UniProtKB - E9PXW9 (E9PXW9_MOUSE)
Protein
Submitted name:
Transcription factor GATA-4
Gene
Gata4
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- activating transcription factor binding Source: Ensembl
- co-SMAD binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- NFAT protein binding Source: Ensembl
- protein kinase binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II transcription factor binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- aortic valve morphogenesis Source: Ensembl
- atrial septum secundum morphogenesis Source: Ensembl
- cell growth involved in cardiac muscle cell development Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- endocardial cushion development Source: Ensembl
- intestinal epithelial cell differentiation Source: Ensembl
- male gonad development Source: Ensembl
- negative regulation of autophagy Source: Ensembl
- positive regulation of BMP signaling pathway Source: Ensembl
- regulation of cardiac muscle cell contraction Source: Ensembl
- response to drug Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to vitamin A Source: Ensembl
- transdifferentiation Source: Ensembl
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor GATA-4Imported |
Gene namesi | Name:Gata4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95664, Gata4 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nuclear body Source: Ensembl
- RNA polymerase II transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | E9PXW9 |
PeptideAtlasi | E9PXW9 |
PRIDEi | E9PXW9 |
ProteomicsDBi | 345384 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021944, Expressed in duodenum and 135 other tissues |
ExpressionAtlasi | E9PXW9, baseline and differential |
Interactioni
GO - Molecular functioni
- activating transcription factor binding Source: Ensembl
- co-SMAD binding Source: Ensembl
- NFAT protein binding Source: Ensembl
- protein kinase binding Source: Ensembl
- RNA polymerase II transcription factor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 265 | GATA-typeInterPro annotationAdd BLAST | 55 | |
Domaini | 265 – 318 | GATA-typeInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 107 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 314 – 393 | DisorderedSequence analysisAdd BLAST | 80 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 60 – 90 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 340 – 364 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 373 – 393 | PolarSequence analysisAdd BLAST | 21 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158349 |
OMAi | KMSPGGH |
OrthoDBi | 807790at2759 |
TreeFami | TF315391 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR008013, GATA_N IPR016375, TF_GATA_4/5/6 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits PF05349, GATA-N, 1 hit |
PIRSFi | PIRSF003028, TF_GATA_4/5/6, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PXW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG
60 70 80 90 100
LSYLQGGGSA AAAGTTSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT
110 120 130 140 150
PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYGSGGGAAG AGLAGREQYG
160 170 180 190 200
RPGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPGR
210 220 230 240 250
HPNLVDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA CGLYHKMNGI
260 270 280 290 300
NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK
310 320 330 340 350
LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAGPAGETLP PSSGASSGNS
360 370 380 390 400
SNATSSSSSS EEMRPIKTEP GLSSHYGHSS SMSQTFSTVS GHGPSIHPVL
410 420 430 440
SALKLSPQGY ASPVTQTSQA SSKQDSWNSL VLADSHGDII TA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ08369 | GATA4_MOUSE | Transcription factor GATA-4 | Gata4 Gata-4 | 441 | Annotation score: | ||
Q3UYJ1 | Q3UYJ1_MOUSE | Transcription factor GATA-4 | Gata4 | 236 | Annotation score: | ||
A4K4Z6 | A4K4Z6_MOUSE | Transcription factor GATA-4 | Gata4 gata4 | 11 | Annotation score: | ||
D3YTQ2 | D3YTQ2_MOUSE | Transcription factor GATA-4 | Gata4 | 15 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090654 Genomic DNA No translation available. AC090962 Genomic DNA No translation available. |
RefSeqi | NP_001297539.1, NM_001310610.1 XP_011243258.1, XM_011244956.2 XP_011243259.1, XM_011244957.2 |
Genome annotation databases
Ensembli | ENSMUST00000067417; ENSMUSP00000066927; ENSMUSG00000021944 |
GeneIDi | 14463 |
UCSCi | uc007uho.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090654 Genomic DNA No translation available. AC090962 Genomic DNA No translation available. |
RefSeqi | NP_001297539.1, NM_001310610.1 XP_011243258.1, XM_011244956.2 XP_011243259.1, XM_011244957.2 |
3D structure databases
SMRi | E9PXW9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9PXW9 |
PeptideAtlasi | E9PXW9 |
PRIDEi | E9PXW9 |
ProteomicsDBi | 345384 |
Protocols and materials databases
Antibodypediai | 3405, 741 antibodies |
DNASUi | 14463 |
Genome annotation databases
Ensembli | ENSMUST00000067417; ENSMUSP00000066927; ENSMUSG00000021944 |
GeneIDi | 14463 |
UCSCi | uc007uho.1, mouse |
Organism-specific databases
CTDi | 2626 |
MGIi | MGI:95664, Gata4 |
Phylogenomic databases
GeneTreei | ENSGT00940000158349 |
OMAi | KMSPGGH |
OrthoDBi | 807790at2759 |
TreeFami | TF315391 |
Miscellaneous databases
BioGRID-ORCSi | 14463, 3 hits in 53 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021944, Expressed in duodenum and 135 other tissues |
ExpressionAtlasi | E9PXW9, baseline and differential |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR008013, GATA_N IPR016375, TF_GATA_4/5/6 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits PF05349, GATA-N, 1 hit |
PIRSFi | PIRSF003028, TF_GATA_4/5/6, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PXW9_MOUSE | |
Accessioni | E9PXW9Primary (citable) accession number: E9PXW9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |