_006541040.1, XM_006540977.3
XP_006541041.1, XM_006540978.3
XP_006541042.1, XM_006540979.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.389909

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026820; ENSMUSP00000026820; ENSMUSG00000025726
ENSMUST00000119083; ENSMUSP00000112421; ENSMUSG00000025726

Database of genes from NCBI RefSeq genomes

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GeneIDi
434203

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:434203

UCSC genome browser

More...
UCSCi
uc009ibs.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109220 Genomic DNA No translation available.
RefSeqiNP_001004184.2, NM_001004184.3
XP_006541039.1, XM_006540976.3
XP_006541040.1, XM_006540977.3
XP_006541041.1, XM_006540978.3
XP_006541042.1, XM_006540979.3
UniGeneiMm.389909

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026820

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026820; ENSMUSP00000026820; ENSMUSG00000025726
ENSMUST00000119083; ENSMUSP00000112421; ENSMUSG00000025726
GeneIDi434203
KEGGimmu:434203
UCSCiuc009ibs.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9154
MGIiMGI:3605073 Slc28a1

Phylogenomic databases

eggNOGiKOG3747 Eukaryota
COG1972 LUCA
GeneTreeiENSGT00390000016025
KOiK11536
OMAiHRWIVQT
OrthoDBi471043at2759
TreeFamiTF314131

Enzyme and pathway databases

ReactomeiR-MMU-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025726 Expressed in 15 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PTHR10590:SF16 PTHR10590:SF16, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PXX9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PXX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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